BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0337.0019.p (327 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0539 [K] COG1609 Transcriptional regulators 216 3e-56 BH1250 [K] COG1609 Transcriptional regulators 202 5e-52 CAC3037 [K] COG1609 Transcriptional regulators 144 2e-34 CAC0360 [K] COG1609 Transcriptional regulators 143 4e-34 HI1635 [K] COG1609 Transcriptional regulators 142 7e-34 >lin0539 [K] COG1609 Transcriptional regulators Length = 322 Score = 216 bits (551), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 123/329 (37%), Positives = 183/329 (55%), Gaps = 9/329 (2%) Query: 1 MANIKEIARIAGVSVTTVSRVLNNHPYVSKDKRTAVLQTIEQLNYTRNMNAVHLITGRTG 60 MANI+EIA++AGVS TVSRV+NN YVS++ R V I++L+Y N+NAV L G T Sbjct: 1 MANIQEIAKLAGVSSATVSRVINNRDYVSEETRKRVQTIIDKLDYVPNINAVSLKKGATK 60 Query: 61 AVAVILPYISSFYFSVVMDGXXXXXXXXXYRLILCQTNYVPEEELKVLDMLRNKEIDGVI 120 + +++P + +V + Y + L T P++EL+ L+MLR K+ID ++ Sbjct: 61 LIGMVIPSFTD-SLNVFLKSFTMMAQEHGYNVTLFMTRIDPDKELEALEMLRQKQIDALV 119 Query: 121 IVSTALKPEVIESYTIYGPVVTCQNSGERQFSSVYIEHYAAFRHGLEYLYGKGHRRIGYC 180 +V + + IE YT YGP+VT Q + SV++ Y + LE+LY KG+R+ Sbjct: 120 LVIRSNDWKTIEHYTKYGPIVTWQRVESEKIPSVFMNQYDGYTLALEHLYAKGYRKFVNV 179 Query: 181 EGRQNGSSASIRQNAFQDFLAEKELLFDPEWM--IFDCMREEDGAEVARRLLDNPDRSGR 238 G G + R AF+DF A EL DP + +DG ++A + + Sbjct: 180 YGNTTGLNTQSRMLAFKDFCARYEL--DPHEFRQFYGQGSRQDGEKIAHWW---SETEHK 234 Query: 239 PEAMMISGDHIAAGLIIEARKHGLKIPEDLAVMGFDNQPIGRLLGITTIDNQLYQMGEAA 298 P+A + D+ AAGL+ EAR+ G +PED A+ GFDN + LL ITTI + E A Sbjct: 235 PDAFLTPNDYFAAGLLTEARRLGYSVPEDFAICGFDNMEVAHLLDITTIHYPVNLQAENA 294 Query: 299 FGIIHEQINGSSLPVTRKLDYRIIERSTV 327 F +I Q+ GS+LP+ LD+ ++ER T Sbjct: 295 FTLIMNQLFGSNLPLL-DLDFHLVERKTT 322 >BH1250 [K] COG1609 Transcriptional regulators Length = 338 Score = 202 bits (515), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 126/339 (37%), Positives = 185/339 (54%), Gaps = 21/339 (6%) Query: 1 MANIKEIARIAGVSVTTVSRVLNNHPYVSKDKRTAVLQTIEQLNYTRNMNAVHLITGRTG 60 MA IKE+A++AG+S TTVSRV+NNHPYVS +KR VL ++QL Y N +A L +T Sbjct: 1 MATIKEVAQLAGLSRTTVSRVINNHPYVSDEKRQQVLDAMKQLGYVPNSSAQRLRRNKTE 60 Query: 61 AVAVILPYISSFYFSVVMDGXXXXXXXXXYRLILCQTNYVPEEELKVLDMLRNKEIDGVI 120 +AV++ I + +FS ++D Y+LILC T E+EL L++LR K++DG+I Sbjct: 61 TIAVVISRIVNPFFSGLVDEMERVASEHGYQLILCNTRQSKEKELSYLELLRTKQVDGII 120 Query: 121 IVSTALKPEVIESYTIYGPVVTCQNSGERQFSSVYIEH-------YAAFRHGLEYLYGKG 173 + S + EVIE YT YGP+V C R S+ + Y A +H LE G Sbjct: 121 MASMQNEWEVIEPYTAYGPMVACNEY--RPGMSIPLVRLNQEEAGYVATKHLLEL----G 174 Query: 174 HRRIGYCEGRQNGSSASIRQNAFQDFLAEKELLFDPEWMIFDCMREEDGAEVARRLLDNP 233 HR+I G + + R+ + L E + EW + +DG RL Sbjct: 175 HRKIACLAGNKAIPLSEDRKAGYLRALQEYGIKVKEEWTYYHAFSIDDGKRWF-RLFQTI 233 Query: 234 DRSGRPEAMMISGDHIAAGLIIEARKHGLKIPEDLAVMGFDNQPIGRLLG--ITTIDNQL 291 + + RP A+ D +AAG++ EA+ HG IP+DLA++GFDNQ I L+ +TTI+ + Sbjct: 234 ETNTRPTAVFTGSDEVAAGILSEAKVHGWNIPKDLAIVGFDNQQIATLVTPRLTTIEQPI 293 Query: 292 YQMG----EAAFGIIHEQINGSSLPVTRKLDYRIIERST 326 +G E F ++ EQIN P +L +R+I R + Sbjct: 294 SLIGRRALEVMFMLLDEQINDLP-PFEERLPFRLIVRES 331 >CAC3037 [K] COG1609 Transcriptional regulators Length = 334 Score = 144 bits (362), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 100/339 (29%), Positives = 176/339 (51%), Gaps = 23/339 (6%) Query: 2 ANIKEIARIAGVSVTTVSRVLNNHPYVSKDKRTAVLQTIEQLNYTRNMNAVHLITGRTGA 61 A+IK++AR A VS+ TVSRVLNN V+++ + V++ I++L+Y N+ A L T RT Sbjct: 3 ASIKDVAREARVSIATVSRVLNNVDVVNEETKKKVMEAIKKLDYRPNIVARSLKTQRTRT 62 Query: 62 VAVILPYISSFYFSVVMDGXXXXXXXXXYRLILCQTNYVPEEELKVLDMLRNKEIDGVII 121 + +++P ISS ++ ++ G Y +ILC T+ +E + +L+ K +DGVI Sbjct: 63 IGIVIPDISSQFYPEIVRGAEDVSNIYNYNVILCNTDLDISKEKDYIRVLKEKMVDGVIY 122 Query: 122 VSTALKPEVIESY-TIYGPVV---TCQNSGERQFSSVYIEHYAAFRHGLEYLYGKGHRRI 177 +S +L PE+++ + P V T ++ E F SV I++ A + YL KG+ +I Sbjct: 123 MSNSLAPEILQLLRDLKIPTVLVETRESEDENAFPSVTIDNAKAAYDAVNYLIKKGNNKI 182 Query: 178 GYCEGRQNGSSASIRQNA-------FQDFLAEKELLFDPEWMIFDCMREEDGAEVARRLL 230 Y G + ++ NA ++ L + + + + F ++ DG + ++ Sbjct: 183 AYV-----GVNPKLKNNARAIIYEGYKKALLDNNIPLNENLIQFGGLKAIDGTDGINVII 237 Query: 231 DNPDRSGRPEAMMISGDHIAAGLIIEARKHGLKIPEDLAVMGFDNQPIGRLL--GITTID 288 + + +A+ + D IA G I R++G+ +P+D+ V+GFDN + +TTI+ Sbjct: 238 ----KKEKIDAVFCACDEIAMGAINALRENGIDVPKDVDVVGFDNIYTSSIFYPKLTTIE 293 Query: 289 NQLYQMGEAAFGIIHEQINGSSLPVTRK-LDYRIIERST 326 Y MG ++ + IN + LDY IIER + Sbjct: 294 QPTYDMGSVGMRMLIKIINKAEPECLHYVLDYNIIERDS 332 >CAC0360 [K] COG1609 Transcriptional regulators Length = 328 Score = 143 bits (360), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 95/330 (28%), Positives = 173/330 (52%), Gaps = 12/330 (3%) Query: 1 MANIKEIARIAGVSVTTVSRVLNNHPYVSKDKRTAVLQTIEQLNYTRNMNAVHLITGRTG 60 M +IK+IAR GVS TVSR LNN +++ + +L+ E+L Y N A LIT +T Sbjct: 1 MVSIKDIARYCGVSAMTVSRALNNSDDIAEATKEKILKVCEELKYKPNSAAKSLITKKTN 60 Query: 61 AVAVILPYISSFYFSVVMDGXXXXXXXXXYRLILCQTNYVPEEELKVLDMLRNKEIDGVI 120 + +I+P I++ Y++ + G Y LILC +N E+K LD L +DG+I Sbjct: 61 MIGLIIPDIANQYYANISKGVSSYIEKHGYGLILCNSNRKKPNEVKYLDFLSEGRVDGII 120 Query: 121 IVSTALKPEVIESYTIYGPVVTCQNSGE-RQFSSVYIEHYAAFRHGLEYLYGKGHRRIGY 179 I+ + E E + P+V N + + + V I++YA + ++ +G+++IG Sbjct: 121 ILPVKPRKEDYEDISRQIPMVMADNFAKGLEVNFVGIDNYAGAIKIITHMVNQGYKKIGV 180 Query: 180 CEGRQNGSSASIRQNAFQDFLAEKELLFDPEWMIFDCMREEDGAEVARRLLDNPDRSGRP 239 G ++ +++S R N ++ L +K + ++ + +I EDG +A L++ Sbjct: 181 ILGDKDSTASSERLNGYKKVLEDKGISYNEDIVIHSNSTFEDGFNIASILIEKG-----V 235 Query: 240 EAMMISGDHIAAGLIIEARKHGLKIPEDLAVMGFDNQPIGRLLGI--TTIDNQLYQMGEA 297 +++ D +A G+I + G+K+PE+L + G+DN +L I TT+D ++G Sbjct: 236 DSIFAINDTVAMGVIKYCYEKGIKLPEELGLAGYDNIEQAAMLTIPLTTVDQDNKKIGTI 295 Query: 298 AFGIIHEQINGSSLPVTRKLDYRIIERSTV 327 A ++ + I G++ +K + I+E + V Sbjct: 296 AAKMLVDAIKGNA----KKTEKIILEPTLV 321 >HI1635 [K] COG1609 Transcriptional regulators Length = 336 Score = 142 bits (358), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 91/315 (28%), Positives = 156/315 (49%), Gaps = 15/315 (4%) Query: 1 MANIKEIARIAGVSVTTVSRVLNNHPYVSKDKRTAVLQTIEQLNYTRNMNAVHLITGRTG 60 MA IK++A++AGVS TTVS V+N +V+KD AVL I+QLNY+ + A L T Sbjct: 1 MATIKDVAKMAGVSTTTVSHVINKTRFVAKDTEEAVLSAIKQLNYSPSAVARSLKVNTTK 60 Query: 61 AVAVILPYISSFYFSVVMDGXXXXXXXXXYRLILCQTNYVPEEELKVLDMLRNKEIDGVI 120 ++ +I+ + YF+ ++ Y L PE+ L+ML K +DG++ Sbjct: 61 SIGMIVTTSEAPYFAEIIHSVEEHCYRQGYSLFCVTHKMDPEKVKNHLEMLAKKRVDGLL 120 Query: 121 IVSTALKPEVIESYTIYGPV-VTCQNSGERQFSSVYIEH-----YAAFRHGLEYLYGKGH 174 ++ + + ++ + + + + + G + V +H Y A +H +E GH Sbjct: 121 VMCSEYTQDSLDLLSSFSTIPMVVMDWGPNANTDVIDDHSFDGGYLATKHLIEC----GH 176 Query: 175 RRIGYCEGRQNGSSASIRQNAFQDFLAEKELLFDPEWMIFDCMREEDGAEVARRLLDNPD 234 ++IG G N ++A R F+ + E +L +P W++ EDG E RLL Sbjct: 177 KKIGIICGELNKTTARTRYEGFEKAMEEAKLTINPSWVLEGAFEPEDGYECMNRLL---T 233 Query: 235 RSGRPEAMMISGDHIAAGLIIEARKHGLKIPEDLAVMGFDNQPIGRLLG--ITTIDNQLY 292 + P A+ D +A G I + GL++PED++++G+D+ R +TTI Sbjct: 234 QEKLPTALFCCNDVMALGAISALTEKGLRVPEDMSIIGYDDIHASRFYAPPLTTIHQSKL 293 Query: 293 QMGEAAFGIIHEQIN 307 ++G A I+ E+I Sbjct: 294 RLGRQAINILLERIT 308 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.321 0.138 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 23,274,662 Number of extensions: 976525 Number of successful extensions: 2121 Number of sequences better than 1.0e-05: 162 Number of HSP's gapped: 1883 Number of HSP's successfully gapped: 163 Length of query: 327 Length of database: 38,378,431 Length adjustment: 107 Effective length of query: 220 Effective length of database: 26,037,693 Effective search space: 5728292460 Effective search space used: 5728292460 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 116 (49.3 bits)