BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0450.0002.p
         (343 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BH3794 [T] COG2206 HD-GYP domain                                      209   6e-54
CAC0277 [T] COG2206 HD-GYP domain                                     162   7e-40
BH0008 [T] COG2206 HD-GYP domain                                      160   3e-39
CAC2620 [T] COG2206 HD-GYP domain                                     155   8e-38
RSc2515 [T] COG2206 HD-GYP domain                                     140   2e-33

>BH3794 [T] COG2206 HD-GYP domain
          Length = 231

 Score =  209 bits (532), Expect = 6e-54,   Method: Compositional matrix adjust.
 Identities = 102/212 (48%), Positives = 139/212 (65%)

Query: 118 ALQTKDDYTYRHNVAVGILSTLLGKWLKLDPEELGMLTIAATLHDIGKIMIPAEILTKPG 177
            ++ KDDYTYRH V V ILS L+G WLKLD   L  LT+ A LHDIGK+ IP  IL KPG
Sbjct: 3   VIKAKDDYTYRHTVGVSILSRLIGTWLKLDEVILKELTLGAVLHDIGKVEIPDAILNKPG 62

Query: 178 PLTDEEFDIMKKHTTHGYELVRDTPGTTHMQALVALQHHERMDGSGYPFGVLGHRITDFS 237
            LT +E+ I++ HT  GY +++++   +   AL+AL+HHER DG+GYP+    + I   S
Sbjct: 63  ALTKDEYRIIQDHTVKGYRIIQESGIYSDTVALMALEHHEREDGTGYPYQKTRNEIHLLS 122

Query: 238 KIVAVTDIFHAMTSDRFYSEAAPLYEVLTQMEDYSFGKLDPYICGVFISKLMQSMIGNEV 297
           KI+AV D+FHAMTSDR Y +   LY+VL QM    FGKL+P I   F+ + M+  IG++ 
Sbjct: 123 KILAVADVFHAMTSDRIYRKGMALYDVLLQMRQDRFGKLEPRITDFFVRRFMEQCIGSKA 182

Query: 298 LLTDGRMGKIIMILAHDPLRPLVNIGEDFIDL 329
            L DG   +I+ I   +P+ P+V  G ++IDL
Sbjct: 183 RLNDGSRVEIVFIPYENPICPIVKQGTNYIDL 214


>CAC0277 [T] COG2206 HD-GYP domain
          Length = 372

 Score =  162 bits (410), Expect = 7e-40,   Method: Compositional matrix adjust.
 Identities = 90/217 (41%), Positives = 127/217 (58%), Gaps = 1/217 (0%)

Query: 106 VSEKNDFFGILAALQTKDDYTYRHNVAVGILSTLLGKWLKLDPEELGMLTIAATLHDIGK 165
           +S+KN   G L  +++ DDYTY+H+V V ++S ++G  LK    EL  L I A LHD+GK
Sbjct: 121 LSQKNVMIG-LVDIKSFDDYTYQHSVNVAVISLIIGIKLKFHKYELFDLCIGALLHDVGK 179

Query: 166 IMIPAEILTKPGPLTDEEFDIMKKHTTHGYELVRDTPGTTHMQALVALQHHERMDGSGYP 225
           + IP+EIL K G LT+EEF IMK+HT  GY+ ++     +    +++LQHHER  G GYP
Sbjct: 180 MFIPSEILNKKGELTEEEFKIMKEHTVRGYDYLKGLYEISVPARIISLQHHERAGGQGYP 239

Query: 226 FGVLGHRITDFSKIVAVTDIFHAMTSDRFYSEAAPLYEVLTQMEDYSFGKLDPYICGVFI 285
            G  G RI+  S+IVAV D++ AMTSDR Y  A    E L  +   S  K D  +   F 
Sbjct: 240 EGRSGERISILSRIVAVADVYDAMTSDRVYRRAIAPNEALEYIMANSGSKFDYKVVQAFS 299

Query: 286 SKLMQSMIGNEVLLTDGRMGKIIMILAHDPLRPLVNI 322
             ++    G+ V L++  +G +  I    PLRP + I
Sbjct: 300 KSVIPYPEGSIVRLSNNEIGVVTKIHEDFPLRPEIKI 336


>BH0008 [T] COG2206 HD-GYP domain
          Length = 360

 Score =  160 bits (405), Expect = 3e-39,   Method: Compositional matrix adjust.
 Identities = 87/235 (37%), Positives = 129/235 (54%), Gaps = 1/235 (0%)

Query: 99  VIPFIQQVSEKNDFFGILAALQTKDDYTYRHNVAVGILSTLLGKWLKLDPEELGMLTIAA 158
           ++P  +++ EK D    L    TK+DY Y H V+VG+LS  LG  L  +  E   + +A 
Sbjct: 115 LLPLFEEIVEKKDVLLQLHHYSTKEDYLYHHAVSVGLLSAFLGAKLGYEKGEWLKIALAG 174

Query: 159 TLHDIGKIMIPAEILTKPGPLTDEEFDIMKKHTTHGYELVRDTPGTTHMQALVALQHHER 218
            L D G   +P  +LTK G  T +E   M+ H  + Y++++  P          LQHHER
Sbjct: 175 ALADCGMAKLPTSLLTKNGLYTLKEKHEMRDHPKYSYQMLKKRPEIDGSLLSAVLQHHER 234

Query: 219 MDGSGYPFGVLGHRITDFSKIVAVTDIFHAMTSDRFYSEAAPLYEVLTQMEDYSFGKLDP 278
            DG+GYP GV G +I  +++I+AV D++HAM S+R Y +    Y VL  +    FGK +P
Sbjct: 235 EDGTGYPLGVRGQKIHFYAQILAVADVYHAMISERKYRKKKSPYMVLEDLAKERFGKFNP 294

Query: 279 YICGVFISKLMQSMIGNEVLLTDGRMGKIIMILAHDPLRPLVNIGE-DFIDLSKN 332
            I  V +S+L Q  +   V LT+ R+G+I+ I    P RP+V +   + I L KN
Sbjct: 295 RIVHVLVSQLTQLSVRTSVRLTNNRLGEIVFIDPMAPTRPMVQLQTGEMIYLMKN 349


>CAC2620 [T] COG2206 HD-GYP domain
          Length = 345

 Score =  155 bits (393), Expect = 8e-38,   Method: Compositional matrix adjust.
 Identities = 91/280 (32%), Positives = 150/280 (53%), Gaps = 13/280 (4%)

Query: 65  QLAVDDCTAAMENIFDQLRYTKSKRLPMLELKNEVIPFIQQVSEKNDFFGILAA---LQT 121
           + ++++ ++ +E+IF+ +   KS  +  L        F Q+V  + +  G++        
Sbjct: 75  EYSLNEFSSNLEDIFNDIDNLKSNGISSLR------NFSQKVQGEFESAGLVIKNIIFYG 128

Query: 122 KDDYTYRHNVAVGILSTLLGKWLKLDPEELGMLTIAATLHDIGKIMIPAEILTKPGPLTD 181
             +  YRH+V V  +S +LGKWL ++ EE+ +LT A+ LHD GK  +   IL K   LT 
Sbjct: 129 SKNNIYRHSVNVAAISFILGKWLGMNEEEINLLTYASLLHDFGKTQLDNSILKKESSLTP 188

Query: 182 EEFDIMKKHTTHGYELVRDTPGTTHMQALVALQHHERMDGSGYPFGVLGHRITDFSKIVA 241
           EE+ + K H    Y L+++ P       L  L HHE++DGSGYP G+  ++I  F+KI+A
Sbjct: 189 EEYAVYKTHPVIAYHLIKEIPDINASVGLGVLMHHEQIDGSGYPLGIKDNKIHKFAKIIA 248

Query: 242 VTDIFHAMTSDRFYSEAAPLYEVLTQMEDYSFGKLDPYICGVFISKLMQSMIGNEVLLTD 301
           + DIF  + SD   +   P +E L  ++D S GKLD     +FI+  +   +G  V L+D
Sbjct: 249 IADIFDKVNSD---NTNGP-FEGLKAIKDLSLGKLDCSYSNMFINHAVNYYMGESVTLSD 304

Query: 302 GRMGKIIMILAHDPLRPLVNIGEDFIDLSKNRHLGIVRVI 341
            R  KII +   +  +PL+   + F+DL   + L +  +I
Sbjct: 305 NRSCKIIKLDTENLTKPLLLADDGFLDLKSEKDLYVKSLI 344


>RSc2515 [T] COG2206 HD-GYP domain
          Length = 402

 Score =  140 bits (354), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 85/259 (32%), Positives = 136/259 (52%), Gaps = 10/259 (3%)

Query: 68  VDDCTAAMENIFDQLRYTKSKRLPMLELKNEVIPFIQQVSEKND----FFGILAALQTKD 123
           +D    A++ +F + R  ++     +E ++   P ++ +S   D        LA L+TKD
Sbjct: 104 IDKAGIAVQAMFAEARMGRT-----IEARD-AQPLVEAISGSVDRHPGALVSLARLKTKD 157

Query: 124 DYTYRHNVAVGILSTLLGKWLKLDPEELGMLTIAATLHDIGKIMIPAEILTKPGPLTDEE 183
            YT+ H+VAV  L   LG+ L L  +E+    +A  LHDIGKI IP E+L KPG LT +E
Sbjct: 158 RYTFLHSVAVCALMVALGRQLGLSDDEVRDAGLAGLLHDIGKIAIPPEVLNKPGALTTDE 217

Query: 184 FDIMKKHTTHGYELVRDTPGTTHMQALVALQHHERMDGSGYPFGVLGHRITDFSKIVAVT 243
           F  +  H   GY+++   P    +   V L HHERMDG+GYP  + G  I+ F+++ A+ 
Sbjct: 218 FRHVIGHPKAGYDILVGDPSMRDIALDVCLHHHERMDGTGYPHKLAGENISLFARMGAIC 277

Query: 244 DIFHAMTSDRFYSEAAPLYEVLTQMEDYSFGKLDPYICGVFISKLMQSMIGNEVLLTDGR 303
           D++ A+TSDR Y +A      + +M ++     DP +   F+  +     G+ V L  GR
Sbjct: 278 DVYDAVTSDRPYKKAWEAAYAIQRMVEWRGNHFDPMVFQAFVKSVGIYPTGSLVRLRSGR 337

Query: 304 MGKIIMILAHDPLRPLVNI 322
           +  ++   +   L P V +
Sbjct: 338 LAVVMEHASGALLSPTVKV 356


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.323    0.140    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 25,889,335
Number of extensions: 1033943
Number of successful extensions: 3375
Number of sequences better than 1.0e-05: 41
Number of HSP's gapped: 3343
Number of HSP's successfully gapped: 41
Length of query: 343
Length of database: 38,378,431
Length adjustment: 107
Effective length of query: 236
Effective length of database: 26,037,693
Effective search space: 6144895548
Effective search space used: 6144895548
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 116 (49.3 bits)