BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0157.0012.p (346 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0008 [T] COG2206 HD-GYP domain 154 2e-37 BH3794 [T] COG2206 HD-GYP domain 149 6e-36 RSc2515 [T] COG2206 HD-GYP domain 130 4e-30 CAC0277 [T] COG2206 HD-GYP domain 125 7e-29 TM1147 [KT] COG3437 Response regulator containing a CheY-like re... 119 8e-27 >BH0008 [T] COG2206 HD-GYP domain Length = 360 Score = 154 bits (389), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 144/270 (53%), Gaps = 2/270 (0%) Query: 78 IDGFESVYMEALTKGSFNQSVVDDILQPSLESLDKHKDVVSLLLLLDREDNYTYNHSLQV 137 + ++ V+ E V IL P E + + KDV+ L +++Y Y+H++ V Sbjct: 90 VANYKKVFQEWAAGTPVEMECVRHILLPLFEEIVEKKDVLLQLHHYSTKEDYLYHHAVSV 149 Query: 138 GMLSYYIATWLGYSKKECYEIGRAGYLIDIGKCRISPELLNKPGKLTAAEYDEVKLHTIY 197 G+LS ++ LGY K E +I AG L D G ++ LL K G T E E++ H Y Sbjct: 150 GLLSAFLGAKLGYEKGEWLKIALAGALADCGMAKLPTSLLTKNGLYTLKEKHEMRDHPKY 209 Query: 198 GYEIIRNSMDDPYTALVA-LQHHEREDGSGYPHNLTKDDIHPYSQIAAVADIYSAMTSER 256 Y++++ + + L A LQHHEREDG+GYP + IH Y+QI AVAD+Y AM SER Sbjct: 210 SYQMLKKRPEIDGSLLSAVLQHHEREDGTGYPLGVRGQKIHFYAQILAVADVYHAMISER 269 Query: 257 IYQSKQELISVLREINTLSFGKLNGKPVQAFIQHLMPNFIGKRVLLSTGDMGVIIMNNPL 316 Y+ K+ VL ++ FGK N + V + L + V L+ +G I+ +P+ Sbjct: 270 KYRKKKSPYMVLEDLAKERFGKFNPRIVHVLVSQLTQLSVRTSVRLTNNRLGEIVFIDPM 329 Query: 317 DVFRPLVQIE-GKFLDLARERTIAVAEIYM 345 RP+VQ++ G+ + L + T+ + ++ + Sbjct: 330 APTRPMVQLQTGEMIYLMKNYTVHIEDVLL 359 >BH3794 [T] COG2206 HD-GYP domain Length = 231 Score = 149 bits (376), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 85/211 (40%), Positives = 123/211 (58%), Gaps = 7/211 (3%) Query: 126 EDNYTYNHSLQVGMLSYYIATWLGYSKKECYEIGRAGYLIDIGKCRISPELLNKPGKLTA 185 +D+YTY H++ V +LS I TWL + E+ L DIGK I +LNKPG LT Sbjct: 7 KDDYTYRHTVGVSILSRLIGTWLKLDEVILKELTLGAVLHDIGKVEIPDAILNKPGALTK 66 Query: 186 AEYDEVKLHTIYGYEIIRNS-MDDPYTALVALQHHEREDGSGYPHNLTKDDIHPYSQIAA 244 EY ++ HT+ GY II+ S + AL+AL+HHEREDG+GYP+ T+++IH S+I A Sbjct: 67 DEYRIIQDHTVKGYRIIQESGIYSDTVALMALEHHEREDGTGYPYQKTRNEIHLLSKILA 126 Query: 245 VADIYSAMTSERIYQSKQELISVLREINTLSFGKLNGKPVQAFIQHLMPNFIGKRVLLST 304 VAD++ AMTS+RIY+ L VL ++ FGKL + F++ M IG + L+ Sbjct: 127 VADVFHAMTSDRIYRKGMALYDVLLQMRQDRFGKLEPRITDFFVRRFMEQCIGSKARLND 186 Query: 305 GDMGVIIM---NNPLDVFRPLVQIEGKFLDL 332 G I+ NP+ P+V+ ++DL Sbjct: 187 GSRVEIVFIPYENPIC---PIVKQGTNYIDL 214 >RSc2515 [T] COG2206 HD-GYP domain Length = 402 Score = 130 bits (326), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 131/271 (48%), Gaps = 5/271 (1%) Query: 58 PAPXXXXXXXXXXXRNFDTMIDGFESVYMEALTKGSFNQSVVDDILQPSLESLDKHKDVV 117 P P R D ++++ EA + +++ S+D+H + Sbjct: 88 PRPATLADEMRRAARIIDKAGIAVQAMFAEARMGRTIEARDAQPLVEAISGSVDRHPGAL 147 Query: 118 SLLLLLDREDNYTYNHSLQVGMLSYYIATWLGYSKKECYEIGRAGYLIDIGKCRISPELL 177 L L +D YT+ HS+ V L + LG S E + G AG L DIGK I PE+L Sbjct: 148 VSLARLKTKDRYTFLHSVAVCALMVALGRQLGLSDDEVRDAGLAGLLHDIGKIAIPPEVL 207 Query: 178 NKPGKLTAAEYDEVKLHTIYGYEIIRN--SMDDPYTAL-VALQHHEREDGSGYPHNLTKD 234 NKPG LT E+ V H GY+I+ SM D AL V L HHER DG+GYPH L + Sbjct: 208 NKPGALTTDEFRHVIGHPKAGYDILVGDPSMRD--IALDVCLHHHERMDGTGYPHKLAGE 265 Query: 235 DIHPYSQIAAVADIYSAMTSERIYQSKQELISVLREINTLSFGKLNGKPVQAFIQHLMPN 294 +I ++++ A+ D+Y A+TS+R Y+ E ++ + + QAF++ + Sbjct: 266 NISLFARMGAICDVYDAVTSDRPYKKAWEAAYAIQRMVEWRGNHFDPMVFQAFVKSVGIY 325 Query: 295 FIGKRVLLSTGDMGVIIMNNPLDVFRPLVQI 325 G V L +G + V++ + + P V++ Sbjct: 326 PTGSLVRLRSGRLAVVMEHASGALLSPTVKV 356 >CAC0277 [T] COG2206 HD-GYP domain Length = 372 Score = 125 bits (315), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 78/220 (35%), Positives = 122/220 (55%), Gaps = 1/220 (0%) Query: 107 LESLDKHKDVVSLLLLLDREDNYTYNHSLQVGMLSYYIATWLGYSKKECYEIGRAGYLID 166 +E + K+V+ L+ + D+YTY HS+ V ++S I L + K E +++ L D Sbjct: 117 IEEILSQKNVMIGLVDIKSFDDYTYQHSVNVAVISLIIGIKLKFHKYELFDLCIGALLHD 176 Query: 167 IGKCRISPELLNKPGKLTAAEYDEVKLHTIYGYEIIRNSMDDPYTA-LVALQHHEREDGS 225 +GK I E+LNK G+LT E+ +K HT+ GY+ ++ + A +++LQHHER G Sbjct: 177 VGKMFIPSEILNKKGELTEEEFKIMKEHTVRGYDYLKGLYEISVPARIISLQHHERAGGQ 236 Query: 226 GYPHNLTKDDIHPYSQIAAVADIYSAMTSERIYQSKQELISVLREINTLSFGKLNGKPVQ 285 GYP + + I S+I AVAD+Y AMTS+R+Y+ L I S K + K VQ Sbjct: 237 GYPEGRSGERISILSRIVAVADVYDAMTSDRVYRRAIAPNEALEYIMANSGSKFDYKVVQ 296 Query: 286 AFIQHLMPNFIGKRVLLSTGDMGVIIMNNPLDVFRPLVQI 325 AF + ++P G V LS ++GV+ + RP ++I Sbjct: 297 AFSKSVIPYPEGSIVRLSNNEIGVVTKIHEDFPLRPEIKI 336 >TM1147 [KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain Length = 387 Score = 119 bits (297), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 71/171 (41%), Positives = 105/171 (61%), Gaps = 4/171 (2%) Query: 122 LLDREDNYTYNHSLQVGMLSYYIATWLGYSKKECYEIGRAGYLIDIGKCRISPELLNKPG 181 +++ +D T+ H+L+VG +S +A +G S + I +A DIGK I +L K G Sbjct: 176 VIELKDYETHEHTLRVGRISALVAEAMGCSSEFVELIEKAAPFHDIGKVFIPESILLKRG 235 Query: 182 KLTAAEYDEVKLHTIYGYEIIRNSMDDPYTAL---VALQHHEREDGSGYPHNLTKDDIHP 238 KLT+ EY+ +KLHTI+GYE+++ S +P +L VAL HHE+ +G GYPH L D+I Sbjct: 236 KLTSDEYEIMKLHTIFGYELLKTS-KNPVLSLAAEVALFHHEKYNGKGYPHGLKGDEIPL 294 Query: 239 YSQIAAVADIYSAMTSERIYQSKQELISVLREINTLSFGKLNGKPVQAFIQ 289 +QIAAVAD + AM S R Y+ ++ +REI LS + V+AF+Q Sbjct: 295 SAQIAAVADSFDAMVSHRPYKIRKSFDEAIREIKDLSGRFYSPFVVKAFVQ 345 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.138 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 25,367,173 Number of extensions: 1011843 Number of successful extensions: 1844 Number of sequences better than 1.0e-05: 40 Number of HSP's gapped: 1812 Number of HSP's successfully gapped: 40 Length of query: 346 Length of database: 38,378,431 Length adjustment: 107 Effective length of query: 239 Effective length of database: 26,037,693 Effective search space: 6223008627 Effective search space used: 6223008627 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 116 (49.3 bits)