BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0391.0011.p (251 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value DR0237 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase... 96 4e-20 CC1584 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase... 91 2e-18 PM0944 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase... 89 5e-18 STM3472 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamas... 88 1e-17 ZppiA [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase)... 88 1e-17 >DR0237 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Length = 252 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 4/127 (3%), Positives = 13/127 (10%), Gaps = 4/127 (3%) Query: 92 GIIKAELYPEVAPNTVNNFISLIQKGFYDGTIFHRVIPGFMIQXXXXXXXXXXXXXYSIA 151 A + + + R Sbjct: 52 RWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYE 111 Query: 152 GEFTANGFTNNLQHTQGVLSMARSQDMNSGGSQFFIMAAAYPSLDGQYAAFGKVTEGQDV 211 + L + A + + Sbjct: 112 LFPHLV---SLLNPQGVLAVQMPDNW-LEPTHVLMREVAWEQNYPDRGREPLAGVHAYYD 167 Query: 212 VDAIVNL 218 + + Sbjct: 168 ILSEAGC 174 >CC1584 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Length = 252 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 6/134 (4%), Positives = 23/134 (17%), Gaps = 10/134 (7%) Query: 83 VVTIEMDNGGIIKAELYPEVAPNTVNNFISLIQKGFYDGTIFHRVIPGFMIQXXXXXXXX 142 + A P +++ + G + T + Sbjct: 10 LHFSA---ERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPA 66 Query: 143 XXXXXY-SIAGEFTANGFTNNLQHTQGVLSMARSQDMNSGGSQFFIMAAAYPSLDGQYAA 201 ++ + + + + S ++ Sbjct: 67 MIAEARSALPDCQ------FVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLL 120 Query: 202 FGKVTEGQDVVDAI 215 + + D Sbjct: 121 NPQGVLAVQMPDNW 134 >PM0944 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Length = 252 Score = 89.4 bits (220), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 7/140 (5%), Positives = 24/140 (17%), Gaps = 18/140 (12%) Query: 90 NGGIIKAELYPEVAPNTVNNFISLIQKGFYDGTIFHRVIPGFMIQXXXXXXXXXXXXXYS 149 + + + A + + D + Q + Sbjct: 7 SLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPA 66 Query: 150 IAGEFTANGFTNNLQHTQGVLSMARSQDMNSGGSQFFIMAAAYPSLDGQ----------- 198 + E + + Q + + F + + + Sbjct: 67 MIAEARSALPDC----QFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNP 122 Query: 199 ---YAAFGKVTEGQDVVDAI 215 A + + Sbjct: 123 QGVLAVQMPDNWLEPTHVLM 142 >STM3472 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Length = 252 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 7/129 (5%), Positives = 16/129 (12%), Gaps = 9/129 (6%) Query: 92 GIIKAELYPEVAPNTVNNFISLIQKGFYDGTIFHRVIPGFMIQXXXXXXXXXXXXXYSIA 151 + R A Sbjct: 38 LGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQ----A 93 Query: 152 GEFTANGFTNNLQHTQGVLSMARSQDMNSGGSQFFIMAAAYPSLD-GQ----YAAFGKVT 206 + + L +N G M + Sbjct: 94 LDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPD 153 Query: 207 EGQDVVDAI 215 G++ + + Sbjct: 154 RGREPLAGV 162 >ZppiA [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Length = 190 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 58/143 (40%), Positives = 73/143 (51%), Gaps = 33/143 (23%) Query: 90 NGGIIKAELYPEVAPNTVNNFISLIQKGFYDGTIFHRVIPGFMIQXXXXXXXXXXXXXYS 149 + G I+ EL + AP +V NF+ + GFY+ T FHRVIPGFMIQ Sbjct: 36 SAGNIELELDKQKAPVSVQNFVDYVNSGFYNNTTFHRVIPGFMIQ--------------- 80 Query: 150 IAGEFT------------ANGFTNNLQHTQGVLSMARSQDMNSGGSQFFIMAAAYPSLD- 196 G FT N N L++T+G ++MAR+ D +S SQFFI A LD Sbjct: 81 -GGGFTEQMQQKKPNPPIKNEADNGLRNTRGTIAMARTADKDSATSQFFINVADNAFLDH 139 Query: 197 GQ----YAAFGKVTEGQDVVDAI 215 GQ YA FGKV +G DV D I Sbjct: 140 GQRDFGYAVFGKVVKGMDVADKI 162 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.137 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 13,305,990 Number of extensions: 418206 Number of successful extensions: 687 Number of sequences better than 1.0e-05: 68 Number of HSP's gapped: 595 Number of HSP's successfully gapped: 70 Length of query: 251 Length of database: 38,378,431 Length adjustment: 104 Effective length of query: 147 Effective length of database: 26,383,695 Effective search space: 3878403165 Effective search space used: 3878403165 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 114 (48.5 bits)