BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0261.0004.p (434 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC1671 [L] COG2256 ATPase related to the helicase subunit of th... 327 2e-89 CAC0326 [L] COG2256 ATPase related to the helicase subunit of th... 318 9e-87 MTH241 [L] COG0470 ATPase involved in DNA replication 82 1e-15 APE1522 [L] COG0470 ATPase involved in DNA replication 80 8e-15 PAE1646 [L] COG0470 ATPase involved in DNA replication 79 1e-14 >CAC1671 [L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase Length = 421 Score = 327 bits (838), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 163/416 (39%), Positives = 265/416 (63%), Gaps = 10/416 (2%) Query: 16 LADRMRPENLDEYIGQEHIVGPGKLLRRAIEADQVSSILLYGPPGCGKTTLAHIISHHTQ 75 LADR+RPEN +E GQ+HI+G GK+L R +++ V +++ YGPPG GKTT+A+II+ T Sbjct: 4 LADRIRPENFNEVFGQKHIIGEGKILDRILKSSLVPNMIFYGPPGTGKTTVANIIAKKTN 63 Query: 76 GEFVRLNAVEASVKDVREVIERAQSNKSLYG-SKTILFLDEVHRFNSSRQDALLPAVEKG 134 F +LNA ASVKDVRE+ + S +L G + +L+LDE+ FN +Q +LL +E G Sbjct: 64 KAFYKLNATTASVKDVREITD---STNTLMGRNGVLLYLDEIQNFNKKQQQSLLEFMENG 120 Query: 135 TIIFIGATTENPFHYVNGALMSRSTLFQLESLTSEHSLVAMRRALADEKRGLGFMQLQAD 194 +I I +TTENP+ YV A++SRST+F+ + L S+ + A+ RA+ K L ++ Sbjct: 121 SITLIASTTENPYFYVYNAILSRSTIFEFKPLESDELMKAVNRAVELIKDELKTTEIIIT 180 Query: 195 EEALQHIADMANGDIRRALNALELAAMTTAPEPDGSVHITLAVAEESIRRPIVKADE--S 252 E+A ++ +++GD+R+ LN++E+A +T P +G++ I L +E ++ ++ D+ Sbjct: 181 EDAKKYAVGVSSGDVRKTLNSIEIAVYSTKPNEEGNIFIDLETMKECTQKNVLNFDKDGD 240 Query: 253 TQYDVLSAFHKSIRGS-SDAALFWFLYAVEKLGMDPMTFIRRLIAASSEDIGLANPQAMV 311 YD+LSAF KSIRGS +DAA+ + ++ G D + RRL+ ++EDIGLA PQA+ Sbjct: 241 NHYDILSAFQKSIRGSDADAAVLYLAMLIK--GGDLKSICRRLLVIAAEDIGLAYPQAIS 298 Query: 312 QAVSALEAYRNNGWPEAKLNIAQAILFAVESPKSNAVVMAISRAMDSIEELKSAEVPLHL 371 + ++ G+PEA++ +A+A++ SPKSN+ + A+ A+ ++ + +P +L Sbjct: 299 IVKACTDSALELGFPEARIPLAEAVILLATSPKSNSAITAVDSALRDLDTINVGSIPDYL 358 Query: 372 RDTHYKGSAALGH-EGYQYPHNFPGHYVKQEYLPKAISRREFYQATEQGNEAKIRH 426 RD HY+G+ LG + Y+YPH++ +YVKQ+YLP + R +Y+ + E K R Sbjct: 359 RDGHYEGAKKLGRMQDYKYPHSYENNYVKQKYLPSNLENRRYYEYGKNKIEEKCRE 414 >CAC0326 [L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase Length = 443 Score = 318 bits (816), Expect = 9e-87, Method: Compositional matrix adjust. Identities = 169/410 (41%), Positives = 258/410 (62%), Gaps = 8/410 (1%) Query: 16 LADRMRPENLDEYIGQEHIVGPGKLLRRAIEADQVSSILLYGPPGCGKTTLAHIISHHTQ 75 LA RMRP NL +YIGQEHI+ GK LR +E D ++S++L+GPPG GKTTLA II+ T+ Sbjct: 17 LAGRMRPRNLSDYIGQEHILEKGKALRNMLEKDSITSMILWGPPGVGKTTLAMIIASTTK 76 Query: 76 GEFVRLNAVEASVKDVREVIERAQSNKSLYGSKTILFLDEVHRFNSSRQDALLPAVEKGT 135 FV +A + +K++++++ +A+ ++ L+G +T+LF+DE+HRFN S+QD LP VEKG Sbjct: 77 CNFVEFSAATSGIKEIKDIMIKAEKDR-LFGIRTLLFIDEIHRFNKSQQDTFLPHVEKGD 135 Query: 136 IIFIGATTENPFHYVNGALMSRSTLFQLESLTSEHSLVAMRRALADEKRGLGFMQLQADE 195 II IGATTENP VN AL+SR +F L+ L++ + ++ AL D RG +Q E Sbjct: 136 IILIGATTENPSFEVNSALLSRCRVFVLKPLSNNDIVKLLKNALTDT-RGFKNKNIQISE 194 Query: 196 EALQHIADMANGDIRRALNALELAAMTTAPEPDGSVHITLAVAEESIRRPIVKADESTQ- 254 + L IA +NGD R ALN LE+A +++ E G V I + E+ ++ + D++ + Sbjct: 195 DLLTLIAVYSNGDARTALNVLEMAVLSSKLE-HGVVTINKGILEDCMQNKALIYDKNGEE 253 Query: 255 -YDVLSAFHKSIRGSS-DAALFWFLYAVEKLGMDPMTFIRRLIAASSEDIGLANPQAMVQ 312 Y+++SA HKS+R S DAA++W +E G DP+ RRLI SSEDIG+A+ A+ Sbjct: 254 HYNLISALHKSMRNSDVDAAIYWLARMLEG-GEDPLYIARRLIRFSSEDIGVADTNALNV 312 Query: 313 AVSALEAYRNNGWPEAKLNIAQAILFAVESPKSNAVVMAISRAMDSIEELKSAEVPLHLR 372 V+ + G PE +N+ +A+++ +PKSN++ MA +A +E ++ VPLHLR Sbjct: 313 TVNVYNSCHYIGMPECSVNLTEAVVYLSLAPKSNSIYMAYEKAKKDAKETLASGVPLHLR 372 Query: 373 DTHYKGSAALGH-EGYQYPHNFPGHYVKQEYLPKAISRREFYQATEQGNE 421 + K + LG+ +GY+Y H+F V + LP + ++Y T +G E Sbjct: 373 NAPTKLMSDLGYSKGYKYAHDFDNKVVDMQCLPDNLKDEKYYFPTTEGRE 422 >MTH241 [L] COG0470 ATPase involved in DNA replication Length = 673 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 8/239 (3%), Positives = 42/239 (17%), Gaps = 16/239 (6%) Query: 17 ADRMRPENLDEYIGQEHIVGPGKLLRRAIEADQVSSILLYGPPGCGKTTLAHIISHHTQG 76 + K + + Y T + + + Sbjct: 9 QAVEFVTGPCLVLAGAGSG---KTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKE 65 Query: 77 EFVRLNAVEASVKDVREVIERAQSNKSLYGSK------TILFLDEVHRFNSSRQDALLPA 130 + + + + + D+ + ++ Sbjct: 66 RVGQTLGRKEARGLMISTFHTLGLDIIKREYAALGMKANFSLFDDTDQLALLKELTEGLI 125 Query: 131 VEKGTIIFIGATTENPFHYVNGALMSRSTLFQLESLTSEHSLVAMRRALADEKRGLGFMQ 190 + ++ +T + + + E + + Sbjct: 126 EDDKVLLQQLISTISNWKNDLKTPSQAAASAIGERDRI-FAHCYGLYDAHLKA------C 178 Query: 191 LQADEEALQHIADMANGDIRRALNALELAAMTTAPEPDGSVHITLAVAEESIRRPIVKA 249 D + L + + + + + + + + + Sbjct: 179 NVLDFDDLILLPTLLLQANEEVRKRWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARF 237 >APE1522 [L] COG0470 ATPase involved in DNA replication Length = 673 Score = 79.7 bits (195), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 18/213 (8%), Positives = 39/213 (18%), Gaps = 17/213 (7%) Query: 15 LLADRMRPENLDEYIGQEHIVGPGKLLRRAIEADQVSSILLYGPPGCGKTTLAHIISHHT 74 + +L G + G K +IS Sbjct: 29 TRVITNKIAHLIRGCGYQARH---IAAVTFTNKAAREMKERVGQTLGRKEARGLMISTFH 85 Query: 75 QGEFVRLNAVEASVKDVREVIERAQSNKSLYGSKT-------ILFLDEVHRFNSSRQDAL 127 + A++ +++ + L + S Sbjct: 86 TLGLDIIKREYAALGMKANFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKND 145 Query: 128 LPAVEKGTIIFIGATTENPFHYVNGALMSRSTLFQLESLTSEHSLVAMRRALADEKRGLG 187 L + IG H L+ L + E+ Sbjct: 146 LKTPSQAAASAIGERDRIFAHCYGLYDAHLKACNVLDFD-DLILLPTLLLQAN-EEVRKR 203 Query: 188 FMQLQADEEALQHIADMANGDIRRALNALELAA 220 + + + D ++L Sbjct: 204 W-----QNKIRYLLVDEYQDTNTSQYELVKLLV 231 >PAE1646 [L] COG0470 ATPase involved in DNA replication Length = 673 Score = 79.3 bits (194), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 10/219 (4%), Positives = 34/219 (15%), Gaps = 29/219 (13%) Query: 18 DRMRPENLDEYIGQEHIVGPGKLLRRAIEADQVSSILLYGPPGCGKTTLAHIISHHTQGE 77 + + R I I G + + + Sbjct: 8 QQAVEFVTGPCLVLAGAGSG---KTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMK 64 Query: 78 FVRLNAVEASVKD------VRE-VIERAQSNKSLYGSKTILFLDEVHRFNSSRQDALLPA 130 + ++ + + G K L + + ++ Sbjct: 65 ERVGQTLGRKEARGLMISTFHTLGLDIIKREYAALGMKANFSLFDDTDQLALLKELTEGL 124 Query: 131 VE---KGTIIFIGATTENPFHYVNGA---LMSRSTLFQLESLTSEHSLVAMRRALADEKR 184 +E I S++ + + + Sbjct: 125 IEDDKVLLQQLIST------ISNWKNDLKTPSQAAASAIGERDRIFAHCYGLYDAHLKA- 177 Query: 185 GLGFMQLQADEEALQHIADMANGDIRRALNALELAAMTT 223 + + + + Sbjct: 178 ------CNVLDFDDLILLPTLLLQANEEVRKRWQNKIRY 210 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.132 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 30,431,696 Number of extensions: 1222667 Number of successful extensions: 6338 Number of sequences better than 1.0e-05: 52 Number of HSP's gapped: 6343 Number of HSP's successfully gapped: 52 Length of query: 434 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 325 Effective length of database: 25,807,025 Effective search space: 8387283125 Effective search space used: 8387283125 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 117 (49.7 bits)