BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0382.0024.p (548 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0616 [V] COG1132 ABC-type multidrug transport system, ATPase ... 477 e-134 Cgl0940 [V] COG1132 ABC-type multidrug transport system, ATPase ... 452 e-127 CAC2393 [V] COG1132 ABC-type multidrug transport system, ATPase ... 446 e-125 TM0287 [V] COG1132 ABC-type multidrug transport system, ATPase a... 406 e-113 L59135 [V] COG1132 ABC-type multidrug transport system, ATPase a... 393 e-109 >lin0616 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 570 Score = 477 bits (1228), Expect = e-134, Method: Compositional matrix adjust. Identities = 241/549 (43%), Positives = 382/549 (69%), Gaps = 2/549 (0%) Query: 1 MAEVYLPTLMSDIVNKGILRKDTRYILEIGEYMILVALFNAVVITLTSYISAKVTVGYGS 60 + +++LPTLMS+I++KG+++ DT YI G M+L++ + ++ + Y+++++++G+G Sbjct: 23 IGQLFLPTLMSNIIDKGVVKGDTDYIWSTGMQMLLISFASVILSVIVVYLASRISMGFGK 82 Query: 61 SLRTAVFAKVQSFSLRELDQIGTASLINRTTNDITQFQQIFTTMLRVIIV-PMILIGSII 119 LR +F KV+ FSL+E D++GT+SLI RTTND+ Q Q + M+R++++ P++L+G II Sbjct: 83 DLRDKIFTKVEDFSLQEFDKVGTSSLITRTTNDVVQIQNVLYMMMRLMVMAPIMLLGGII 142 Query: 120 MAVSKNAQLSLVFLAVLPVLGLCTAVIGKKSMRFFKAMQEKLDQLNLIARENLKGIRVIR 179 MAV ++A+LSL+F+ VLP+L L ++G K+M FK++Q+K+D+LN + RE L GIRV+R Sbjct: 143 MAVGRDAKLSLIFVVVLPLLLLLVVILGGKAMPMFKSLQKKMDKLNRVIREGLTGIRVVR 202 Query: 180 AFHQMEGETQRFHEASKDLTAVSVKANLTIALVMPLMMLIMNAATLAVLWYGGKFIGSGS 239 +F++ E E ++F EA+ D ++K N ++L+ PLMML+MN ++A++W G FIG+G Sbjct: 203 SFNRNEDELEKFEEANADYATTAIKVNRLLSLMSPLMMLLMNLTSIAIVWIGSIFIGNGD 262 Query: 240 MQIGDLMAXXXXXXXXXXCIVFVSMMFSVMPRARASAERIQEVLALTPDIQDKRQGRSGE 299 M++GDLMA + +S +F ++PRA ASAERI EVL + +I + ++ Sbjct: 263 MEVGDLMAFIQYAMQIMMSFMMLSAVFIMIPRAGASAERINEVLDMKAEILNPENPKTS- 321 Query: 300 SGKGRIEFRNVTFSYPGAERPALRDVSFLAGPGKTLAIIGGTGSGKSALINLIPRFYDSQ 359 + ++ F +VTF Y GAE+P + D++F A G+T+AIIG TG+GKS LIN+IPRFYD + Sbjct: 322 TPPAKLSFEHVTFRYEGAEKPVIEDITFEAKAGETIAIIGSTGAGKSTLINMIPRFYDVE 381 Query: 360 EGSILLDGVDIKEIPLQSLRARMGVVPQQTVLFGGTVADNLRVGSRNAAPEEIRKAAEMA 419 G + ++G+D++E+ LR ++G+VPQ+ VLF GT+A N+R G +A EEI A A Sbjct: 382 SGVVKINGIDVREMDQSKLRQKIGLVPQKAVLFTGTIASNMRYGKEDATDEEIWAALRTA 441 Query: 420 QAHEFILRMEGGYAAEITQGGTNLSGGQKQRLAIARALVRRPDIYIXXXXXXXXXXXXXX 479 QA F+ ++ G + + QGG N SGGQKQRL+IAR+L+R+P+IYI Sbjct: 442 QAENFVSKLANGLGSRVEQGGNNFSGGQKQRLSIARSLIRKPEIYIFDDSFSALDFKTDA 501 Query: 480 HLRNALKKETSAATVIIVAQRVSTVMDADTILVMDQGCIAGMGTHKELLDTCAAYKEIVS 539 LR ALK ET+ A +IVAQR+++V+++D I+V+++G IAG+GTH+EL ++ Y+EI+ Sbjct: 502 KLREALKAETTEAVTLIVAQRITSVVNSDQIIVLNEGKIAGIGTHEELKESNKIYQEIMK 561 Query: 540 SQLSGEASA 548 SQLS E A Sbjct: 562 SQLSEEEIA 570 >Cgl0940 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 577 Score = 452 bits (1162), Expect = e-127, Method: Compositional matrix adjust. Identities = 237/551 (43%), Positives = 338/551 (61%), Gaps = 5/551 (0%) Query: 1 MAEVYLPTLMSDIVNKGILRKDTRYILEIGEYMILVALFNAVVITLTSYISAKVTVGYGS 60 + + LPTL +DI++ G++ D YI G M+ + L Y +K+++ G Sbjct: 29 ITSLLLPTLNADIIDNGVVTGDIGYIWHTGGIMLALTLVQVACAIAGVYFGSKLSMRVGR 88 Query: 61 SLRTAVFAKVQSFSLRELDQIGTASLINRTTNDITQFQ---QIFTTMLRVIIVPMILIGS 117 LR+A+F KV +FS RE+ Q G SLI R TND+ Q Q Q+ +T++ I PM+ IG Sbjct: 89 DLRSAIFGKVVNFSEREMGQFGAPSLITRNTNDVQQVQMLVQMTSTLM--ISAPMLAIGG 146 Query: 118 IIMAVSKNAQLSLVFLAVLPVLGLCTAVIGKKSMRFFKAMQEKLDQLNLIARENLKGIRV 177 IIMAV ++ LS + + +PVL + A+I + + F+ MQ+++D++N I RE L GIRV Sbjct: 147 IIMAVRQDLGLSWLMVVSIPVLIIVVALIIVRMVPLFQTMQKRIDRINQIIREQLTGIRV 206 Query: 178 IRAFHQMEGETQRFHEASKDLTAVSVKANLTIALVMPLMMLIMNAATLAVLWYGGKFIGS 237 IRAF + + E +RF ASKD+ + V+ +AL+ P +MLIMN + +AV+W+G + S Sbjct: 207 IRAFVREDVERERFTTASKDVADIGVRTGNLMALMFPAVMLIMNLSAVAVIWFGAFQVES 266 Query: 238 GSMQIGDLMAXXXXXXXXXXCIVFVSMMFSVMPRARASAERIQEVLALTPDIQDKRQGRS 297 G QIG L A ++ + MF ++PRA SA+RI EVL TP +Q Sbjct: 267 GETQIGTLFAFLQYIMQILMGVMMAAFMFVMVPRAAVSADRIGEVLETTPSVQAPETPAQ 326 Query: 298 GESGKGRIEFRNVTFSYPGAERPALRDVSFLAGPGKTLAIIGGTGSGKSALINLIPRFYD 357 + G I F N TF+YPGA+ P L +VSF PG T AIIG TGSGK+ LI L+PR +D Sbjct: 327 PSTSAGEIVFNNATFAYPGADDPVLNNVSFRVAPGSTTAIIGSTGSGKTTLIGLVPRLFD 386 Query: 358 SQEGSILLDGVDIKEIPLQSLRARMGVVPQQTVLFGGTVADNLRVGSRNAAPEEIRKAAE 417 EG + +DG D++E L R+G+VPQ++ LF GT+A NLR G+ +A ++ +A Sbjct: 387 VTEGDVTVDGTDVREFEPLKLWDRIGLVPQKSFLFSGTIASNLRYGNEDATETQLWQALA 446 Query: 418 MAQAHEFILRMEGGYAAEITQGGTNLSGGQKQRLAIARALVRRPDIYIXXXXXXXXXXXX 477 +AQA +F+ M G +EI QGGTN+SGGQ+QRLAIARAL+++P+IYI Sbjct: 447 IAQAADFVREMPEGLDSEIAQGGTNVSGGQRQRLAIARALLKQPEIYIFDDSFSALDVST 506 Query: 478 XXHLRNALKKETSAATVIIVAQRVSTVMDADTILVMDQGCIAGMGTHKELLDTCAAYKEI 537 LR AL AT +IVAQRVST+ DAD I+V+D G + G+GTH LL+TC Y+EI Sbjct: 507 DAALRRALSTNLPDATKLIVAQRVSTIRDADQIVVLDNGEVVGIGTHTNLLNTCGTYREI 566 Query: 538 VSSQLSGEASA 548 V SQ + +A + Sbjct: 567 VESQETAQAQS 577 >CAC2393 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 577 Score = 446 bits (1146), Expect = e-125, Method: Compositional matrix adjust. Identities = 230/548 (41%), Positives = 337/548 (61%), Gaps = 4/548 (0%) Query: 3 EVYLPTLMSDIVNKGILRKDTRYILEIGEYMILVALFNAVVITLTSYISAKVTVGYGSSL 62 E+ +PT+M I +KGI KD YI++IG MIL+A+F + Y ++ + G+G+ L Sbjct: 29 EISIPTIMVLITDKGISTKDNGYIVKIGIIMILMAIFGVMASFTCQYFASIASQGFGTIL 88 Query: 63 RTAVFAKVQSFSLRELDQIGTASLINRTTNDITQFQQIFTTMLRVII-VPMILIGSIIMA 121 R +F K+ +FS E+D+ GTASLINR TND+ Q Q +R+ I VP + IG IIMA Sbjct: 89 RNELFKKIGTFSYNEIDEFGTASLINRVTNDVNQLQLALAMFIRLAIRVPFLCIGGIIMA 148 Query: 122 VSKNAQLSLVFLAVLPVLGLCTAVIGKKSMRFFKAMQEKLDQLNLIARENLKGIRVIRAF 181 + + +LS + +PV +I KS+ +K +Q KLD L LI RENL GIRVIRAF Sbjct: 149 MFLDVKLSTIMYLSIPVFAFVVYLIMSKSLPLYKVVQRKLDSLALILRENLSGIRVIRAF 208 Query: 182 HQMEGETQRFHEASKDLTAVSVKANLTIALVMPLMMLIMNAATLAVLWYGGKFIGSGSMQ 241 +ME E +RF ++++LT ++ AL+ PL +IMN + LA+LW+GG + G++ Sbjct: 209 SKMEREKERFKNSNEELTNEVIRVGKISALMNPLTSIIMNFSVLAILWFGGTRVNGGAIT 268 Query: 242 IGDLMAXXXXXXXXXXCIVFVSMMFSVMPRARASAERIQEVLALTPDIQ--DKRQGRSGE 299 G ++A ++ V+ + + +A ASA R++EV I D ++ + + Sbjct: 269 RGKIIAYINYTNLVLSALIIVANLIVIFTKAAASAARVEEVFNTEISINYLDNKEFKKED 328 Query: 300 -SGKGRIEFRNVTFSYPGAERPALRDVSFLAGPGKTLAIIGGTGSGKSALINLIPRFYDS 358 I+F NV FSY ++ A+ D+SF G+T+ IIGGTG+GK+ LINLIPR YD+ Sbjct: 329 IRDASLIKFDNVAFSYKNSKEYAISDISFEIKKGQTVGIIGGTGAGKTTLINLIPRLYDT 388 Query: 359 QEGSILLDGVDIKEIPLQSLRARMGVVPQQTVLFGGTVADNLRVGSRNAAPEEIRKAAEM 418 +G + ++G+D+K P L ++GVVPQ+ +LF GT+ +N+ G NA+ EEI+ AA++ Sbjct: 389 AKGQVFINGIDVKNYPKTVLEEKIGVVPQKAILFSGTIFENISWGRENASLEEIKDAAKI 448 Query: 419 AQAHEFILRMEGGYAAEITQGGTNLSGGQKQRLAIARALVRRPDIYIXXXXXXXXXXXXX 478 A EFI ++ Y I+QGG N SGGQKQRL IARALV++P+I I Sbjct: 449 GMASEFIEKLPKKYDTNISQGGANFSGGQKQRLTIARALVKKPEILILDDSLSALDYATD 508 Query: 479 XHLRNALKKETSAATVIIVAQRVSTVMDADTILVMDQGCIAGMGTHKELLDTCAAYKEIV 538 LR LK+ + TV++V QR+ST+ DAD I+V+D G +AG+GTH ELL+ YKEI Sbjct: 509 AALRQELKENSKDMTVLMVTQRISTIKDADLIIVLDDGKVAGVGTHNELLEESEVYKEIC 568 Query: 539 SSQLSGEA 546 +SQLS EA Sbjct: 569 NSQLSKEA 576 >TM0287 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 577 Score = 406 bits (1043), Expect = e-113, Method: Compositional matrix adjust. Identities = 206/537 (38%), Positives = 323/537 (60%), Gaps = 1/537 (0%) Query: 7 PTLMSDIVNKGILRKDTRYILEIGEYMILVALFNAVVITLTSYISAKVTVGYGSSLRTAV 66 PTL++ IV++GI R D +L+ G M++VAL AV + ++ + +G+ LR + Sbjct: 33 PTLLARIVDEGIARGDFSLVLKTGILMLIVALIGAVGGIGCTVFASYASQNFGADLRRDL 92 Query: 67 FAKVQSFSLRELDQIGTASLINRTTNDITQFQQIFTTMLRVII-VPMILIGSIIMAVSKN 125 F KV SFS+ +++ T+SLI R TND+TQ Q + +LR+++ P++ +G I+MAVS N Sbjct: 93 FRKVLSFSISNVNRFHTSSLITRLTNDVTQLQNLVMMLLRIVVRAPLLFVGGIVMAVSIN 152 Query: 126 AQLSLVFLAVLPVLGLCTAVIGKKSMRFFKAMQEKLDQLNLIARENLKGIRVIRAFHQME 185 +LS V + ++P + L + KK F+ +QE D++N + RENL G+RV+RAF + E Sbjct: 153 VKLSSVLIFLIPPIVLLFVWLTKKGNPLFRKIQESTDEVNRVVRENLLGVRVVRAFRREE 212 Query: 186 GETQRFHEASKDLTAVSVKANLTIALVMPLMMLIMNAATLAVLWYGGKFIGSGSMQIGDL 245 E + F +A++ L + A I +PL + I+N +AVLW+GG + + M+IG + Sbjct: 213 YENENFRKANESLRRSIISAFSLIVFALPLFIFIVNMGMIAVLWFGGVLVRNNQMEIGSI 272 Query: 246 MAXXXXXXXXXXCIVFVSMMFSVMPRARASAERIQEVLALTPDIQDKRQGRSGESGKGRI 305 MA ++ + + + + RA ASA+R+ EVL P I++ + + +G + Sbjct: 273 MAYTNYLMQIMFSLMMIGNILNFIVRASASAKRVLEVLNEKPAIEEADNALALPNVEGSV 332 Query: 306 EFRNVTFSYPGAERPALRDVSFLAGPGKTLAIIGGTGSGKSALINLIPRFYDSQEGSILL 365 F NV F Y P L V+F PG +A++G TGSGKS L+NLIPR D + G + + Sbjct: 333 SFENVEFRYFENTDPVLSGVNFSVKPGSLVAVLGETGSGKSTLMNLIPRLIDPERGRVEV 392 Query: 366 DGVDIKEIPLQSLRARMGVVPQQTVLFGGTVADNLRVGSRNAAPEEIRKAAEMAQAHEFI 425 D +D++ + L+ LR + VPQ+TVLF GT+ +NL+ G +A +EI +AA++AQ H+FI Sbjct: 393 DELDVRTVKLKDLRGHISAVPQETVLFSGTIKENLKWGREDATDDEIVEAAKIAQIHDFI 452 Query: 426 LRMEGGYAAEITQGGTNLSGGQKQRLAIARALVRRPDIYIXXXXXXXXXXXXXXHLRNAL 485 + + GY + + +GG N SGGQKQRL+IARALV++P + I + + L Sbjct: 453 ISLPEGYDSRVERGGRNFSGGQKQRLSIARALVKKPKVLILDDCTSSVDPITEKRILDGL 512 Query: 486 KKETSAATVIIVAQRVSTVMDADTILVMDQGCIAGMGTHKELLDTCAAYKEIVSSQL 542 K+ T T I+ Q++ T + AD ILV+ +G +AG GTHKELL+ C Y+EI SQ Sbjct: 513 KRYTKGCTTFIITQKIPTALLADKILVLHEGKVAGFGTHKELLEHCKPYREIYESQF 569 >L59135 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 611 Score = 393 bits (1009), Expect = e-109, Method: Compositional matrix adjust. Identities = 219/567 (38%), Positives = 327/567 (57%), Gaps = 23/567 (4%) Query: 1 MAEVYLPTLMSDIVNKGILRKDTRYILEIGEYMILVALFNAVVITLTSYISAKVTVGYGS 60 + ++LPT+ +DI+NKGI + D +YI +G M+ V+L + + Y ++K + G G Sbjct: 26 VTNLWLPTITADIINKGIGQSDMKYIWFMGLIMLFVSLASWLSAIGNVYFASKQSQGLGL 85 Query: 61 SLRTAVFAKVQSFSLRELDQIGTASLINRTTNDITQFQQIFTTMLRVIIV-PMILIGSII 119 LR +F KV R + G A+LI RTTND+TQ Q +F TMLR++++ PM+LIGSI Sbjct: 86 KLRHDLFKKVLFMDERNFQEFGDATLITRTTNDVTQLQNVFQTMLRMMLMAPMMLIGSIF 145 Query: 120 MAVSKNAQLSLVFLAVLPVLGLCTAVIGKKSMRFFKAMQEKLDQLNLIARENLKGIRVIR 179 MA + L LVFL LP+L L + SM F++MQ K+D++NLI ++ L G+RVIR Sbjct: 146 MAWKLSHDLLLVFLIALPILTLAVVINIAISMPRFRSMQTKVDKINLIFQQGLTGVRVIR 205 Query: 180 AFHQMEGETQRFHEASKDLTAVSVKANLTIALVMPLMMLIMNAATLAVLWYGGKFIGSGS 239 AF + + E +F EA++DLT S TIA++MP+M +I++ + ++W+G I Sbjct: 206 AFRRDQYEIDKFDEANRDLTHTSQVVLTTIAMLMPIMTVILSFTNIGIVWFGAHLISKNM 265 Query: 240 MQIGDLMAXXXXXXXXXXCIVFVSMMFSVMPRARASAERIQEVLALTPDIQD-------- 291 M++G L+A + +S + ++PRA+ SA R++E+L I D Sbjct: 266 MEMGSLVAFLTYATQILMSFMQLSAVAVMVPRAQVSAVRVREILESKDKITDENSSISVE 325 Query: 292 --KRQGRSGE---------SGKGRIEFRNVTFSYPGAERPALRDVSFLAGPGKTLAIIGG 340 KRQ S + S + + +V+F + A+R AL D+S G+TLAIIGG Sbjct: 326 ALKRQRLSSDGNDKLSESNSVRNSLALNHVSFKFDEAKRQALSDLSVNVAAGQTLAIIGG 385 Query: 341 TGSGKSALINLIPRFYDSQEGSILLDGVDIKEIPLQSLRARMGVVPQQTVLFGGTVADNL 400 TGSGKS ++NLI R D GS+ +DG DI++I L ++ Q+ LF GTV NL Sbjct: 386 TGSGKSTILNLIARLIDPTNGSVTIDGTDIRQISQYDLHEKVSFTQQKAQLFSGTVRSNL 445 Query: 401 RVGSRNAAPEEIRKAAEMAQAHEFILRMEGGYAAEITQGGTNLSGGQKQRLAIARALVRR 460 + G +A EE+ +A E+AQA +F+ R +GG + Q G N SGGQKQR++IAR L++ Sbjct: 446 QFGKSDATDEEMWQALEIAQAADFV-REQGGLELAVEQNGANFSGGQKQRISIARTLIKE 504 Query: 461 PDIYIXXXXXXXXXXXXXXHLRNALKKETSAATVI--IVAQRVSTVMDADTILVMDQGCI 518 +IY+ LR A+ I IVAQR++TVM AD ILV++ G Sbjct: 505 AEIYLFDDSFSALDFATDRQLRTAINHSEKHKNKIKVIVAQRIATVMSADQILVLENGIA 564 Query: 519 AGMGTHKELLDTCAAYKEIVSSQLSGE 545 G+GTH+ L +C Y+E + SQLS + Sbjct: 565 VGLGTHESLAKSCPQYQETMQSQLSDD 591 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.322 0.136 0.372 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 34,108,065 Number of extensions: 1303672 Number of successful extensions: 17799 Number of sequences better than 1.0e-05: 1408 Number of HSP's gapped: 16613 Number of HSP's successfully gapped: 1451 Length of query: 548 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 437 Effective length of database: 25,576,357 Effective search space: 11176868009 Effective search space used: 11176868009 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 118 (50.1 bits)