BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0382.0029.p (1606 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_pksL_1 [Q] COG3321 Polyketide synthase modules and related pr... 437 e-122 BS_pksK_2 [Q] COG3321 Polyketide synthase modules and related pr... 413 e-114 BS_pksL_2 [Q] COG3321 Polyketide synthase modules and related pr... 408 e-113 all1648_1 [Q] COG3321 Polyketide synthase modules and related pr... 393 e-108 all1649 [Q] COG3321 Polyketide synthase modules and related prot... 387 e-106 >BS_pksL_1 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1814 Score = 437 bits (1125), Expect = e-122, Method: Compositional matrix adjust. Identities = 292/957 (30%), Positives = 468/957 (48%), Gaps = 115/957 (12%) Query: 38 DIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARFI 97 DIAIIG++ R PKA+N E+W+NL G DC E + + D+ I Sbjct: 324 DIAIIGLAGRYPKAANIHEFWNNLKEGKDCVSEIPE-------------SRWDWQRLEGI 370 Query: 98 SEEEAED-CKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 + +D K GG+++D D FD + F I+P+EA+ MDP R+ LET W IEDAGY Sbjct: 371 TSPSGKDISKWGGFIDDPDCFDPQFFRITPREAETMDPQERLFLETCWETIEDAGYTPKT 430 Query: 157 IYGSQ-------TSLYVGKDHVNDTLYRYVTEDESTS-----MTGNWPGLMAGRINYLLN 204 + + ++ G H + TL V +E+++ ++ N+ +A R++Y N Sbjct: 431 LAKPKGRNKRQHVGVFAGVMHKDYTL---VGAEEASAENVFPLSLNY-AQIANRVSYFCN 486 Query: 205 LKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFP-RFSTARKSMMESQD 263 G SM +D+ CSS L VHLA ++++ EC++A+ ++L + P ++ T M S D Sbjct: 487 FHGPSMAVDTVCSSSLTAVHLALESIRHGECDVALAGGVNLSLHPNKYMTYGVWDMFSTD 546 Query: 264 DRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNA 323 +TF K+ DG ++G+ AV+LKPL +A +DGD IYAVIKGSAVN+ G +G++ P+ Sbjct: 547 GHCRTFGKDGDGYVPAEGIGAVLLKPLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPSP 606 Query: 324 VAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGS 383 V+Q +++ E IDP TI Y+EAHGTGT LGDPIEI+GL AF ++T QFC IGS Sbjct: 607 VSQADLIETCLEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIGS 666 Query: 384 VKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPK 443 VK+NIGH + +G++ L KV L + H + S+H +E N ++F KSP +V + W + Sbjct: 667 VKSNIGHAESAAGISGLSKVALQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQ 726 Query: 444 SVL---------PRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPE----YEIFTVSA 490 V+ PRRAGI+SFG G+NAH+++EE QAA + + + +SA Sbjct: 727 PVIKENGEDVPYPRRAGISSFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSA 786 Query: 491 KTEHSLRQLIHQYAEFFRQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKL 550 + + LR + +F G + + ++ YT + GR R++ + +EL ++ Sbjct: 787 RNQERLRVYAKRLLDFLHDGIQ--IRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAF 844 Query: 551 ASNGLSDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYL 610 I G+ C K R SE + LLE+ Sbjct: 845 -------IEGRKAIQHCWKGRVSRG----------SEPSRPAESVHKLLEQ--------- 878 Query: 611 ILNLAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSELEVSVKN 670 L +I + G+ V+W L+Y +K + +SLPTY F+RV YW +++++ ++ Sbjct: 879 -RKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVRYWVPKAEKKTDRSKQERH 937 Query: 671 ISHPLIDQCLADSMDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRLYH 730 I HPL+ Q ++D + + + F + L DH I G V+PG LEM R A R Sbjct: 938 ILHPLLHQNVSD-ISGVRFRSAFT-GREFFLKDHVIKGEHVLPGAALLEMVRAAVERAAA 995 Query: 731 TDY---LELRDVFFFTPLSVGQTEDKQVHTIVKKEKGYTRFIIA----SQEQGKWITHAE 783 + LR++ + P +V + + + +E G F I S E+ I + + Sbjct: 996 DQFPTGFRLRNIVWVRPFAVTEQQKDIDVRLYPEENGEITFEICRDPESAEESP-IVYGQ 1054 Query: 784 GKAYNPADESKDAERLIFDLAAARNDSRKETIKVKYEDTSLS---------SKVFSFGPR 834 G A + E + ++ E +K Y +LS +G Sbjct: 1055 GSAVL----CEAGENPVINI---------EELKASYNGRTLSPFDCYEAYTEMGIHYGDS 1101 Query: 835 WLNFKEVILDHNEQLVELELSEAFKGDLEELILHPSLLDNAANVFIG-------EDDDDS 887 + N LV+L + + ILHPS++D+A IG +D Sbjct: 1102 HRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRLGGATSLEDRK 1161 Query: 888 TFLPLSYKNIKIYSAMPQHFYA---YVQKKSGNKETKTCDIQLIDMQGRIFVEIKDY 941 LP + ++++I+ +A Y + + + DI L + +G++ V + Y Sbjct: 1162 AMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEGQVCVRLTSY 1218 Score = 106 bits (264), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 121/483 (25%), Positives = 206/483 (42%), Gaps = 78/483 (16%) Query: 1150 ISEEIQRIESKYQVALRSGKRYTCELDRHEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEI 1209 I EE +R + GKR+ + EH + K++GVY Sbjct: 1367 ILEENRRYPRDTHIRHWQGKRFVSKWKEVSGEHLSAD-MPWKDKGVYLITGGAGGLGFIF 1425 Query: 1210 ARYLAGK-NAVHIALMNRSKLPEAASWDQLIQENPEHKLSRKLQAIKDIRESGSEVSCYS 1268 A +A + N + L RS L E RK + +K +++ G + Sbjct: 1426 ATEIANQTNDAVVILTGRSPLDE-----------------RKKKKLKALQKLGIQAIYRQ 1468 Query: 1269 CDIADPDQVNEVVQDLKGKYGRIHGIFHCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWIL 1328 D+AD V+ ++++ + YG + GI H AG+ + F +K K V++PKV G L Sbjct: 1469 ADLADKQTVDALLKETQNVYGDLDGIIHSAGLIKDNFIMKKKKEEVQTVLAPKVAGLIHL 1528 Query: 1329 DQATREENLEFFILFSSINAIFGGSGQGDYTAANAYLDSFSYSRN------KRGARTISI 1382 D+AT++ L+FFILFSS G +GQ DY ANA++++FS RN KR +T+S+ Sbjct: 1529 DEATKDIPLDFFILFSSGAGAVGSAGQADYAMANAFMNAFSEYRNGQAELHKRYGKTLSV 1588 Query: 1383 NWPAWSEVGIAADYGITEESSVFHMLTVKQALNFMD-EMAAGGITHAIPGSLNRPLLASV 1441 WP W + G+ D + ML + + M+ + + H + L+AS Sbjct: 1589 CWPLWKDGGMQID------AETARMLKRETGMVAMETDRGIQALYHGWTSGKPQVLVAS- 1641 Query: 1442 QDQLPFTLSGAIRSKLKGTGRTRTEP---------KETPEIEAAGDI---VLKGKGTEYS 1489 ++ IR+ L TG + + +E + + G+I +L+ K Y Sbjct: 1642 ------GVTDRIRAFLHETGHGKGQSHNIKKSSLNQEAEKADMIGEIDEEILREKAENY- 1694 Query: 1490 ETEKNIAQMYSLILDMH--ELDLYESFNAMGGDSIMATQLLKLIDK-----------KYP 1536 Q+ S ++ + ++D G DSIM + ++K +Y Sbjct: 1695 -----FKQVLSSVIKLPAGQIDAEAPLEDYGIDSIMIMHVTGQLEKVFGSLSKTLFFEYQ 1749 Query: 1537 DIVDISDIFTYSSVVELAEYIDRESHRSTPPAPVKAETVSEPVEQELRDLIENLKKGTID 1596 DI ++ F S +L + + E+ + + E SEP +QE+ + K G + Sbjct: 1750 DIRSLTRYFIDSRREKLLDILGFETGKPS------VERKSEPEKQEIP--VIPRKSGFLP 1801 Query: 1597 VQD 1599 +QD Sbjct: 1802 LQD 1804 >BS_pksK_2 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1575 Score = 413 bits (1062), Expect = e-114, Method: Compositional matrix adjust. Identities = 289/938 (30%), Positives = 460/938 (49%), Gaps = 85/938 (9%) Query: 39 IAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHI---KPIVNNKAYADFMGAR 95 +AIIGISC P A N DE+W NL G + F KE ++ K I N AD++ A+ Sbjct: 2 VAIIGISCEFPGAKNHDEFWENLRDGKESIAFFNKEELQRFGISKEIAEN---ADYVPAK 58 Query: 96 FISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGD 155 ++ D+FD F ISPK+A+ MDP R+LL W AIEDAGYA Sbjct: 59 -------------ASIDGKDRFDPSFFQISPKDAEFMDPQLRMLLTHSWKAIEDAGYAAR 105 Query: 156 KIYGSQTSLYVGKDH-------VNDTLYRYVTEDESTSMTGNWPGLMAGRINYLLNLKGN 208 +I QTS+++ + +DT T D S G + I++ L L+G Sbjct: 106 QI--PQTSVFMSASNNSYRALLPSDTTESLETPDGYVSWVLAQSGTIPTMISHKLGLRGP 163 Query: 209 SMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSMME-SQDDRVK 267 S + + CSS L+G+H A +L + E + A+V +L + + S D +K Sbjct: 164 SYFVHANCSSSLIGLHSAYKSLLSGESDYALVGGATLHTESNIGYVHQPGLNFSSDGHIK 223 Query: 268 TFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASN-GLTAPNAVAQ 326 FD +ADG +GVA V+LK + A +DGD+IYA+++G VNNDGA G AP+ Q Sbjct: 224 AFDASADGMIGGEGVAVVLLKKAADAVKDGDHIYALLRGIGVNNDGADKVGFYAPSVKGQ 283 Query: 327 EEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKA 386 +V+ + ++ P +I Y+EAHGTGTKLGDPIE+ LTN + ++T+K QFCGIGSVK Sbjct: 284 ADVVQQVMNQTKVQPESICYVEAHGTGTKLGDPIELAALTNVYRQYTNKTQFCGIGSVKT 343 Query: 387 NIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVL 446 NIGH +GLA IKVV+S+ H + S+++KEPN + SP +V ++ + + Sbjct: 344 NIGHLDTAAGLAGCIKVVMSLYHQELAPSVNYKEPNPNTDLASSPFYVVDQKKTLSREIK 403 Query: 447 PRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPEYEIFTVSAKTEHSLRQLIHQYAEF 506 RA ++SFG GTN H + E+ + + G I +SAK + L++ + Sbjct: 404 THRAALSSFGLGGTNTHAIFEQFKRDSDKGKIDGT--CIVPISAKNKERLQEYAEDILAY 461 Query: 507 F-RQGTE-TNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGLSDISG--KG 562 R+G E + L + YT + GR +R+ I EL+Q+++ NG + I G +G Sbjct: 462 LERRGFENSQLPDFAYTLQVGREAMEHRVVFIADHVNELKQRLTDFI-NGNTAIEGCFQG 520 Query: 563 VYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNLYV 622 ++ ++ S + D E+ RK +K + ++ ++ Sbjct: 521 SKHNAREV-SWLTEDEDSAELI----RKWMAKG-----------------KVNKLAEMWS 558 Query: 623 KGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSELEVSVKNIS----HPLIDQ 678 KGA ++W +Y+ + +SLPTY F + YW DR+ ++S HPL+ Q Sbjct: 559 KGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQISGNQTGIGSIHPLLHQ 618 Query: 679 CLADSMDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMG-----RKACSRLYHTDY 733 +D E +S+ F + L DH + G V+PG YLEM + A S + Sbjct: 619 NTSD-FSEQKFSSVF-TGDEFFLRDHVVRGKPVLPGVAYLEMAYAAINQAAGSEIGQDVR 676 Query: 734 LELRDVFFFTPLSVGQTEDKQVHTIVKKEKGYTRF-IIASQEQG-KWITHAEGKAYNPAD 791 + L + P+ V + + ++ +E G F I ++QE G + H++G A+ Sbjct: 677 IRLNHTVWVQPVVVDRHSAQVDISLFPEEDGKITFDIYSTQEDGDDPVIHSQGS----AE 732 Query: 792 ESKDAERLIFDLA-AARNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFKEVILDHNEQLV 850 + AE + DL +R + + ++ + S +F GP + K V + + E L Sbjct: 733 LASAAETPVADLTEMSRRCGKGKMSPDQFYEEGRSRGMFH-GPAFQGIKNVNIGNREVLA 791 Query: 851 ELELSEAFKGDLEELILHPSLLDNAANV----FIGEDDDDSTFLPLSYKNIKIYSAMPQH 906 +L+L E G E+ +LHPS++D+A + E D LP + + +++ Sbjct: 792 QLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQELTDQKLILPFALEELEVIKGCSSS 851 Query: 907 FYAYVQKKSGNKE---TKTCDIQLIDMQGRIFVEIKDY 941 +AY + + + DI +ID G + V IK + Sbjct: 852 MWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGF 889 Score = 128 bits (321), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 119/460 (25%), Positives = 204/460 (44%), Gaps = 62/460 (13%) Query: 1116 LGAALFGLGTVLTQEFKNIHCRALDVDRETPAELISEEIQ-----RIESKYQVALRSGKR 1170 L A + GL EF + + +++ E P E+I ++ R Q+ +G R Sbjct: 1008 LFAGVSGLFKTAEIEFSKLTAQVIEI--EKPEEMIDLHLKLKDDSRRPFDKQIRYEAGYR 1065 Query: 1171 YTCELDRHEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGKNAVH-IALMNRSKL 1229 + + + +++GVY L A+ +A + I L RS L Sbjct: 1066 FVKGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKEIANRTGRSTIVLTGRSVL 1125 Query: 1230 PEAASWDQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYG 1289 E +EN +L+A++ I G+EV D++D V +++++K +YG Sbjct: 1126 SED-------KEN-------ELEALRSI---GAEVVYREADVSDQHAVRHLLEEIKERYG 1168 Query: 1290 RIHGIFHCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAI 1349 ++GI H AG + + F K F EV+ PKV+G +D+ +++ L+FFI FSS++ Sbjct: 1169 TLNGIIHGAGSSKDRFIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGC 1228 Query: 1350 FGGSGQGDYTAANAYLDSFS-YSRN-----KRGARTISINWPAWSEVGIAADYGITEESS 1403 G +GQ DY AAN+++D+F+ Y R+ KR TIS NWP W E G+ G +E Sbjct: 1229 LGNAGQADYAAANSFMDAFAEYRRSLAASKKRFGSTISFNWPLWEEGGMQV--GAEDEK- 1285 Query: 1404 VFHMLTVKQALNFMDEMAAGGITHAIPGSLNRPLLASVQDQLPFT----LSGAIRSKLKG 1459 ML + + I ++P + ++ QL LS ++K Sbjct: 1286 --RMLKTTGMVPMPTDSGLKAFYQGIVS--DKPQVFVMEGQLQKMKQKLLSAGSKAKRND 1341 Query: 1460 TGRTRTEPKETPEIEAAGDIVLKGKGTEYSETEKNIAQMYSLILDMH--ELDLYESFNAM 1517 + + +T ++EAA + QM IL ++ ++D+ + Sbjct: 1342 QRKADQDQGQTRKLEAA------------------LIQMVGAILKVNTDDIDVNTELSEY 1383 Query: 1518 GGDSIMATQLLKLIDKKYPDIVDISDIFTYSSVVELAEYI 1557 G DS+ T I++K+ + + F Y SV LAEY+ Sbjct: 1384 GFDSVTFTVFTNKINEKFQLELTPTIFFEYGSVQSLAEYV 1423 >BS_pksL_2 [Q] COG3321 Polyketide synthase modules and related proteins Length = 211 Score = 408 bits (1049), Expect = e-113, Method: Compositional matrix adjust. Identities = 0/653 (0%), Positives = 0/653 (0%), Gaps = 62/653 (9%) Query: 37 EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARF 96 + I RL + + N + + + + Sbjct: 2 NKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKAT---AKLYPVA 58 Query: 97 ISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 LE + + + + + Sbjct: 59 --------NTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAA 110 Query: 157 IYGSQTS-LYVGKDHVNDTLYR----YVTEDE----STSMTGNWPGLMAGRINYLLNLKG 207 + +N T T + L + Sbjct: 111 LEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPG-KNVEQVEEKLLKVVPA 169 Query: 208 NSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFP-RFSTARKSMMESQDDRV 266 V + C + + + Sbjct: 170 EFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVDI 229 Query: 267 KTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQ 326 Sbjct: 230 289 Query: 327 EEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKA 386 Sbjct: 290 349 Query: 387 NIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSV- 445 Sbjct: 350 409 Query: 446 --------LPRRAGINSFGFVGTNAHVVVEE-APDQAATSEAAGPEYEIFTVSAKTEHSL 496 Sbjct: 410 469 Query: 497 RQLIHQYAEFFRQGT--ETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNG 554 Sbjct: 470 ------- 522 Query: 555 LSDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLL---EEIVNDTSGYLI 611 Sbjct: 523 ----------------- 565 Query: 612 L-NLAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSE 663 Sbjct: 566 618 >all1648_1 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1041 Score = 393 bits (1010), Expect = e-108, Method: Compositional matrix adjust. Identities = 212/557 (38%), Positives = 321/557 (57%), Gaps = 29/557 (5%) Query: 4 VQTYIFEQVKQHKLTQEEAKQMLRELKSEGAKKEDIAIIGISCRLP-KASNTDEYWSNLM 62 +QT +++ + +EA+ + L E + E IAI+G+ CR P A+N +++W L Sbjct: 1 MQTQDLTPLQKAIIALKEARTKIESL--ERTQNEPIAIVGMGCRFPGDANNPEKFWELLR 58 Query: 63 GGLD--CKVEFQKEMIEHI---KPIVNNKAYADFMGARFISEEEAEDCKMGGYLEDVDKF 117 G D V Q+ I+ P V NK YA + GG++ +VD+F Sbjct: 59 QGKDGITTVPPQRWDIDAYYDDDPDVPNKMYARY----------------GGFINNVDQF 102 Query: 118 DAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDKIYGSQTSLYVG---KDHVNDT 174 D + F I+P+EA A+DP R+LLE W A+E+AG A K+ G+QT ++VG D+ Sbjct: 103 DPQFFGITPREAIALDPQQRLLLEVSWEALENAGIAPQKLTGTQTGVFVGIGIDDYAKRQ 162 Query: 175 LYRYVTEDESTSMTGNWPGLMAGRINYLLNLKGNSMVLDSACSSGLLGVHLACNALKNKE 234 + ++ D T +GN AGR++YLL L+G S+ +D+ACS+ L+ +HLAC +L+N E Sbjct: 163 IKHHIPIDAYTG-SGNAFCFAAGRLSYLLGLQGPSLAIDTACSTSLVTIHLACQSLRNGE 221 Query: 235 CEMAIVSAISLGIFPRFST-ARKSMMESQDDRVKTFDKNADGTFFSDGVAAVILKPLSKA 293 C +A+ +SL + P + K+ S D R KTFD++A+G +G V+LK LS A Sbjct: 222 CNLALAGGVSLMLSPEVTLYLSKTRALSPDGRCKTFDRDANGYVRGEGCGMVVLKRLSSA 281 Query: 294 RQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTG 353 DGD+I AVI+GSAVN DGAS+GLT PN AQ+ V+ +A +A++ P I Y+EAHGTG Sbjct: 282 VADGDHILAVIRGSAVNQDGASSGLTVPNGTAQQAVIRQALANAKVTPAQISYLEAHGTG 341 Query: 354 TKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKANIGHTVAVSGLASLIKVVLSMKHNVIP 413 T LGDPIE++ + F K +GSVK NIGH +G+ASL+KV+LS++H IP Sbjct: 342 TALGDPIEVRAIDGVFGKGRSPNHPLILGSVKTNIGHLEIAAGMASLLKVILSLQHQEIP 401 Query: 414 SSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVLPRRAGINSFGFVGTNAHVVVEEAPDQA 473 ++F+E N + + + + W + PR AGI+SFG GTNAH+++EE P Sbjct: 402 PHLNFQELNPDLAASAKSLKIPTSIIPWQPTEQPRMAGISSFGLSGTNAHIIIEEPPQLT 461 Query: 474 ATSEAAGPEYEIFTVSAKTEHSLRQLIHQYAEFFRQGTETNLSNICYTAKTGRGHYAYRL 533 T + +SAK+E +L L + R ETN +++ ++A TGRG + +RL Sbjct: 462 VTPAEVDRPLHVLMLSAKSEAALHTLATDWEHLLRNHPETNFADLAFSANTGRGSFNHRL 521 Query: 534 ALIVKSYEELEQKISKL 550 A+I +S + Q ++ Sbjct: 522 AIIAQSTAQARQNLAAF 538 >all1649 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1570 Score = 387 bits (993), Expect = e-106, Method: Compositional matrix adjust. Identities = 206/521 (39%), Positives = 302/521 (57%), Gaps = 16/521 (3%) Query: 37 EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARF 96 E IAIIGI CR P A + +W L G+D E E + N M AR+ Sbjct: 2 EPIAIIGIGCRFPGADSPQAFWQLLSNGVDAITEIPAERWNIDEFYDRNPETPGKMNARY 61 Query: 97 ISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 GG+L VD+FD F ISP+EA MDP R+LLE W A+EDAG ++ Sbjct: 62 -----------GGFLSQVDRFDPHFFGISPREALLMDPQQRLLLEVAWEALEDAGIVREQ 110 Query: 157 IYGSQTSLYVG--KDHVNDTLYRYVTEDESTSMTGNWPGLMAGRINYLLNLKGNSMVLDS 214 + GS+T ++VG + + + + + +TGN + AGR++YL NL+G S+ +D+ Sbjct: 111 LTGSKTGVFVGISTNDYSRIHPEFDSNPQGYDLTGNCINIAAGRLSYLFNLRGPSLAVDT 170 Query: 215 ACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSMME-SQDDRVKTFDKNA 273 ACSS L+ VHLAC ++ N+E MAI S ++L + P + A + S D R KTFD++A Sbjct: 171 ACSSSLVAVHLACQSIWNQESSMAIASGVNLVLSPIGNIALSKLKALSPDGRCKTFDESA 230 Query: 274 DGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQEEVLLKA 333 +G S+G +ILKP+++A D D IYAVI+GSA+N+DG S GLT P AQE ++ +A Sbjct: 231 NGYVRSEGAGCIILKPIAQALADHDPIYAVIRGSAINHDGRSKGLTVPYGPAQESLIRQA 290 Query: 334 WEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKANIGHTVA 393 + AQ+ P I Y+E HGTGT LGDPIE + + D A C +G+VK+NIGH A Sbjct: 291 LQQAQVQPKEISYVELHGTGTPLGDPIEAMAIGAVLGEGRDAAHPCLVGAVKSNIGHLEA 350 Query: 394 VSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVLPRRAGIN 453 +G+AS+IK+ L++K+ IP S+HF +PN I F + P+ V + WPKS +AG++ Sbjct: 351 AAGIASIIKMALALKYQQIPPSLHFHQPNPYIPFDQLPLRVQTSLIPWPKSKYGAKAGVS 410 Query: 454 SFGFVGTNAHVVVEEAPDQAATSEAAGPEYEIFTVSAKTEHSLRQLIHQYAEFF--RQGT 511 SFGF GTNAHV++E + + + +SA T +++ L Y + ++ T Sbjct: 411 SFGFSGTNAHVILEGVSSFNSPEQQTCKFPHLLPLSAHTPAAVQTLALGYQDLINAQKLT 470 Query: 512 ETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLAS 552 + N+CY+A R H +YR A++V S E+L + LA+ Sbjct: 471 PEFVQNLCYSASVRRTHQSYRSAVVVNSPEDLPSCLQALAT 511 Score = 164 bits (415), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 125/462 (27%), Positives = 216/462 (46%), Gaps = 30/462 (6%) Query: 937 EIKDYVLKKVNHLLT---LFKENDDLSGAFYRLNWVQAEPAAEGRRGHEGTVLVFKDTQG 993 E K ++ + + L T K DLS A YR+ W + + + L+F D QG Sbjct: 917 EAKQFIPQLLQLLATGKSTAKITQDLSNARYRIEWQLSPLTVDNKTSEAERWLIFSDNQG 976 Query: 994 IYENIAGPLQNKAADTIQVEFGEAYKRLTPNHYVIQGTEN-DYINLMNEIKDRNIRQILH 1052 + + +A + + I V GE+Y++L+ +HY I + D+ L+ +I + I ++++ Sbjct: 977 LGQELAAVVND---SCILVSSGESYEKLSSSHYQINPHQAADFQQLLADISE-PITKVVY 1032 Query: 1053 LSSITGEAAATCADLADQQNRSLHSLFYLAKSISSNKIKENIDVVLISDNVTEVTGHEQE 1112 L S+ + +L + Q + L YL ++++ K + + + VT + Sbjct: 1033 LWSLD-----SSINLENSQPQCYSHLLYLVQALAKISSKIAPQLWIGTQQAQAVTPSCHQ 1087 Query: 1113 INPLGAALFGLGTVLTQEFKNIHCRALDV-DRETPAELISEEIQRIESKYQVALRSGKRY 1171 IN L+G+G V+ E+ + +D +++ A I E+ + +VA R GKRY Sbjct: 1088 INVAQTPLWGMGQVIALEYPQLWGGLIDFGNQDVAATAIIAEMTAKTGEDRVAFRDGKRY 1147 Query: 1172 TCELDRHEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGKNAVHIALMNRSKLPE 1231 L Q L G Y L +A +L + A H+ L +R L Sbjct: 1148 VARLMPISAPLPAPQPL--ISDGSYLITGGLGALGLTLAEWLVQQGARHLVLTSRQGL-- 1203 Query: 1232 AASWDQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRI 1291 + ++ E K Q I+ + G+ V + D++D Q++++ ++ ++ Sbjct: 1204 -------LNQSEE-----KQQKIRALENQGATVKVVAADVSDYQQMSQLFAQIQLNSPKL 1251 Query: 1292 HGIFHCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFG 1351 GI H AGV + + F +V PKVTG W L Q T++ +L+FF+ FSS++A+ G Sbjct: 1252 RGIIHAAGVLNDCSIAQMDSETFTKVFQPKVTGAWNLHQLTQDLSLDFFVCFSSMSALLG 1311 Query: 1352 GSGQGDYTAANAYLDSFSYSRNKRGARTISINWPAWSEVGIA 1393 GQ Y AAN++LD Y R G +SINW W+E G+A Sbjct: 1312 SRGQLHYAAANSFLDGLVYHRQSLGLPGLSINWGPWAEGGMA 1353 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.133 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 116,200,761 Number of extensions: 4961138 Number of successful extensions: 11345 Number of sequences better than 1.0e-05: 109 Number of HSP's gapped: 11022 Number of HSP's successfully gapped: 137 Length of query: 1606 Length of database: 38,378,431 Length adjustment: 120 Effective length of query: 1486 Effective length of database: 24,538,351 Effective search space: 36463989586 Effective search space used: 36463989586 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 123 (52.0 bits)