BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0176.0015.p (504 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0179_3 [F] COG0516 IMP dehydrogenase/GMP reductase 438 e-123 lin0179_2 [R] COG0517 FOG: CBS domain 177 5e-44 TM1347_3 [F] COG0516 IMP dehydrogenase/GMP reductase 168 2e-41 aq_2023_3 [F] COG0516 IMP dehydrogenase/GMP reductase 162 9e-40 BH0020_3 [F] COG0516 IMP dehydrogenase/GMP reductase 160 3e-39 >lin0179_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 438 bits (1127), Expect = e-123, Method: Compositional matrix adjust. Identities = 14/272 (5%), Positives = 43/272 (15%), Gaps = 3/272 (1%) Query: 227 DSNKQLIVGAGINSRDYKERVPALVEAGADVLCIDSSDGYSEWQAETIHYIKETFGDNVK 286 ++ + S + + ++ + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 287 VGAGNVVDKEGFLYLVEAGADFIKVGIGGGSICITREQKGIGRGQASSVIEVAAARQEYY 346 +L + I G + + I A Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 347 EQTGIYVPICSDGGIVHDYHIVLALAMGADFVMLGRYFARFDESPGRKLLVGGNFVKEYW 406 QT D D + ++ Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 407 GEGSSRARNWQRYDFGNADKESKLEFEEGVDSFIPYAGRLKDNLDLSISKIKSTMCNCGA 466 R D + ++ + S + + + ++ +C Sbjct: 181 ETAFGVMRYLHLADKHD---LPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLG 237 Query: 467 LTIPQLQQQAKITLVSSTTIYEGGAHDVMLKE 498 + + ++ Sbjct: 238 FGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQ 269 >lin0179_2 [R] COG0517 FOG: CBS domain Length = 139 Score = 177 bits (448), Expect = 5e-44, Method: Composition-based stats. Identities = 78/137 (56%), Positives = 109/137 (79%) Query: 89 QVEMVRRVKKFKAGFVLSDSNLRPEDTLKDVLELKARSGHSTIAITDNGEPTGQLMGIVT 148 + MV RVK KAGFV+SDSN+ P+ TL+D+L+LK ++GHST+A+T++G G+L+GIVT Sbjct: 2 EAAMVSRVKNHKAGFVISDSNISPDKTLQDILDLKEKTGHSTVAVTEDGTAHGKLLGIVT 61 Query: 149 SRDYRENRLPPDCRITEFMTPLSSLIYAREGITLTEANDMIWDHKLNCLPIVNSSGNLVH 208 SRDYR R+ PD ++ +FMTP L+ A++ TL EAN++IWDHKLN LP+V+ + +LVH Sbjct: 62 SRDYRVTRMSPDEKVADFMTPFEKLVTAKKSTTLKEANNIIWDHKLNALPLVDDNEHLVH 121 Query: 209 LVFRKDYDSHQEYPLEL 225 +VFRKDYDS++E LEL Sbjct: 122 MVFRKDYDSNKENKLEL 138 >TM1347_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 168 bits (426), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 18/281 (6%), Positives = 43/281 (15%), Gaps = 9/281 (3%) Query: 220 EYPLELHDSNKQLIVGAGI-NSRDYKERVPALVEAGADVLCIDSSDGYSEWQAETIHYIK 278 L +G ++ + A ++ Sbjct: 4 HRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQG 63 Query: 279 ETFGDNVKVGAGNVVDKEGFLYLVEAGADFIKVGIGGGSICITREQKGIGRGQASSVIEV 338 T V +E + + G + S Sbjct: 64 LTETY-VGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQ 122 Query: 339 AAARQEYYEQTGIYVPICSDGGIVHDYHIVLALAMGADFVMLGRYFARFDESPGRKLLVG 398 Y V +L A + K+ Sbjct: 123 TDYLDLY------QVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYI 176 Query: 399 GNFVKEYWGEGSSRARNWQRYDFGNADKESKLEFEEGVDSFIPYAGRLKDNLDLSISKIK 458 G + +G + ++ + A + ++ Sbjct: 177 GVSNETAFGVMRYLHLADKHDLPRIVTIQNPY-SLLNRSFEVGLAEVSQYEGVELLAYSC 235 Query: 459 STMCNCGALTIPQLQQQAKITLVSSTTIYEGGAHDVMLKEK 499 + + + S G Sbjct: 236 LGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAA 276 >aq_2023_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 162 bits (411), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 25/281 (8%), Positives = 47/281 (16%), Gaps = 10/281 (3%) Query: 218 HQEYPLELHDSNKQLIVGAGINS-RDYKERVPALVEAGADVLCIDSSDGYSEWQAETIHY 276 L +G ++ + A ++ Sbjct: 2 QYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPET 61 Query: 277 IKETFGDNVKVGAGNVVDKEGFLYLVEAGADFIKVGIGGGSICITREQKGIGRGQASSVI 336 T V +E + + G + S Sbjct: 62 QGLTE-TYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 337 EVAAARQEYYEQTGIYVPICSDGGIVHDYHIVLALAMGADFVMLGRYFARFDESPGRKLL 396 Y V +L A + K+ Sbjct: 121 LQTDYLDLY------QVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIR 174 Query: 397 VGGNFVKEYWGEGSSRARNWQRYDFGNADKESKLEF-EEGVDSFIPYAGRLKDNLDLSIS 455 G + +G ++D + ++L Sbjct: 175 YIGVSNETAFGVMRYLHLA-DKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAY 233 Query: 456 KIKSTMCNCGALTIPQLQQQAKITLVSSTTIYEGGAHDVML 496 G A+ TL S T Y G + Sbjct: 234 SCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAV 274 >BH0020_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 160 bits (406), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 18/281 (6%), Positives = 43/281 (15%), Gaps = 9/281 (3%) Query: 220 EYPLELHDSNKQLIVGAGIN-SRDYKERVPALVEAGADVLCIDSSDGYSEWQAETIHYIK 278 L +G ++ + A ++ Sbjct: 4 HRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQG 63 Query: 279 ETFGDNVKVGAGNVVDKEGFLYLVEAGADFIKVGIGGGSICITREQKGIGRGQASSVIEV 338 T V +E + + G + S Sbjct: 64 LTETY-VGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQ 122 Query: 339 AAARQEYYEQTGIYVPICSDGGIVHDYHIVLALAMGADFVMLGRYFARFDESPGRKLLVG 398 Y V +L A + K+ Sbjct: 123 TDYLDLY------QVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYI 176 Query: 399 GNFVKEYWGEGSSRARNWQRYDFGNADKESKLEFEEGVDSFIPYAGRLKDNLDLSISKIK 458 G + +G + ++ + A + ++ Sbjct: 177 GVSNETAFGVMRYLHLADKHDLPRIVTIQNPY-SLLNRSFEVGLAEVSQYEGVELLAYSC 235 Query: 459 STMCNCGALTIPQLQQQAKITLVSSTTIYEGGAHDVMLKEK 499 + + + S G Sbjct: 236 LGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAA 276 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.135 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,931,339 Number of extensions: 1527153 Number of successful extensions: 6944 Number of sequences better than 1.0e-05: 148 Number of HSP's gapped: 6712 Number of HSP's successfully gapped: 148 Length of query: 504 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 393 Effective length of database: 25,576,357 Effective search space: 10051508301 Effective search space used: 10051508301 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 118 (50.1 bits)