BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0178.0022.p (475 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll1629 [F] COG0044 Dihydroorotase and related cyclic amidohydro... 414 e-115 AGc4328 [F] COG0044 Dihydroorotase and related cyclic amidohydro... 405 e-113 SMc01821 [F] COG0044 Dihydroorotase and related cyclic amidohydr... 404 e-112 BMEI1644 [F] COG0044 Dihydroorotase and related cyclic amidohydr... 402 e-112 PA0441 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 382 e-106 >mll1629 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 414 bits (1065), Expect = e-115, Method: Compositional matrix adjust. Identities = 0/457 (0%), Positives = 0/457 (0%), Gaps = 6/457 (1%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M+ + + G + + + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQL--DYAVAQGINLIDVAEMYPVPPR 58 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 + ++ + + ++ + +A+ D Sbjct: 59 PETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIR-EALHDS 117 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 L L+ + + + D + + + Sbjct: 118 LKRLQTDYLDLYQVHWPQRPTN-CFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYI 176 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 V E + + A + G A L + Sbjct: 177 GVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCL 236 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFE-GAKYVWSPPLREEWNQAV 299 K + + + + V Sbjct: 237 GFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFV 296 Query: 300 LWDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRI 359 + L + Sbjct: 297 RRQPFVASTLLGATTMDQLKTNI- 355 Query: 360 SLNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFE 419 Sbjct: 356 415 Query: 420 GMEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRK 456 Sbjct: 416 452 >AGc4328 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 506 Score = 405 bits (1041), Expect = e-113, Method: Compositional matrix adjust. Identities = 203/471 (43%), Positives = 290/471 (61%), Gaps = 11/471 (2%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 + +IKNG IVTA TY D+ IE G I IG +L G I+DA+ CY+ PGGIDPH H Sbjct: 23 IATIIKNGTIVTADLTYKADIRIEGGRITEIGPDLT--GGTILDATECYIMPGGIDPHVH 80 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 L+MPF GT +ADDFE +DFCL GQ L A+ W +K+ +A DY Sbjct: 81 LEMPFMGTYSADDFESGTRAALAGGTTMVVDFCLPDPGQSLLDALQRWDNKAT-RANCDY 139 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 SFH+ V+ ++V E+ +++ +GI S K FMAYK +D ++ + GA+ Sbjct: 140 SFHMAVTWWGERVFNEMKTVVQEKGINSFKHFMAYKGALMVNDDEMFASFSRCAELGAIP 199 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 VHAENGD++ + E+ +A GN P HA +RPP +EGEAT RA + ++ G+ LYVVH Sbjct: 200 FVHAENGDIVAQMQEKLMAEGNVGPEAHAYSRPPSVEGEATNRAIIIADMAGAPLYVVHT 259 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFE-GAKYVWSPPLREEWNQAV 299 +C +A I AR+ G+RVYGE Q+L+LD++ D++ A+ V SPP R +Q Sbjct: 260 SCEQAHEAIRRARQNGMRVYGEPLIQHLILDESEYANADWDHAARRVMSPPFRNRQHQDS 319 Query: 300 LWDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRI 359 LW L SG+LQ + +D C+F + QK GLGDF KIPNG +EDR +L++ GV GR+ Sbjct: 320 LWAGLASGSLQCVATDHCAFTTE-QKRFGLGDFRKIPNGTGGLEDRMPLLWTHGVATGRL 378 Query: 360 SLNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFE 419 ++N+FV + ST+ AK+ ++P+KG I VGSDADIV++DP++E+T+SA + +DYN FE Sbjct: 379 TMNEFVAVTSTNIAKILNIYPRKGAILVGSDADIVVWDPALEKTISAASQQSAIDYNVFE 438 Query: 420 GMEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEAEAPHPLQAKA 470 G +VKG P LSRG + + Q G G+++ R P+P ++A Sbjct: 439 GQKVKGLPRYTLSRGLVSVEEGTIETQEGHGQFVARD------PYPAVSRA 483 >SMc01821 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 404 bits (1037), Expect = e-112, Method: Compositional matrix adjust. Identities = 0/461 (0%), Positives = 0/461 (0%), Gaps = 5/461 (1%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M+ + + G + + + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQL--DYAVAQGINLIDVAEMYPVPPR 58 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 + ++ + + ++ + +A+ D Sbjct: 59 PETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIR-EALHDS 117 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 L L+ + + G + D Q A + + Sbjct: 118 LKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIG 177 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 + + V+ YL E E Y Sbjct: 178 VSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLG 237 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFE-GAKYVWSPPLREEWNQAV 299 + A+ G R + +QT + A+ P + Sbjct: 238 FGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVR 297 Query: 300 LWDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRI 359 + S L DQ N + Sbjct: 298 RQPFVASTLLGATTMDQLKTNIE- 356 Query: 360 SLNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFE 419 Sbjct: 357 416 Query: 420 GMEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEA 460 Sbjct: 417 457 >BMEI1644 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 402 bits (1032), Expect = e-112, Method: Compositional matrix adjust. Identities = 0/455 (0%), Positives = 0/455 (0%), Gaps = 6/455 (1%) Query: 3 KMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTHLD 62 + G+ E A + + + L Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVA--QGINLIDVAEMYPVPPRPETQGLT 65 Query: 63 MPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDYSF 122 + G A + + + D + Sbjct: 66 ETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALH-DSLKRLQTD 124 Query: 123 HLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALVMV 182 +L + +++ + + + + Sbjct: 125 YLDLYQVHWPQRPTNCFGKL-GYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETA 183 Query: 183 HAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHVTC 242 + Y L R E+ + + L S L +T Sbjct: 184 FGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTG 243 Query: 243 AEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFE-GAKYVWSPPLREEWNQAVLW 301 R L A L Q + Sbjct: 244 KYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVA 303 Query: 302 DALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRISL 361 L Sbjct: 304 STLLGATTMDQLKTNIESLHL- 362 Query: 362 NKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEGM 421 Sbjct: 363 422 Query: 422 EVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRK 456 Sbjct: 423 457 >PA0441 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 382 bits (981), Expect = e-106, Method: Compositional matrix adjust. Identities = 0/460 (0%), Positives = 0/460 (0%), Gaps = 4/460 (0%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAP-GAEIIDASGCYVFPGGIDPHT 59 M+ + + G + + A+ I+ Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 60 HLDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVID 119 + +P Q ++ + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREAL-HDSLK 119 Query: 120 YSFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGAL 179 + G + A D Y+ + G Sbjct: 120 RLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 180 VMVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVH 239 + + L T ++L G A EL Sbjct: 180 NETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFG 239 Query: 240 VTCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDF-EGAKYVWSPPLREEWNQA 298 + A + T + D + + Sbjct: 240 TLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQ 299 Query: 299 VLWDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGR 358 + GA + Sbjct: 300 PFVASTLLGATTMDQLKTNIESLH- 358 Query: 359 ISLNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPF 418 Sbjct: 359 418 Query: 419 EGMEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRF 458 Sbjct: 419 458 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.136 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,041,251 Number of extensions: 1496389 Number of successful extensions: 4532 Number of sequences better than 1.0e-05: 33 Number of HSP's gapped: 4474 Number of HSP's successfully gapped: 34 Length of query: 475 Length of database: 38,378,431 Length adjustment: 110 Effective length of query: 365 Effective length of database: 25,691,691 Effective search space: 9377467215 Effective search space used: 9377467215 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 118 (50.1 bits)