BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0382.0030.p (1606 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_pksL_1 [Q] COG3321 Polyketide synthase modules and related pr... 530 e-150 BS_pksL_2 [Q] COG3321 Polyketide synthase modules and related pr... 401 e-111 all1649 [Q] COG3321 Polyketide synthase modules and related prot... 394 e-109 all1648_1 [Q] COG3321 Polyketide synthase modules and related pr... 391 e-108 all2635 [Q] COG3321 Polyketide synthase modules and related prot... 387 e-107 >BS_pksL_1 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1814 Score = 530 bits (1365), Expect = e-150, Method: Compositional matrix adjust. Identities = 469/1611 (29%), Positives = 731/1611 (45%), Gaps = 275/1611 (17%) Query: 40 DIAIIGMSGKFGEANDLRAFWEVLLKGKECIREIPLHRKADADRYLEFSGGKSPHEDTQY 99 DIAIIG++G++ +A ++ FW L +GK+C+ EIP R D R G SP Sbjct: 324 DIAIIGLAGRYPKAANIHEFWNNLKEGKDCVSEIPESR-WDWQR---LEGITSPSGKDIS 379 Query: 100 TRIAYLDEIDKFDCGFFGILPNEAKLIDPRQRLFLESAWSTLEDAGYGGGKLC---GSKT 156 ++D+ D FD FF I P EA+ +DP++RLFLE+ W T+EDAGY L G Sbjct: 380 KWGGFIDDPDCFDPQFFRITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNK 439 Query: 157 GVYVGLSSDGXXXXEYFKLIEQGDPSLIGL--STAGNIKSV------IAGRLAYILDFKG 208 +VG+ F + D +L+G ++A N+ + IA R++Y +F G Sbjct: 440 RQHVGV----------FAGVMHKDYTLVGAEEASAENVFPLSLNYAQIANRVSYFCNFHG 489 Query: 209 PSMMIDTACSSSLVALHVACQAIKNHECEAALVGGVNIKIFPKTEEENNLNIGI---TSS 265 PSM +DT CSSSL A+H+A ++I++ EC+ AL GGVN+ + P + G+ S+ Sbjct: 490 PSMAVDTVCSSSLTAVHLALESIRHGECDVALAGGVNLSLHPN----KYMTYGVWDMFST 545 Query: 266 DSSIRTFDDQADGTNSGEGVAAVLIKPLDKAIRDRDHIYAVIKGSAVNQDGSSVGITAPN 325 D RTF DG EG+ AVL+KPL +A D D IYAVIKGSAVN G+ GI+ P+ Sbjct: 546 DGHCRTFGKDGDGYVPAEGIGAVLLKPLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPS 605 Query: 326 MTAQENVITDAWKEARIDPQTVTYWEAHGTGTKLGDPIEVHAIHRAFNRFTDRKQFCAIG 385 +Q ++I ++ IDP+T++Y EAHGTGT LGDPIE+ + +AF ++T +QFC+IG Sbjct: 606 PVSQADLIETCLEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIG 665 Query: 386 SVKTNIGHLDSLAGLAGLIKAVMAIQYRKIPPSLHFKVPNRNIQFSSSPVYVNDQTTDWK 445 SVK+NIGH +S AG++GL K + + ++K+ PSLH + N + F SP YV +T WK Sbjct: 666 SVKSNIGHAESAAGISGLSKVALQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWK 725 Query: 446 -------GYDGVY--RCGISSFGLSGTNAHVVLEGPPPLEQRQD-----EVPANHIFTVS 491 G D Y R GISSFG +G+NAH++LE P QD + + + +S Sbjct: 726 QPVIKENGEDVPYPRRAGISSFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLS 785 Query: 492 AKTEASLEKLILNYLEFLGKEQELRISDLCYTVNTGRLPNQCRIAMIVSSTEELIRKLKL 551 A+ + L L+FL ++I DL YT+ GR P + R++ + S +EL +LK Sbjct: 786 ARNQERLRVYAKRLLDFL--HDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKA 843 Query: 552 LARNGAGTYKAEDIYYRKLERNLKFIGKSMTGSGGLTESSHKSIADLQL--LCGAYCDGA 609 G + + ++ R + ES HK + +L + + +G+ Sbjct: 844 FIE---GRKAIQHCWKGRVSRG--------SEPSRPAESVHKLLEQRKLDQIAEQWANGS 892 Query: 610 DMDFEGIYRQLDCRKVSWPTYAFEQKRLWVELPESR--RSLTAARTRHPLLQERAVSSLN 667 +D++ +Y +++S PTY FE+ R WV E + RS HPLL + VS ++ Sbjct: 893 GVDWKLLYEGSKPKRISLPTYPFERVRYWVPKAEKKTDRSKQERHILHPLLHQN-VSDIS 951 Query: 668 LEVYVSYLNVQDFWVLNEHQVNDACVIPGTAYLDMAKEIGTRHFGEARDIILSDVSFLNL 727 + S ++F+ L +H + V+PG A L+M + R A D + N+ Sbjct: 952 GVRFRSAFTGREFF-LKDHVIKGEHVLPGAALLEMVRAAVER---AAADQFPTGFRLRNI 1007 Query: 728 LKVEKDEVKEIHTIVNIK-----DDALKFTVASRASAAEEW-IKHAEAWIGRKERQPHTT 781 + V V E ++++ + + F + +AEE I + + E + Sbjct: 1008 VWVRPFAVTEQQKDIDVRLYPEENGEITFEICRDPESAEESPIVYGQGSAVLCEAGENPV 1067 Query: 782 YDIETLKTTYDSVYAIRRNQSWPVIEESSYTSVQYVEDTNRPESIINVGGRWKCTNAIYR 841 +IE LK +Y+ R S P +YT E I+ G + +++Y Sbjct: 1068 INIEELKASYNG-----RTLS-PFDCYEAYT-----------EMGIHYGDSHRAIDSLYA 1110 Query: 842 SKEGVLCELEIQAEYAEDLEQFYLHPAMMDCAVNA------GTFTINED--TYLPYYYKE 893 + GVL +L + ++ + + LHP+M+D A A G T ED LP+ ++ Sbjct: 1111 GENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRLGGATSLEDRKAMLPFAIQD 1170 Query: 894 FRIFGPTPKKFYSYIT--KKNNENEETGKFDLLLLNEQGEVFGEISSYIVKRVHSFTPLE 951 RIF ++ IT + + + K D+ L NE+G+V ++SY + + T E Sbjct: 1171 VRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEGQVCVRLTSYSARVLE--TDQE 1228 Query: 952 QPSAQKSIYHKLGWVEKNEYKLLRRSEANGGILLFHNQAKLAGEIIASLRQAGKKVIEAI 1011 P SEAN +L H + A E + KV+ Sbjct: 1229 GP-----------------------SEANDTLLFEHIWEERAAERQELIEYDTYKVV--- 1262 Query: 1012 PGQAFSERGEQAYSLGGR---------QEDYDKLFAAIELQKISQIIHLMTIQDHSAEGG 1062 + GEQ SL E D+ F +Q +I LM HS GG Sbjct: 1263 ----VCDVGEQMESLQNHLDCTVLQHDTETIDERFEGYAIQLFEEIKQLM----HSKTGG 1314 Query: 1063 HQQLEYNLKLGLDSLFYLSQSIMKHPNDPVELVLFAEHVHRISGSETAVNPHHAAFFGLG 1122 H ++ + LD LS GL Sbjct: 1315 HTFIQVAVP-ALDEPQLLS-----------------------------------GLTGLL 1338 Query: 1123 KVLGKEYSKLNVRCIDIDGETRAAECIREINGEKQVEL---VGYREGRPYVQELQAVPVP 1179 K E KL + I+I+ A E + ++ + + +G+ +V + + V Sbjct: 1339 KTAELENPKLTGQLIEIETGMSAGELFEILEENRRYPRDTHIRHWQGKRFVSKWKEVSGE 1398 Query: 1180 ALPDQQAEIKKDGVYIITXXXXXXXXEVARYLSSLAK-VNLILVGRSGLSHPIDPGSKNH 1238 L K GVY+IT A +++ +IL GRS P+D K Sbjct: 1399 HL-SADMPWKDKGVYLITGGAGGLGFIFATEIANQTNDAVVILTGRS----PLDERKKKK 1453 Query: 1239 TRTEIMNHIRANGSNVDCY-QADVADEREMQAMLAQLRQRYTSINGIFHCAGVAGEGFIF 1297 + I+A Y QAD+AD++ + A+L + + Y ++GI H AG+ + FI Sbjct: 1454 LKALQKLGIQA------IYRQADLADKQTVDALLKETQNVYGDLDGIIHSAGLIKDNFIM 1507 Query: 1298 RKDKAAFDRVTRPKIQGTRILDKLTAEDKLDFFVMFSSITSLSGSMGQADYTAANAYLDS 1357 +K K V PK+ G LD+ T + LDFF++FSS GS GQADY ANA++++ Sbjct: 1508 KKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQADYAMANAFMNA 1567 Query: 1358 YAEYRS----LIKPEQKTLTINWCGWKDTGMLADYRNK--LGKEAGTEENQNEQGFKNI- 1410 ++EYR+ L K KTL++ W WKD GM D L +E G + ++G + + Sbjct: 1568 FSEYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMVAMETDRGIQALY 1627 Query: 1411 --------------GTREAIEAL---------------NVVLNKEISKV-IIGELDDKVF 1440 G + I A LN+E K +IGE+D+++ Sbjct: 1628 HGWTSGKPQVLVASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEAEKADMIGEIDEEIL 1687 Query: 1441 GLYKDQITFSLAPEIAARIRPTRPKAPGHTGLPPVPMEHRDYSGIESAIVKAWVKVLGLE 1500 R KA + + + S+++K L Sbjct: 1688 ----------------------REKAENY------------FKQVLSSVIK-----LPAG 1708 Query: 1501 QININDKFYDLGGDSISAIYLVKEIGKVFPSLIDISDIFTYPSISEMSDYI 1551 QI+ D G DSI +++ ++ KVF SL + F Y I ++ Y Sbjct: 1709 QIDAEAPLEDYGIDSIMIMHVTGQLEKVFGSL-SKTLFFEYQDIRSLTRYF 1758 >BS_pksL_2 [Q] COG3321 Polyketide synthase modules and related proteins Length = 211 Score = 401 bits (1031), Expect = e-111, Method: Compositional matrix adjust. Identities = 0/629 (0%), Positives = 0/629 (0%), Gaps = 46/629 (7%) Query: 40 DIAIIGMSGKFGEANDLRAFWEVLLKGKECIREIPLHRKADADRYLEFSGGKSPHEDTQY 99 + + + E N E + + L + + + Sbjct: 3 KAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSA---QATDVSVNKATAKLYPVAN 59 Query: 100 TRIAYLDEIDKFDCGFFGILPNEAKLIDPRQRLFLESAWSTLEDAGYGGGKLCGSKTGVY 159 T A L+ + + + + + + L + GV Sbjct: 60 TPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAAL-EALPGVG 118 Query: 160 VGLSSDGXXXXEYFKLIEQGDPSLI---GLSTAGNIKSVIAGRLAYILDFKGPSMMIDTA 216 ++ + I A K+V + + Sbjct: 119 RKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPG-KNVEQVEEKLLKVVPAEFKVDCHH 177 Query: 217 CSSSLVALHVACQAIKNHECEAALVGGVNIKIFPKTEEENNLNIG---ITSSDSSIRTFD 273 Sbjct: 178 ---- 233 Query: 274 DQADGTNSGEGVAAVLIKPLDKAIRDRDHIYAVIKGSAVNQDGSSVGITAPNMTAQENVI 333 Sbjct: 234 293 Query: 334 TDAWKEARIDPQTVTYWEAHGTGTKLGDPIEVHAIHRAFNRFTDRKQFCAIGSVKTNIGH 393 Sbjct: 294 353 Query: 394 LDSLAGLAGLIKAVMAIQYRKIPPSLHFKVPNRNIQFSSSPVYVNDQTTDWK-------G 446 Sbjct: 354 413 Query: 447 YD-GVYR-CGISSFGLSGTNAHVVLE--GPPPLEQRQDEVPANHIFTVSAKTEASLEKLI 502 Sbjct: 414 473 Query: 503 LNYLEFLGKEQELRISDL---CYTVNTGRLPNQCRIAMIVSSTEELIRKLKLLARNGAGT 559 Sbjct: 474 ---- 529 Query: 560 YKAEDIYYRKLERNLKFIGK-------SMTGSGGLTESSHKSIADLQLLCGAYCDGADMD 612 Sbjct: 530 ------ 583 Query: 613 FEGIYRQLDCRKVSWPTYAFEQKRLWVEL 641 Sbjct: 584 612 >all1649 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1570 Score = 394 bits (1012), Expect = e-109, Method: Compositional matrix adjust. Identities = 213/523 (40%), Positives = 315/523 (60%), Gaps = 26/523 (4%) Query: 41 IAIIGMSGKFGEANDLRAFWEVLLKGKECIREIPLHRKADADRYLEFSGGKSPHEDTQYT 100 IAIIG+ +F A+ +AFW++L G + I EIP R + D + + + + +Y Sbjct: 4 IAIIGIGCRFPGADSPQAFWQLLSNGVDAITEIPAERW-NIDEFYDRNPETPGKMNARYG 62 Query: 101 RIAYLDEIDKFDCGFFGILPNEAKLIDPRQRLFLESAWSTLEDAGYGGGKLCGSKTGVYV 160 +L ++D+FD FFGI P EA L+DP+QRL LE AW LEDAG +L GSKTGV+V Sbjct: 63 --GFLSQVDRFDPHFFGISPREALLMDPQQRLLLEVAWEALEDAGIVREQLTGSKTGVFV 120 Query: 161 GLSSDGXXXXEYFKLIEQGDPSLIGLSTAGNIKSVIAGRLAYILDFKGPSMMIDTACSSS 220 G+S++ +Y ++ + D + G GN ++ AGRL+Y+ + +GPS+ +DTACSSS Sbjct: 121 GISTN-----DYSRIHPEFDSNPQGYDLTGNCINIAAGRLSYLFNLRGPSLAVDTACSSS 175 Query: 221 LVALHVACQAIKNHECEAALVGGVNIKIFPKTEEENNLNIGIT-----SSDSSIRTFDDQ 275 LVA+H+ACQ+I N E A+ GVN+ + P NI ++ S D +TFD+ Sbjct: 176 LVAVHLACQSIWNQESSMAIASGVNLVLSPIG------NIALSKLKALSPDGRCKTFDES 229 Query: 276 ADGTNSGEGVAAVLIKPLDKAIRDRDHIYAVIKGSAVNQDGSSVGITAPNMTAQENVITD 335 A+G EG +++KP+ +A+ D D IYAVI+GSA+N DG S G+T P AQE++I Sbjct: 230 ANGYVRSEGAGCIILKPIAQALADHDPIYAVIRGSAINHDGRSKGLTVPYGPAQESLIRQ 289 Query: 336 AWKEARIDPQTVTYWEAHGTGTKLGDPIEVHAIHRAFNRFTDRKQFCAIGSVKTNIGHLD 395 A ++A++ P+ ++Y E HGTGT LGDPIE AI D C +G+VK+NIGHL+ Sbjct: 290 ALQQAQVQPKEISYVELHGTGTPLGDPIEAMAIGAVLGEGRDAAHPCLVGAVKSNIGHLE 349 Query: 396 SLAGLAGLIKAVMAIQYRKIPPSLHFKVPNRNIQFSSSPVYVNDQTTDWKGYDGVYRCGI 455 + AG+A +IK +A++Y++IPPSLHF PN I F P+ V W + G+ Sbjct: 350 AAAGIASIIKMALALKYQQIPPSLHFHQPNPYIPFDQLPLRVQTSLIPWPKSKYGAKAGV 409 Query: 456 SSFGLSGTNAHVVLEGPPPL---EQRQDEVPANHIFTVSAKTEASLEKLILNYLEFLGKE 512 SSFG SGTNAHV+LEG EQ+ + P H+ +SA T A+++ L L Y + + + Sbjct: 410 SSFGFSGTNAHVILEGVSSFNSPEQQTCKFP--HLLPLSAHTPAAVQTLALGYQDLINAQ 467 Query: 513 QELR--ISDLCYTVNTGRLPNQCRIAMIVSSTEELIRKLKLLA 553 + + +LCY+ + R R A++V+S E+L L+ LA Sbjct: 468 KLTPEFVQNLCYSASVRRTHQSYRSAVVVNSPEDLPSCLQALA 510 Score = 157 bits (396), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 148/584 (25%), Positives = 262/584 (44%), Gaps = 54/584 (9%) Query: 984 LLFHNQAKLAGEIIASLRQAGKKVIEAIPGQAFSERGEQAYSLGGRQE-DYDKLFAAIEL 1042 L+F + L E+ A + + I G+++ + Y + Q D+ +L A I Sbjct: 969 LIFSDNQGLGQELAAVVNDS---CILVSSGESYEKLSSSHYQINPHQAADFQQLLADIS- 1024 Query: 1043 QKISQIIHLMTIQDHSAEGGHQQLEYNLKLGLDSLFYLSQSIMKHPND-PVELVLFAEHV 1101 + I+++++L ++ D S LE + L YL Q++ K + +L + + Sbjct: 1025 EPITKVVYLWSL-DSSIN-----LENSQPQCYSHLLYLVQALAKISSKIAPQLWIGTQQA 1078 Query: 1102 HRISGSETAVNPHHAAFFGLGKVLGKEYSKLNVRCIDIDGETRAAECI-REINGEKQVEL 1160 ++ S +N +G+G+V+ EY +L ID + AA I E+ + + Sbjct: 1079 QAVTPSCHQINVAQTPLWGMGQVIALEYPQLWGGLIDFGNQDVAATAIIAEMTAKTGEDR 1138 Query: 1161 VGYREGRPYVQELQAVPVPALPDQQAEIKKDGVYIITXXXXXXXXEVARYLSSLAKVNLI 1220 V +R+G+ YV L + P LP Q I DG Y+IT +A +L +L+ Sbjct: 1139 VAFRDGKRYVARLMPISAP-LPAPQPLIS-DGSYLITGGLGALGLTLAEWLVQQGARHLV 1196 Query: 1221 LVGRSGLSHPIDPGSKNHTRTEIMNHIRANGSNVDCYQADVADEREMQAMLAQLRQRYTS 1280 L R GL + ++ + + + + G+ V ADV+D ++M + AQ++ Sbjct: 1197 LTSRQGLLN------QSEEKQQKIRALENQGATVKVVAADVSDYQQMSQLFAQIQLNSPK 1250 Query: 1281 INGIFHCAGVAGEGFIFRKDKAAFDRVTRPKIQGTRILDKLTAEDKLDFFVMFSSITSLS 1340 + GI H AGV + I + D F +V +PK+ G L +LT + LDFFV FSS+++L Sbjct: 1251 LRGIIHAAGVLNDCSIAQMDSETFTKVFQPKVTGAWNLHQLTQDLSLDFFVCFSSMSALL 1310 Query: 1341 GSMGQADYTAANAYLDSYAEYR-SLIKPEQKTLTINWCGWKDTGMLADYRNKLGKEAGTE 1399 GS GQ Y AAN++LD +R SL P L+INW W + GM G E Sbjct: 1311 GSRGQLHYAAANSFLDGLVYHRQSLGLP---GLSINWGPWAEGGMATQ---------GYE 1358 Query: 1400 ENQNEQGFKNIGTREAIEALNVVLNKEISKVIIGELDDKVFG---LYKDQITFSLAPEIA 1456 G + + A++ L +L + ++ ++ FG K ++ F + Sbjct: 1359 VGLKRMGIEPLEPTAALQVLGGLLGSASMQTMVAAINWSAFGKIVAAKGRVAF-----LE 1413 Query: 1457 ARIRPTRPKAPGHTG------LPPVPMEHRDYSGIESAIVKAWVKVLGLEQ---ININDK 1507 A + T+ G G L P+ HR + + + + + +VLG + Sbjct: 1414 ALL--TQESKDGSNGENFRQKLSAAPL-HRRPALLTTQVQQEVAQVLGHSGSYVPEVEQG 1470 Query: 1508 FYDLGGDSISAIYLVKEIGKVFPSLIDISDIFTYPSISEMSDYI 1551 F+D+G DS+ ++ + + + + +F PSI ++ Y+ Sbjct: 1471 FFDMGMDSLMSVQFRHSLEALLAVSLPSTLVFECPSIGDVVSYL 1514 >all1648_1 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1041 Score = 391 bits (1004), Expect = e-108, Method: Compositional matrix adjust. Identities = 225/556 (40%), Positives = 324/556 (58%), Gaps = 36/556 (6%) Query: 1 MKNGFISLKELKASAFTASTLESEDRLLRDSAVKPMSESDIAIIGMSGKF-GEANDLRAF 59 ++ I+LKE + + +ES +R IAI+GM +F G+AN+ F Sbjct: 9 LQKAIIALKEAR------TKIESLER---------TQNEPIAIVGMGCRFPGDANNPEKF 53 Query: 60 WEVLLKGKECIREIPLHRKADADRYLEFSGGKSPH-EDTQYTRIA-YLDEIDKFDCGFFG 117 WE+L +GK+ I +P R D D Y + P + Y R +++ +D+FD FFG Sbjct: 54 WELLRQGKDGITTVPPQRW-DIDAYYD----DDPDVPNKMYARYGGFINNVDQFDPQFFG 108 Query: 118 ILPNEAKLIDPRQRLFLESAWSTLEDAGYGGGKLCGSKTGVYVGLSSDGXXXXEYFKLIE 177 I P EA +DP+QRL LE +W LE+AG KL G++TGV+VG+ D +Y K Sbjct: 109 ITPREAIALDPQQRLLLEVSWEALENAGIAPQKLTGTQTGVFVGIGID-----DYAKRQI 163 Query: 178 QGDPSLIGLSTAGNIKSVIAGRLAYILDFKGPSMMIDTACSSSLVALHVACQAIKNHECE 237 + + + +GN AGRL+Y+L +GPS+ IDTACS+SLV +H+ACQ+++N EC Sbjct: 164 KHHIPIDAYTGSGNAFCFAAGRLSYLLGLQGPSLAIDTACSTSLVTIHLACQSLRNGECN 223 Query: 238 AALVGGVNIKIFPKTEEENNLNIGIT---SSDSSIRTFDDQADGTNSGEGVAAVLIKPLD 294 AL GGV++ + P E L + T S D +TFD A+G GEG V++K L Sbjct: 224 LALAGGVSLMLSP----EVTLYLSKTRALSPDGRCKTFDRDANGYVRGEGCGMVVLKRLS 279 Query: 295 KAIRDRDHIYAVIKGSAVNQDGSSVGITAPNMTAQENVITDAWKEARIDPQTVTYWEAHG 354 A+ D DHI AVI+GSAVNQDG+S G+T PN TAQ+ VI A A++ P ++Y EAHG Sbjct: 280 SAVADGDHILAVIRGSAVNQDGASSGLTVPNGTAQQAVIRQALANAKVTPAQISYLEAHG 339 Query: 355 TGTKLGDPIEVHAIHRAFNRFTDRKQFCAIGSVKTNIGHLDSLAGLAGLIKAVMAIQYRK 414 TGT LGDPIEV AI F + +GSVKTNIGHL+ AG+A L+K ++++Q+++ Sbjct: 340 TGTALGDPIEVRAIDGVFGKGRSPNHPLILGSVKTNIGHLEIAAGMASLLKVILSLQHQE 399 Query: 415 IPPSLHFKVPNRNIQFSSSPVYVNDQTTDWKGYDGVYRCGISSFGLSGTNAHVVLEGPPP 474 IPP L+F+ N ++ S+ + + W+ + GISSFGLSGTNAH+++E PP Sbjct: 400 IPPHLNFQELNPDLAASAKSLKIPTSIIPWQPTEQPRMAGISSFGLSGTNAHIIIEEPPQ 459 Query: 475 LEQRQDEVPAN-HIFTVSAKTEASLEKLILNYLEFLGKEQELRISDLCYTVNTGRLPNQC 533 L EV H+ +SAK+EA+L L ++ L E +DL ++ NTGR Sbjct: 460 LTVTPAEVDRPLHVLMLSAKSEAALHTLATDWEHLLRNHPETNFADLAFSANTGRGSFNH 519 Query: 534 RIAMIVSSTEELIRKL 549 R+A+I ST + + L Sbjct: 520 RLAIIAQSTAQARQNL 535 >all2635 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1565 Score = 387 bits (994), Expect = e-107, Method: Compositional matrix adjust. Identities = 222/544 (40%), Positives = 325/544 (59%), Gaps = 27/544 (4%) Query: 32 AVKPMSESDIAIIGMSGKFGEANDLRAFWEVLLKGKECIREIPLHRKADADRYLEFSGGK 91 AV+ ++AI+GM+G+F A ++ FW+ L G I+ + ++ L +G K Sbjct: 30 AVELERSEEVAIVGMAGRFPGAKNVDEFWDNLKNGINSIKFL-------SNEDLLANGVK 82 Query: 92 SPHEDTQ-YTRI-AYLDEIDKFDCGFFGILPNEAKLIDPRQRLFLESAWSTLEDAGYGGG 149 + + Q Y R A L ID+FD GFFG P EA+++DP+ RLFLE AW LE+AGY Sbjct: 83 AEDLEKQNYVRAYASLAGIDEFDAGFFGYSPREAEILDPQHRLFLECAWEALENAGYDSE 142 Query: 150 KLCGSKTGVYVG--LSSDGXXXXEYFKLIEQGDPSLIGLSTAGNIKSVIAGRLAYILDFK 207 + G+ VY G L+S E D + + +S N+ ++ R++Y L+ Sbjct: 143 QYSGN-IAVYGGAALNSYLVNLASNSNYRENSDRTQVVIS---NVMGLMPTRVSYKLNLT 198 Query: 208 GPSMMIDTACSSSLVALHVACQAIKNHECEAALVGGVNIKIFPKT----EEENNLNIGIT 263 G S I T CS+SLV++H+ACQ++ N EC+ AL GGV+I I K +E+ G+ Sbjct: 199 GASCGIQTGCSTSLVSVHIACQSLLNKECDIALAGGVSIGIGEKAGYLYQED-----GVL 253 Query: 264 SSDSSIRTFDDQADGTNSGEGVAAVLIKPLDKAIRDRDHIYAVIKGSAVNQDGSS-VGIT 322 S D R FD A GT G GV V++K L AI+D DHIYA+IK +A+N DGS VG+T Sbjct: 254 SPDGYCRAFDVNAKGTVFGNGVGIVVLKRLRDAIQDGDHIYAIIKATAINNDGSQKVGLT 313 Query: 323 APNMTAQENVITDAWKEARIDPQTVTYWEAHGTGTKLGDPIEVHAIHRAFNRFTDRKQFC 382 AP++T Q IT A +A+I+P+T+ Y E HGTGT LGDPIE+ A+ +AF+ T +KQFC Sbjct: 314 APSVTGQAKAITTALTKAKINPETIQYIETHGTGTALGDPIEIAALTKAFSPHTHQKQFC 373 Query: 383 AIGSVKTNIGHLDSLAGLAGLIKAVMAIQYRKIPPSLHFKVPNRNIQFSSSPVYVNDQTT 442 A+GSVKTNIGHLD+ AG++GLIK +A+++++IPPSL+F N I F++SP +VN Q T Sbjct: 374 AVGSVKTNIGHLDAAAGISGLIKTALALKHKQIPPSLNFTAANPQIDFANSPFFVNTQLT 433 Query: 443 DWKGYDGVYRCGISSFGLSGTNAHVVL-EGPPPLEQRQDEVPAN-HIFTVSAKTEASLEK 500 W + R G+SSFG+ GTNAH +L E P + + + N H+ +SAK+E +LE+ Sbjct: 434 PWINHQHPRRAGVSSFGMGGTNAHAILEEAPTQFKIQNSKFKINYHLLCLSAKSEKALEQ 493 Query: 501 LILNYLEFLGKEQELRISDLCYTVNTGRLPNQCRIAMIVSSTEELIRKLKLLARNGAGTY 560 +N L K EL ++D+ YT+ GR R ++ + + I L + + +Y Sbjct: 494 ATINLATHLQKHPELNLADVAYTLQIGRRAFNHRRCLVCQTPAQAIEILTGVDASQLLSY 553 Query: 561 KAED 564 E+ Sbjct: 554 SPEN 557 Score = 139 bits (349), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 155/615 (25%), Positives = 267/615 (43%), Gaps = 80/615 (13%) Query: 972 KLLRRSEA--NGGILLFHNQAKLAGE-IIASLRQAGKKVIEAIPGQAFSERGEQAYSLGG 1028 K L RS A N L A AGE ++ L++ G++V+ PG+ F++ G+ Sbjct: 961 KPLLRSAAPLNKQRYLVFCHAGNAGERLVQHLQETGQEVVTVKPGEGFTQEGDNYAIAPH 1020 Query: 1029 RQEDYDKLFAAIELQKISQ----IIHLMTIQDHSAEGGHQQLEYNLKLGLDSLFYLSQSI 1084 EDY L+ ++LQ + IIH T+Q+ + + LG SL +L+Q++ Sbjct: 1021 NPEDYKTLW--LQLQTDDKLPDVIIHSWTLQERT------NFQQQQNLGFYSLLWLTQAL 1072 Query: 1085 MKHPNDPVELVLFAEHVHRISGSETAVNPHHAAFFGLGKVLGKEYSKLNVRCIDID-GET 1143 + + + + + V + G+E +NP A GL KV+ +EY L + ID+ + Sbjct: 1073 S---SSSLSIYVLTQQVQNVLGNEN-LNPDDATILGLVKVIPQEYPNLTCQHIDVSISDI 1128 Query: 1144 RAAECIREINGEKQVE------------LVGYREGRPYVQELQAVPVPALPDQQAEIKKD 1191 + +REIN + V YR ++QE Q + +P Q + Sbjct: 1129 NFQQLVREINIPPVLSDTLPLEKGGLRMSVAYRGKTRWIQEFQPISLPE--PTQLPLITG 1186 Query: 1192 GVYIITXXXXXXXXEV-ARYLSSLAKVNLILVGRSGLSHP--IDPGSKNHTRTEIMNHI- 1247 GVY+I + A++L++ L+ +GRS L P D H R + ++H Sbjct: 1187 GVYVIAGDLVEGLGLIYAKFLAATVNAKLVFLGRSDLPQPKEWDNWLATHGRQDAVSHCI 1246 Query: 1248 --RANGSNVDC----YQADVADEREMQAMLAQLRQRYTSINGIFHCAGVAGE---GFIFR 1298 C D+A+ +++ +AQ R+ ING+ H AGV G+ I Sbjct: 1247 QQLQGLQAQGCEFLFTTVDLAEISQVEDAIAQALTRFGKINGVIH-AGVMGDRASCLIRN 1305 Query: 1299 KDKAAFDRVTRPKIQGTRILDKLTAEDKLDFFVMFSSITSLSGSMGQADYTAANAYLDSY 1358 ++ KI G L+ LDFF++ SS++++ G +G A Y AN ++D+ Sbjct: 1306 LTIPECEKQFHTKIHGLLALETALKNQPLDFFLLQSSLSAVVGGIGFAAYAGANCFMDAI 1365 Query: 1359 AEYRSLIKPEQKTLTINWCGWKDTGMLADYRNKLGKEAGTEENQNEQGFKNIGTREAIEA 1418 A R+ ++INW D LA+ G +++ ++ E I A Sbjct: 1366 AHQRTQ-NSNTHWISINW----DAVSLAEITTSTGATLIDLAMTSQEVWQ---VTERILA 1417 Query: 1419 LNVVLNKEISKVIIGELDDKVFGLYKDQITFSLA-PEIAARIRPTRPKAPGHTGLPPVPM 1477 + +S V +L + +Q T + A P+I A T LPP Sbjct: 1418 QPIAAQITVSPV---DLASRQQSQPLEQSTTNHARPQITA------------TYLPP--- 1459 Query: 1478 EHRDYSGIESAIVKAWVKVLGLEQININDKFYDLGGDSISAIYLVKEIGKVFPSLIDISD 1537 + IE+ + + +LG+ I +ND F++LGG S+ AI V ++ + F + + Sbjct: 1460 ----SNEIEARVTQVMESLLGIAPIGVNDNFFELGGHSLLAIQAVSQLREEFQVELPMRQ 1515 Query: 1538 -IFTYPSISEMSDYI 1551 +F P+I ++ I Sbjct: 1516 FLFESPTIGGIAKII 1530 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.134 0.390 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 118,840,513 Number of extensions: 5121130 Number of successful extensions: 9760 Number of sequences better than 1.0e-05: 116 Number of HSP's gapped: 9423 Number of HSP's successfully gapped: 137 Length of query: 1606 Length of database: 38,378,431 Length adjustment: 120 Effective length of query: 1486 Effective length of database: 24,538,351 Effective search space: 36463989586 Effective search space used: 36463989586 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 123 (52.0 bits)