BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0442.0003.p (431 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll0079 [F] COG0015 Adenylosuccinate lyase 451 e-126 STM1095 [T] COG0642 Signal transduction histidine kinase 451 e-126 BMEI1117 [F] COG0015 Adenylosuccinate lyase 447 e-125 SMc00508 [F] COG0015 Adenylosuccinate lyase 443 e-124 AGc3377 [F] COG0015 Adenylosuccinate lyase 442 e-124 >mll0079 [F] COG0015 Adenylosuccinate lyase Length = 435 Score = 451 bits (1160), Expect = e-126, Method: Compositional matrix adjust. Identities = 219/431 (50%), Positives = 298/431 (69%), Gaps = 3/431 (0%) Query: 1 MIERYSRPEMRAIWTEENKFNAWLEVELCACEAWAELGVIPHEDAAKLRKN---AKFDIG 57 MI RYSRPEM AIW+ E +F W E+E AC+A AELGVIP E A + + AKFD+ Sbjct: 1 MIPRYSRPEMVAIWSPETRFRIWFEIEAHACDALAELGVIPKEAAKTIWEKGGAAKFDVE 60 Query: 58 RINEIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLRQANEILEKDI 117 +I+EIE T+HDVIAF ++E +G + +++H G+TS+DV+DT L +A++IL DI Sbjct: 61 KIDEIERVTKHDVIAFLTHLAEFVGPDARFIHQGMTSSDVLDTCFAVQLTRASDILLADI 120 Query: 118 INFIEILKDKALAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRHAANGVQF 177 + LK +A +KDT +GR+HG+HAEPTTFG+K+A Y E R ER HA + Sbjct: 121 DGLLAALKRRAFEHKDTVTIGRSHGIHAEPTTFGIKLAQAYAEFSRCRERLVHAREDIAT 180 Query: 178 GKISGAVGTYANIDPFVEEFVCRKLGTSPAPISTQTLQRDRHAEYMAALALVATSLDKFA 237 ISGAVGT+ANI+P+VEE V KLG P P+STQ + RDRHA + A L ++A+S+++ A Sbjct: 181 CAISGAVGTFANIEPYVEEHVAAKLGLKPEPVSTQVIPRDRHAMFFATLGVIASSMERLA 240 Query: 238 TEIRALQKSEIREVEEAFAKGQKGSSAMPHKRNPIGCENISGLSRVIRGHMMTAYENVPL 297 TEIR LQ++E+ E EE F+ GQKGSSAMPHKRNP+ EN++GL+R++R + A E+V L Sbjct: 241 TEIRHLQRTEVLEAEEYFSPGQKGSSAMPHKRNPVLTENLTGLARMVRSMALPAMEDVAL 300 Query: 298 WHERDISHSSVERIILPDATMLLNYMLNRFGNIVKNLTVFPDNMKRNMNRTFGVPFSGRI 357 WHERDISHSSVER+I PDAT+ L++ L+R +V L V+P+NM RNMN+ G+ S R+ Sbjct: 301 WHERDISHSSVERMIGPDATVTLDFALSRLTGVVDKLVVYPENMLRNMNKFRGLVHSQRV 360 Query: 358 LTKLIDKGFSREQAYDTVQPRAMQAWEEQTQFRDIVEATPEITAVLSPEEIEDAFNPSWH 417 + L G SRE +Y VQ AM+ WE+ F + + A E+TA L EI + F+ +H Sbjct: 361 MLALTQAGLSREDSYRLVQRNAMKVWEQGADFLEELLADKEVTAALPEAEIREKFDLGYH 420 Query: 418 LKHVDTIFRKL 428 KHVDTIFR++ Sbjct: 421 TKHVDTIFRRV 431 >STM1095 [T] COG0642 Signal transduction histidine kinase Length = 454 Score = 451 bits (1159), Expect = e-126, Method: Compositional matrix adjust. Identities = 25/429 (5%), Positives = 72/429 (16%) Query: 1 MIERYSRPEMRAIWTEENKFNAWLEVELCACEAWAELGVIPHEDAAKLRKNAKFDIGRIN 60 M++ + + EL + + Sbjct: 1 MVKLSMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGA 60 Query: 61 EIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLRQANEILEKDIINF 120 E + L + + + + D + N E Sbjct: 61 RPENLPLYFNRMVDTKQDILLIHSATGHNVAINHSGIPDQRFNEIPLTKNITRETLFRQA 120 Query: 121 IEILKDKALAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRHAANGVQFGKI 180 ++ + A+ A T +M Y + + Sbjct: 121 VQGTELTAVRVSARSGDDPLTLTIARLATERRQMLAQYRRNSLLMSLIAILVCSALSPLV 180 Query: 181 SGAVGTYANIDPFVEEFVCRKLGTSPAPISTQTLQRDRHAEYMAALALVATSLDKFATEI 240 + P ++ + + + + + + Sbjct: 181 IRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERLNQF 240 Query: 241 RALQKSEIREVEEAFAKGQKGSSAMPHKRNPIGCENISGLSRVIRGHMMTAYENVPLWHE 300 E+R + + + + + +T E Sbjct: 241 ADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLARAE 300 Query: 301 RDISHSSVERIILPDATMLLNYMLNRFGNIVKNLTVFPDNMKRNMNRTFGVPFSGRILTK 360 + + L + L+ + + + +LT Sbjct: 301 HQNIAVKKQPVSLNALVENMLDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNLLTN 360 Query: 361 LIDKGFSREQAYDTVQPRAMQAWEEQTQFRDIVEATPEITAVLSPEEIEDAFNPSWHLKH 420 I A ++ + Sbjct: 361 AIRYSDENAVIRIESAYDDNVAEIRVANPGSHPADADKLFRRFWRGDNARHTAGFGLGLS 420 Query: 421 VDTIFRKLE 429 + L Sbjct: 421 LVNAIALLH 429 >BMEI1117 [F] COG0015 Adenylosuccinate lyase Length = 433 Score = 447 bits (1150), Expect = e-125, Method: Compositional matrix adjust. Identities = 222/431 (51%), Positives = 296/431 (68%), Gaps = 3/431 (0%) Query: 1 MIERYSRPEMRAIWTEENKFNAWLEVELCACEAWAELGVIPHEDAAKLRKN---AKFDIG 57 MI RYSRPEM AIW+ E KF W E+E ACEA AELGVIP E A + + AKFD+ Sbjct: 1 MIPRYSRPEMVAIWSPETKFRIWFEIEAYACEALAELGVIPKEAARTIWEKGSVAKFDVA 60 Query: 58 RINEIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLRQANEILEKDI 117 RI+EIE T+HDVIAF ++E +G + ++VH G+TS+DV+DT L L +A ++L D+ Sbjct: 61 RIDEIEAVTKHDVIAFLTHLAEFIGPDSRFVHQGMTSSDVLDTTLNVQLVRAADLLLADL 120 Query: 118 INFIEILKDKALAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRHAANGVQF 177 +E LK +A +KDT +GR+HG+HAEPTT GL A +Y EM RN R A + Sbjct: 121 DRVLEALKKRAFEHKDTVRIGRSHGIHAEPTTMGLTFARFYAEMSRNRARLVAARAEIAT 180 Query: 178 GKISGAVGTYANIDPFVEEFVCRKLGTSPAPISTQTLQRDRHAEYMAALALVATSLDKFA 237 G ISGAVGT+ANIDP VEE+VC KLG P+STQ + RDRHA + A L ++A+S++ A Sbjct: 181 GAISGAVGTFANIDPRVEEYVCAKLGLEAEPVSTQVIPRDRHAMFFATLGVIASSMENIA 240 Query: 238 TEIRALQKSEIREVEEAFAKGQKGSSAMPHKRNPIGCENISGLSRVIRGHMMTAYENVPL 297 EIR +Q++E+ E EE F+ GQKGSSAMPHKRNP+ EN++GL+R++R + A ENV L Sbjct: 241 IEIRHMQRTEVLEAEEFFSPGQKGSSAMPHKRNPVLTENLTGLARLVRMSVTPAMENVAL 300 Query: 298 WHERDISHSSVERIILPDATMLLNYMLNRFGNIVKNLTVFPDNMKRNMNRTFGVPFSGRI 357 WHERDISHSSVER I PD T+ L++ LNR +++ L ++PDNM +NMN+ G+ S R+ Sbjct: 301 WHERDISHSSVERAIGPDTTITLDFALNRLAGVIEKLVIYPDNMLKNMNKFRGLVHSQRV 360 Query: 358 LTKLIDKGFSREQAYDTVQPRAMQAWEEQTQFRDIVEATPEITAVLSPEEIEDAFNPSWH 417 L L G SRE AY VQ AM+ WE+ F + + A E+ A LS E+I + F+ +H Sbjct: 361 LLALTQAGVSREDAYRLVQRNAMKVWEQSVDFLEELLADTEVRAALSEEQIREKFDLGYH 420 Query: 418 LKHVDTIFRKL 428 KHVDTIF+++ Sbjct: 421 TKHVDTIFKRV 431 >SMc00508 [F] COG0015 Adenylosuccinate lyase Length = 435 Score = 443 bits (1139), Expect = e-124, Method: Compositional matrix adjust. Identities = 222/431 (51%), Positives = 296/431 (68%), Gaps = 3/431 (0%) Query: 1 MIERYSRPEMRAIWTEENKFNAWLEVELCACEAWAELGVIPHEDAAKLRKN---AKFDIG 57 MI RYSRPEM AIW+ E KF W E+E AC+A AE+GVIP E A + + A FD+ Sbjct: 1 MISRYSRPEMVAIWSPETKFRIWFEIEAHACDALAEIGVIPKEAAKTIWEKGGAATFDVA 60 Query: 58 RINEIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLRQANEILEKDI 117 RI+EIE T+HDVIAF ++E +G + +++H G+TS+DV+DT L +A ++L D+ Sbjct: 61 RIDEIEAVTKHDVIAFLTHLAEFVGPDSRFIHQGMTSSDVLDTCFNIQLVRATDLLLADL 120 Query: 118 INFIEILKDKALAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRHAANGVQF 177 +E LK +A +KDT +GR+HG+HAEPTTFG+K+AL Y E R +R A + Sbjct: 121 DKLLEALKRRAFEHKDTVTIGRSHGIHAEPTTFGVKLALAYAEFDRCKQRLLAAREEIAT 180 Query: 178 GKISGAVGTYANIDPFVEEFVCRKLGTSPAPISTQTLQRDRHAEYMAALALVATSLDKFA 237 ISGAVGT+ANIDP VEE V LG P P+STQ + RDRHA Y A L +VA+S+++ A Sbjct: 181 CAISGAVGTFANIDPRVEEHVAEALGLKPEPVSTQVIPRDRHAMYFATLGVVASSIERLA 240 Query: 238 TEIRALQKSEIREVEEAFAKGQKGSSAMPHKRNPIGCENISGLSRVIRGHMMTAYENVPL 297 TEIR LQ++E+ E EE F+ GQKGSSAMPHKRNP+ EN++GLSR++R ++ A ENV L Sbjct: 241 TEIRHLQRTEVLEAEEYFSPGQKGSSAMPHKRNPVLTENLTGLSRMVRAFVVPAMENVAL 300 Query: 298 WHERDISHSSVERIILPDATMLLNYMLNRFGNIVKNLTVFPDNMKRNMNRTFGVPFSGRI 357 WHERDISHSSVER+I PDAT+ L++ L R ++ L V+PDNM +NMN+ G+ S R+ Sbjct: 301 WHERDISHSSVERMIGPDATVTLDFALARLTGVIDKLLVYPDNMLKNMNKFRGLVHSQRV 360 Query: 358 LTKLIDKGFSREQAYDTVQPRAMQAWEEQTQFRDIVEATPEITAVLSPEEIEDAFNPSWH 417 L L G SRE AY VQ AM+ WE+ F + + A E+ A LS E+I + F+ +H Sbjct: 361 LLALTQAGVSREDAYRLVQRNAMKVWEQGKDFLEELLADTEVRAALSEEDIREKFDLGYH 420 Query: 418 LKHVDTIFRKL 428 KHVDTIFR++ Sbjct: 421 TKHVDTIFRRV 431 >AGc3377 [F] COG0015 Adenylosuccinate lyase Length = 289 Score = 442 bits (1137), Expect = e-124, Method: Compositional matrix adjust. Identities = 0/431 (0%), Positives = 0/431 (0%), Gaps = 3/431 (0%) Query: 1 MIERYSRPEMRAIWTEENKFNAWLEVELCACEAWAELGVIPHEDAAKL---RKNAKFDIG 57 + Y R+ + + K + Sbjct: 16 FVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKEGKPGAAVGGNAT 75 Query: 58 RINEIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLRQANEILEKDI 117 ++ D + + + L + + Sbjct: 76 IPHKEAAYRLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNLDERHPGWDKTQR 135 Query: 118 INFIEILKDKALAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRHAANGVQF 177 + T + + + Sbjct: 136 AVVFGAGGASRAVIQSLRDRDVAEIHVVNRTVERARELADRFGPRVFSHPQAALQEVMHG 195 Query: 178 GKISGAVGTYANIDPFVEEFVCRKLGTSPAPISTQTLQRDRHAEYMAALALVATSLDKFA 237 + + L + + MA +AT Sbjct: 196 AGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQEQGIATVDGLGM 255 Query: 238 TEIRALQKSEIREVEEAFAKGQKGSSAMPHKRNPIGCENISGLSRVIRGHMMTAYENVPL 297 Sbjct: 256 315 Query: 298 WHERDISHSSVERIILPDATMLLNYMLNRFGNIVKNLTVFPDNMKRNMNRTFGVPFSGRI 357 Sbjct: 316 375 Query: 358 LTKLIDKGFSREQAYDTVQPRAMQAWEEQTQFRDIVEATPEITAVLSPEEIEDAFNPSWH 417 Sbjct: 376 435 Query: 418 LKHVDTIFRKL 428 Sbjct: 436 446 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.134 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 32,218,598 Number of extensions: 1243191 Number of successful extensions: 2617 Number of sequences better than 1.0e-05: 32 Number of HSP's gapped: 2563 Number of HSP's successfully gapped: 32 Length of query: 431 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 322 Effective length of database: 25,807,025 Effective search space: 8309862050 Effective search space used: 8309862050 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 117 (49.7 bits)