BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0217.0007.p (210 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMb20965 [V] COG1680 Beta-lactamase class C and other penicillin... 78 1e-14 PA4347 [V] COG1680 Beta-lactamase class C and other penicillin b... 72 9e-13 CC0869 [V] COG1680 Beta-lactamase class C and other penicillin b... 67 1e-11 PA5542 [V] COG1680 Beta-lactamase class C and other penicillin b... 59 5e-09 CC1568 [V] COG1680 Beta-lactamase class C and other penicillin b... 59 6e-09 >SMb20965 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 9/154 (5%), Positives = 30/154 (19%), Gaps = 6/154 (3%) Query: 40 LHSFMLLRHGAVVAEAWWSPYRPELPHSLYSLSKSFTSTAIGLAVAEGLLTV-EDKVVSF 98 + ++ + ++S + + + F Sbjct: 39 GCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIF 98 Query: 99 FPEDAPADISPNLANMNISHLLMMGTGHTEDTT-SFMENSEDGNWVKAFLQLPVGKTPGT 157 ++ LL +++E + A+ Q + Sbjct: 99 ANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREP 158 Query: 158 HFLYNTGATYMLSAILQKVSGLTLL----EYLEP 187 + + A + T + Sbjct: 159 LAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQA 192 >PA4347 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 13/200 (6%), Positives = 27/200 (13%), Gaps = 24/200 (12%) Query: 16 PEAQGISSAAISAFLKHM-----EKQRLGLHS--FMLLRHGAVVAEAWWSPYRPELPHSL 68 A + R L F+ Sbjct: 46 TALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQW 105 Query: 69 YSLSKSFTSTAIGLAVAEGLLTVEDKVVSFFPEDAPADISPNLANMNISHLLMMGTG--H 126 + L +G+L V+ P + + Sbjct: 106 LPDHYELFPHLVSLLNPQGVLAVQMPDNWLEP---THVLMREV---AWEQNYPDRGREPL 159 Query: 127 TED--------TTSFMENSEDGNWVKAFL-QLPVGKTPGTHFLYNTGATYMLSAILQKVS 177 + + + L S + Sbjct: 160 AGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLK 219 Query: 178 GLTLLEYLEPRLFAPLGIHN 197 + + L I Sbjct: 220 RYHQMLEEQYPLQENGQILL 239 >CC0869 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 14/188 (7%), Positives = 42/188 (22%), Gaps = 12/188 (6%) Query: 17 EAQGISSAAISAFLKHMEKQ-RLGLHSFMLLRHGAVVAEAWWSPYRPELPHSLYSLSKSF 75 A+ A +E + A++ + W + + S ++++ Sbjct: 13 SAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEAR 72 Query: 76 TSTAIGLAVAEGLLT-VEDKVVSFFPEDAPADISPNLANMNISHLLMMGTG---HTEDTT 131 ++ V + + + +A S + + + Sbjct: 73 SALPDCQFVEADIRNWQPVQALDLIFANA----SLQWLPDHYELFPHLVSLLNPQGVLAV 128 Query: 132 SFMENS---EDGNWVKAFLQLPVGKTPGTHFLYNTGATYMLSAILQKVSGLTLLEYLEPR 188 +N + + +LS +V Y + Sbjct: 129 QMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMP 188 Query: 189 LFAPLGIH 196 + Sbjct: 189 SHQAIIDW 196 >PA5542 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 0/213 (0%), Positives = 0/213 (0%), Gaps = 25/213 (11%) Query: 1 VIMENLITRPLPRSLPEAQ----GISSAAISAFLKHMEKQRLGLHSFMLLRHGAVVAEAW 56 + + + + L H + Sbjct: 63 SSPAMIAEARSALPDCQFVEADIRNWQPVQALD---LIFANAS--LQWLPDHYELFPHLV 117 Query: 57 WSPYRPELPHSLYSLSKSFTSTAIGLAVAEGLLTVEDKVVSFFPEDAPADISPNLANMNI 116 + + + + VA + A ++ + Sbjct: 118 SLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYY----DILSEAG 173 Query: 117 SHLLMMGTGHTEDTTSFMENSED------------GNWVKAFLQLPVGKTPGTHFLYNTG 164 + + T + S + + L L Sbjct: 174 CEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQE 233 Query: 165 ATYMLSAILQKVSGLTLLEYLEPRLFAPLGIHN 197 Sbjct: 234 266 >CC1568 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 15/217 (6%), Positives = 31/217 (14%), Gaps = 37/217 (17%) Query: 16 PEAQGISSAAISAFLKHM----EKQRLGLHSFMLLRHGAVV-----AEAWWS--PYRPEL 64 G ++ + R A+ +L Sbjct: 37 DLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDL 96 Query: 65 PHSLYSLSKSFTSTAIGLAVAEGLLTVEDKVVSFFPEDA-----------------PADI 107 + SL + + L V Sbjct: 97 IFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGR 156 Query: 108 SPNLANMNISHLLMMGTGHTEDT-------TSFMENSEDGNWVKAFLQLPVGKTPGTHFL 160 P + ++ G D + L+ + + Sbjct: 157 EPLAGVH-AYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQ 215 Query: 161 YNTGATYMLSAILQKVSGLTLLEYLEPRLFAPLGIHN 197 Y Q L + Sbjct: 216 LFL-KRYHQMLEEQYPLQENGQILLAFPRLFIVARRM 251 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.133 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 15,884,724 Number of extensions: 657411 Number of successful extensions: 1206 Number of sequences better than 1.0e-05: 13 Number of HSP's gapped: 1209 Number of HSP's successfully gapped: 13 Length of query: 210 Length of database: 38,378,431 Length adjustment: 102 Effective length of query: 108 Effective length of database: 26,614,363 Effective search space: 2874351204 Effective search space used: 2874351204 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 113 (48.1 bits)