BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0243.0001.p (398 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_bltR_1 [K] COG0789 Predicted transcriptional regulators 303 5e-82 BS_bltD [KR] COG0454 Histone acetyltransferase HPA2 and related ... 303 5e-82 BS_blt [GEPR] COG0477 Permeases of the major facilitator superfa... 303 5e-82 BS_bltR_2 [KT] COG4978 Transcriptional regulator, effector-bindi... 303 5e-82 BS_bmrR_1 [K] COG0789 Predicted transcriptional regulators 273 5e-73 >BS_bltR_1 [K] COG0789 Predicted transcriptional regulators Length = 400 Score = 303 bits (775), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 178/388 (45%), Positives = 246/388 (63%), Gaps = 7/388 (1%) Query: 2 LLLMLNIFLAFTGIGLVVPIMPTYMNEXXXXXXXXXXXXAAFSLTQLILSPLAGGLSDRM 61 ++L+ NIF+AF GIGL++P+MP++M AAF+++QLI SP AG DR Sbjct: 13 IILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRF 72 Query: 62 GRKKIIVGGLVVFALSELLFGLAESSWLLFASRMLGGAGAAMIMPAVMAYVADTTSMEER 121 GRKK+I+ GL++F+LSEL+FGL + + SR+LGG AA IMPAV AYVAD T+++ER Sbjct: 73 GRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKER 132 Query: 122 AKGMGLINAAITTGFIIGPGLGGYLAELGIRXXXXXXXXXXXXXXXMTLFVLPESRSSAE 181 +K MG ++AAI+TGFIIGPG GG++A GIR ++F+L ES S E Sbjct: 133 SKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEE 192 Query: 182 LGAAKSTQENKDSKDS-LITQLVRSYREPYFFGLVIVFVLSFGLANYETVFGLFVDHKFG 240 Q + +K+S I L RS YF +IVFV++FGL+ YETVF LF DHKFG Sbjct: 193 -----RHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFG 247 Query: 241 FTPKDIAFVITFGSISGAVIQVTAFSWILNRFGENKVIXXXXXXXXXXXXXXXFVHGYWA 300 FTPKDIA +IT SI VIQV F ++N+ GE ++I + G+ Sbjct: 248 FTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLT 307 Query: 301 IVTVTFIVFLAMDILRPAVGTQLSKMASESQQGFVMGMNSAYTSLGNIAGPIVAGVLFDL 360 ++ VT +FLA D+LRPA+ LS MA +QQGFV GMNS YTSLGNI GP + G+LFDL Sbjct: 308 VLLVTCFIFLAFDLLRPALTAHLSNMAG-NQQGFVAGMNSTYTSLGNIFGPALGGILFDL 366 Query: 361 DINLPYTVAALVLMLCFIMSLGSRKRMN 388 +I+ P+ A V+++ +++ +++ N Sbjct: 367 NIHYPFLFAGFVMIVGLGLTMVWKEKKN 394 >BS_bltD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 400 Score = 303 bits (775), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 178/388 (45%), Positives = 246/388 (63%), Gaps = 7/388 (1%) Query: 2 LLLMLNIFLAFTGIGLVVPIMPTYMNEXXXXXXXXXXXXAAFSLTQLILSPLAGGLSDRM 61 ++L+ NIF+AF GIGL++P+MP++M AAF+++QLI SP AG DR Sbjct: 13 IILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRF 72 Query: 62 GRKKIIVGGLVVFALSELLFGLAESSWLLFASRMLGGAGAAMIMPAVMAYVADTTSMEER 121 GRKK+I+ GL++F+LSEL+FGL + + SR+LGG AA IMPAV AYVAD T+++ER Sbjct: 73 GRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKER 132 Query: 122 AKGMGLINAAITTGFIIGPGLGGYLAELGIRXXXXXXXXXXXXXXXMTLFVLPESRSSAE 181 +K MG ++AAI+TGFIIGPG GG++A GIR ++F+L ES S E Sbjct: 133 SKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEE 192 Query: 182 LGAAKSTQENKDSKDS-LITQLVRSYREPYFFGLVIVFVLSFGLANYETVFGLFVDHKFG 240 Q + +K+S I L RS YF +IVFV++FGL+ YETVF LF DHKFG Sbjct: 193 -----RHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFG 247 Query: 241 FTPKDIAFVITFGSISGAVIQVTAFSWILNRFGENKVIXXXXXXXXXXXXXXXFVHGYWA 300 FTPKDIA +IT SI VIQV F ++N+ GE ++I + G+ Sbjct: 248 FTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLT 307 Query: 301 IVTVTFIVFLAMDILRPAVGTQLSKMASESQQGFVMGMNSAYTSLGNIAGPIVAGVLFDL 360 ++ VT +FLA D+LRPA+ LS MA +QQGFV GMNS YTSLGNI GP + G+LFDL Sbjct: 308 VLLVTCFIFLAFDLLRPALTAHLSNMAG-NQQGFVAGMNSTYTSLGNIFGPALGGILFDL 366 Query: 361 DINLPYTVAALVLMLCFIMSLGSRKRMN 388 +I+ P+ A V+++ +++ +++ N Sbjct: 367 NIHYPFLFAGFVMIVGLGLTMVWKEKKN 394 >BS_blt [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 400 Score = 303 bits (775), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 178/388 (45%), Positives = 246/388 (63%), Gaps = 7/388 (1%) Query: 2 LLLMLNIFLAFTGIGLVVPIMPTYMNEXXXXXXXXXXXXAAFSLTQLILSPLAGGLSDRM 61 ++L+ NIF+AF GIGL++P+MP++M AAF+++QLI SP AG DR Sbjct: 13 IILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRF 72 Query: 62 GRKKIIVGGLVVFALSELLFGLAESSWLLFASRMLGGAGAAMIMPAVMAYVADTTSMEER 121 GRKK+I+ GL++F+LSEL+FGL + + SR+LGG AA IMPAV AYVAD T+++ER Sbjct: 73 GRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKER 132 Query: 122 AKGMGLINAAITTGFIIGPGLGGYLAELGIRXXXXXXXXXXXXXXXMTLFVLPESRSSAE 181 +K MG ++AAI+TGFIIGPG GG++A GIR ++F+L ES S E Sbjct: 133 SKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEE 192 Query: 182 LGAAKSTQENKDSKDS-LITQLVRSYREPYFFGLVIVFVLSFGLANYETVFGLFVDHKFG 240 Q + +K+S I L RS YF +IVFV++FGL+ YETVF LF DHKFG Sbjct: 193 -----RHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFG 247 Query: 241 FTPKDIAFVITFGSISGAVIQVTAFSWILNRFGENKVIXXXXXXXXXXXXXXXFVHGYWA 300 FTPKDIA +IT SI VIQV F ++N+ GE ++I + G+ Sbjct: 248 FTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLT 307 Query: 301 IVTVTFIVFLAMDILRPAVGTQLSKMASESQQGFVMGMNSAYTSLGNIAGPIVAGVLFDL 360 ++ VT +FLA D+LRPA+ LS MA +QQGFV GMNS YTSLGNI GP + G+LFDL Sbjct: 308 VLLVTCFIFLAFDLLRPALTAHLSNMAG-NQQGFVAGMNSTYTSLGNIFGPALGGILFDL 366 Query: 361 DINLPYTVAALVLMLCFIMSLGSRKRMN 388 +I+ P+ A V+++ +++ +++ N Sbjct: 367 NIHYPFLFAGFVMIVGLGLTMVWKEKKN 394 >BS_bltR_2 [KT] COG4978 Transcriptional regulator, effector-binding domain/component Length = 400 Score = 303 bits (775), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 178/388 (45%), Positives = 246/388 (63%), Gaps = 7/388 (1%) Query: 2 LLLMLNIFLAFTGIGLVVPIMPTYMNEXXXXXXXXXXXXAAFSLTQLILSPLAGGLSDRM 61 ++L+ NIF+AF GIGL++P+MP++M AAF+++QLI SP AG DR Sbjct: 13 IILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRF 72 Query: 62 GRKKIIVGGLVVFALSELLFGLAESSWLLFASRMLGGAGAAMIMPAVMAYVADTTSMEER 121 GRKK+I+ GL++F+LSEL+FGL + + SR+LGG AA IMPAV AYVAD T+++ER Sbjct: 73 GRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKER 132 Query: 122 AKGMGLINAAITTGFIIGPGLGGYLAELGIRXXXXXXXXXXXXXXXMTLFVLPESRSSAE 181 +K MG ++AAI+TGFIIGPG GG++A GIR ++F+L ES S E Sbjct: 133 SKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEE 192 Query: 182 LGAAKSTQENKDSKDS-LITQLVRSYREPYFFGLVIVFVLSFGLANYETVFGLFVDHKFG 240 Q + +K+S I L RS YF +IVFV++FGL+ YETVF LF DHKFG Sbjct: 193 -----RHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFG 247 Query: 241 FTPKDIAFVITFGSISGAVIQVTAFSWILNRFGENKVIXXXXXXXXXXXXXXXFVHGYWA 300 FTPKDIA +IT SI VIQV F ++N+ GE ++I + G+ Sbjct: 248 FTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLT 307 Query: 301 IVTVTFIVFLAMDILRPAVGTQLSKMASESQQGFVMGMNSAYTSLGNIAGPIVAGVLFDL 360 ++ VT +FLA D+LRPA+ LS MA +QQGFV GMNS YTSLGNI GP + G+LFDL Sbjct: 308 VLLVTCFIFLAFDLLRPALTAHLSNMAG-NQQGFVAGMNSTYTSLGNIFGPALGGILFDL 366 Query: 361 DINLPYTVAALVLMLCFIMSLGSRKRMN 388 +I+ P+ A V+++ +++ +++ N Sbjct: 367 NIHYPFLFAGFVMIVGLGLTMVWKEKKN 394 >BS_bmrR_1 [K] COG0789 Predicted transcriptional regulators Length = 389 Score = 273 bits (697), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 165/371 (44%), Positives = 227/371 (61%), Gaps = 11/371 (2%) Query: 3 LLMLNIFLAFTGIGLVVPIMPTYMNEXXXXXXXXXXXXAAFSLTQLILSPLAGGLSDRMG 62 +L+ N+F+AF GIGLV+P+ PT MNE A F++TQLI+SP+AG DR G Sbjct: 10 ILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVGYMVACFAITQLIVSPIAGRWVDRFG 69 Query: 63 RKKIIVGGLVVFALSELLFGLAESSWLLFASRMLGGAGAAMIMPAVMAYVADTTSMEERA 122 RK +IV GL+ F++SE LFG+ ++ +LF SRMLGG A IMP V A++AD T+++ R Sbjct: 70 RKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRMLGGISAPFIMPGVTAFIADITTIKTRP 129 Query: 123 KGMGLINAAITTGFIIGPGLGGYLAELGIRXXXXXXXXXXXXXXXMTLFVLPESRSSAEL 182 K +G ++AAI+TGFIIGPG+GG+LAE+ R +++ L E + E Sbjct: 130 KALGYMSAAISTGFIIGPGIGGFLAEVHSRLPFFFAAAFALLAAILSILTLREPERNPE- 188 Query: 183 GAAKSTQENKDSKDSLITQLVRSYREPYFFGLVIVFVLSFGLANYETVFGLFVDHKFGFT 242 QE K K T R + YF +I+ + SFGLA++E++F LFVDHKFGFT Sbjct: 189 -----NQEIKGQK----TGFKRIFAPMYFIAFLIILISSFGLASFESLFALFVDHKFGFT 239 Query: 243 PKDIAFVITFGSISGAVIQVTAFSWILNRFGENKVIXXXXXXXXXXXXXXXFVHGYWAIV 302 DIA +IT G+I GA+ QV F FGE +I VH Y AI+ Sbjct: 240 ASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIRYSLILSTSLVFLLTTVHSYVAIL 299 Query: 303 TVTFIVFLAMDILRPAVGTQLSKMASESQQGFVMGMNSAYTSLGNIAGPIVAGVLFDLDI 362 VT VF+ D++RPAV T LSK+A ++QGF GMNS +TS+GN+ GPI+ G+LFD+D+ Sbjct: 300 LVTVTVFVGFDLMRPAVTTYLSKIAG-NEQGFAGGMNSMFTSIGNVFGPIIGGMLFDIDV 358 Query: 363 NLPYTVAALVL 373 N P+ A + L Sbjct: 359 NYPFYFATVTL 369 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.326 0.141 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 24,630,553 Number of extensions: 878140 Number of successful extensions: 3399 Number of sequences better than 1.0e-05: 97 Number of HSP's gapped: 3330 Number of HSP's successfully gapped: 103 Length of query: 398 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 289 Effective length of database: 25,807,025 Effective search space: 7458230225 Effective search space used: 7458230225 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 117 (49.7 bits)