BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0188.0067.p (221 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value L0239 [T] COG0664 cAMP-binding proteins - catabolite gene activa... 103 1e-22 slr0449 [T] COG0664 cAMP-binding proteins - catabolite gene acti... 99 4e-21 AGl974 [T] COG0664 cAMP-binding proteins - catabolite gene activ... 90 4e-18 DR2362 [T] COG0664 cAMP-binding proteins - catabolite gene activ... 88 9e-18 BMEII0986 [T] COG0664 cAMP-binding proteins - catabolite gene ac... 87 1e-17 >L0239 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Length = 222 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 116/215 (53%), Gaps = 9/215 (4%) Query: 1 VPVFESLSDKELEMIEAIIESHHYNRGQQVFREGEESDSLFVVKNGLIKLTQSNEEGKQH 60 VP+FE L++++L +E I+E H + ++ ++ L +V G +K++Q ++ GK+ Sbjct: 12 VPLFEKLAEQDLTKVEKIVE-HKKIKKGEIIISPDKEPLLVIVAQGALKISQLSQSGKEQ 70 Query: 61 VVRYLFPGDYFGQFALLHHKRNNFTAEIVESGRVCRLRRKDFLPLLEQNASLAFSFLMSM 120 ++R + GDY G+ ALL + + +C LR+ DF LL SL+ L Sbjct: 71 LLRIIEAGDYEGEGALLGVTNGQLYGQAMIDSTICFLRQSDFETLLTTYPSLSLQLLKLN 130 Query: 121 SEQLQQAEETAGVMHMFEVETRLARLLVKLTYSNKTEPFSPTRNQVIELPSAKKEIAAMI 180 +++ AE AG + + +VE RLA + L+ ++ + F E+P KE+A I Sbjct: 131 AKKYLAAEHQAGFLALDDVEARLAHYFLNLSATSDSIYF--------EIPMKLKELANYI 182 Query: 181 GTTAETLSRKLHKLEAGNIIAVRKRSVEIIDMEAL 215 GT+ ET+SRK+ E II+ + R ++++D E L Sbjct: 183 GTSPETISRKIKVFEENKIISRQGRMIKLLDKEKL 217 >slr0449 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Length = 238 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 113/213 (53%), Gaps = 2/213 (0%) Query: 3 VFESLSDKELEMIEAIIESHHYNRGQQVFREGEESDSLFVVKNGLIKLTQSNEEGKQHVV 62 +F+++ LEMI AI + Y +G VF+EG++ F+V++G +K+ + GK+ ++ Sbjct: 16 MFQNIDSHHLEMITAIAQVKSYGKGDVVFKEGDKPKGFFIVRSGRVKIYKIAPGGKEQIL 75 Query: 63 RYLFPGDYFGQFALLHHKRNNFTAEIVESGRVCRLRRKDFLPLLEQNASLAFSFLMSMSE 122 R G++F + A+ + +A ++ + R FL +L Q+ +LA + L S+S Sbjct: 76 RIFHRGEHFAEIAVFDNLPFPASAATLDQAEMIFFPRSPFLEMLAQHPTLALNMLSSLSR 135 Query: 123 QLQQAEETAGVMHMFEVETRLARLLVKLTYSNKTEPFSPTRNQVIELPSAKKEIAAMIGT 182 L+ + +V RLA L++L + + ++LP K ++AA +GT Sbjct: 136 HLRHLTAVIEELSFKDVPQRLASYLLRLGGVDTGTVEVLSLWVTLDLP--KSQLAAQLGT 193 Query: 183 TAETLSRKLHKLEAGNIIAVRKRSVEIIDMEAL 215 TLSR ++L+ ++IAV+ ++++D + L Sbjct: 194 IPATLSRAFYQLKNEDLIAVKGAEIQLLDCDRL 226 >AGl974 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Length = 82 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 0/217 (0%), Positives = 0/217 (0%), Gaps = 5/217 (2%) Query: 3 VFESLSDKELEMIEAIIESHHYNRGQQVFREGEESDSLFVVKNGLIKLTQSNEEGKQHVV 62 + + E + E + ++ V +++ + Sbjct: 15 EGGAAAVDSDEPVVGNSEVKKLEDRVRELERMLGRKTMEVEILREALSKADSKKRISRPI 74 Query: 63 RYLFPGDYFGQFALLHHKRNNFTAEIVESGRVCRLRRKDFLP-LLEQNASLAFSFLMSMS 121 Sbjct: 75 - 133 Query: 122 EQLQQAEETAGVMHMFEVETRLARLLVKLTYSNKTEPFSPTRNQVIELPSAKKEIAAMIG 181 Sbjct: 134 --- 190 Query: 182 TTAETLSRKLHKLEAGNIIAVRKRSVEIIDMEALCQI 218 Sbjct: 191 227 >DR2362 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Length = 297 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 15/215 (6%), Positives = 46/215 (21%), Gaps = 8/215 (3%) Query: 3 VFESLSDKELEMIEAIIESHHYNRGQQVFREGEESDSLFVVKNGLIKLTQSNEEGKQHVV 62 ++ ++ + ++ I++ N + Sbjct: 15 SPFKIAPEKEQDLKTIVDDKKIIISVVSEPGFNIRVRKNESNNSHEIVLTVASLEYIWAF 74 Query: 63 RYLFPGDYFGQFALLHHKRNNFTAEIVESGRVCRLRRKDFLPLLEQNASLAFSFLMSMSE 122 F + +F + K L+ ++ E Sbjct: 75 SNFFWVFTQEYSKSQKNNDEHFDLTGKNRLKKSDELLKWARKNLQTTGCESWPKKCPKPE 134 Query: 123 QLQQAEETAGVMHMFEVETRLARLLVKLTYSNKTEPFSPTRNQVIE--LPSAKKEIAAMI 180 Q E + V + L ++++ ++ + Sbjct: 135 AYLQGSEDSQVASEIFLCAIAWILHHEISHV-----VLQHPLVTTAFSTQEEREADSHAT 189 Query: 181 GTTAETLSRKLHKLEAGNIIAVRKRSVEIIDMEAL 215 L +L+ + + + I +E Sbjct: 190 KWILGNLYESAPELKKRALG-IATAVLCIQSLEVE 223 >BMEII0986 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Length = 231 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 113/215 (52%), Gaps = 7/215 (3%) Query: 3 VFESLSDKELEMIEAIIESHHYNRGQQVFREGEESDSLFVVKNGLIKLTQSNEEGKQHVV 62 +F + D EL+ + + S +G+ +F +G+E+ +++ +G +K+ Q +G+Q +V Sbjct: 14 LFAKMRDDELDRLVSYATSRRVPQGESIFEQGDEASCFYLLLHGRLKVNQVTPDGQQIIV 73 Query: 63 RYLFPGDYFGQFALLHHKRNNF--TAEIVESGRVCRLRRKDFLPLLEQNASLAFSFLMSM 120 R + PGD FG L +RN++ TA V V + + +EQN LA + + ++ Sbjct: 74 RMVHPGDLFGFARAL--QRNDYPGTATAVMESIVLAWPTELWDYFVEQNPGLAMNAIQTI 131 Query: 121 SEQLQQAEETAGVMHMFEVETRLARLLVKLTYSNKTEPFSPTRNQVIELPSAKKEIAAMI 180 ++L++A M EVE R+A +++L+ + + R I+ P ++++IA M Sbjct: 132 GKRLEEAHTRIREMSTEEVERRVAHAVLRLSRQAGKKEETGIR---IDFPISRQDIAEMT 188 Query: 181 GTTAETLSRKLHKLEAGNIIAVRKRSVEIIDMEAL 215 GTT T+SR L E ++ ++ + ++D L Sbjct: 189 GTTLHTVSRILSNWETKGLVQGGRQKLLVLDSAGL 223 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.134 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 14,771,750 Number of extensions: 508433 Number of successful extensions: 1194 Number of sequences better than 1.0e-05: 64 Number of HSP's gapped: 1169 Number of HSP's successfully gapped: 64 Length of query: 221 Length of database: 38,378,431 Length adjustment: 102 Effective length of query: 119 Effective length of database: 26,614,363 Effective search space: 3167109197 Effective search space used: 3167109197 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 114 (48.5 bits)