BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0450.0026.p (699 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yheH [V] COG1132 ABC-type multidrug transport system, ATPase ... 788 0.0 lin1691 [V] COG1132 ABC-type multidrug transport system, ATPase ... 436 e-122 SP1839 [V] COG1132 ABC-type multidrug transport system, ATPase a... 405 e-113 L102979 [V] COG1132 ABC-type multidrug transport system, ATPase ... 369 e-101 CAC2756 [V] COG1132 ABC-type multidrug transport system, ATPase ... 362 1e-99 >BS_yheH [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 673 Score = 788 bits (2036), Expect = 0.0, Method: Compositional matrix adjust. Identities = 384/667 (57%), Positives = 513/667 (76%), Gaps = 12/667 (1%) Query: 9 GKRLLQYALTAKKTFIAALLLLSIGVAAELAGPFIAKSMIDNHMLAIEKPYFQTSSSEE- 67 GK L +YAL +K I A+LLL++ V AEL GPFI K MID+H+L IEK +++ + ++ Sbjct: 4 GKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGIEKTWYEAAEKDKN 63 Query: 68 AAEYKNAYYKRGDRFAPDEAKGQEIRLLQAGKSFYFINMPVAQPEGERTFREGKLHIQRG 127 A ++ Y R DR +K +E + Q G +FYF++ V+ +G RT +GKL I G Sbjct: 64 AVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQAVS-FDGNRTVSDGKLTITNG 122 Query: 128 DTEAVYPAVKLSADELFSFYKPELPGIYELVGLYALFLVISIFAEFGKTYWLQSSANQVI 187 D Y A KL+ ELF FY+PE+ G+ L+ LY LV S+F ++G+ Y LQ SAN++I Sbjct: 123 DKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLLVFSVFFQYGQHYLLQMSANRII 182 Query: 188 RKLRTDVYAHIQRLPVYFFDNLPAGKVVSRVTNDTEAVKDLFIAVLSNFSTGIINIIGVY 247 +K+R DV++HIQ++P+ +FDNLPAGKVV+R+TNDTEA++DL++ VLS F T I + G++ Sbjct: 183 QKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIF 242 Query: 248 VALFLLDIRLGLVSLFIVPIVILWIVLYRKIATKYNTIIRSRLSEINAIINESIQGMSII 307 ALFLLD++L V L IVPI+ LW V+YR+ A+ YN IRS S+INA +NESIQGM+II Sbjct: 243 TALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMTII 302 Query: 308 RIFRRQKQSTEEFEKLNDDYLKYQNKMLNLNAFTSHNLVNSLRSLSFVLVLWYFGFGSLD 367 + FR QK++ EFE+LN+ + +QN+MLNLN+ SHNLVN +R+L+FV ++W+FG SL+ Sbjct: 303 QAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFVCLIWHFGGASLN 362 Query: 368 GSTFVSLGVLYAFVDVLGRMFQPITGMVNQLANLDSSMVSAGRVFTLM-----DEPGEPV 422 + VS+GVLYAFVD L R+FQPITG+VNQ + L+ + VSAGRVF L+ +E GEP Sbjct: 363 AAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELARVSAGRVFELLEEKNTEEAGEPA 422 Query: 423 TDGTMPRYKGNVVFKDVSFAYKK-DFVLKNISFEARPGETVALVGHTGSGKSSIINLLFR 481 + R G V F+DVSFAY++ + VLK+ISF A+ GETVALVGHTGSGKSSI+NLLFR Sbjct: 423 KE----RALGRVEFRDVSFAYQEGEEVLKHISFTAQKGETVALVGHTGSGKSSILNLLFR 478 Query: 482 FYDPQRGTITIDGQEVKSIPKQWLRSHMGIVLQDPYLFTGTIASNVSLGDERISRERVER 541 FYD Q+G + IDG+ + ++ +Q LRSHMGIVLQDPYLF+GTI SNVSL DER++ E ++ Sbjct: 479 FYDAQKGDVLIDGKSIYNMSRQELRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKN 538 Query: 542 ALQEVGADKLLAHLPHGFDEPVVEKGSTLSAGQRQLISFARALSFDPAILILDEATSNID 601 AL++VGA+ LL LP G +EPV+EKGSTLS+G+RQLISFARAL+FDPAILILDEAT++ID Sbjct: 539 ALRQVGAEPLLKKLPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDEATAHID 598 Query: 602 TETESLIQDALEVLKKGRTTFIIAHRLSTIRSADQILVLHHGEIVERGSHDELMALGGRY 661 TETE++IQ AL+V+K+GRTTF+IAHRLSTIR+ADQILVL GEIVERG+H+ELMAL G+Y Sbjct: 599 TETEAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEELMALEGQY 658 Query: 662 FRMYQLQ 668 ++MY+LQ Sbjct: 659 YQMYELQ 665 >lin1691 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 601 Score = 436 bits (1122), Expect = e-122, Method: Compositional matrix adjust. Identities = 229/496 (46%), Positives = 329/496 (66%), Gaps = 8/496 (1%) Query: 178 WLQSSANQVIRKLRTDVYAHIQRLPVYFFDNLPAGKVVSRVTNDTEAVKDLFIAVLSNFS 237 + Q A ++++++R D++ + L + +FD PAG +VSRVTNDTEAVKD+FI VLS Sbjct: 99 YFQKIALEIVQQMRIDIFTKLHSLGMRYFDKTPAGSIVSRVTNDTEAVKDMFINVLSTAI 158 Query: 238 TGIINIIGVYVALFLLDIRLGLVSLFIVPIVILWIVLYRKIATKYNTIIRSRLSEINAII 297 + ++G+Y A+F L+++L L SL + P+++ I +YRK ++++ R +LS++NA I Sbjct: 159 QSLFMLVGIYAAMFALNVQLALYSLLLFPLIVFIIFVYRKYSSQFYRARREKLSQLNAKI 218 Query: 298 NESIQGMSIIRIFRRQKQSTEEFEKLNDDYLKYQNKMLNLNAFTSHNLVNSLRSLSFVLV 357 ESI GMSI++ F ++++ +EFE +N DY K + NA ++ + +L+ V++ Sbjct: 219 AESISGMSIVQQFNQERRLVKEFEHINKDYYDVGMKNIKFNALLLGPAIDLIYALAVVII 278 Query: 358 LWYFGFGSLDGSTFVSLGVLYAFVDVLGRMFQPITGMVNQLANLDSSMVSAGRVFTLMDE 417 L +FG SL G V++G +YAFV R + I ++ +LA ++ +A RVF +MDE Sbjct: 279 LSFFGAESLTGP--VAIGTIYAFVSYFDRFLEAIYNVMERLAMYQEAITAASRVFRIMDE 336 Query: 418 PGEPVTDGTMPRYK---GNVVFKDVSFAYK--KDFVLKNISFEARPGETVALVGHTGSGK 472 E P K + FKDVSFAY+ +D VLKNISF A PG+TVALVGHTGSGK Sbjct: 337 TEEVPAQLNDPEAKITRAKIEFKDVSFAYEGGRD-VLKNISFTAEPGQTVALVGHTGSGK 395 Query: 473 SSIINLLFRFYDPQRGTITIDGQEVKSIPKQWLRSHMGIVLQDPYLFTGTIASNVSLGDE 532 SSIINL+ RFY+ +RG I IDG+ +KS LR G+VLQD ++F G I +N+ L D+ Sbjct: 396 SSIINLMMRFYEFERGDILIDGKSIKSHEIAELRKKTGLVLQDSFMFYGDINTNIRLYDK 455 Query: 533 RISRERVERALQEVGADKLLAHLPHGFDEPVVEKGSTLSAGQRQLISFARALSFDPAILI 592 I+ E++ A + V AD + L + V+E+G++ S+GQRQLISFAR + +P IL+ Sbjct: 456 NITDEQIVDAAKFVQADGFIQTLSDQYQHKVIERGASFSSGQRQLISFARTVVTNPQILV 515 Query: 593 LDEATSNIDTETESLIQDALEVLKKGRTTFIIAHRLSTIRSADQILVLHHGEIVERGSHD 652 LDEAT+NIDTETESLIQ L+ +++GRTT IAHRLSTI+ AD ILVL G I+ERG+HD Sbjct: 516 LDEATANIDTETESLIQTGLKRMREGRTTIAIAHRLSTIKDADLILVLSKGRIIERGTHD 575 Query: 653 ELMALGGRYFRMYQLQ 668 L+A G Y MYQLQ Sbjct: 576 SLIAEQGVYHSMYQLQ 591 >SP1839 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 583 Score = 405 bits (1042), Expect = e-113, Method: Compositional matrix adjust. Identities = 214/515 (41%), Positives = 340/515 (66%), Gaps = 7/515 (1%) Query: 157 LVGLYALFLVISIFAEFGKTYWLQSSANQVIRKLRTDVYAHIQRLPVYFFDNLPAGKVVS 216 L+ Y L+++ ++ G + + S + ++R +R D +A++++L + +FD PAG +VS Sbjct: 65 LLVYYGLYILQTVVQYVGNLLFARVSYS-IVRDIRRDAFANMEKLGMSYFDKTPAGSIVS 123 Query: 217 RVTNDTEAVKDLFIAVLSNFSTGIINIIGVYVALFLLDIRLGLVSLFIVPIVILWIVLYR 276 R+TNDTE + D+F +LS+F + + + + +LD RL + L +P++ L + LYR Sbjct: 124 RLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVLDFRLTALVLLFLPLIFLLVNLYR 183 Query: 277 KIATKYNTIIRSRLSEINAIINESIQGMSIIRIFRRQKQSTEEFEKLNDDYLKYQNKMLN 336 K + K RS LS+IN+ + E+I+G+ II+ F ++K+ EF+++N ++L Y N+ + Sbjct: 184 KKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFNQEKRLQAEFDEINQEHLVYANRSVA 243 Query: 337 LNAFTSHNLVNSLRSLSFVLVLWYFGFGSLDGSTFVSLGVLYAFVDVLGRMFQPITGMVN 396 L+A ++ L+ L + +++ YFG+ S +++G +YAF+ + R+F P+ + Sbjct: 244 LDALFLRPAMSLLKLLGYAVLMAYFGYRGF--SIGITVGTMYAFIQYINRLFDPLIEVTQ 301 Query: 397 QLANLDSSMVSAGRVFTLMDEPG-EPVTD-GTMPRYKGNVVFKDVSFAYK-KDFVLKNIS 453 + L ++MVSAGRVF L+DE EP+ + G +GN+ F+ V F+Y K +L +IS Sbjct: 302 NFSTLQTAMVSAGRVFALIDERTYEPLQENGQAKVQEGNIRFEHVCFSYDGKHPILDDIS 361 Query: 454 FEARPGETVALVGHTGSGKSSIINLLFRFYDPQRGTITIDGQEVKSIPKQWLRSHMGIVL 513 F GET+A VGHTGSGKSSIIN+L RFY+ Q G + +D +++ ++ LR ++G+VL Sbjct: 362 FSVNKGETIAFVGHTGSGKSSIINVLMRFYEFQSGRVLLDDVDIRDFSQEELRKNIGLVL 421 Query: 514 QDPYLFTGTIASNVSLGDERISRERVERALQEVGADKLLAHLPHGFDEPVVEKGSTLSAG 573 Q+P+L+ GTI SN+++ E S E+V+ A V AD + LP G+D PV E+GS+ S G Sbjct: 422 QEPFLYHGTIKSNIAMYQE-TSDEQVQAAAAFVDADSFIQELPQGYDSPVSERGSSFSTG 480 Query: 574 QRQLISFARALSFDPAILILDEATSNIDTETESLIQDALEVLKKGRTTFIIAHRLSTIRS 633 QRQL++FAR ++ P ILILDEAT+NID+ETESL+Q +L +++GRTT IAHRLSTI+ Sbjct: 481 QRQLLAFARTVASQPKILILDEATANIDSETESLVQASLAKMRQGRTTIAIAHRLSTIQD 540 Query: 634 ADQILVLHHGEIVERGSHDELMALGGRYFRMYQLQ 668 A+ I VL G I+E G+H+EL+ALGG Y +MY LQ Sbjct: 541 ANCIYVLDKGRIIESGTHEELLALGGTYHKMYSLQ 575 >L102979 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 608 Score = 369 bits (947), Expect = e-101, Method: Compositional matrix adjust. Identities = 216/537 (40%), Positives = 342/537 (63%), Gaps = 26/537 (4%) Query: 154 IYELVGLYALFLVISIFAEFGKTYWLQSSANQVIRKLRTDVYAHIQRLPVYFFDNLPAGK 213 I+ GLY + +I+ A F K +LQ+ + V + +R VY I +L + +FD P G Sbjct: 70 IFYFAGLYLILAIINSIAFFFKWNYLQNGSIFVNQYIRKKVYRKIHQLGMRYFDQKPTGW 129 Query: 214 VVSRVTNDTEAVKDLFIAVLSNFSTGIINIIGVYVALFLLDIRLGLVSLFIVPIVILWIV 273 +++R+TNDT+ F L N T +++II ++ALF++D ++ LV L I+P++IL ++ Sbjct: 130 LITRITNDTDLFD--FWQTLFNALTSLLSIIIAFIALFIIDHQIALVMLLILPLLILAVL 187 Query: 274 LYRKIATKYNTIIRSRLSEINAIINESIQGMSIIRIFRRQKQSTEEFEKLNDDYLKYQNK 333 +Y+K++TK + ++ SE+N +NE I GM II+ FR++ + EFEK ND+Y Y+ + Sbjct: 188 IYQKVSTKVYQAMLAKRSELNTKLNEYISGMRIIQQFRQESRLGNEFEKTNDEYYGYRKR 247 Query: 334 MLNLNAFTSHNLVNSLRSLSFVLVLWYFGFGSLDGSTFVSLGVLYAFVDVLGRMFQPITG 393 ++ +N LVN L ++S V+VL + SL V G++YAF+ + F PI+G Sbjct: 248 VIQINGILLSPLVNFLMAISIVVVLLMYSNRSLHA--VVEAGLIYAFISNVQIYFNPISG 305 Query: 394 MVNQLANLDSSMVSAGRVFTLMDE----PGEPVTDGTMPRY-----------------KG 432 +++ L+N + +V++ R+ T+M+E P + ++ +G Sbjct: 306 LMDSLSNFSNGLVASSRIKTIMEEKEFAPQQGISTSVSKNVDEKFTDRKSVSNSPIIQEG 365 Query: 433 NVVFKDVSFAYKKDF-VLKNISFEARPGETVALVGHTGSGKSSIINLLFRFYDPQRGTIT 491 + F++VSF+Y + VLKNISF PGET+A VGHTGSGKSSIIN+ RFY+ G + Sbjct: 366 KIEFRNVSFSYDGEHQVLKNISFIVNPGETLAFVGHTGSGKSSIINVFMRFYEFTEGQVL 425 Query: 492 IDGQEVKSIPKQWLRSHMGIVLQDPYLFTGTIASNVSLGDERISRERVERALQEVGADKL 551 ID Q+++S K+ LR +G+VLQD ++F ++ N+ + + +I+ + + A + V ADK Sbjct: 426 IDDQDIRSYSKEELRKKIGLVLQDSFMFVASVTDNIKMMNPQITDQAAKEAARFVQADKF 485 Query: 552 LAHLPHGFDEPVVEKGSTLSAGQRQLISFARALSFDPAILILDEATSNIDTETESLIQDA 611 + L +G++ V+E G+ SAG+RQLI+FAR + +P IL+LDEAT+NIDTETE+LIQ+ Sbjct: 486 IKDLENGYETKVIEGGAAFSAGERQLINFARTIVRNPKILLLDEATANIDTETEALIQEG 545 Query: 612 LEVLKKGRTTFIIAHRLSTIRSADQILVLHHGEIVERGSHDELMALGGRYFRMYQLQ 668 L +++ RTT IAHRLSTI+ ADQILVL+ GEI+ERG+HD+L+ L G Y MY++Q Sbjct: 546 LINMRQNRTTMAIAHRLSTIKDADQILVLNKGEIIERGNHDQLLELNGYYADMYRIQ 602 >CAC2756 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 592 Score = 362 bits (929), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 205/534 (38%), Positives = 331/534 (61%), Gaps = 14/534 (2%) Query: 136 VKLSADELFSFYKPELPGIYELVGL-YALFLVISI--FAEFGKTYWLQSSANQVIRKLRT 192 +K+S D+ F K G Y + + + F V+++ F + + S+A +++ LR+ Sbjct: 54 LKVSIDD-FLVGKRVQSGFYSISSMGFLYFGVVALGGFFSISEANLINSAAQSIMKGLRS 112 Query: 193 DVYAHIQRLPVYFFDNLPAGKVVSRVTNDTEAVKDLFIAVLSNFSTGIINIIGVYVALFL 252 V+ IQ LP+ + D +G +++R TND EA+ +++ V+ + I ++G+ A+ Sbjct: 113 SVFKTIQLLPLSYLDKTSSGSLITRATNDVEALSEMYTDVIISLFQDIFLLLGIIYAMLS 172 Query: 253 LDIRLGLVSLFIVPIVILWIVLYRKIATKYN-TIIRSRLSEINAIINESIQGMSIIRIFR 311 L+I L L+S ++PI + ++V K K N ++S + +IN + E++ GM +++IF Sbjct: 173 LNIELSLISFSVIPI-MFFLVFSLKTRIKRNFAKMKSLIGKINGFMAENLSGMKLVQIFT 231 Query: 312 RQKQSTEEFEKLNDDYLKYQNKMLNLNAFTSHNLVNSLRSLSFVLVLWYFGFGSLDGSTF 371 +K+ EF+ LN++Y + LN+ N ++LS L+LWY G + T Sbjct: 232 AEKEKRREFKALNNEYFNATLFQVRLNSIL-RPASNVFQNLSIALLLWY-GMAKIANHT- 288 Query: 372 VSLGVLYAFVDVLGRMFQPITGMVNQLANLDSSMVSAGRVFTLMDEP--GEPVTDGT-MP 428 + +GVLYAF + + F PI+ + + + S++VSA R+F L+D+ E + G M Sbjct: 289 IQIGVLYAFTSYIRQFFDPISDLADSYTTIQSALVSADRIFELLDKKIILEDLHKGIPMK 348 Query: 429 RYKGNVVFKDVSFAY-KKDFVLKNISFEARPGETVALVGHTGSGKSSIINLLFRFYDPQR 487 + +G+V FKDV F+Y K+F+LK ++F+ GET A VG TG+GK++II+L+ FY Q+ Sbjct: 349 KIEGDVEFKDVWFSYDNKNFILKGLNFKINKGETAAFVGETGAGKTTIISLISGFYKVQK 408 Query: 488 GTITIDGQEVKSIPKQWLRSHMGIVLQDPYLFTGTIASNVSLGDERISRERVERALQEVG 547 G I IDG + SI LR ++ +VLQD +LF+G I SN++L D + + + A++ Sbjct: 409 GEILIDGVNINSIRPSDLRKNVAVVLQDVFLFSGNIKSNITLND-FVPEDVINSAVEASF 467 Query: 548 ADKLLAHLPHGFDEPVVEKGSTLSAGQRQLISFARALSFDPAILILDEATSNIDTETESL 607 A + LP+ +EPV+E+G T SAGQ+QL+SFARA++ P+I +LDEAT+NIDT TE L Sbjct: 468 AKDFIEKLPNKLNEPVMERGKTFSAGQKQLLSFARAIAHTPSIFVLDEATANIDTYTEKL 527 Query: 608 IQDALEVLKKGRTTFIIAHRLSTIRSADQILVLHHGEIVERGSHDELMALGGRY 661 IQ A+E + + +TTFIIAHRLSTIR+AD+ILV+ +G+IVE G+H+ELM G Y Sbjct: 528 IQKAIENITRDKTTFIIAHRLSTIRNADKILVIDNGKIVEMGNHNELMKKDGYY 581 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.322 0.138 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 48,026,304 Number of extensions: 2007388 Number of successful extensions: 20456 Number of sequences better than 1.0e-05: 2001 Number of HSP's gapped: 18058 Number of HSP's successfully gapped: 2144 Length of query: 699 Length of database: 38,378,431 Length adjustment: 113 Effective length of query: 586 Effective length of database: 25,345,689 Effective search space: 14852573754 Effective search space used: 14852573754 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 119 (50.4 bits)