BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0264.0017.p (426 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2538 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 534 e-151 BS_pyrC [F] COG0044 Dihydroorotase and related cyclic amidohydro... 418 e-117 DR1106 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 303 3e-82 PA0401 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 238 1e-62 BMEII0669 [F] COG0044 Dihydroorotase and related cyclic amidohyd... 236 6e-62 >BH2538 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 534 bits (1375), Expect = e-151, Method: Compositional matrix adjust. Identities = 0/425 (0%), Positives = 0/425 (0%), Gaps = 4/425 (0%) Query: 2 IIKNASVLNGEGVLERKHIVVQDGIISAIKDGSEAVDEAGEIVEAEGKLLIPGLIDMHVH 61 S L + + + + + + + + Sbjct: 4 HRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAV--AQGINLIDVAEMYPVPPRPET 61 Query: 62 LREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVKVLP 121 + + ++ P+ K+ Sbjct: 62 QGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 122 YAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAHCED 181 +TD V + + + I + Sbjct: 122 QTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNE 181 Query: 182 NSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSVRLI 241 + + + I N ++ ++ LAE + + + Sbjct: 182 TAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTL 241 Query: 242 RQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDGTID 301 G K + + R ++ L Sbjct: 242 TGKYLNGAKPAGARNTLFSRFTRYSGEQTQK--AVAAYVDIARRHGLDPAQMALAFVRRQ 299 Query: 302 IIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTADPAR 361 Sbjct: 300 359 Query: 362 VFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVNGTA 421 Sbjct: 360 419 Query: 422 VWTEE 426 Sbjct: 420 424 >BS_pyrC [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 348 Score = 418 bits (1074), Expect = e-117, Method: Compositional matrix adjust. Identities = 0/427 (0%), Positives = 0/427 (0%), Gaps = 10/427 (2%) Query: 2 IIKNASVLNGEGVLERKHIVVQDGIISAIKDGSEAVDEAGEIVEAEGKLLIPGLIDMHVH 61 + + + + SE A + + + Sbjct: 4 PSQVLKIRRPDDWHLHLRDGDMLKTVVPY--TSEIYGRAIVMPNLAPPVTTVEAAVAYRQ 61 Query: 62 LREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVKVLP 121 + + + V + Sbjct: 62 RILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSID 121 Query: 122 YAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAHCED 181 + + E + + + + ++ V H Sbjct: 122 AIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITT 181 Query: 182 NSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSVRLI 241 + AA + + + VG + Sbjct: 182 KDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCL-PILKRNIHQQALRELVA 240 Query: 242 RQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDGTID 301 + + + H S G + + + Sbjct: 241 SGFNRVFLGTDSAPHARHRKESSCGCAGCFN--APTALGSYATVFEEMNALQHFEAFCSV 298 Query: 302 IIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDL---SLLVQRMTAD 358 + + + ++ G+ Sbjct: 299 NGPQFYGLPVNDTFIELVREEQQVAESIALTDDT--LVPFLAGETVRWSV 356 Query: 359 PARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVN 418 Sbjct: 357 416 Query: 419 GTAVWTE 425 Sbjct: 417 423 >DR1106 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 303 bits (776), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 0/414 (0%), Positives = 0/414 (0%), Gaps = 9/414 (2%) Query: 13 GVLERKHIVVQDGIISAIKDGSEAVDEAGEIVEAEGKLLIPGLIDMHVHLREPGFEHKET 72 V + G ++ D + + + +M+ P + Sbjct: 12 EVSTLGLGTMTFGEQNSEADAHA-----QLDYAVAQGINLIDVAEMYPVPPRPETQGLTE 66 Query: 73 IETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVKVLPYAAITKNELGR 132 G A G + + + + + + L + Sbjct: 67 TYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYL 126 Query: 133 ELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAHCEDNSLVEGCAVAE 192 +L + SA + + A + + A Sbjct: 127 DLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGV 186 Query: 193 GTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSVRLIRQAKEIGIKVT 252 + +P + + + G+ + E + K Sbjct: 187 MRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYL 246 Query: 253 AEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDGTIDIIVTDHAPHSE 312 P + + +T + + D+ V + Sbjct: 247 NGAKPAGARNTLFSRFTRYS--GEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVAS 304 Query: 313 EEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTADPARVFRLNTGSLTV 372 + Sbjct: 305 TLLGATTMDQLKTNIESLHLELSEDVLA-- 362 Query: 373 GLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVNGTAVWTEE 426 Sbjct: 363 416 >PA0401 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 238 bits (608), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 0/381 (0%), Positives = 0/381 (0%), Gaps = 4/381 (1%) Query: 39 EAGEIVEAEGKLLIPGLIDMHVHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVT 98 G + ++ L E + + N + + Sbjct: 41 AQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIR 100 Query: 99 DSPEIVQFVKDKAAEAGLVKVLPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSA 158 + + +A L ++ + K + + V + Sbjct: 101 PDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDT 160 Query: 159 QMMKDAMKIAAGLDMPVIAHCEDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDIL 218 + A + +++ ++ +A+ + P + Sbjct: 161 LDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLA 220 Query: 219 LAEATGVHYHVCHVSTEQSVRLIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKT 278 + + + + Sbjct: 221 EVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVD- 279 Query: 279 PPPLRSRRDVEACIAGLLDGTIDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYT 338 R D + + T + ++ ++ + A Sbjct: 280 -IARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVH 338 Query: 339 AFVATGKWDLSLLVQRMTADPARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKG 398 Sbjct: 339 -- 396 Query: 399 RNTPFGGWKLKGWPVKTWVNG 419 Sbjct: 397 417 >BMEII0669 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 236 bits (602), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 0/431 (0%), Positives = 0/431 (0%), Gaps = 14/431 (3%) Query: 1 VIIKNASVLN-GEGVLERKHIVVQDGIISAIKDGSEAVD----EAGEIVEAEGKLLIPGL 55 I ++S+ G+ + + ++ E P Sbjct: 4 HRIPHSSLEVSTLGLGTMTFGEQNSEADAHA--QLDYAVAQGINLIDVAEMYPVPPRPET 61 Query: 56 IDMHVHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAG 115 + + E ++ G + + ++ + + Sbjct: 62 QGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 116 LVKVLPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPV 175 L + + + + + + A KI Sbjct: 122 QTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNE 181 Query: 176 IAHCEDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTE 235 A L + N S + + + Y T Sbjct: 182 TAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTL 241 Query: 236 QSVRLIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGL 295 L + + A L + A + Sbjct: 242 TGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAV--AAYVDIARRHGLDPAQMALAFVRRQ 299 Query: 296 LDGTIDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSL--LVQ 353 ++ + ++ Sbjct: 300 PFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIE--- 356 Query: 354 RMTADPARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPV 413 Sbjct: 357 416 Query: 414 KTWVNGTAVWT 424 Sbjct: 417 427 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.135 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 31,836,657 Number of extensions: 1376976 Number of successful extensions: 3410 Number of sequences better than 1.0e-05: 32 Number of HSP's gapped: 3342 Number of HSP's successfully gapped: 34 Length of query: 426 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 317 Effective length of database: 25,807,025 Effective search space: 8180826925 Effective search space used: 8180826925 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 117 (49.7 bits)