BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0407.0012.p
         (294 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

TVN1496 [GER] COG0697 Permeases of the drug/metabolite transport...    59   1e-08
Ta1494 [GER] COG0697 Permeases of the drug/metabolite transporte...    56   7e-08
PA2101 [GER] COG0697 Permeases of the drug/metabolite transporte...    50   6e-06

>TVN1496 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT)
           superfamily
          Length = 285

 Score = 58.5 bits (140), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 61/264 (23%), Positives = 104/264 (39%), Gaps = 4/264 (1%)

Query: 2   QQQRKTIALLIFLVIVWGINWPLSKIALHYAPPLLFAGIRTXXXXXXXXXXXXPKLKELQ 61
            ++  +I+ L+F+  +WG+ +P+ K    Y  P+ F  +R              K+K ++
Sbjct: 3   SREVLSISTLVFVTFIWGVTFPIIKDVFLYLSPVNFLALRFAVSTLLFLPVVIKKIKHVK 62

Query: 62  FRRLWPVYLVSAFLSIVFYYGFQTIGLQYVPSGLFSAIVFLQPVLLGIFAWLWLGESMYX 121
               W   L++  L  + YY  QTIGL Y    L   I  +  V + I ++L+L   +  
Sbjct: 63  SEE-WKAGLIAGTLLFIAYY-LQTIGLLYTQPALSGTITGIYVVFVPIISYLYLRRRIAH 120

Query: 122 XXXXXXXXXXXXXXXXXIGGFTGSISVPGIVXXXXXXXXWAFATVYTKRNAARVDMLWMT 181
                              G +      G          +A   VY  ++A+ +D    +
Sbjct: 121 VEVYSSAFAFIGLVLMSYSGLSNVSIELGDFMTLAAAVFYAMQLVYVSKHASHIDTFVFS 180

Query: 182 AMQIMIGGLVLLAAGSATESWSDITWNAAFIVNTLFISVFVIALGWMVYFSLIKEGEAGK 241
            +QI +                 IT  +AF+V  LF +VF   L   VY S + +    K
Sbjct: 181 FIQIAVAAFFSAVFIPTFPEPFKITIYSAFVV--LFTAVFATFLATYVYVSALSKMNVTK 238

Query: 242 VGSFTFLIPLISIGSSVVLLHERI 265
           VG      P+ +  +SV+L  E+I
Sbjct: 239 VGVILIGEPIFADLTSVILYGEKI 262


>Ta1494 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT)
           superfamily
          Length = 285

 Score = 55.8 bits (133), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 64/266 (24%), Positives = 108/266 (40%), Gaps = 8/266 (3%)

Query: 2   QQQRKTIALLIFLVIVWGINWPLSKIALHYAPPLLFAGIRTXXXXXXXXXXXXPKLKELQ 61
           ++    +ALLIF+  +WG+ +P+ K    Y  P+ F  +R              KL  +Q
Sbjct: 3   RKDAIYLALLIFVTFIWGVTFPMIKDVFAYLSPVSFLAVRFAVASLIFLPFVYRKL--IQ 60

Query: 62  FRRLWPVYLVSA--FLSIVFYYGFQTIGLQYVPSGLFSAIVFLQPVLLGIFAWLWLGESM 119
             R    Y V A  FL I +Y   QT+GL+Y    L   I  +  V + I ++L+L   +
Sbjct: 61  TNRNTIKYGVVAGIFLFIAYY--LQTVGLKYTEPALSGTITGIYVVFVPIISYLYLKRRV 118

Query: 120 YXXXXXXXXXXXXXXXXXXIGGFTGSISVPGIVXXXXXXXXWAFATVYTKRNAARVDMLW 179
                                G        G +        +A   VY  + A+ VD L 
Sbjct: 119 MRIEVYSSVFAFLGLVLMSYSGLHNLAIESGDILTFIAAIFYAMQLVYISKYASNVDPLV 178

Query: 180 MTAMQIMIGGLVLLAAGSATESWSDITWNAAFIVNTLFISVFVIALGWMVYFSLIKEGEA 239
            + +QI++ G++ LA           ++ A F++  +F ++F   L   VY S +     
Sbjct: 179 FSFLQIVVVGVLSLAFMPTDMYPIVFSYYALFVI--VFTAIFATFLATYVYVSALSRMNV 236

Query: 240 GKVGSFTFLIPLISIGSSVVLLHERI 265
            KVG      P+ +  +S+ L +E +
Sbjct: 237 TKVGVILIGEPIFADITSIFLFNEPV 262


>PA2101 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT)
           superfamily
          Length = 296

 Score = 49.7 bits (117), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 71/252 (28%), Positives = 105/252 (41%), Gaps = 16/252 (6%)

Query: 7   TIALLIFLVIVWGINWPLSKIALHYAPPLLFAGIRTXXXXXXXXXXXXPKLKELQF-RRL 65
           T  L + + I WG  W   KIA+   PPL  AG+R              + + + F RRL
Sbjct: 6   TAVLFLVVCISWGTTWLGIKIAVESVPPLTAAGLRFLIAFPLFLLFARLRHETIFFPRRL 65

Query: 66  WP--VYLVSAFLSIVFYYGFQTIGLQYVPSGLFSAIVFLQPVLLGIFAWLWLGESMYXXX 123
               V++   + S+ +Y      G QYV SGL + +    PV + IF+ ++L E +Y   
Sbjct: 66  LAFFVFVTLGYFSVPYY--LLNYGEQYVASGLTALLFSSMPVFILIFSAIFLRERIYLSQ 123

Query: 124 XXXXXX--XXXXXXXXXIGGFTGSISVPGIVXXXXXXXXWAFATVYTKRNAARVDMLWMT 181
                             G       + G++         A + V TKR  A + ++   
Sbjct: 124 ILGIAIGFGSLFMIIRSQGLHLDYTELLGVLAILLAAIMHALSYVITKRQGADIGVITFN 183

Query: 182 AMQIMIGGLVLLAAGSATE--SWSDITWN--AAFIVNTLFISVFVIALGWMVYFSLIKEG 237
            + I I GL L  AG   E  + S +T    AA I   L  SV     G++VYF L+K  
Sbjct: 184 TLPIGIAGLGLFMAGLVMEHPNLSAVTSRSWAALIYLGLVASVG----GFIVYFFLLKR- 238

Query: 238 EAGKVGSFTFLI 249
            +  V SF F+I
Sbjct: 239 LSPVVLSFVFII 250


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.330    0.142    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 16,640,744
Number of extensions: 510451
Number of successful extensions: 2085
Number of sequences better than 1.0e-05: 10
Number of HSP's gapped: 2102
Number of HSP's successfully gapped: 10
Length of query: 294
Length of database: 38,378,431
Length adjustment: 106
Effective length of query: 188
Effective length of database: 26,153,027
Effective search space: 4916769076
Effective search space used: 4916769076
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 115 (48.9 bits)