BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0307.0075.p (736 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ydfJ [R] COG2409 Predicted drug exporters of the RND superfamily 579 e-165 CAC3431 [R] COG2409 Predicted drug exporters of the RND superfamily 538 e-153 Cgl0232 [R] COG2409 Predicted drug exporters of the RND superfamily 364 e-100 Cgl0900 [R] COG2409 Predicted drug exporters of the RND superfamily 287 5e-77 Rv0202c [R] COG2409 Predicted drug exporters of the RND superfamily 233 1e-60 >BS_ydfJ [R] COG2409 Predicted drug exporters of the RND superfamily Length = 427 Score = 579 bits (1493), Expect = e-165, Method: Compositional matrix adjust. Identities = 0/708 (0%), Positives = 0/708 (0%), Gaps = 11/708 (1%) Query: 1 MAKILYRLGFWSAKNRLKVLLGSITXXXXXXXXXXSMGVHFGEETSIPGLASQKTLEVME 60 M LY LG + + S G + + + Sbjct: 1 MDFQLYSLGAALVFHEIFFPESSTAMALILAMGTYGAGYVARIVGAFIFGKMGDRIGRKK 60 Query: 61 KEFPN-PQSGLGKTQLVLKAPDNERLSSETAKQLVTAKLKEVAADPEVTSVVSPYDNHSL 119 F G ++ A L+ + Sbjct: 61 VLFITITMMG--ICTTLIGVLPTYAQIGVFAPILLVTLRIIQGLGAGAEISGAGTMLAEY 118 Query: 120 NADSTIGYATITYAVPGDEVTDESKDSVNEIAESLRDAGWQAELIGD-GYVKMATSSPTE 178 G + A+ + T + + L A + Sbjct: 119 APKGKRGIISSFVAMGTNCGTLSATAIWAFMFFILSKEELLAWGWRIPFLASVVVMVFAI 178 Query: 179 XXXXXXXXXXXXXXXXXXXTGVLPIVTAXXXXXXXXXXXXXXTSFLDVPSFALSLAGMLG 238 A F + L + G Sbjct: 179 WLRMNLKESPVFEKVNDSNQPTAKPAPAGSMFQSKSFWLATGLRFGQAGNSGLIQTFLAG 238 Query: 239 LAVGIDYALFIIARYRQQLAEGYERREAIAIANGTAGSAVVFAGVTVIIALVGFSFVGVP 298 V I ++ + + + + + + ++ + Sbjct: 239 YLVQTLLFNKAIPTDALMISSILGFMTIPFLGWLSDKIGRRIPYIIMNTSAIVLAWPMLS 298 Query: 299 FLTAMGMAGALTVFTAILMTIFVVPAILDLLGGKVKAPAKRAGSKQKPAGRSNLWGRFVT 358 + A + + I++ V + L + + + Sbjct: 299 IIVDKSYAPSTIMVALIVIHNCAVLGLFALENITMAEMFGCKNRFT--RMAISKEIGGLI 356 Query: 359 GHPXXXXXXXXXXXXXXXXPFFHMETGLGNDGHKSPDKTERRAYDLLSEAYGEGYHGPLV 418 + + D A + Sbjct: 357 ASGFGPILAGIFCTMTESWYPIAIMIMAYSVIGLISALKMPEVKDRDLSALEDAAEDQPR 416 Query: 419 LLAE-TDGGKEAAANLNKVIEEVKTYPNVAMVNPAVTAPSGKVSLITVMPATGPNDSATI 477 ++ Sbjct: 417 VVRAA 476 Query: 478 DLVHLIRDKAPEIEQQDHIKIGVTGSTAVNIDITQKLNQALPEFCLIIVGLAFVLLMLVF 537 Sbjct: 477 ---- 532 Query: 538 RSILVPIKAVLGFILSLGATLGFVTYVVQDGHFQKLFGFYAEAPVFNFLPIIVVGVLFGL 597 Sbjct: 533 592 Query: 598 AMDYEVFLVSRMREEFKKSGDAKKSVLAGIRHSGGVVTAAGLIMVAVFTGFILAEEPMVK 657 Sbjct: 593 652 Query: 658 VMGLALAFGVLFDAFIVRMLIVPGVMTLLGKSAWYFPKWLDRLLPNLD 705 Sbjct: 653 700 >CAC3431 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 729 Score = 538 bits (1387), Expect = e-153, Method: Compositional matrix adjust. Identities = 295/717 (41%), Positives = 422/717 (58%), Gaps = 13/717 (1%) Query: 1 MAKILYRLGFWSAKNRLKVLLGSITXXXXXXXXXXSMGVHFGEETSIPGLASQKTLEVME 60 MAK+LY LG W K +V++ + + G+ F + SIPG S+K +++ Sbjct: 1 MAKLLYNLGSWVYKRPKRVIVAWVVFLAILGVAVLNTGIKFSDNFSIPGSKSEKAGNMLK 60 Query: 61 KEFPNPQSGLGKT---QLVLKAPDNERLSSETAKQLVTA-KLKEVAADPEVTSVVSPYDN 116 K + KT +L+ K + L + + K + K K D +V + PY Sbjct: 61 KATESQSKSSNKTTTIRLIFKVEKGKDLMTPSVKIAINKLKTKIQGKDKKVMYISDPYAM 120 Query: 117 HSLNADSTIGYATITYAVPGDEVTDESKDSVNEIAESLRDAGWQAELIGD-GYVKMATSS 175 +++ + I YA ITY + +EVT++ K+ V + RDAG Q EL GD + + Sbjct: 121 GTISKNKKIAYADITYNIKNEEVTEKDKNIVFNNIKITRDAGIQTELGGDVAFSGIEAVG 180 Query: 176 PTEXXXXXXXXXXXXXXXXXXXTGVLPIVTAXXXXXXXXXXXXXXTSFLDVPSFALSLAG 235 P++ ++PI TA ++ +D F+LSLA Sbjct: 181 PSDAVGLAIAFIVLLITFRLFMAALMPIATAAVGLASGVLCIFISSNSVDTLIFSLSLAA 240 Query: 236 MLGLAVGIDYALFIIARYRQQLAEGYERREAIAIANGTAGSAVVFAGVTVIIALVGFSFV 295 M+GLAVGIDYALFII+RYR+ LAEGY+R+E++A A TAGS+V+FAGVTVIIAL G S V Sbjct: 241 MIGLAVGIDYALFIISRYRENLAEGYDRQESLARAMATAGSSVLFAGVTVIIALSGLSLV 300 Query: 296 GVPFLTAMGMAGALTVFTAILMTIFVVPAILDLLGGKVKAPAKRA------GSKQKPAGR 349 GVPFL MG+ A V AI+ ++ VPA + + ++ K SK K Sbjct: 301 GVPFLRTMGLDAAAVVLLAIISSLTAVPAFISIAKDRISIYKKNKIFNIIKSSKYKNKED 360 Query: 350 SNLWGRFVTGHPXXXXXXXXXXXXXXXXPFFHMETGLGNDGHKSPDKTERRAYDLLSEAY 409 S WG V+ HP ++E G+ + G K + TER+ YD+++E + Sbjct: 361 SK-WGSIVSKHPAVIAIAVVIVTALFSYQALNLELGIPDKGSKPIESTERKGYDIMAEGF 419 Query: 410 GEGYHGPLVLLAETDGGK-EAAANLNKVIEEVKTYPNVAMVNPAVTAPSGKVSLITVMPA 468 G+G +GPL+L+A+ K L ++ +E+ PN+ + P + + K+++I ++P Sbjct: 420 GKGVNGPLILVADASKVKGNYMITLQEIEKEIGKLPNIKSITPPIPVGNNKLAMINLVPK 479 Query: 469 TGPNDSATIDLVHLIRDKAPEIEQQDHIKIGVTGSTAVNIDITQKLNQALPEFCLIIVGL 528 +GPND T +LV I +K+ I + + + TG+TAVNID L++ +P+F L+IVGL Sbjct: 480 SGPNDKETKELVKAINEKSENIRKYKKVDLMETGATAVNIDTDVTLSKVMPKFILVIVGL 539 Query: 529 AFVLLMLVFRSILVPIKAVLGFILSLGATLGFVTYVVQDGHFQKLFGFYAEAPVFNFLPI 588 A +L++LVFRSILVPIKAVLGF++++ +TLGF V+Q+GH LF A P+ FLPI Sbjct: 540 AIILMVLVFRSILVPIKAVLGFLMTILSTLGFGVIVLQNGHLAGLFNVAAREPILCFLPI 599 Query: 589 IVVGVLFGLAMDYEVFLVSRMREEFKKSGDAKKSVLAGIRHSGGVVTAAGLIMVAVFTGF 648 +V G+LFGLAMDYEVFLVSRMRE + ++GDA+KSV+ GI++SG VVT+A LIM AVF GF Sbjct: 600 LVTGILFGLAMDYEVFLVSRMRESYTQTGDARKSVILGIKNSGKVVTSAALIMTAVFLGF 659 Query: 649 ILAEEPMVKVMGLALAFGVLFDAFIVRMLIVPGVMTLLGKSAWYFPKWLDRLLPNLD 705 + VK MG+ LAFGVLFDAF++RM VP VM LLGK AWY PKWLDR+LPN+D Sbjct: 660 AFNVDANVKEMGITLAFGVLFDAFVIRMTFVPAVMILLGKKAWYMPKWLDRILPNID 716 >Cgl0232 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 801 Score = 364 bits (934), Expect = e-100, Method: Compositional matrix adjust. Identities = 264/809 (32%), Positives = 390/809 (48%), Gaps = 101/809 (12%) Query: 1 MAKILYRLGFWSAKNRLKVLLGSITXXXXXXXXXXSMGVHFGEETSIPGLASQKTLEVME 60 MAK+L+RLG WS + V+ + +M F +I S + Sbjct: 1 MAKLLFRLGRWSYNRKWIVISAWLLILAIVGGLALTMQKGFSNSFTIEDTPSIDATVSLV 60 Query: 61 KEFP---NPQSGLGKTQLVLKAPDNERLSSE---TAKQLVTAKLKEVAAD---------- 104 + FP NP + G +V ++P+ L TA V +++ D Sbjct: 61 ENFPDQTNPVTAAG-VNVVFQSPEGTTLDDPQMMTAMDAVVDYIEDNLPDFGGGERFGNP 119 Query: 105 --------------------PEVTSVVSPYDNHSLNADSTIGYATITYAVPGDE-VTDES 143 PE T+ + L+ D TIGY + V E V + Sbjct: 120 VEVSPALEEMVIEQMTSMGLPEETAAKDAANLAVLSEDKTIGYTSFNIDVEAAEYVEQKH 179 Query: 144 KDSVNEIAESLRDAGWQAELIGDGY---VKMATSSPTEXXXXXXXXXXXXXXXXXXXTGV 200 +D +NE + D G + E G + +++ T+S E Sbjct: 180 RDVINEAMQIGEDLGVRVEAGGPAFGDPIQIETTS--EIIGIGIAFIVLIFTFGSLIAAG 237 Query: 201 LPIVTAXXXXXXXXXXXXXXTSFLDVPSFALSLAGMLGLAVGIDYALFIIARYRQQLAEG 260 LP++TA T+F D+ + LA M+GLAVGIDYALFI++RYR + Sbjct: 238 LPLITAVIGVGIGALAIVLATAFTDLNNVTPVLAVMIGLAVGIDYALFILSRYRAEYKR- 296 Query: 261 YERREAIAIANGTAGSAVVFAGVTVIIALVGFSFVGVPFLTAMGMAGALTVFTAILMTIF 320 R +A +A GTAGSAVVFAG TVIIALV + FLTAMG++ A TVF A+L+ + Sbjct: 297 MPRADAAGMAVGTAGSAVVFAGATVIIALVALIIADIGFLTAMGISAAFTVFVAVLIALT 356 Query: 321 VVPAILDLLGG---KVKAPA-------KRAGSK---QKPAGRSNLWGRFVTGHPXXXXXX 367 +PA+L + GG K K P K+ + ++ GRS W + V P Sbjct: 357 FIPALLGVFGGHAFKGKIPGIGGNPTPKQTWEQALNRRSKGRS--WVKLVQKAPGLVVAV 414 Query: 368 XXXXXXXXXXPFFHMETGLGNDGHKSPDKTERRAYDLLSEAYGEGYHGPLVLLAET---- 423 P +++ L +D + D T+R++ DL++E +G G + P +++ +T Sbjct: 415 VVLGLGALTIPAMNLQLSLPSDSTSNIDTTQRQSADLMAEGFGAGVNAPFLVIVDTHEVN 474 Query: 424 ------------------DGGKEAAANLNKVIEEVKTY-PNVAMVNPAVTAPSGKVSL-- 462 + +E AA + +TY N+ + N + + + + Sbjct: 475 ADSTALQPLIEAQEPEEGEFDREQAARFATYMYVTQTYNSNIDVKNAQIISVNDDFTAAQ 534 Query: 463 ITVMPATGPNDSATIDLVHLIRDKAPEIEQQDHIKIGVTGSTAVNIDITQKLNQALPEFC 522 I V P TGP D T +L+H++R + +IE ++G TG TAV +DIT++L A+P + Sbjct: 535 ILVTPYTGPADKETPELMHVLRAQEAQIEDVTGTELGTTGFTAVQLDITEQLEDAMPVYL 594 Query: 523 LIIVGLAFVLLMLVFRSILVPIKAVLGFILSLGATLGFVTYVVQDGHFQKLFGFYAE--A 580 ++VGLA LL+LVFRS+LVP+ A LGF+LS+GA G V Q+G FG + Sbjct: 595 AVVVGLAIFLLILVFRSLLVPLVAGLGFLLSVGAAFGATVLVWQEG-----FGGFVNTPG 649 Query: 581 PVFNFLPIIVVGVLFGLAMDYEVFLVSRMREEF----------KKSGDAKKSVLAGIRHS 630 P+ +F+PI ++GV FGLAMDY+VFLV+RMRE + K ++SV+ G Sbjct: 650 PLISFMPIFLIGVTFGLAMDYQVFLVTRMREHYTHHNGKGQPGSKYTPVEQSVIEGFTQG 709 Query: 631 GGVVTAAGLIMVAVFTGFILAEEPMVKVMGLALAFGVLFDAFIVRMLIVPGVMTLLGKSA 690 VVTAA LIM+AVF FI P +K+ G AL GV FDAF +RM +VP M L+GK+ Sbjct: 710 SRVVTAAALIMIAVFVAFIDQPLPFIKIFGFALGAGVFFDAFFIRMGLVPASMFLMGKAT 769 Query: 691 WYFPKWLDRLLPNLDXXXXXXXXXXXKKQ 719 W+ PKWLDR+LP+LD +KQ Sbjct: 770 WWMPKWLDRILPSLDIEGTALEKEWEEKQ 798 >Cgl0900 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 736 Score = 287 bits (734), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 232/715 (32%), Positives = 341/715 (47%), Gaps = 69/715 (9%) Query: 56 LEVMEKEFPNPQSGLGKT--QLVLKAPDNERLSSETAKQLVTAKLKEVAAD---PEVTSV 110 +E M++ FP +V++AP+ + L+ V L EV A + SV Sbjct: 1 MEKMQERFPGSDDATSAPTGSVVIQAPEGKTLTDPEVGAEVNQMLDEVRATGVLKDADSV 60 Query: 111 VSPY--------------------------DNHS---LNADSTIGYATITY-AVPGDEVT 140 V P D S L+AD T G ++T+ A +++ Sbjct: 61 VDPVLAAQGVAAQMTPALEAQGVPAEKIAADIESISPLSADETTGIISMTFDADSAMDIS 120 Query: 141 DESKDSVNEIAESLRDAGWQAELIGDGYVKMATS--SPTEXXXXXXXXXXXXXXXXXXXT 198 E ++ V I + D G+ + ATS +E Sbjct: 121 AEDREKVTNILDEYDDGDLTVVYNGNVFGAAATSLDMTSELIGLLVAAVVLIVTFGSFIA 180 Query: 199 GVLPIVTAXXXXXXXXXXXXXXTSFLD-VPSFALSLAGMLGLAVGIDYALFIIARYRQQL 257 +P+++A T+F D V +LA M+GLAVGIDYALFI++R+R +L Sbjct: 181 AGMPLISAIIGVGIGIMGIQLATAFTDSVNDMTPTLASMIGLAVGIDYALFIVSRFRNEL 240 Query: 258 -----AEGYERRE---------------AIAIANGTAGSAVVFAGVTVIIALVGFSFVGV 297 A E +E A+ +A GTAGSAVVFAG TV+IALV S + + Sbjct: 241 ISQTGANDLEPKELAERLRTMPLAARAHAMGMAVGTAGSAVVFAGTTVLIALVALSIINI 300 Query: 298 PFLTAMGMAGALTVFTAILMTIFVVPAILDLLGGKV---KAPAKRAGSKQKPAGRSNL-W 353 PFLT M +A A+TV A+L+ + +PA+L LLG ++ + P + + L W Sbjct: 301 PFLTVMAIAAAITVAIAVLVALSFLPALLGLLGTRIFAARVPGPKVPDPEDEKPTMGLKW 360 Query: 354 GRFVTGHPXXXXXXXXXXXXXXXXPFFHMETGLGNDGHKSPDKTERRAYDLLSEAYGEGY 413 R V P P +M + DG + R AYD+ ++A+G G Sbjct: 361 VRLVRKMPVAYLLVGVVLLGAIAIPATNMRLAMPTDGTSTLGTAPRTAYDMTADAFGPGR 420 Query: 414 HGPLVLLAETDGGKEAAANL--NKVIEEVKTYPNVAMVNPAVTAPSGKVSLITVMPATGP 471 + P++ L + E L + +E+ V T + + I + P Sbjct: 421 NAPMIALIDATDVPEEERPLVFGQAVEQFLNTDGVKNAQITQTTENFDTAQILITPEFDA 480 Query: 472 NDSATIDLVHLIRDKAPEIEQQDHIKIGVTGSTAVNIDITQKLNQALPEFCLIIVGLAFV 531 D T + + +R A G+TG T + DI+ +L L + LI++ LAF+ Sbjct: 481 IDERTSETLATLRADAETFADDTGATYGITGVTPIYDDISARLGDVLVPYVLIVLVLAFL 540 Query: 532 LLMLVFRSILVPIKAVLGFILSLGATLGFVTYVVQDGHFQKLFGFYAE-APVFNFLPIIV 590 +L+LVFRSI VP+ A LGF LS+ AT G + Q+G F G + P+ +FLPI++ Sbjct: 541 VLLLVFRSIWVPLIAALGFGLSVLATFGATVAIFQEGAF----GIIDDPQPLLSFLPIML 596 Query: 591 VGVLFGLAMDYEVFLVSRMREEFKKSGDAKKSVLAGIRHSGGVVTAAGLIMVAVFTGFIL 650 +G++FGLAMDY++FLV+RMRE F K A + G +H VVTAA LIMV+VF FI Sbjct: 597 IGLVFGLAMDYQIFLVTRMREGFTKGKTAGNATSNGFKHGARVVTAAALIMVSVFAAFIA 656 Query: 651 AEEPMVKVMGLALAFGVLFDAFIVRMLIVPGVMTLLGKSAWYFPKWLDRLLPNLD 705 + +K MG ALA V FDAF+VRM+I+P M LL AW+ PKWLD++LPN+D Sbjct: 657 QDMAFIKTMGFALAVAVFFDAFVVRMMIIPATMFLLDDKAWWLPKWLDKILPNVD 711 >Rv0202c [R] COG2409 Predicted drug exporters of the RND superfamily Length = 966 Score = 233 bits (593), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 151/490 (30%), Positives = 252/490 (51%), Gaps = 21/490 (4%) Query: 229 FALSLAGMLGLAVGIDYALFIIARYRQQLAEGYERREAIAIANGTAGSAVVFAGVTVIIA 288 F S M G+A+ +DY+LFI+ RYR++L G +A+ A T+G AVV +G+TVI + Sbjct: 233 FVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIAS 292 Query: 289 LVGFSFVGVPFLTAMGMAGALTVFTAILMTIFVVPAILDLLGGKVKAPAKRAG----SKQ 344 L G + P L +M L V A+L + + PA+L +A AKR+ S++ Sbjct: 293 LTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFA---RAAAKRSALVHWSRR 349 Query: 345 KPAGRSNLWGRFV---TGHPXXXXXXXXXXXXXXXXPFFHMETGLGNDGHKSPDKTE--R 399 + +S W R+V P P M LGN + D + R Sbjct: 350 PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMV--LGNSLLRQFDSSHEIR 407 Query: 400 RAYDLLSEAYGEGYHGPLVLLAETDGGKEAAANLNKVIEEVK----TYPNVAMVNPAVTA 455 ++A G G GP+ +L D G +A ++ I ++ PNV V P A Sbjct: 408 TGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFA 467 Query: 456 PSGKVSLITVMPATGPNDSATIDLVHLIRDKAPEIEQQDHIKIGVTGSTAVNIDITQKLN 515 +L++ + + P D D + +R + P + + +G G TA+ D +++ Sbjct: 468 DDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVG--GPTALIKDFDDRVS 525 Query: 516 QALPEFCLIIVGLAFVLLMLVFRSILVPIKAVLGFILSLGATLGFVTYVVQDGHFQKLFG 575 P + + +AF++L++ RS+ + K VL +LS+ A G + V Q G + + G Sbjct: 526 ATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWG-WARGLG 584 Query: 576 FYAEAPVFNFLPIIVVGVLFGLAMDYEVFLVSRMREEFKKSGDAKKSVLAGIRHSGGVVT 635 F A + + +P +V+ + FGL+MDYE+FL++R+RE F ++G + +V G+R S +T Sbjct: 585 FPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT 644 Query: 636 AAGLIMVAVFTGFILAEEPMVKVMGLALAFGVLFDAFIVRMLIVPGVMTLLGKSAWYFPK 695 +A LIM+AVF GF A P+V +G+A A + DA +VR+++VP +M + + W+ P+ Sbjct: 645 SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPR 704 Query: 696 WLDRLLPNLD 705 WL +LP++D Sbjct: 705 WLAHILPSVD 714 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.137 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 48,805,540 Number of extensions: 1978070 Number of successful extensions: 12409 Number of sequences better than 1.0e-05: 33 Number of HSP's gapped: 12292 Number of HSP's successfully gapped: 68 Length of query: 736 Length of database: 38,378,431 Length adjustment: 114 Effective length of query: 622 Effective length of database: 25,230,355 Effective search space: 15693280810 Effective search space used: 15693280810 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 120 (50.8 bits)