BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0247.0034.p (417 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MT1458_2 [H] COG0807 GTP cyclohydrolase II 244 1e-64 Rv1415_2 [H] COG0807 GTP cyclohydrolase II 244 1e-64 PA4047 [H] COG0807 GTP cyclohydrolase II 229 8e-60 RSc0713_1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 228 1e-59 NMB1254 [H] COG0807 GTP cyclohydrolase II 226 5e-59 >MT1458_2 [H] COG0807 GTP cyclohydrolase II Length = 220 Score = 244 bits (624), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 123/209 (58%), Positives = 156/209 (74%), Gaps = 6/209 (2%) Query: 210 EQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGDISGE----EPVLVRVHSECL 265 E+ + R ++PT G+F+ I YT+ +D EHVALV+G+I+G + VLVRVHSECL Sbjct: 1 EKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECL 60 Query: 266 TGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMR-QEGRGIGLINKLRAYKLQEEGLDT 324 TGDVF S RCDCGPQ +AAL + GRGV+LYMR EGRGIGL++KL+AY+LQ+ G DT Sbjct: 61 TGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADT 120 Query: 325 VDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLEGYGLEVVERVPIQMP 384 VDANLKLG PAD RDYGIGAQIL DLGVR ++L+TNNP K GL+GYGL ++ERVP+ + Sbjct: 121 VDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVR 180 Query: 385 ENKDNTNYLHTKQAKLGH-LLTFDNIEQN 412 N +N YL TK+ KLGH L D+ ++ Sbjct: 181 ANAENIRYLMTKRDKLGHDLAGLDDFHES 209 >Rv1415_2 [H] COG0807 GTP cyclohydrolase II Length = 220 Score = 244 bits (624), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 123/209 (58%), Positives = 156/209 (74%), Gaps = 6/209 (2%) Query: 210 EQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGDISGE----EPVLVRVHSECL 265 E+ + R ++PT G+F+ I YT+ +D EHVALV+G+I+G + VLVRVHSECL Sbjct: 1 EKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECL 60 Query: 266 TGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMR-QEGRGIGLINKLRAYKLQEEGLDT 324 TGDVF S RCDCGPQ +AAL + GRGV+LYMR EGRGIGL++KL+AY+LQ+ G DT Sbjct: 61 TGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADT 120 Query: 325 VDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLEGYGLEVVERVPIQMP 384 VDANLKLG PAD RDYGIGAQIL DLGVR ++L+TNNP K GL+GYGL ++ERVP+ + Sbjct: 121 VDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVR 180 Query: 385 ENKDNTNYLHTKQAKLGH-LLTFDNIEQN 412 N +N YL TK+ KLGH L D+ ++ Sbjct: 181 ANAENIRYLMTKRDKLGHDLAGLDDFHES 209 >PA4047 [H] COG0807 GTP cyclohydrolase II Length = 205 Score = 229 bits (583), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 112/188 (59%), Positives = 133/188 (70%) Query: 217 VSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGDISGEEPVLVRVHSECLTGDVFHSHRCD 276 + KLPT FG+F + +E KEHVAL GDI+ PVL R+HSECLTGD S RCD Sbjct: 7 AASKLPTPFGEFTMHGFLDEESGKEHVALSMGDIADGAPVLGRLHSECLTGDALFSLRCD 66 Query: 277 CGPQFEAALRQIEAAGRGVLLYMRQEGRGIGLINKLRAYKLQEEGLDTVDANLKLGFPAD 336 CG Q E AL I GRGVLLY+RQEGRGIGL+NK+RAY+LQ+ G DTV+ANL+LGF AD Sbjct: 67 CGFQLEGALAAIAEEGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANLQLGFGAD 126 Query: 337 LRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLEGYGLEVVERVPIQMPENKDNTNYLHTK 396 RDY + +L LGV ++LMTNNPRK+K LE Y + V ERVP+Q NK N YL TK Sbjct: 127 QRDYAMCQPMLAHLGVSSLRLMTNNPRKVKALESYAITVAERVPLQKGLNKHNRRYLATK 186 Query: 397 QAKLGHLL 404 KLGH+L Sbjct: 187 AGKLGHML 194 >RSc0713_1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase Length = 226 Score = 228 bits (581), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 111/198 (56%), Positives = 146/198 (73%), Gaps = 1/198 (0%) Query: 14 IEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCVPITAERA 73 +E+ I ++ G+++I+VD+EDRENEGD I A+ TPE INFM GRGL+C+ +TAER Sbjct: 29 VEEIIAEIRAGRMVILVDEEDRENEGDLILAADFVTPEAINFMARFGRGLICLTLTAERC 88 Query: 74 AELDLQPMVAHNTDNHGTAFTVSVDHKD-TTTGISAAERSKTIQALMDPEAKPSDFRRPG 132 +LDL MV N HGT FTVS++ + TTGISAA+R++T+Q + A P D +PG Sbjct: 89 RQLDLPLMVTRNGTPHGTNFTVSIEAAEGVTTGISAADRARTVQVAVARSASPDDLVQPG 148 Query: 133 HMFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLVEIARKH 192 H+FPL+A+ GGVL R+GHTEA DLA + G PASVICE++K+DGTMARLPDLVE AR+H Sbjct: 149 HIFPLMAQPGGVLMRAGHTEAGCDLASLAGLTPASVICEIMKDDGTMARLPDLVEFAREH 208 Query: 193 ELKLISIKDLIHYRNEKE 210 LK+ +I DLI YR+ E Sbjct: 209 GLKIGTIADLIQYRSRTE 226 >NMB1254 [H] COG0807 GTP cyclohydrolase II Length = 197 Score = 226 bits (576), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 103/195 (52%), Positives = 142/195 (72%), Gaps = 1/195 (0%) Query: 211 QLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGDISGEEPVLVRVHSECLTGDVF 270 +++ S +LPT++G F T+ E + +EHVAL G+ S PVL R+HSECLTGD Sbjct: 3 EMLNHVASCRLPTEWGVF-TMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDAL 61 Query: 271 HSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGIGLINKLRAYKLQEEGLDTVDANLK 330 S +CDCGPQ EAA+R ++ GRG+++Y+RQEGRGIGLINK+RAY LQ++G+DTV+ANL Sbjct: 62 FSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLA 121 Query: 331 LGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLEGYGLEVVERVPIQMPENKDNT 390 LG P D RD+ + I + LG+R +KL+TNNP KI+ L+ G+ VVER+P+ + EN +N Sbjct: 122 LGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENK 181 Query: 391 NYLHTKQAKLGHLLT 405 YL TK KLGHL++ Sbjct: 182 RYLQTKADKLGHLMS 196 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 31,246,221 Number of extensions: 1375917 Number of successful extensions: 2455 Number of sequences better than 1.0e-05: 31 Number of HSP's gapped: 2417 Number of HSP's successfully gapped: 31 Length of query: 417 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 308 Effective length of database: 25,807,025 Effective search space: 7948563700 Effective search space used: 7948563700 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 117 (49.7 bits)