BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0437.0002.p (365 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC0290 [T] COG0642 Signal transduction histidine kinase 127 3e-29 STM0398 [T] COG0642 Signal transduction histidine kinase 102 1e-21 BS_resE_4 [T] COG0642 Signal transduction histidine kinase 95 2e-19 ECs0450 [T] COG0642 Signal transduction histidine kinase 93 8e-19 BS_phoR_2 [T] COG2202 FOG: PAS/PAC domain 92 1e-18 >CAC0290 [T] COG0642 Signal transduction histidine kinase Length = 467 Score = 127 bits (319), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 74/312 (23%), Positives = 152/312 (48%), Gaps = 17/312 (5%) Query: 55 SFLAVCLAALAFYLWSLMKPVFYMLTWLKRLAQGHYDEPSRSNWRGRPLSGNQLKLPYTL 114 + + + + ++ + KP+ +L +++ L+ G+Y + N R + + Sbjct: 170 NLIIILIFGYIYFARKMGKPLEKVLIYIEELSNGNY----KINEREK-----------GI 214 Query: 115 FREIIGQMSMLTLALQXXXXXXXXXXXXXXSWIAGVRHDLKTPLAYIRGYSSMIAAADQY 174 ++ + +++L+ L WI+ + HD+KTPL+ I+G+S I ++Y Sbjct: 215 YKYVFKNLNVLSKVLMDNKNRKKKIDELRDQWISSIGHDMKTPLSSIKGFSE-ILKDNEY 273 Query: 175 QWSTAEIIQFGSLMEQKTIQVEQLIEDMNASYQLDGSEGPLSRESTEMAGFIRQIVTDVA 234 + E+ ++ ++ K++ +E+LI D+N SY+L + + ++ + +++ IV + Sbjct: 274 DFEKDEVREYAGIIYDKSLYMEELINDLNFSYKLRNNCVNIKKKKIYFSQWLKDIVYKLH 333 Query: 235 DHPLAAQHTFAFNTAGEKCL-DIDQRMIRRALHNLLWNAVVHNPAGCHIEAEVYWDQHGL 293 P + E + DID+ M++RA N++ N +++N IE V ++ + Sbjct: 334 SSPEFKDRNVNIDKINENLIVDIDELMMKRAFVNIITNFLMYNDNRSTIEVGVKIEEGFI 393 Query: 294 TVEIRDNGTGIDAETLERLNTAEDNVLSARARLAGSGLGMALAKGFVTRHDGTMTVHSKP 353 I+DNG GI + +E + + + GSGLGMA+A V H+G V SK Sbjct: 394 KTTIKDNGKGIPEKDIEHIFERYYRGTNTTSNSKGSGLGMAIANDIVKLHEGFCDVKSKE 453 Query: 354 QQGTRITLFFLF 365 +GT +T+F + Sbjct: 454 GEGTELTIFLKY 465 >STM0398 [T] COG0642 Signal transduction histidine kinase Length = 431 Score = 102 bits (253), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 111/220 (50%), Gaps = 5/220 (2%) Query: 145 SWIAGVRHDLKTPLAYIRGYSSMIAAADQYQWSTAEIIQFGSLMEQKTIQVEQLIEDMNA 204 ++ A V H+L+TPL ++GY M+ + +T E + M ++T ++E L++ + Sbjct: 206 NFFANVSHELRTPLTVLQGYLEMMQE-QALEGATRE--KALHTMREQTYRMEGLVKQLLT 262 Query: 205 SYQLDGSEGPLSRESTEMAGFIRQIVTDVADHPLAAQHTFAFNTAGEKCLDIDQRMIRRA 264 +++ + L E ++ +R +V A +HTF F + ++ +R A Sbjct: 263 LSKIEAAPALLLNEKVDVPMMLR-VVEREAQTLSQQKHTFTFEVDDSLSVLGNEEQLRSA 321 Query: 265 LHNLLWNAVVHNPAGCHIEAEVYWDQHGLTVEIRDNGTGIDAETLERLNTAEDNVLSARA 324 + NL++NAV H PAG HI HG I+DNG GI AE + RL V AR+ Sbjct: 322 ISNLVYNAVNHTPAGTHITVSWRRVAHGAEFCIQDNGPGIAAEHIPRLTERFYRVDKARS 381 Query: 325 R-LAGSGLGMALAKGFVTRHDGTMTVHSKPQQGTRITLFF 363 R GSGLG+A+ K + H+ + + S P +GTR + Sbjct: 382 RQTGGSGLGLAIVKHALNHHESRLEIDSSPGKGTRFSFVL 421 >BS_resE_4 [T] COG0642 Signal transduction histidine kinase Length = 269 Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 117/227 (51%), Gaps = 18/227 (7%) Query: 146 WIAGVRHDLKTPLAYIRGYSSMIAAADQYQWSTAEIIQFGSLMEQKTIQVEQLIEDMNAS 205 +IA V H+L+TP++ ++GYS I D S + + ++ +++++ +L+ D+ Sbjct: 48 FIANVSHELRTPISMLQGYSEAIV--DDIASSEEDRKEIAQIIYDESLRMGRLVNDLLDL 105 Query: 206 YQLDGSEGPLSRESTEMAGFIRQIVTDVA----DHPLAAQHTFAFNTAGEKCLDIDQRMI 261 +++ L E + F+ +I+ + + +A H + E+ D+ + Sbjct: 106 ARMESGHTGLHYEKINVNEFLEKIIRKFSGVAKEKNIALDHDISLT---EEEFMFDEDKM 162 Query: 262 RRALHNLLWNAVVHNPAGCHIEAEVYWDQHGLTVEIRDNGTGIDAETL----ERLNTAED 317 + NL+ NA+ H AG + V+ + GL ++I+D+G+GI E L ER A+ Sbjct: 163 EQVFTNLIDNALRHTSAGGSVSISVHSVKDGLKIDIKDSGSGIPEEDLPFIFERFYKAD- 221 Query: 318 NVLSARAR-LAGSGLGMALAKGFVTRHDGTMTVHSKPQQGTRITLFF 363 AR R AG+GLG+A+ K V H+G++TVHS+ +GT + + Sbjct: 222 ---KARTRGRAGTGLGLAIVKNIVEAHNGSITVHSRIDKGTTFSFYI 265 >ECs0450 [T] COG0642 Signal transduction histidine kinase Length = 431 Score = 92.8 bits (229), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 104/218 (47%), Gaps = 5/218 (2%) Query: 145 SWIAGVRHDLKTPLAYIRGYSSMIAAADQYQWSTAEIIQFGSLMEQKTIQVEQLIEDMNA 204 ++ A V H+L+TPL ++GY M+ D+ A + M ++T ++E L++ + Sbjct: 206 NFFANVSHELRTPLTVLQGYLEMM---DEQPLEGAVREKALHTMREQTQRMEGLVKQLLT 262 Query: 205 SYQLDGSEGPLSRESTEMAGFIRQIVTDVADHPLAAQHTFAFNTAGEKCLDIDQRMIRRA 264 +++ + L E ++ +R +V A + TF F + ++ +R Sbjct: 263 LSKIEAAPTQLLNEKVDVPMMLR-VVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSV 321 Query: 265 LHNLLWNAVVHNPAGCHIEAEVYWDQHGLTVEIRDNGTGIDAETLERLNTAEDNVLSARA 324 + NL++NAV H P G HI HG + DNG GI E + RL V AR+ Sbjct: 322 ISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARS 381 Query: 325 R-LAGSGLGMALAKGFVTRHDGTMTVHSKPQQGTRITL 361 R GSGLG+A+ K V H+ + + S +GTR + Sbjct: 382 RQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSF 419 >BS_phoR_2 [T] COG2202 FOG: PAS/PAC domain Length = 431 Score = 92.4 bits (228), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 105/218 (48%), Gaps = 5/218 (2%) Query: 145 SWIAGVRHDLKTPLAYIRGYSSMIAAADQYQWSTAEIIQFGSLMEQKTIQVEQLIEDMNA 204 ++ A V H+L+TPL ++GY M+ ++ A + M ++T ++E L++ + Sbjct: 206 NFFANVSHELRTPLTVLQGYLEMM---NEQPLEGAVREKALHTMREQTQRMEGLVKQLLT 262 Query: 205 SYQLDGSEGPLSRESTEMAGFIRQIVTDVADHPLAAQHTFAFNTAGEKCLDIDQRMIRRA 264 +++ + L E ++ +R +V A + TF F + ++ +R A Sbjct: 263 LSKIEAAPTHLLNEKVDVPMMLR-VVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSA 321 Query: 265 LHNLLWNAVVHNPAGCHIEAEVYWDQHGLTVEIRDNGTGIDAETLERLNTAEDNVLSARA 324 + NL++NAV H P G HI HG + DNG GI E + RL V AR+ Sbjct: 322 ISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARS 381 Query: 325 R-LAGSGLGMALAKGFVTRHDGTMTVHSKPQQGTRITL 361 R GSGLG+A+ K V H+ + + S +GTR + Sbjct: 382 RQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSF 419 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.324 0.136 0.423 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 23,563,581 Number of extensions: 849915 Number of successful extensions: 4175 Number of sequences better than 1.0e-05: 113 Number of HSP's gapped: 4113 Number of HSP's successfully gapped: 113 Length of query: 365 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 257 Effective length of database: 25,922,359 Effective search space: 6662046263 Effective search space used: 6662046263 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 116 (49.3 bits)