BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0280.0019.p (434 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin1430 [R] COG0612 Predicted Zn-dependent peptidases 428 e-120 BH2392 [R] COG0612 Predicted Zn-dependent peptidases 427 e-119 BS_ymfH [R] COG0612 Predicted Zn-dependent peptidases 403 e-112 SA1122 [R] COG0612 Predicted Zn-dependent peptidases 350 3e-96 L31393 [R] COG0612 Predicted Zn-dependent peptidases 268 2e-71 >lin1430 [R] COG0612 Predicted Zn-dependent peptidases Length = 428 Score = 428 bits (1101), Expect = e-120, Method: Compositional matrix adjust. Identities = 212/435 (48%), Positives = 289/435 (66%), Gaps = 10/435 (2%) Query: 1 VEKIHYEKLQETLYHEVMDNGLQVYVLPKPAFLKTYATFATKYGSVDNHFKVAGGEE-TT 59 +EKI +E+++E ++HE M NGLQVY+LPK F KTYA F T YG++DN+F G E T Sbjct: 1 MEKITFEQVKEAVFHEKMSNGLQVYLLPKQGFSKTYAVFTTNYGAIDNNFVPIGETEFTK 60 Query: 60 VPDGIAHFLEHKMFEEPEGDIFATFASNGASANAFTSFDQTVYLFSATENIETNLSTLVD 119 VPDGIAHFLEHKMFE+ +GD+F F GA NAFTSF +T YLFS+T +E NL TL+D Sbjct: 61 VPDGIAHFLEHKMFEKEDGDVFFKFGEKGAFTNAFTSFTKTAYLFSSTSRVEENLETLID 120 Query: 120 FVQRPYFTDENVEKEKGIIGQEINMYADNPDWRVYFGLIEAMYSKHPVHIDIAGTIESIA 179 FVQ PYFT+E VEKEKGIIGQEI MY D+PD+R YFG+IE MY HPV IDIAGT+ESIA Sbjct: 121 FVQEPYFTEETVEKEKGIIGQEIRMYDDDPDFRAYFGVIENMYHNHPVKIDIAGTVESIA 180 Query: 180 TITKETLYTCYNSFYHPSNMLLFVVGGVDPEKVFELIRNNQNGKSYGKQGEXXXXKQGEI 239 I K+ LY CYN+FYHPSNM+LFVVG ++PE++ IR NQ K + + I Sbjct: 181 EINKDLLYLCYNTFYHPSNMVLFVVGNLEPEEMMNQIRANQAKKDF--------TEAAPI 232 Query: 240 QRIFEEEPVQVAAKVKESKLAVSMPKMLFGFKEKVEGLTGEAAVRRXXXXXXXXXXXXGS 299 +R F EEP VA K ++ V + K + G KE + L G+ A+++ G+ Sbjct: 233 KRHFPEEPKTVAVKERKIHFPVQIAKNMVGIKEDIGSLEGQVALKQEIIGDVALEMLFGT 292 Query: 300 STALYQKLYDEELISDSFGHEFNSSPQYAFSAIGGDTKDTDLLLKRIKEEINLVLASGFA 359 ++ Y +LY++ +I DSFG+++ ++F +GGD KD D+ +I E I +G Sbjct: 293 TSDTYLELYNQGIIDDSFGYDYTLQDSFSFVLVGGDAKDPDMQTTKIIEAIQAAAKNGLN 352 Query: 360 EKDFERARKKKIGGYLRMLNSPESIAHEFTRYQFRGGDLFEVLPLYESITLEEVNERLRS 419 E D ++K+IG +LR LNSPE IA++F++Y + LF++LPL E++TLEEVN ++ Sbjct: 353 EADLALVKRKRIGQFLRSLNSPEFIANQFSQYVMKSASLFDILPLMETVTLEEVNNFVK- 411 Query: 420 HVDWEQLAVSLVVSP 434 ++D E+ S + P Sbjct: 412 NLDSEERTTSFQLLP 426 >BH2392 [R] COG0612 Predicted Zn-dependent peptidases Length = 432 Score = 427 bits (1098), Expect = e-119, Method: Compositional matrix adjust. Identities = 219/429 (51%), Positives = 282/429 (65%), Gaps = 9/429 (2%) Query: 4 IHYEKLQETLYHEVMDNGLQVYVLPKPAFLKTYATFATKYGSVDNHF-KVAGGEETTVPD 62 + +E+LQETLYHE + NGL VY+LPK F KTYATF TKYGS+D+ F + E VPD Sbjct: 4 VTFEQLQETLYHEKLANGLDVYILPKTGFNKTYATFTTKYGSIDSEFIPLNQKEALHVPD 63 Query: 63 GIAHFLEHKMFEEPEGDIFATFASNGASANAFTSFDQTVYLFSATENIETNLSTLVDFVQ 122 GIAHFLEHKMFE+ EGD+F F+ GAS NAFTSF +T YLFS+T N++ N+ TL+DFVQ Sbjct: 64 GIAHFLEHKMFEDEEGDVFQLFSKQGASCNAFTSFTRTAYLFSSTTNVKKNVETLLDFVQ 123 Query: 123 RPYFTDENVEKEKGIIGQEINMYADNPDWRVYFGLIEAMYSKHPVHIDIAGTIESIATIT 182 PYFT+E+VEKEKGIIGQEI MY DNPDWR YFG+IE MY HPV IDIAGTI SI+ IT Sbjct: 124 HPYFTEESVEKEKGIIGQEITMYDDNPDWRNYFGVIENMYEHHPVKIDIAGTIPSISKIT 183 Query: 183 KETLYTCYNSFYHPSNMLLFVVGGVDPEKVFELIRNNQNGKSYGKQGEXXXXKQGEIQRI 242 K+ LYTCY +FYHPSNMLLF+VG VD ++ L++ NQ K + G+IQR Sbjct: 184 KDLLYTCYETFYHPSNMLLFIVGPVDVNEMMTLVKENQGKKEF--------KPAGDIQRF 235 Query: 243 FEEEPVQVAAKVKESKLAVSMPKMLFGFKEKVEGLTGEAAVRRXXXXXXXXXXXXGSSTA 302 F EP +VA ++V PK L G+KEK G+ + R G + Sbjct: 236 FPAEPEKVAKPHSVISMSVQTPKCLVGYKEKQPVRQGKDLLVRELGINVLLELMFGQGSK 295 Query: 303 LYQKLYDEELISDSFGHEFNSSPQYAFSAIGGDTKDTDLLLKRIKEEINLVLASGFAEKD 362 Y++L DE LI+D+F + S + F+ +GGDTK + L +RI+E + E Sbjct: 296 QYEQLDDEGLINDTFSFDHTSEYGFGFTIMGGDTKSPNRLAERIEEMVEAFKEQPLDEAA 355 Query: 363 FERARKKKIGGYLRMLNSPESIAHEFTRYQFRGGDLFEVLPLYESITLEEVNERLRSHVD 422 +R KKKIGG+LR LNSPE IA++FTRY+F +LF+V+P ES+T+E++ + L H Sbjct: 356 VKRVIKKKIGGFLRSLNSPEFIANQFTRYEFNKMNLFDVVPTLESLTVEKLTDILHDHFQ 415 Query: 423 WEQLAVSLV 431 E+ V V Sbjct: 416 KERFTVCQV 424 >BS_ymfH [R] COG0612 Predicted Zn-dependent peptidases Length = 103 Score = 403 bits (1035), Expect = e-112, Method: Compositional matrix adjust. Identities = 0/417 (0%), Positives = 0/417 (0%), Gaps = 16/417 (3%) Query: 20 NGLQVYVLPKPAFLKTYATFATKYGSVDNHFKVAGGEETT-VPDGIAHFLEHKMFEEPEG 78 ++V +P+ G+ VP +F + Sbjct: 8 TRVKVEADNRPSVDTHPPGVQPSPGTGGTRHHNFMLCVVLAVPVFSLVLSGTALFTKQRR 67 Query: 79 DIFATFASNGASANAFTSFDQTVYLFSATENIETNLSTLVDFVQRPYFTDENVEKEKGII 138 Sbjct: 68 127 Query: 139 GQEINMYADNPDWRVYFGLIEAMYSKHPVHIDIAGTIESIATITKETLYTCYNSFYHPSN 198 Sbjct: 128 187 Query: 199 MLLFVVGGVDPEKVFELIRNNQNGKSYGKQGEXXXXKQGEIQRIFEEEPVQVAAKVKESK 258 Sbjct: 188 -------- 239 Query: 259 LAVSMPKMLFGFKEKVEGLTGEAAVRRXXXXXXXXXXXXGSSTALYQKLYDEELISDSFG 318 Sbjct: 240 299 Query: 319 HEFNSSPQYAFSAIGGDTKDTDLLLKRIKEEINLVLASG---FAEKDFERARKKKIGGYL 375 Sbjct: 300 ---- 355 Query: 376 RMLNSPESIAHEFTRYQFRGGDLFEVLPLYESITLEEVNERLRSHVDWEQLAVSLVV 432 Sbjct: 356 412 >SA1122 [R] COG0612 Predicted Zn-dependent peptidases Length = 428 Score = 350 bits (898), Expect = 3e-96, Method: Compositional matrix adjust. Identities = 172/422 (40%), Positives = 269/422 (63%), Gaps = 9/422 (2%) Query: 5 HYEKLQETLYHEVMDNGLQVYVLPKPAFLKTYATFATKYGSVDNHFKVAGGEE-TTVPDG 63 +YE + E ++ + ++NGL+++++PKP F KT+ T+ T++GS+DN FK G ++ TVPDG Sbjct: 5 YYELIDERVFEQELENGLRLFIIPKPGFQKTFVTYTTQFGSLDNQFKPLGQDQFVTVPDG 64 Query: 64 IAHFLEHKMFEEPEGDIFATFASNGASANAFTSFDQTVYLFSATENIETNLSTLVDFVQR 123 +AHFLEHK+FE+ E D+F FA + A ANAFTSFD+T YLFSAT+NIE N+ L+ V+ Sbjct: 65 VAHFLEHKLFEKEEEDLFTAFAEDNAQANAFTSFDRTSYLFSATDNIENNIKRLLTMVET 124 Query: 124 PYFTDENVEKEKGIIGQEINMYADNPDWRVYFGLIEAMYSKHPVHIDIAGTIESIATITK 183 PYFT E V+KEKGII +EI MY + P +++ F + AMY +HP+ +DIAG++ESI ITK Sbjct: 125 PYFTKETVDKEKGIIAEEIKMYQEQPGYKLMFNTLRAMYQRHPIRVDIAGSVESIYDITK 184 Query: 184 ETLYTCYNSFYHPSNMLLFVVGGVDPEKVFELIRNNQNGKSYGKQGEXXXXKQGEIQRIF 243 + LY CY +FYHPSNM+LFVVG V+PE++ +++ +++ ++ Q +I+R Sbjct: 185 DDLYLCYETFYHPSNMVLFVVGDVNPEEICRIVKQHEDARN--------KVNQPKIERGL 236 Query: 244 EEEPVQVAAKVKESKLAVSMPKMLFGFKEKVEGLTGEAAVRRXXXXXXXXXXXXGSSTAL 303 +EP V + + P+++ GFK K + V+R G T Sbjct: 237 VDEPEDVKEAFVTESMKIQSPRLMLGFKNKPLQEAPQKYVQRDLEMSLFFELIFGEETDF 296 Query: 304 YQKLYDEELISDSFGHEFNSSPQYAFSAIGGDTKDTDLLLKRIKEEINLVLASGFAEKDF 363 YQ L +E LI D+FG++F P Y+FS + T++ D L K + +E+ + + F Sbjct: 297 YQNLLNEGLIDDTFGYQFVLEPTYSFSIVTSATEEPDKLKKLLLDELRDKKGNFQDAEAF 356 Query: 364 ERARKKKIGGYLRMLNSPESIAHEFTRYQFRGGDLFEVLPLYESITLEEVNERLRSHVDW 423 E +K+ IG ++ LNSPE IA+++T+ F G +F++L + E+ITL+ +NE +++ Sbjct: 357 ELLKKQFIGEFISSLNSPEYIANQYTKLYFEGVSVFDMLDIVENITLDSINETSSLYLNL 416 Query: 424 EQ 425 +Q Sbjct: 417 DQ 418 >L31393 [R] COG0612 Predicted Zn-dependent peptidases Length = 410 Score = 268 bits (684), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 159/422 (37%), Positives = 229/422 (54%), Gaps = 18/422 (4%) Query: 18 MDNGLQVYVLPKPAFLKTYATFATKYGSVDNHFKVAGGEE-TTVPDGIAHFLEHKMFEEP 76 M NGL VY LPK + +TY F T +GS+D F G E T P+GIAHFLEHK+FE+ Sbjct: 1 MPNGLTVYYLPKADYNRTYGLFTTNFGSLDTSFVPLGESEFQTFPEGIAHFLEHKLFEKE 60 Query: 77 EGDIFATFASNGASANAFTSFDQTVYLFSATENIETNLSTLVDFVQRPYFTDENVEKEKG 136 EGD+ F + GA NAFTSF +T YLFS EN L+DFVQ+PYFT ENVEKE+G Sbjct: 61 EGDVMYKFGALGAQTNAFTSFSRTSYLFSTRENSYECTELLLDFVQKPYFTKENVEKEQG 120 Query: 137 IIGQEINMYADNPDWRVYFGLIEAMYSKHPVHIDIAGTIESIATITKETLYTCYNSFYHP 196 II QEI MY D+ DWR++ GL+E MY P+ DIAGT +I IT + LY Y FYHP Sbjct: 121 IIQQEIQMYQDDSDWRLFAGLLEKMYPDSPLAADIAGTPATINAITADDLYKNYEVFYHP 180 Query: 197 SNMLLFVVGGVDPEKVFELIRNNQNGKSYGKQGEXXXXKQGEIQR--IFEEEPVQVAAKV 254 NM LF+ G D E + + +R+NQ K + EIQR I EP+ + Sbjct: 181 KNMNLFLTGPFDIEMMSDFVRSNQAKKDFA--------DLSEIQRKEIKASEPISGESL- 231 Query: 255 KESKLAVSMPKMLFGFK-EKVEGLTGEAAVRRXXXXXXXXXXXXGSSTALYQKLYDEELI 313 +L V+MPK G + E + + G ++ Y++LY+ LI Sbjct: 232 ---ELEVAMPKFALGLRGEDQLSSDSKTLFKYKLANQLFLDLLFGRTSQRYEELYNSGLI 288 Query: 314 SDSFGHEFNSSPQYAFSAIGGDTKDTDLLLKRIKEEI-NLVLASGFAEKDFERARKKKIG 372 DSFG F+ ++ F+ + DT++ +L + ++E I + + F+E+ + +++ +G Sbjct: 289 DDSFGFSFDLDKRFHFAVLTADTENPQILGQTLQEAIKSYKIDRDFSEEHLDLLKREMLG 348 Query: 373 GYLRMLNSPESIAHEFTRYQFRGGDLFEVLPLYESITLEEVNERLRSHVDWEQLAVSLVV 432 Y LNS E IA++F+ + F+ + + ++L E+ E+ E V + Sbjct: 349 DYFSSLNSLEYIANQFSSEIYGDLTFFDFPEILKELSLSEI-EKFADQFISEMKKVEFTI 407 Query: 433 SP 434 P Sbjct: 408 LP 409 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.135 0.383 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 30,839,155 Number of extensions: 1273736 Number of successful extensions: 3680 Number of sequences better than 1.0e-05: 45 Number of HSP's gapped: 3610 Number of HSP's successfully gapped: 45 Length of query: 434 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 325 Effective length of database: 25,807,025 Effective search space: 8387283125 Effective search space used: 8387283125 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 117 (49.7 bits)