BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0178.0021.p (429 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEI1639_1 [F] COG0167 Dihydroorotate dehydrogenase 365 e-100 mll1643_1 [F] COG0167 Dihydroorotate dehydrogenase 361 1e-99 PA0439_1 [F] COG0167 Dihydroorotate dehydrogenase 360 3e-99 SMc01815_1 [F] COG0167 Dihydroorotate dehydrogenase 355 9e-98 STM2187_1 [F] COG0167 Dihydroorotate dehydrogenase 237 3e-62 >BMEI1639_1 [F] COG0167 Dihydroorotate dehydrogenase Length = 326 Score = 365 bits (936), Expect = e-100, Method: Compositional matrix adjust. Identities = 177/323 (54%), Positives = 229/323 (70%), Gaps = 5/323 (1%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLG---DPIINTSS- 56 MADLS + GIKSPNPFWLASAPPT+ Y V+RAF+AGWGG VWKTLG P++N + Sbjct: 1 MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNGP 60 Query: 57 RFAAVHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHE 116 R+ A+H +R+ G NNIELITDRPLE+NL+E+ E K R+P+ A++AS+MV ++E W Sbjct: 61 RYGAIHGADRRLLGLNNIELITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKA 120 Query: 117 IVKRAEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTP 176 I+ E G DG+ELNFGCPHGM+ERGMGAA GQ P+ V W K+ + PVI KLTP Sbjct: 121 ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGMVVKWCKQYSRMPVITKLTP 180 Query: 177 NITDITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPI 236 NITDI AR A G DA+SLINTINS+ VD+ + + +P++ G+G+HGGYCGPAVKPI Sbjct: 181 NITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI 240 Query: 237 ALSMVAECARD-RXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMI 295 AL+MVAE ARD TWQD EF+ +G +QVCTA M +GF++V EMI Sbjct: 241 ALNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMI 300 Query: 296 DGLNNYLDDKGLASVTELIGKSV 318 DGL++++D KG ++ + G +V Sbjct: 301 DGLSDWMDSKGYQTLDDFQGCAV 323 >mll1643_1 [F] COG0167 Dihydroorotate dehydrogenase Length = 331 Score = 361 bits (926), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 175/329 (53%), Positives = 230/329 (69%), Gaps = 5/329 (1%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGD---PIINTSS- 56 MADL + GIKSPNPFWLASAPPT+ Y V RAF+AGWGG VWKTLG+ P++N + Sbjct: 1 MADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGP 60 Query: 57 RFAAVHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHE 116 R+ A+ +R+ G NNIELITDR L+ NL+E+ + K +P+ A++AS+MV ++ W Sbjct: 61 RYGAIWGADRRLLGLNNIELITDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKA 120 Query: 117 IVKRAEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTP 176 I+ E G DG+ELNFGCPHGM+ERGMGAA GQ P+ +E W K+ PVI KLTP Sbjct: 121 ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVVRWCKQYTRMPVITKLTP 180 Query: 177 NITDITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPI 236 NITDI AR A GG DA+SLINTINS+ GVD+ S+ +P + G+G+HGGYCGPAVKPI Sbjct: 181 NITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPI 240 Query: 237 ALSMVAECARD-RXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMI 295 A++MVAE ARD TW+D EF+ +G+ +QVCTA M +GF+IV EMI Sbjct: 241 AMNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMI 300 Query: 296 DGLNNYLDDKGLASVTELIGKSVPKYSNW 324 GL N++D+KG S+ ++IG++ P ++W Sbjct: 301 AGLENWMDEKGHRSLDDIIGRATPNVTDW 329 >PA0439_1 [F] COG0167 Dihydroorotate dehydrogenase Length = 330 Score = 360 bits (923), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 187/328 (57%), Positives = 227/328 (69%), Gaps = 5/328 (1%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLG-DPI-INTSSRF 58 MADLSI+ AGIKSPNPFWLASAPPT+ Y V RA++AGWGG VWKTLG DP +N SSR+ Sbjct: 2 MADLSIEFAGIKSPNPFWLASAPPTDKAYNVVRAYQAGWGGVVWKTLGEDPAAVNVSSRY 61 Query: 59 AAVHFNGQR-VAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEI 117 +A HF R V G NNIELITDR LE+NL+EI + KK +P+ A++ SLMV +E W I Sbjct: 62 SA-HFGPNRQVQGINNIELITDRSLEINLREIAQVKKDWPDRALIVSLMVPCVEESWKYI 120 Query: 118 VKRAEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPN 177 + EA G DG+ELNFGCPHGM ERGMGAA GQ P+ VE T W K + PVIVKLTPN Sbjct: 121 LPLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEMVTRWCKAHCSLPVIVKLTPN 180 Query: 178 ITDITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIA 237 ITDI AR A +GGADA+SLINTINS+ VD+ +P VG Q HGGYCG AVKPIA Sbjct: 181 ITDIRQSARAAHRGGADAVSLINTINSITSVDLERMVALPVVGTQSTHGGYCGSAVKPIA 240 Query: 238 LSMVAECARD-RXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMID 296 L+MVAE ARD + +W+D EF+ +G +QVCTA M HGFRIV +M D Sbjct: 241 LNMVAEIARDPQTRGLPICGIGGIGSWRDAAEFVALGCGAVQVCTAAMLHGFRIVEDMQD 300 Query: 297 GLNNYLDDKGLASVTELIGKSVPKYSNW 324 GL ++D G +++ G +V ++W Sbjct: 301 GLARWMDSHGYQRLSDFSGGAVGNTTDW 328 >SMc01815_1 [F] COG0167 Dihydroorotate dehydrogenase Length = 326 Score = 355 bits (910), Expect = 9e-98, Method: Compositional matrix adjust. Identities = 173/324 (53%), Positives = 230/324 (70%), Gaps = 5/324 (1%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGD---PIINTSS- 56 MADL + GIKSPNPFWLASAPPT+ Y V+RAF+AGWGG VWKTLG+ P++N + Sbjct: 1 MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP 60 Query: 57 RFAAVHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHE 116 R+ A+ +R+ GFNNIELITDR L VNL+E+ + K +P+ A++AS+MV ++ W Sbjct: 61 RYGAIWGADRRLLGFNNIELITDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKA 120 Query: 117 IVKRAEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTP 176 I+ E G DG+ELNFGCPHGM+ERGMG+A GQ P+ +E W K+ PVI KLTP Sbjct: 121 ILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIEMVVRWCKQYTRMPVITKLTP 180 Query: 177 NITDITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPI 236 NITDI AR A GG DA+SLINTINS+ GV++ +++ P++ G+G+HGGYCGPAVKPI Sbjct: 181 NITDIRKPARAAKAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPI 240 Query: 237 ALSMVAECARD-RXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMI 295 AL+MVAE ARD TW+D EFM +G+ +QVCTA M +GF+IV EMI Sbjct: 241 ALNMVAEIARDPETYGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMI 300 Query: 296 DGLNNYLDDKGLASVTELIGKSVP 319 GL++++D KG ++ ++ G++VP Sbjct: 301 TGLSDWMDAKGHRTLDDISGRAVP 324 >STM2187_1 [F] COG0167 Dihydroorotate dehydrogenase Length = 326 Score = 237 bits (604), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 126/315 (40%), Positives = 183/315 (58%), Gaps = 4/315 (1%) Query: 3 DLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIIN-TSSRFAAV 61 DLS+ G+K PNPF L+S+P N +A++ GWGG V+KT+G I N S RF + Sbjct: 5 DLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHL 64 Query: 62 HFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKRA 121 GF N+E I + PLE NL I K+ +P+ ++AS+M E +Q+ W E+ + Sbjct: 65 TKEDTGFIGFKNMEQIAEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQ-WQELARLV 123 Query: 122 EAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITDI 181 E G D +E NF CP M MG+ GQ P+LVE VK ++ P++ K+TPNI D+ Sbjct: 124 EEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSSLPMLAKMTPNIGDM 182 Query: 182 TVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSMV 241 VA A +GGAD I+ INT+ S+ +D++ +P V G+ + GY G AVKPIAL + Sbjct: 183 CEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALRFI 242 Query: 242 AEC-ARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 + TW+D EF+L+G+ +QV T +M +G+RIV +M GL++ Sbjct: 243 QQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 Query: 301 YLDDKGLASVTELIG 315 YL D+G AS+ E+IG Sbjct: 303 YLADQGFASLQEMIG 317 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.134 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 31,077,529 Number of extensions: 1247401 Number of successful extensions: 3067 Number of sequences better than 1.0e-05: 16 Number of HSP's gapped: 3042 Number of HSP's successfully gapped: 16 Length of query: 429 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 320 Effective length of database: 25,807,025 Effective search space: 8258248000 Effective search space used: 8258248000 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 117 (49.7 bits)