BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0280.0026.p (562 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2398 [R] COG0595 Predicted hydrolase of the metallo-beta-lacta... 667 0.0 BS_ykqC [R] COG0595 Predicted hydrolase of the metallo-beta-lact... 600 e-171 BH2662 [R] COG0595 Predicted hydrolase of the metallo-beta-lacta... 587 e-167 lin1026 [R] COG0595 Predicted hydrolase of the metallo-beta-lact... 575 e-164 SA0940 [R] COG0595 Predicted hydrolase of the metallo-beta-lacta... 540 e-153 >BH2398 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Length = 252 Score = 667 bits (1721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/559 (0%), Positives = 0/559 (0%), Gaps = 6/559 (1%) Query: 4 KNNNDKLTIFALGGVGEIGKNMYVVQYGNDIVVVDAGLKFPEEDMLGIDIVIPDISYLTE 63 N F+ + + V N V D G L + Sbjct: 3 DWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGID 62 Query: 64 NRDKVRGIVLTHGHEDHIGGLSYVLKNLNVPVYGTRLTLGLVENKLKEANLLGETKRILI 123 + + + + + L + Sbjct: 63 SSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNP 122 Query: 124 NEDSEIELGSSLKVTFFRTNHSIPDSVGVCIETPEGNVVHTGDFKFDHTPVNGQFANLHR 183 +++ + + + + + + + Sbjct: 123 QGVLAVQMPDN-WLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRT 181 Query: 184 MAEIGQRGVLALMSDSTNAEKPGFTPSEKNVGIVLEDIFRKAEQRVVVATFASNVHRIQQ 243 A++ T + L + + Sbjct: 182 TYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAF 241 Query: 244 VVNAAESTGRKITVIGRSMVNVVSIASELGYLHVPDGMLIEPEEMNRMAGNRVVVLCXXX 303 Sbjct: 242 --- 298 Query: 304 XGSQGEPMSALTRMARSSHRKVDILPGDTVIIAATPVPGNEKYVGRTIDELFRLGANVIY 363 Sbjct: 299 358 Query: 364 XXXXXXXXXXXXXXQEELKLMLNLMKPKYFLPIHGEFRMQRRHALLAESVGVEPANIFIT 423 Sbjct: 359 -- 416 Query: 424 ELGEVIEISGGSARRAGKVTAXXXXXXXXXXXXXXXXXLRDRKLLSQDGILVVVVTLSKQ 483 Sbjct: 417 476 Query: 484 NGAIVSGPDIISRGFVYVRESEGLLDEANRIVSGTLQRLMSEKVNEWASLKTSVKDSLGR 543 Sbjct: 477 536 Query: 544 FLYEQTRRRPMILPIIMEV 562 Sbjct: 537 555 >BS_ykqC [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Length = 252 Score = 600 bits (1548), Expect = e-171, Method: Compositional matrix adjust. Identities = 0/556 (0%), Positives = 0/556 (0%), Gaps = 6/556 (1%) Query: 7 NDKLTIFALGGVGEIGKNMYVVQYGNDIVVVDAGLKFPEEDMLGIDIVIPDISYLTENRD 66 F+ + + V N V D G L ++ Sbjct: 6 PSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSP 65 Query: 67 KVRGIVLTHGHEDHIGGLSYVLKNLNVPVYGTRLTLGLVENKLKEANLLGETKRILINED 126 + + + + L + Sbjct: 66 AMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGV 125 Query: 127 SEIELGSSLKVTFFRTNHSIPDSVGVCIETPEGNVVHTGDFKFDHTPVNGQFANLHRMAE 186 +++ + + + + + + G ++ R Sbjct: 126 LAVQMPDN-WLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEA-GCEVDIWRTTY 183 Query: 187 IGQRGVLALMSDSTNAEKPGFTPSEKNVGIVLEDIFRKAEQRVVVATFASNVHRIQQVVN 246 Q + D A + + R + N + Sbjct: 184 YHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFPR 243 Query: 247 AAESTGRKITVIGRSMVNVVSIASELGYLHVPDGMLIEPEEMNRMAGNRVVVLCXXXXGS 306 Sbjct: 244 --- 300 Query: 307 QGEPMSALTRMARSSHRKVDILPGDTVIIAATPVPGNEKYVGRTIDELFRLGANVIYXXX 366 Sbjct: 301 - 359 Query: 367 XXXXXXXXXXXQEELKLMLNLMKPKYFLPIHGEFRMQRRHALLAESVGVEPANIFITELG 426 Sbjct: 360 419 Query: 427 EVIEISGGSARRAGKVTAXXXXXXXXXXXXXXXXXLRDRKLLSQDGILVVVVTLSKQNGA 486 Sbjct: 420 479 Query: 487 IVSGPDIISRGFVYVRESEGLLDEANRIVSGTLQRLMSEKVNEWASLKTSVKDSLGRFLY 546 Sbjct: 480 539 Query: 547 EQTRRRPMILPIIMEV 562 Sbjct: 540 555 >BH2662 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Length = 252 Score = 587 bits (1513), Expect = e-167, Method: Compositional matrix adjust. Identities = 0/560 (0%), Positives = 0/560 (0%), Gaps = 6/560 (1%) Query: 3 KKNNNDKLTIFALGGVGEIGKNMYVVQYGNDIVVVDAGLKFPEEDMLGIDIVIPDISYLT 62 N F+ + + V N V D G L Sbjct: 2 SDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGI 61 Query: 63 ENRDKVRGIVLTHGHEDHIGGLSYVLKNLNVPVYGTRLTLGLVENKLKEANLLGETKRIL 122 ++ + + + + L + Sbjct: 62 DSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLN 121 Query: 123 INEDSEIELGSSLKVTFFRTNHSIPDSVGVCIETPEGNVVHTGDFKFDHTPVNGQFANLH 182 +++ + + + + + + G ++ Sbjct: 122 PQGVLAVQMPDN-WLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEA-GCEVDIW 179 Query: 183 RMAEIGQRGVLALMSDSTNAEKPGFTPSEKNVGIVLEDIFRKAEQRVVVATFASNVHRIQ 242 R Q + D A + + R + N + Sbjct: 180 RTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILL 239 Query: 243 QVVNAAESTGRKITVIGRSMVNVVSIASELGYLHVPDGMLIEPEEMNRMAGNRVVVLCXX 302 Sbjct: 240 -- 297 Query: 303 XXGSQGEPMSALTRMARSSHRKVDILPGDTVIIAATPVPGNEKYVGRTIDELFRLGANVI 362 Sbjct: 298 - 356 Query: 363 YXXXXXXXXXXXXXXQEELKLMLNLMKPKYFLPIHGEFRMQRRHALLAESVGVEPANIFI 422 Sbjct: 357 - 415 Query: 423 TELGEVIEISGGSARRAGKVTAXXXXXXXXXXXXXXXXXLRDRKLLSQDGILVVVVTLSK 482 Sbjct: 416 475 Query: 483 QNGAIVSGPDIISRGFVYVRESEGLLDEANRIVSGTLQRLMSEKVNEWASLKTSVKDSLG 542 Sbjct: 476 535 Query: 543 RFLYEQTRRRPMILPIIMEV 562 Sbjct: 536 555 >lin1026 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Length = 252 Score = 575 bits (1482), Expect = e-164, Method: Compositional matrix adjust. Identities = 0/556 (0%), Positives = 0/556 (0%), Gaps = 6/556 (1%) Query: 7 NDKLTIFALGGVGEIGKNMYVVQYGNDIVVVDAGLKFPEEDMLGIDIVIPDISYLTENRD 66 F+ + + V N V D G L ++ Sbjct: 6 PSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSP 65 Query: 67 KVRGIVLTHGHEDHIGGLSYVLKNLNVPVYGTRLTLGLVENKLKEANLLGETKRILINED 126 + + + + L + Sbjct: 66 AMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGV 125 Query: 127 SEIELGSSLKVTFFRTNHSIPDSVGVCIETPEGNVVHTGDFKFDHTPVNGQFANLHRMAE 186 +++ + + + + + + G ++ R Sbjct: 126 LAVQMPDN-WLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEA-GCEVDIWRTTY 183 Query: 187 IGQRGVLALMSDSTNAEKPGFTPSEKNVGIVLEDIFRKAEQRVVVATFASNVHRIQQVVN 246 Q + D A + + R + N + Sbjct: 184 YHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFPR 243 Query: 247 AAESTGRKITVIGRSMVNVVSIASELGYLHVPDGMLIEPEEMNRMAGNRVVVLCXXXXGS 306 Sbjct: 244 --- 300 Query: 307 QGEPMSALTRMARSSHRKVDILPGDTVIIAATPVPGNEKYVGRTIDELFRLGANVIYXXX 366 Sbjct: 301 360 Query: 367 XXXXXXXXXXXQEELKLMLNLMKPKYFLPIHGEFRMQRRHALLAESVGVEPANIFITELG 426 Sbjct: 361 - 419 Query: 427 EVIEISGGSARRAGKVTAXXXXXXXXXXXXXXXXXLRDRKLLSQDGILVVVVTLSKQNGA 486 Sbjct: 420 479 Query: 487 IVSGPDIISRGFVYVRESEGLLDEANRIVSGTLQRLMSEKVNEWASLKTSVKDSLGRFLY 546 Sbjct: 480 539 Query: 547 EQTRRRPMILPIIMEV 562 Sbjct: 540 555 >SA0940 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Length = 252 Score = 540 bits (1392), Expect = e-153, Method: Compositional matrix adjust. Identities = 0/561 (0%), Positives = 0/561 (0%), Gaps = 7/561 (1%) Query: 3 KKNNNDKLTIFALGGVGEIGKNMYVVQYGNDIVVVDAGLKFPEEDMLGIDIVIPDISYLT 62 N F+ + + V N V D G L Sbjct: 2 SDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGI 61 Query: 63 ENRDKVRGIVLTHGHEDHIGGLSYVLKNLNVPVYGTRLTLGLVENKLKEANLLGETKRIL 122 ++ + + + + L + Sbjct: 62 DSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLN 121 Query: 123 INEDSEIELGSSLKVTFFRTNHSIPDSVGVCIETPEGNVVHTGDFKFDHTPVNGQFANLH 182 ++ + + + + + G ++ Sbjct: 122 PQGVLAVQ-MPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEA-GCEVDIW 179 Query: 183 RMAEIGQRGVLALMSDSTNAEKPGFTPSEKNVGIVLEDIFRKAEQRVVVATFASNVHRIQ 242 R Q + D A + + R + N + Sbjct: 180 RTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILL 239 Query: 243 QVVNAAESTGRKITVIGRSMVNVVSIASELGYLHVPDGMLIEPEEMNRMAGNRVVVLCXX 302 Sbjct: 240 -- 297 Query: 303 XXGSQGEPMSALTRMARSSHRKVDILPGDTVIIAATPVPGNEKYVGRTIDELFRLGANVI 362 Sbjct: 298 - 356 Query: 363 YXXXXXXXXXXXXXXQEELKLMLNLMKPKYFLPIHGEFRMQRRHALLAESVGVEPANIFI 422 Sbjct: 357 - 415 Query: 423 TELGEVIEISGGSARRAGKVTAXXXXXXXXXXXXXXXXXLRDRKLLSQDGILVVVVTLSK 482 Sbjct: 416 475 Query: 483 QNGAIVSGPDIISRGFVYVRESEGLLDEANR-IVSGTLQRLMSEKVNEWASLKTSVKDSL 541 Sbjct: 476 535 Query: 542 GRFLYEQTRRRPMILPIIMEV 562 Sbjct: 536 556 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.137 0.383 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 38,444,157 Number of extensions: 1538978 Number of successful extensions: 3964 Number of sequences better than 1.0e-05: 30 Number of HSP's gapped: 3846 Number of HSP's successfully gapped: 30 Length of query: 562 Length of database: 38,378,431 Length adjustment: 112 Effective length of query: 450 Effective length of database: 25,461,023 Effective search space: 11457460350 Effective search space used: 11457460350 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 118 (50.1 bits)