BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0290.0040.p (214 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC2973 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase 189 4e-48 ML0022_2 [T] COG1716 FOG: FHA domain 180 1e-45 CAC0394 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase 122 5e-28 CC1495 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase 115 6e-26 SMc02043 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase 100 2e-21 >CAC2973 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase Length = 213 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 95/212 (44%), Positives = 135/212 (63%), Gaps = 1/212 (0%) Query: 2 MKKIKVLQNITSVGVVAVIRADNADDAVKMSAACIEGGLNNIEVTFTTPDADVAIKRLAA 61 MK+++ ++ ++ G+VAVIRA++ + ++ A I+GG+ IE+T T P A IK L+ Sbjct: 1 MKRLETIRKMSEYGLVAVIRAESKEQGARVIDAVIKGGIKAIEITMTVPGALDIIKELSE 60 Query: 62 EYGSR-AVIGAGTVLDPLTARIAILAGXXXXXXXXXXXXTAKMCNLYGIPYMPGCMTLNE 120 Y + +IGAGTVLDP TAR ILAG T +CN Y IP MPG MT+ E Sbjct: 61 VYKDQDVIIGAGTVLDPETARACILAGAKFIVSPNLNRETVILCNRYRIPTMPGIMTVKE 120 Query: 121 MKEALKLGVDVLKLFPGSAFGPDYVKAVKGPMPHVNIMPTGGVDLNNMEKWIANGCIAVG 180 EAL+LGV+++K+FPG+ GP + + KGP+P N MP+GGV L+N++ WI G +AV Sbjct: 121 AIEALELGVEIIKVFPGNVSGPSIISSFKGPLPQANFMPSGGVSLSNVKDWIKAGAVAVS 180 Query: 181 IGGNLTAPAKEGRYDQITELAAKYVAKFKEIK 212 GG LT AK G YD +TE AAK+V + + + Sbjct: 181 TGGELTKGAKTGDYDAVTETAAKFVEELNKAR 212 >ML0022_2 [T] COG1716 FOG: FHA domain Length = 91 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 0/212 (0%), Positives = 0/212 (0%), Gaps = 1/212 (0%) Query: 2 MKKIKVLQNITSVGVVAVIRADNADDAVKMSAACIEGGLNNIEVTFTTPDADVAIKRLAA 61 + ++ T DA + + Sbjct: 1 ILQLDDGSGRTYQLREGSNIVGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNG 60 Query: 62 EY-GSRAVIGAGTVLDPLTARIAILAGXXXXXXXXXXXXTAKMCNLYGIPYMPGCMTLNE 120 Sbjct: 61 TTV 120 Query: 121 MKEALKLGVDVLKLFPGSAFGPDYVKAVKGPMPHVNIMPTGGVDLNNMEKWIANGCIAVG 180 Sbjct: 121 180 Query: 181 IGGNLTAPAKEGRYDQITELAAKYVAKFKEIK 212 Sbjct: 181 212 >CAC0394 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase Length = 208 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 70/181 (38%), Positives = 96/181 (53%), Gaps = 1/181 (0%) Query: 17 VAVIRADNADDAVKMSAACIEGGLNNIEVTFTTPDADVAIKRLAAEYGSRAVIGAGTVLD 76 +AV+R A KMS I G++ IEVT++ DA IK L EY ++IGAGTV+ Sbjct: 15 IAVVRCSEFSLAEKMSKRLISQGIDTIEVTYSVKDAGKLIKALKDEY-PNSLIGAGTVVT 73 Query: 77 PLTARIAILAGXXXXXXXXXXXXTAKMCNLYGIPYMPGCMTLNEMKEALKLGVDVLKLFP 136 A+ AI G + C I G T E +A LG D++K+FP Sbjct: 74 AAQAKEAIDYGADFIVSPCIVEEVCEYCVKNDIACSQGTATPTEAFKAASLGADIIKIFP 133 Query: 137 GSAFGPDYVKAVKGPMPHVNIMPTGGVDLNNMEKWIANGCIAVGIGGNLTAPAKEGRYDQ 196 GS+F P Y+K +KGP P + MPTGGV +N+++W NG AVG+GG T E ++ Sbjct: 134 GSSFKPSYIKELKGPFPDFDCMPTGGVSDSNVKEWFDNGAFAVGLGGYFTKNITEDNLEE 193 Query: 197 I 197 I Sbjct: 194 I 194 >CC1495 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase Length = 224 Score = 115 bits (287), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 70/188 (37%), Positives = 101/188 (53%), Gaps = 6/188 (3%) Query: 4 KIKVLQNITSVGVVAVIRADNADDAVKMSAACIEGGLNNIEVTFTTPDAD---VAIKRLA 60 ++ VL + GV+ V + + + AC +GG IE T A + R Sbjct: 5 RMAVLTALMDQGVIPVFYHPDVEVCKNVIQACADGGAPCIEFTNRGDFASHVFYEVTRYF 64 Query: 61 AEYGSRAVIGAGTVLDPLTARIAILAGXXXXXXXXXXXXTAKMCNLYGIPYMPGCMTLNE 120 AE R ++G G+++D TA I I G AK+CN IPY PGC + +E Sbjct: 65 AEADPRVIMGVGSIVDAPTAGIYIANGAKFVVGPILNADVAKVCNRRKIPYSPGCGSASE 124 Query: 121 MKEALKLGVDVLKLFPGSAF-GPDYVKAVKGPMPHVNIMPTGGVDLN--NMEKWIANGCI 177 + A +LG +++K+FPGS+ GPD+VKAV GPMP IMPTGGVD + +++KW G + Sbjct: 125 ISYAEELGCEIVKVFPGSSVGGPDFVKAVLGPMPWTRIMPTGGVDPDEASVKKWFGAGIV 184 Query: 178 AVGIGGNL 185 A G+G L Sbjct: 185 AAGMGSKL 192 >SMc02043 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase Length = 217 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 66/200 (33%), Positives = 99/200 (49%), Gaps = 8/200 (4%) Query: 5 IKVLQNITSVGVVAVIRADNADDAVKMSAACIEGGLNNIEVTFTTPDADVAIKRLAAEYG 64 I ++GVV VI + + DAV ++ A +EGGL E+TF T +A + + AE Sbjct: 2 IAPFDQAATLGVVPVIAIERSSDAVALADALLEGGLPLAEITFRT-EAAAEVIAIMAEKR 60 Query: 65 SRAVIGAGTVLDPLTARIAILAGXXXXXXXXXXXXTAKMCNLYGIPYMPGCMTLNEMKEA 124 ++GAGT+L P R AI AG P+ PG MT +++ Sbjct: 61 PELLVGAGTILTPDALRAAISAGARFGLAPGFDAEIVAAAKAKDFPFAPGIMTPSDLTAV 120 Query: 125 LKLGVDVLKLFPG-SAFGPDYVKAVKGPMPHV--NIMPTGGVDLNNMEKWIANGCIAVGI 181 + G+ + K FP +A GP ++A+ P H+ +PTGGV L+NM +W+ G +A + Sbjct: 121 SRNGLKLAKFFPAKAAGGPSMLEAISAPFAHLGTRFVPTGGVSLDNMHEWLKLGAVA-AV 179 Query: 182 GGNLTAPAK---EGRYDQIT 198 GG A EGR+ IT Sbjct: 180 GGTWIATKADIGEGRWADIT 199 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.136 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 14,879,103 Number of extensions: 566950 Number of successful extensions: 1537 Number of sequences better than 1.0e-05: 20 Number of HSP's gapped: 1497 Number of HSP's successfully gapped: 20 Length of query: 214 Length of database: 38,378,431 Length adjustment: 102 Effective length of query: 112 Effective length of database: 26,614,363 Effective search space: 2980808656 Effective search space used: 2980808656 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 113 (48.1 bits)