BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0266.0001.p (579 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC2392 [V] COG1132 ABC-type multidrug transport system, ATPase ... 606 e-173 lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase ... 471 e-132 TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase a... 464 e-130 Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase ... 443 e-124 BS_yfiC [V] COG1132 ABC-type multidrug transport system, ATPase ... 430 e-120 >CAC2392 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 579 Score = 606 bits (1563), Expect = e-173, Method: Compositional matrix adjust. Identities = 296/571 (51%), Positives = 400/571 (70%) Query: 6 TWKRIIVYTKQHRGIAIAAVFCAILSVVASLIGPLLIGRTVDQMAGLGQVDFDQVLRLLL 65 T R+ Y +++ ++ A++S V PL++G+ +D + G+VDF+ +L++++ Sbjct: 5 TLFRLASYVGKYKMYMFISLIFALISNVLIAFMPLIVGKGIDNIKSQGKVDFNNLLKIII 64 Query: 66 ILAAVYIAGSFFGWLLTYYTNRIAYRTVYDLRRELFDKLNVLPLKFHDNHPQGDSISRFV 125 +LAAVY+ S F WL T N +AY TV DLR E K++ LPLK+ D +P GD +SR Sbjct: 65 VLAAVYLISSIFTWLFTAVANILAYNTVRDLRNEALSKISTLPLKYFDVNPHGDIMSRLT 124 Query: 126 NDMDAVSDGLLQGFSTLLTGVVTIAGAIGLMLYISPVMTLVVLLSAPAAFYVARFITTRS 185 NDMDA+SDGL QG + +VTI +I LML +S +T +++L P F++A FIT RS Sbjct: 125 NDMDAISDGLFQGITQFFPAIVTIISSILLMLSLSIKLTGIIILMTPLCFFIASFITKRS 184 Query: 186 QKLFREQARILGGLNGYVEEIVGGQKVVQAFRYEDHSFAEFSGRNNELYQTGVKAQFYGS 245 K+F++Q +G LNGY+EEI+G +K+V+ F YE + +FS N+ LY G AQFY S Sbjct: 185 NKMFKQQQNTVGELNGYIEEIIGNEKIVKLFGYEKRAEKKFSEINSRLYNCGQLAQFYSS 244 Query: 246 LSNPSTRLVNNITFSVIAMIGSALVIGGHFTVGDLSSFLIYSNLFAKPFNEITGVITQLQ 305 L+NPSTR VNNIT+ ++ +G L + ++G +SSFL YS F++P N +TGV TQLQ Sbjct: 245 LTNPSTRFVNNITYVLVGAVGGLLAVLSGLSIGTISSFLTYSTQFSQPINNVTGVATQLQ 304 Query: 306 SATASAQRIFAILDLPPETQDAEDARVLGISQGTIQFDNVSFAYSPERPLIRNFSLEVKP 365 +A ASA+R+F+ILD PE +D E A+ +G I F+NVSF+Y+ ++PLI NFS+++K Sbjct: 305 AAFASAERVFSILDEIPEKKDNEGAKKFEHCEGNISFNNVSFSYNKKQPLIENFSVDIKK 364 Query: 366 GTRVAIVGQTGAGKTTLVNLLMRFYDVDSGSIKLDGTDIRAITRDSLRRNFGMVLQDTWL 425 G+ +AIVG TGAGKTT+VNLLMRFYD+D G I +DG DI + R+ +R FGMVLQDTWL Sbjct: 365 GSTIAIVGPTGAGKTTMVNLLMRFYDIDGGKITIDGKDINKMKRNDVRGQFGMVLQDTWL 424 Query: 426 YGGTIRDNIAYGKPXXXXXXXXXXXXXXXXHSFIKRLPEGYATKISGSGDNLSQGQKQLL 485 + GTI++NIAYGKP H+FIKRL +GY T+I+ SG NLS+GQKQLL Sbjct: 425 FEGTIKENIAYGKPDASMEEIESAAKKAYIHNFIKRLSDGYDTRITESGGNLSEGQKQLL 484 Query: 486 TIARVMLADPPMLILDEATSSIDTLTEARIQKAFLAMISGRTSFVIAHRLSTIREADVIL 545 TIARVML +PPMLILDEATSS+DT TE +IQ AFL M+ GRTSFVIAHRLSTI++AD+IL Sbjct: 485 TIARVMLINPPMLILDEATSSVDTRTEIKIQNAFLKMMEGRTSFVIAHRLSTIKDADLIL 544 Query: 546 YMKDGDIVESGTHEELLQRGGHYARLYNSQF 576 MK+G IVE G HEEL+ G Y +Y SQF Sbjct: 545 VMKNGHIVERGKHEELVNSEGLYREIYESQF 575 >lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 605 Score = 471 bits (1211), Expect = e-132, Method: Compositional matrix adjust. Identities = 254/583 (43%), Positives = 360/583 (61%), Gaps = 11/583 (1%) Query: 2 NAGATWKRIIVYTKQHRGIAIAAVFC-AILSVVASLIGPLLIGRTVDQ-----MAGLGQV 55 N T R++ Y K R +AI VF AILS + ++ P +G+ + M+ G + Sbjct: 20 NFKQTLFRLLGYMKP-RSVAIIVVFIFAILSTIFNIFSPKELGKATTEIFKGVMSPEG-I 77 Query: 56 DFDQVLRLLLILAAVYIAGSFFGWLLTYYTNRIAYRTVYDLRRELFDKLNVLPLKFHDNH 115 + D++ +L+I+ +Y+ S F ++ Y + +A RTVYD+R++L K+ LPLK++D Sbjct: 78 NNDKIFNILMIVLVLYLGSSLFSFIQQYVMSSVAQRTVYDMRKDLKAKMARLPLKYYDTR 137 Query: 116 PQGDSISRFVNDMDAVSDGLLQGFSTLLTGVVTIAGAIGLMLYISPVMTLVVLLSAPAAF 175 GD +SR VNDMD +++ L Q + +T +V + G + +ML IS MTL+VL++ P + Sbjct: 138 SNGDILSRSVNDMDNIANTLQQSLTQAITAIVQMIGVLIMMLTISWQMTLIVLVTVPISI 197 Query: 176 YVARFITTRSQKLFREQARILGGLNGYVEEIVGGQKVVQAFRYEDHSFAEFSGRNNELYQ 235 + I RSQ+ F Q R LG LN VEE GGQ +++AF E + +F N + ++ Sbjct: 198 ILVAIIAGRSQRYFGAQQRNLGILNDTVEETYGGQTIIKAFGQEKKTLVKFDEVNEDYFK 257 Query: 236 TGVKAQFYGSLSNPSTRLVNNITFSVIAMIGSALVIGGHFTVGDLSSFLIYSNLFAKPFN 295 KAQF + P + V N+ + + + G V G VGD+ SF Y LF +P + Sbjct: 258 AAKKAQFISGIMMPVMQFVGNLGYVGVCVAGGIFVTNGTLQVGDIQSFTQYVQLFTQPIS 317 Query: 296 EITGVITQLQSATASAQRIFAILDLPPETQ--DAEDARVLGISQGTIQFDNVSFAYSPER 353 + + +QS ASA+R+F ++D E A +V G + +I FD+V F Y+P++ Sbjct: 318 SVANIANIIQSTIASAERVFEMMDEEEEKDEIPANVNQVAG-EEHSIVFDHVKFGYTPDK 376 Query: 354 PLIRNFSLEVKPGTRVAIVGQTGAGKTTLVNLLMRFYDVDSGSIKLDGTDIRAITRDSLR 413 PL+ + ++ V+ G VAIVG TGAGKTT++NLLMRFYDVD G I++ G D R +T+D++R Sbjct: 377 PLMTDLNIHVEEGQMVAIVGPTGAGKTTIINLLMRFYDVDGGEIRMRGIDTRDMTKDAVR 436 Query: 414 RNFGMVLQDTWLYGGTIRDNIAYGKPXXXXXXXXXXXXXXXXHSFIKRLPEGYATKISGS 473 FGMVLQDTWL+ GTI DNIAYG+ FI+RLP GY T ++ Sbjct: 437 EKFGMVLQDTWLFNGTIADNIAYGREGATKDEVIGAAKAAYADDFIRRLPNGYDTILNEE 496 Query: 474 GDNLSQGQKQLLTIARVMLADPPMLILDEATSSIDTLTEARIQKAFLAMISGRTSFVIAH 533 G N+SQGQKQLLTIAR +L+DP +LILDEATSS+DT TE IQ A ++ GRTSFVIAH Sbjct: 497 GSNISQGQKQLLTIARAILSDPSILILDEATSSVDTRTELNIQLAMGNLMEGRTSFVIAH 556 Query: 534 RLSTIREADVILYMKDGDIVESGTHEELLQRGGHYARLYNSQF 576 RLSTIR+AD+IL M G ++E GTH+ELL G YA LYNSQF Sbjct: 557 RLSTIRDADLILVMNHGSVIEQGTHQELLDAKGFYADLYNSQF 599 >TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 598 Score = 464 bits (1193), Expect = e-130, Method: Compositional matrix adjust. Identities = 236/578 (40%), Positives = 355/578 (61%), Gaps = 3/578 (0%) Query: 2 NAGATWKRIIVYTKQHRGIAIAAVFCAILSVVASLIGPLLIGRTVDQMAGLGQVDFDQVL 61 N AT +R++ Y + H I +S + ++ P LIG+T+D + FD + Sbjct: 20 NPTATLRRLLGYLRPHTFTLIMVFVFVTVSSILGVLSPYLIGKTIDVV--FVPRRFDLLP 77 Query: 62 RLLLILAAVYIAGSFFGWLLTYYTNRIAYRTVYDLRRELFDKLNVLPLKFHDNHPQGDSI 121 R +LIL +Y S WL ++ V+ LR+ELF+KL +P+ F D P GD I Sbjct: 78 RYMLILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELFEKLQRVPVGFFDRTPHGDII 137 Query: 122 SRFVNDMDAVSDGLLQGFSTLLTGVVTIAGAIGLMLYISPVMTLVVLLSAPAAFYVARFI 181 SR +ND+D +++ L +G+VT+AGA+ +M ++ +++LV L P + + + Sbjct: 138 SRVINDVDNINNVLGNSIIQFFSGIVTLAGAVIMMFRVNVILSLVTLSIVPLTVLITQIV 197 Query: 182 TTRSQKLFREQARILGGLNGYVEEIVGGQKVVQAFRYEDHSFAEFSGRNNELYQTGVKAQ 241 +++++K F E R+LG LNG +EE + G V++ F E+ +F N L + G KAQ Sbjct: 198 SSQTRKYFYENQRVLGQLNGIIEEDISGLTVIKLFTREEKEMEKFDRVNESLRKVGTKAQ 257 Query: 242 FYGSLSNPSTRLVNNITFSVIAMIGSALVIGGHFTVGDLSSFLIYSNLFAKPFNEITGVI 301 + + P +VNN+ F++I+ G L + TVG +++F+ YS F +P NE++ Sbjct: 258 IFSGVLPPLMNMVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSNQF 317 Query: 302 TQLQSATASAQRIFAILDLPPETQDAEDARVLGISQGTIQFDNVSFAYSPERPLIRNFSL 361 +Q A ASA+RIF ILDL E +D DA L +G I+F NV F+Y ++P++++ + Sbjct: 318 NMIQMALASAERIFEILDL-EEEKDDPDAVELREVRGEIEFKNVWFSYDKKKPVLKDITF 376 Query: 362 EVKPGTRVAIVGQTGAGKTTLVNLLMRFYDVDSGSIKLDGTDIRAITRDSLRRNFGMVLQ 421 +KPG +VA+VG TG+GKTT+VNLLMRFYDVD G I +DG DIR I R SLR + G+VLQ Sbjct: 377 HIKPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGIDIRKIKRSSLRSSIGIVLQ 436 Query: 422 DTWLYGGTIRDNIAYGKPXXXXXXXXXXXXXXXXHSFIKRLPEGYATKISGSGDNLSQGQ 481 DT L+ T+++N+ YG P FIK LPEGY T ++ +G++LSQGQ Sbjct: 437 DTILFSTTVKENLKYGNPGATDEEIKEAAKLTHSDHFIKHLPEGYETVLTDNGEDLSQGQ 496 Query: 482 KQLLTIARVMLADPPMLILDEATSSIDTLTEARIQKAFLAMISGRTSFVIAHRLSTIREA 541 +QLL I R LA+P +LILDEATS++DT TE IQ A ++ G+TS +IAHRL+TI+ A Sbjct: 497 RQLLAITRAFLANPKILILDEATSNVDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIKNA 556 Query: 542 DVILYMKDGDIVESGTHEELLQRGGHYARLYNSQFAAV 579 D+I+ ++DG+IVE G H+EL+Q+ G Y L+ SQ+ V Sbjct: 557 DLIIVLRDGEIVEMGKHDELIQKRGFYYELFTSQYGLV 594 >Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 656 Score = 443 bits (1140), Expect = e-124, Method: Compositional matrix adjust. Identities = 244/621 (39%), Positives = 346/621 (55%), Gaps = 44/621 (7%) Query: 2 NAGATWKRIIVYTKQHRGIAIAAVFCAILSVVASLIGPLLIGRTVD-------------- 47 N G + KR+ R I +F A+LSV +++GP L+G+ + Sbjct: 24 NFGPSAKRLFGILGHDRNTLIFVIFLAVLSVGLTVLGPWLLGKATNVVFEGFLSKRMPAG 83 Query: 48 --------QMAGLGQ-----------------VDFDQVLRLLLILAAVYIAGSFFGWLLT 82 Q+ G+ +DF+++ +L ++ Y+ GS Sbjct: 84 ASKEDIIAQLQAAGKHNQASMMEDMNLVPGSGIDFEKLAMILGLVIGAYLIGSLLSLFQA 143 Query: 83 YYTNRIAYRTVYDLRRELFDKLNVLPLKFHDNHPQGDSISRFVNDMDAVSDGLLQGFSTL 142 NRI ++ LR E+ +K++ LPL + D+ +GD +SR ND+D + L Q S Sbjct: 144 RMLNRIVQSAMHRLRMEVEEKIHRLPLSYFDSIKRGDLLSRVTNDVDNIGQSLQQTLSQA 203 Query: 143 LTGVVTIAGAIGLMLYISPVMTLVVLLSAPAAFYVARFITTRSQKLFREQARILGGLNGY 202 +T ++T+ G + +M ISP++ LV L+S P V + +RSQKLF EQ + G LN Sbjct: 204 ITSLLTVIGVLVMMFIISPLLALVALVSIPVTIVVTVVVASRSQKLFAEQWKQTGILNAR 263 Query: 203 VEEIVGGQKVVQAFRYEDHSFAEFSGRNNELYQTGVKAQFYGSLSNPSTRLVNNITFSVI 262 VEE G VV+ F ++ F N +Y+ AQF + P+ V N+++ I Sbjct: 264 VEETYSGHAVVKVFGHQKDVQEAFEEENQAVYKASFGAQFISGIIMPTMMFVGNLSYVAI 323 Query: 263 AMIGSALVIGGHFTVGDLSSFLIYSNLFAKPFNEITGVITQLQSATASAQRIFAILDLPP 322 A++G V G ++G + SF+ YS F +P +++ + LQS ASA+R+F ++D Sbjct: 324 AVVGGLQVASGSLSIGGVQSFIQYSRQFTQPLSQLGSMANLLQSGVASAERVFELIDEDE 383 Query: 323 ETQDAEDARVLGISQGTIQFDNVSFAYSPERPLIRNFSLEVKPGTRVAIVGQTGAGKTTL 382 + D + ++F +VSF YS +RPLI N LEV+ G+ +AIVG TGAGKTTL Sbjct: 384 QDSDPAQPNTVAAGANRLEFKDVSFGYSEDRPLINNLDLEVRSGSTIAIVGPTGAGKTTL 443 Query: 383 VNLLMRFYDVDSGSIKL-----DGTDIRAITRDSLRRNFGMVLQDTWLYGGTIRDNIAYG 437 VNL+MRFYD++SGSI L D DIR + R+ LR GMVLQDTWL+ GTIRDNI YG Sbjct: 444 VNLIMRFYDINSGSITLGETAQDAVDIRTMAREDLRSRTGMVLQDTWLFAGTIRDNILYG 503 Query: 438 KPXXXXXXXXXXXXXXXXHSFIKRLPEGYATKISGSGDNLSQGQKQLLTIARVMLADPPM 497 +P F++ LPEGY T + NLS G++QL+TIAR LA+P + Sbjct: 504 RPEATEEEMLAASKAAYVDRFVRSLPEGYDTVLDDEAMNLSVGERQLITIARAFLANPRL 563 Query: 498 LILDEATSSIDTLTEARIQKAFLAMISGRTSFVIAHRLSTIREADVILYMKDGDIVESGT 557 LILDEATSS+DT TE IQ+A + RT+FVIAHRLSTIR+A++IL MKDG+IVE G Sbjct: 564 LILDEATSSVDTRTELLIQRAMSKLRQDRTAFVIAHRLSTIRDANLILMMKDGEIVEQGN 623 Query: 558 HEELLQRGGHYARLYNSQFAA 578 H EL+ G Y LYNSQF A Sbjct: 624 HRELMALEGAYWELYNSQFNA 644 >BS_yfiC [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 285 Score = 430 bits (1106), Expect = e-120, Method: Compositional matrix adjust. Identities = 0/571 (0%), Positives = 0/571 (0%), Gaps = 2/571 (0%) Query: 6 TWKRIIVYTKQHRGIAIAAVFCAILSVVASLIGPLLIGRTVDQMAGLGQVDFDQVLRLLL 65 + I ++ + V + + A V L + Sbjct: 34 FLQGFIFMSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGA-WAPV-AGVKRCLDI 91 Query: 66 ILAAVYIAGSFFGWLLTYYTNRIAYRTVYDLRRELFDKLNVLPLKFHDNHPQGDSISRFV 125 + +A + + + + H Sbjct: 92 GAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQ 151 Query: 126 NDMDAVSDGLLQGFSTLLTGVVTIAGAIGLMLYISPVMTLVVLLSAPAAFYVARFITTRS 185 + + T +L+ + + Sbjct: 152 QTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPE 211 Query: 186 QKLFREQARILGGLNGYVEEIVGGQKVVQAFRYEDHSFAEFSGRNNELYQTGVKAQFYGS 245 Q L + + +F+ +G S Sbjct: 212 QIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYS 271 Query: 246 LSNPSTRLVNNITFSVIAMIGSALVIGGHFTVGDLSSFLIYSNLFAKPFNEITGVITQLQ 305 Sbjct: 272 331 Query: 306 SATASAQRIFAILDLPPETQDAEDARVLGISQGTIQFDNVSFAYSPERPLIRNFSLEVKP 365 Sbjct: 332 391 Query: 366 GTRVAIVGQTGAGKTTLVNLLMRFYDVDSGSIKLDGTDIRAITRDSLRRNFGMVLQDTWL 425 Sbjct: 392 451 Query: 426 YGGTIRDNIAYGKPXXXXXXXXXXXXXXXXHSFIKRLPEGYATKISGSGDNLSQGQKQLL 485 Sbjct: 452 511 Query: 486 TIARVMLADPPMLILDEATSSIDTLTEARIQKAFLAMISGRTSFVIAHRLSTIREADVIL 545 Sbjct: 512 571 Query: 546 YMKDGDIVESGTHEELLQRGGHYARLYNSQF 576 Sbjct: 572 602 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.323 0.139 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 39,565,420 Number of extensions: 1632320 Number of successful extensions: 20091 Number of sequences better than 1.0e-05: 1126 Number of HSP's gapped: 18977 Number of HSP's successfully gapped: 1175 Length of query: 579 Length of database: 38,378,431 Length adjustment: 112 Effective length of query: 467 Effective length of database: 25,461,023 Effective search space: 11890297741 Effective search space used: 11890297741 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 119 (50.4 bits)