BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0444.0021.p
         (113 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

CAC3674 [R] COG0517 FOG: CBS domain                                   130   5e-31
BH2710 [R] COG0517 FOG: CBS domain                                    111   2e-25
CAC3008 [R] COG0517 FOG: CBS domain                                    73   9e-14
SPy0364 [R] COG0517 FOG: CBS domain                                    51   4e-07
BH1482 [R] COG0517 FOG: CBS domain                                     47   5e-06

>CAC3674 [R] COG0517 FOG: CBS domain
          Length = 140

 Score =  130 bits (327), Expect = 5e-31,   Method: Compositional matrix adjust.
 Identities = 53/106 (50%), Positives = 83/106 (78%)

Query: 1   MLEALEQLEHHYYSAIPIINEEGKYVGTLSEGDLLWKFKNTAGLNFENMREVTVSEIQQH 60
           M +ALE++E+H Y+AIPI+++ GKY+GTL+EGDLLWK KNT  ++F+   +V++ +I +H
Sbjct: 22  MRQALERMEYHRYTAIPILDDNGKYIGTLTEGDLLWKLKNTPEIDFQTTNKVSIKDIPRH 81

Query: 61  VHNESVEIHAQMEDMLTLAADQNFVPVVDDKGIFLGIIRRKDIIEY 106
           ++N  V I + +ED+++ +  QNFVPVVDD  +F+GII+R DI+ Y
Sbjct: 82  MNNRPVHIDSDIEDLISKSVSQNFVPVVDDNNVFIGIIKRSDIMNY 127


>BH2710 [R] COG0517 FOG: CBS domain
          Length = 144

 Score =  111 bits (278), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 50/91 (54%), Positives = 72/91 (79%)

Query: 1   MLEALEQLEHHYYSAIPIINEEGKYVGTLSEGDLLWKFKNTAGLNFENMREVTVSEIQQH 60
           M + +E++E+H Y+AIPI+++EGKYVGT++EGDLLWK K+T  L FEN   V++ EI+Q 
Sbjct: 22  MRQVIERMEYHNYTAIPILDKEGKYVGTITEGDLLWKMKHTPNLTFENTESVSLKEIEQK 81

Query: 61  VHNESVEIHAQMEDMLTLAADQNFVPVVDDK 91
           + N  V I A+++D+L+LA  QNFVPVVDD+
Sbjct: 82  MVNLPVHIDAEIDDLLSLAIAQNFVPVVDDQ 112


>CAC3008 [R] COG0517 FOG: CBS domain
          Length = 133

 Score = 73.2 bits (178), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 35/104 (33%), Positives = 68/104 (65%)

Query: 3   EALEQLEHHYYSAIPIINEEGKYVGTLSEGDLLWKFKNTAGLNFENMREVTVSEIQQHVH 62
           +A E+++++    + I+N++G+YVG +++ DL+ K KN+  L+ ++  +V + +I +HV 
Sbjct: 24  QAFERMKYYKCHELIILNDKGEYVGFITKEDLVKKIKNSPNLHLKDFNKVGILDIIKHVI 83

Query: 63  NESVEIHAQMEDMLTLAADQNFVPVVDDKGIFLGIIRRKDIIEY 106
           N  + I+  +ED+     + NFVPV DD   F+GI+++ DI+ Y
Sbjct: 84  NNPININYNVEDISIPMCNTNFVPVADDNNKFIGIVKKDDILNY 127


>SPy0364 [R] COG0517 FOG: CBS domain
          Length = 153

 Score = 51.2 bits (121), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 30/100 (30%), Positives = 54/100 (54%), Gaps = 16/100 (16%)

Query: 13  YSAIPIINEEGKYVGTLSEGDLLWKFKNTAGLNFENMREVTVSEIQQ-------HVHNES 65
           +S +P+I  E KYVGT+S  D++          +++ R++T  E+ Q       +   E+
Sbjct: 45  FSRVPVITREKKYVGTISISDIMM---------YQSKRQLTDWEMSQTDIGEMVNTKIET 95

Query: 66  VEIHAQMEDMLTLAADQNFVPVVDDKGIFLGIIRRKDIIE 105
           + I + + +++    D  F+PVVD    F+GII RK I++
Sbjct: 96  ISITSSLTEIMHKLIDFPFLPVVDRANRFVGIITRKSILK 135


>BH1482 [R] COG0517 FOG: CBS domain
          Length = 146

 Score = 47.4 bits (111), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 5/101 (4%)

Query: 13  YSAIPIINEEGKYVGTLSEGDLLWKFKNTAGLNFENMREVTVSEIQQHVHNESVEIH--A 70
           Y+AIP+++E  K  G +S+  +L        +  E +  + V ++   ++ E   IH  A
Sbjct: 45  YTAIPVLDEHSKLHGVISKSLILDALLGVERIEMERLAHLVVKDV---MNPEIPTIHHKA 101

Query: 71  QMEDMLTLAADQNFVPVVDDKGIFLGIIRRKDIIEYYTRNI 111
                L ++    F+ ++DD G FLGI+ R  I+ +  R +
Sbjct: 102 SFSRALKVSIAHPFICILDDDGSFLGILTRSTILSFINRQL 142


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.318    0.136    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 8,343,119
Number of extensions: 340152
Number of successful extensions: 1008
Number of sequences better than 1.0e-05: 7
Number of HSP's gapped: 1012
Number of HSP's successfully gapped: 7
Length of query: 113
Length of database: 38,378,431
Length adjustment: 80
Effective length of query: 33
Effective length of database: 29,151,711
Effective search space: 962006463
Effective search space used: 962006463
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 109 (46.6 bits)