BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0124.0007.p (986 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2849 [V] COG0841 Cation/multidrug efflux pump 210 1e-53 RSp0670_2 [V] COG0841 Cation/multidrug efflux pump 197 9e-50 SMc01457 [V] COG0841 Cation/multidrug efflux pump 192 2e-48 yegO [V] COG0841 Cation/multidrug efflux pump 177 1e-43 ECs2884 [V] COG0841 Cation/multidrug efflux pump 176 2e-43 >YPO2849 [V] COG0841 Cation/multidrug efflux pump Length = 1024 Score = 210 bits (534), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 232/995 (23%), Positives = 417/995 (41%), Gaps = 51/995 (5%) Query: 16 YTSLPMEFMPEADNPQVTVTVLGPGQDAHSMEANVTKPIEAATSAVKGKTEQMSTSGDGY 75 ++ LP+ +P+ D P + V+ PG D +M ++V P+E A + G E STS G Sbjct: 29 FSLLPVSPLPQVDYPVIMVSASMPGADPETMASSVATPLERALGRIAGVNEMTSTSSLGS 88 Query: 76 AKVDIYFDGKTDMKDAAQEVEKAVGALH--FPEGV-MDPFIVQLNTSMIPISQLTVSFDE 132 ++ + FD D+ AA++V+ A+ A P G+ P ++N S PI +T++ D Sbjct: 89 TRIILQFDLNRDINGAARDVQAALNAAQSLLPSGMPSRPTYRKMNPSDAPIMIMTLTSDT 148 Query: 133 GITKDNLKLAEETILPELQKIDGVANVALYGKTAPQVNVKLNPQAMAAKGIATAQVLGLL 192 A + ++ + +GV++V + G + P V V+LNP A+ +G++ V + Sbjct: 149 FSQGQLYDYASTKLAQKIAQTEGVSDVTVGGSSLPAVRVELNPSALFNQGVSLDAVRQAI 208 Query: 193 QGRSVSASIGEQTIGGQTGNVNVVSSIDSIDTLKKLPV----APGVTLQDIA-AVEAVTD 247 +V G V I + + + L V V LQD+A +++V D Sbjct: 209 SAANVRRPQGSVDAAETHWQVQANDEIKTAEGYRPLIVHYNNGSPVRLQDVANVIDSVQD 268 Query: 248 QESVSRSNGKDVLFAVITKEANANAVDVGGKVRDVAKDLTASV-KNAEVAVIFSTSDMVV 306 + S G+ + VI++E AN + ++R L AS+ + ++ + S + Sbjct: 269 VRNAGMSAGQPAVLLVISREPGANIIATVDRIRAELPALRASIPASIQLNIAQDRSPTIR 328 Query: 307 TSVNSMMREVLLGALFATLVILVFLRNVRATLITAVSIPLSLAVTLYLLDVSGITLNIVT 366 S++ + R +++ LV+ +FLR+ RATLI AV++P+SL T + + G +LN ++ Sbjct: 329 ASLDEVERSLVIAVALVILVVFIFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLS 388 Query: 367 LXXXXXXXXRLVDDSIVVIENIHRRMQKEPFSIHMIISATREXXXXXXXXXXXXXXXFLP 426 L +VDD+IVV+ENI R ++ + RE F+P Sbjct: 389 LMALTIATGFVVDDAIVVLENISRHLEAGVKPKVAALRGVREVGFTVLSMSISLVAVFIP 448 Query: 427 MGLLNGSLQAFLLPFAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEHEPSRRFGHF- 485 + L+ G FA + + R FG Sbjct: 449 LLLMAGLPGRLFREFAVTLSVAIGISLVISLTLTPMMCAWLLRSHPKGQQQRIRGFGKVL 508 Query: 486 ----------LEWNLRH-KWIXXXXXXXXXXXSVAAYVTMPKGALDASNASNVTVQLVYP 534 L W L H +W+ +V Y+++PK + + + Sbjct: 509 LAIQQGYGRSLNWALSHTRWV-MVVLLSTIALNVWLYISIPKTFFPEQDTGRMMGFIQAD 567 Query: 535 NDVPVKEVLEKGKQLEAELMKQPQAETVIMMTGNSADSAQWGSVTSLTQVDYTVMMKKDA 594 + + + +K K + P ++V TG S ++ GS+ + + ++ Sbjct: 568 QSISFQSMQQKLKDFMQIVGADPAVDSVTGFTGGSRTNS--GSMF----ISLKPLSERQE 621 Query: 595 DAQVFLDQVRGWQKSYAGATL---TANEXXXXXXXXTSEY-VDIVGDDLKSINSXXXXXX 650 AQ + ++RG GA L + + + Y ++ DDL ++ Sbjct: 622 TAQQVITRLRGKLAKEPGANLFLSSVQDIRVGGRHSNAAYQFTLLADDLAALREWEPKVR 681 Query: 651 XXXXXXDGVQKVTSNMEDTKPVFA--FKVNPVAANAQEISMQLAAMLNPVPLGQIELDGS 708 + V S+ +D A + +A ++S A + N QI Sbjct: 682 AALAKLPQLADVNSDQQDKGAEMALTYDRETMARLGIDVSEANALLNNAFGQRQISTIYQ 741 Query: 709 PAG---VVLEPVLQPKGQKDLENI----TIMTAGGPQPLSTLAALEVTDQPAMLYHKDGK 761 P VV+E + P+ +D+ ++ I + G PLS A + + P + H+ Sbjct: 742 PLNQYKVVME--VAPEYTQDVSSLDKMFVINSNGQSIPLSYFAKWQPANAPLAVNHQGLS 799 Query: 762 PYVRITAEV-DPKKVSAIGADIQKQTDRITLPAGVT-LFAGGASADQAGDFNDLGMTALI 819 I+ + D +S A +++ + +P+ V FAG A Q + L + + Sbjct: 800 AASTISFNLPDGGSLSEATAAVERAMTELGVPSTVRGAFAGTAQVFQETLKSQLWLI-MA 858 Query: 820 SIGLVYLIMVLTFKTLRAPLAIMFSLPXXXXXXXXXXXXXXXTPDFTALFGALMLIGIVV 879 +I VY+++ + +++ PL I+ +LP AL G ++LIGIV Sbjct: 859 AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFDAPFSLIALIGIMLLIGIVK 918 Query: 880 TNAIVLIDRI--KQNEEHMSVRESIIEAARTRLRPILMTAIATICAMLPLLFGHSEQGSI 937 NAI+++D Q ++S RE+I +A+ R RPI+MT +A + LPL+ S G+ Sbjct: 919 KNAIMMVDFALDAQRNGNISAREAIFQASLLRFRPIIMTTLAALFGALPLVL-SSGDGAE 977 Query: 938 VSQSLAIVVIGGXXXXXXXXXXXXXXIYELLYFRK 972 + Q L I ++GG IY LYF + Sbjct: 978 LRQPLGITIVGGLVVSQLLTLYTTPVIY--LYFDR 1010 >RSp0670_2 [V] COG0841 Cation/multidrug efflux pump Length = 1029 Score = 197 bits (500), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 223/955 (23%), Positives = 381/955 (39%), Gaps = 57/955 (5%) Query: 15 SYTSLPMEFMPEADNPQVTVTVLGPGQDAHSMEANVTKPIEAATSAVKGKTEQMSTSGDG 74 S+ L ++ P+ D P V+VT PG ME VT+ +E + +++ ST DG Sbjct: 28 SFRMLSIQNFPDIDFPAVSVTATLPGATPSQMETEVTRKVEDSIASIGAIKHISSTINDG 87 Query: 75 YAKVDIYFDGKTDMKDAAQEVEKAVGAL--HFPEGVMDPFIVQLNTSMIPISQLTVSFDE 132 + + F + D+++A +V AV + P V +P I ++ + +P+ V Sbjct: 88 SSTTMVEFQLEKDVQEAVNDVRDAVSRIRAQLPSDVQEPVISRVTFASMPVLTYAVQATG 147 Query: 133 GITKDNLKLAEETILPELQKIDGVANVALYGKTAPQVNVKLNPQAMAAKGIATAQVLGLL 192 +D + T+ L + GVA V G +V V+L+P + A + A++ L Sbjct: 148 MDAEDLSWYVDNTVNKRLLSVRGVAKVTRQGGADREVRVQLDPVRLQALNVTAAEISVQL 207 Query: 193 QGRSVSASIGEQTIGGQTGNVNVVSSIDSIDTLKKL--PVAPG--VTLQDIAAV-EAVTD 247 +G A G IGGQ V + ++ S L ++ P++ G + L D+A V + + Sbjct: 208 RGMQQEAPGGRGNIGGQEQAVRTLGTVKSAAELARMDIPLSDGRRIRLSDVADVRDTAAE 267 Query: 248 QESVSRSNGKDVLFAVITKEANANAVDVGGKVRDVAKDLTASVKNAEVAVIFSTSDMVVT 307 ++ GK V+ + + A+ + V VR L A N V +++ V Sbjct: 268 PRQMALLEGKPVVSFQVFRSRGASEISVAQDVRAAIAGLQAERPNVRVTEVYNLVKPVSD 327 Query: 308 SVNSMMREVLLGALFATLVILVFLRNVRATLITAVSIPLSLAVTLYLLDVSGITLNIVTL 367 + + M + GA+ A LV+ +FLR+ RAT ++AV++PLS+ T + + G TLN VTL Sbjct: 328 AYRASMHALYEGAILAVLVVWLFLRDWRATFVSAVALPLSIIPTFAAMQMLGFTLNGVTL 387 Query: 368 XXXXXXXXRLVDDSIVVIENI--HRRMQKEPFSIHMIISATREXXXXXXXXXXXXXXXFL 425 LVDD+IV +ENI H R K PF M A +E FL Sbjct: 388 LALTLVVGILVDDAIVEVENIVRHLRNGKPPFEAAM--EAAQEIGLAVIATSLTLVAVFL 445 Query: 426 PMGLLNGSLQAFLLPFAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEHEPSR----- 480 P + G F F + E +R Sbjct: 446 PTAFMGGISGKFFRQFG----WTASIAVLASLLVARLLTPMMAAYLLKPQREGNRDGWIM 501 Query: 481 -RFGHFLEWNLRHKWIXXXXXXXXXXXSVAAYVTMPKGALDASNASNVTVQLVYPNDVPV 539 R+ W L H W SVA +P L + + + + + P + Sbjct: 502 TRYLRAARWCLAHPWRTSGMAAAFLAASVAIIGLIPATFLPPEDWAQLQMTVEMPPGSTI 561 Query: 540 ---KEVLEKGKQLEAELMKQPQAETVI------MMTGNSADSAQWGSVTSLTQVDYTVMM 590 +E E+ +Q+ Q T I + G+S + G++T + T Sbjct: 562 AQTREATERVRQVVRTHKDVRQVYTAIGSGVMAGVPGSSGGEVRTGTLT----ISLTGRH 617 Query: 591 KKDADAQVFLDQVRGWQKSYAGATLTANEXXXXXXXXTSEYVDIV--GDDLKSINSXXXX 648 ++ Q ++R +S G + + E + IV GDD ++ + Sbjct: 618 ERHISQQQVQRELRERLESVPGVRIAFG------AVGSGEQLQIVLTGDDPATLQAAARD 671 Query: 649 XXXXXXXXDGVQKVTSNMEDTKPVFAFKVNPVAANAQEISMQLAAMLNPVPLGQI----- 703 G+ +TS+ +P + P A A + + AA+ V + Sbjct: 672 VMRDLRSVPGLGAITSSASLLRPEIVIR--PDFARAAQQGVTAAAIGQAVRVATAGDYDV 729 Query: 704 ---ELDGSPAGVVLEPVLQPKGQKDLENITIMTA---GGPQPLSTLAALEVTDQPAMLYH 757 +L+ V + L P + ++ I + G PL +A + ++ PA + Sbjct: 730 NLPKLNLPERQVYIRVELDPAARHQIDTIRQLRVPGRNGAVPLENIADIALSSGPAQIDR 789 Query: 758 KDGKPYVRITAEVDPKKVSAIGADIQKQTDRITLPAGVTLFAGGASADQAGDFNDLGMTA 817 D V I+ ++ + + ++ LP GV A G F + Sbjct: 790 FDRSRNVTISVGLEGGALGEVNQAVEALPSVRKLPPGVHRIASGDVEGMQELFGGFLLAM 849 Query: 818 LISIGLVYLIMVLTFKTLRAPLAIMFSLPXXXXXXXXXXXXXXXTPDFTALFGALMLIGI 877 + VY ++VL F P+ I+ +LP + AL G LML+GI Sbjct: 850 FAGVLCVYAVLVLLFHDFTQPVTILAALPLSVGGAFGLLALFGFSLSLPALIGLLMLMGI 909 Query: 878 VVTNAIVLIDR--IKQNEEHMSVRESIIEAARTRLRPILMTAIATICAMLPLLFG 930 V N+I+L++ + + + MS E++I+A R RPI+MT +A M+P+ G Sbjct: 910 VTKNSILLVEYAIVARRDFGMSRTEALIDACHKRARPIVMTTVAMTAGMVPMALG 964 >SMc01457 [V] COG0841 Cation/multidrug efflux pump Length = 1044 Score = 192 bits (489), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 234/981 (23%), Positives = 405/981 (41%), Gaps = 72/981 (7%) Query: 15 SYTSLPMEFMPEADNPQVTVTVLGPGQDAHSMEANVTKPIEAATSAVKGKTEQMSTSGDG 74 ++ + + +P+ D P V+VT G +++ VT IE A S V+G S+S G Sbjct: 45 AWNGVEIRELPQVDQPVVSVTTEFDGASPETIDREVTSVIEGAVSRVQGIKGISSSSSFG 104 Query: 75 YAKVDIYFDGKTDMKDAAQEVEKAVGAL--HFPEGVMDPFIVQLNTSMIPISQLTVSFDE 132 ++V + F TD+ AA +V A+G + P+ +P IV+ ++ PI +L ++ D Sbjct: 105 RSRVTLEFSDTTDIGQAANDVRDALGRITGQLPDDADEPRIVKADSDSQPIMRLALTSDT 164 Query: 133 GITKDNLKLAEETILPELQKIDGVANVALYGKTAPQVNVKLNPQAMAAKGIATAQVLGLL 192 D L E I L ++GVA+V +YG + LN +A +G+ A + L Sbjct: 165 MSMDDMTLLVENEISDRLAAVEGVADVTVYGDQEKIFRIDLNQAKLAGRGVTVANLREAL 224 Query: 193 QGRSVSASIGEQTIGGQTGNVNVVSSIDSIDTLKKLPVAPGVTLQDIAAVEAVTDQ-ESV 251 S G T Q +V + + + + + L + V L+D+A V D S Sbjct: 225 SDASYDVPAGSLTSASQDISVRATADLQTPEQFENLMLGNNVRLRDVATVTLGPDTGTSA 284 Query: 252 SRSNGKDVLFAVITKEANANAVDVGGKVRDVAKDLTASVKNAEVAVIFSTSDMVVTSVNS 311 RSNG++ + I ++A +N VD+ VR V +++ + + ++ D V +N Sbjct: 285 LRSNGREGIGLGIIRQAQSNTVDISEGVRSVVDAISSDILPTGTELKITSDDAVF--ING 342 Query: 312 MMREV---LLGALF-ATLVILVFLRNVRATLITAVSIPLSLAVTLYLLDVSGITLNIVTL 367 + EV L A+F TLVI +FL + RATLI +++P++L T+ + ++G ++NI+TL Sbjct: 343 AIHEVEIALFVAVFIVTLVIYLFLLDWRATLIPTITMPIALIGTVAAIYLAGFSINILTL 402 Query: 368 XXXXXXXXRLVDDSIVVIENIHRRMQKEPFSIHMIISATREXXXXXXXXXXXXXXXFLPM 427 +VDD+IVV+ENI RR + + T E F+P+ Sbjct: 403 LAIVLATGLVVDDAIVVLENIVRRRAEGLGPRAAAVHGTLEVFFAVLATTATLAAVFVPL 462 Query: 428 GLLNGSLQAFLLPFAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEHEPSRRFGH--- 484 L G F + +RFG Sbjct: 463 SFLPGQTGGLFREFGFVLAFSILLSSFVSLTLCPMLASRMLTKEPHEHDGVMQRFGRRAS 522 Query: 485 -FLEWNLRHK----WIXXXXXXXXXXXSVAAYVTMPKGALDASNASNVTVQLVYPNDVPV 539 F LR I ++T+ + S V +++ P V + Sbjct: 523 AFYRVTLRACLNAPLIVFAVAAFFTAAGALGFLTLKSELTPNEDRSQVMLRINAPQGVSL 582 Query: 540 KEVLEKGKQLEA---ELMKQPQAETVIMMTGNSADSAQWGSVTSLTQVDYTVMMKKDADA 596 + + +++E L+K + V ++G + V +L + ++ Sbjct: 583 EYTQAQLRRIEEGLQPLLKSGEISNVFSISGQGGSANSGFMVLTLAPWEE----RERTQG 638 Query: 597 QVFLDQVRGWQK--SYAGATLTANEXXXXXXXXTSEYVDIVGDDLKSINSXXXXXXXXXX 654 Q+ D R K S T+ AN + V +VG+D + Sbjct: 639 QIVADINRATSKIPSVRAFTIQANSLGIRGAGSGLQ-VALVGNDYTKLG----------- 686 Query: 655 XXDGVQKVTSNMEDTKPVFAFKVNPVAANAQ------------------EISMQLAAMLN 696 D K+ MEDT ++N A AQ +S L AML+ Sbjct: 687 --DAAAKLVRAMEDTGRFENVRLNYEANQAQLSVTIDRERASDLGVDIGGLSWALQAMLD 744 Query: 697 PVPLGQIELDGSPAGVVL----EPVLQPKGQKDLENITIMTAGGP-QPLSTLAALEVTDQ 751 + I ++G V L EP+ P DL+NI + G P+S++A +E Sbjct: 745 GSSVVDIFVEGEAYPVKLLSSTEPLNDP---TDLQNIFVKAGDGRIVPMSSIATVEEKAV 801 Query: 752 PAMLYHKDGKPYVRITAEVDPKKVSAIGADIQKQTDRITLPAG--VTLFAGGASADQAGD 809 L + V ++A + + ++ LP G V A A+ D+ + Sbjct: 802 APQLSRESQLRAVSLSAGLKSDLALGEALSMVEEMAEPLLPPGSRVMPLAEAATLDE--N 859 Query: 810 FNDLGMTALISIGLVYLIMVLTFKTLRAPLAIMFSLPXXXXXXXXXXXXXXXTPDFTALF 869 N L +T ++ +++L++ F++ + L IM ++P T + + Sbjct: 860 ANGLFVTFGFALVIIFLVLAAQFESFVSGLIIMSTVPLGLACAVFAMIVTGNTLNIYSQI 919 Query: 870 GALMLIGIVVTNAIVLIDRIKQ-NEEHMSVRESIIEAARTRLRPILMTAIATICAMLPLL 928 G +ML+GI+ N I++++ Q + VR +I AA RLRP++MT IAT+ +PL+ Sbjct: 920 GLVMLVGIMAKNGILIVEFANQLRDRGQDVRSAIENAANIRLRPVMMTMIATVVGAVPLV 979 Query: 929 FGHSEQGSIVSQSLAIVVIGG 949 S G+ +L V++GG Sbjct: 980 LA-SGAGAEARIALGWVLVGG 999 >yegO [V] COG0841 Cation/multidrug efflux pump Length = 1025 Score = 177 bits (448), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 226/994 (22%), Positives = 405/994 (40%), Gaps = 49/994 (4%) Query: 16 YTSLPMEFMPEADNPQVTVTVLGPGQDAHSMEANVTKPIEAATSAVKGKTEQMSTSGDGY 75 + LP+ +P+ D P + V+ PG +M ++V P+E + + G +E S+S G Sbjct: 29 FRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGS 88 Query: 76 AKVDIYFDGKTDMKDAAQEVEKAVGALH--FPEGV-MDPFIVQLNTSMIPISQLTVSFDE 132 ++ + FD D+ AA++V+ A+ A P G+ P + N S PI LT++ D Sbjct: 89 TRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDT 148 Query: 133 GITKDNLKLAEETILPELQKIDGVANVALYGKTAPQVNVKLNPQAMAAKGIATAQVLGLL 192 + A + P + +IDGV +V + G + P V V LNPQA+ +G++ V + Sbjct: 149 YSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAV 208 Query: 193 QGRSVSASIGEQTIGGQTGNVNVVSSIDSIDTLKKLPV----APGVTLQDIAAV-EAVTD 247 +V G G + + + + L + V L D+A V ++V D Sbjct: 209 SNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQD 268 Query: 248 QESVSRSNGKDVLFAVITKEANANAVDVGGKVRDVAKDLTASVKNA-EVAVIFSTSDMVV 306 + +N K + +I K AN + +R +L ++ A ++ + S + Sbjct: 269 VRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIR 328 Query: 307 TSVNSMMREVLLGALFATLVILVFLRNVRATLITAVSIPLSLAVTLYLLDVSGITLNIVT 366 S+ + + +++ LV+ +FLR+ RAT+I AVS+P+SL T + + G +LN ++ Sbjct: 329 ASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLS 388 Query: 367 LXXXXXXXXRLVDDSIVVIENIHRRMQKEPFSIHMIISATREXXXXXXXXXXXXXXXFLP 426 L +VDD+IVV+ENI R ++ + + TRE FLP Sbjct: 389 LMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLP 448 Query: 427 MGLLNGSLQAFLLPFAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEHEPSRRFGHF- 485 + L+ G L FA +E + R FG Sbjct: 449 LLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRML 508 Query: 486 ----------LEWNLRHKWIXXXXXXXXXXXSVAAYVTMPKGALDASNASNVTVQLVYPN 535 L+W L H + ++ Y+++PK + + + Sbjct: 509 VALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQ 568 Query: 536 DVPVKEVLEKGKQLEAELMKQPQAETVIMMTGNSADSAQWGSVTSLTQVDYTVMMKKDAD 595 + + + K + + P + V TG S ++ +T L D ++ Sbjct: 569 SISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFIT-LKPRD-----ERSET 622 Query: 596 AQVFLDQVRGWQKSYAGATL---TANEXXXXXXXXTSEY-VDIVGDDLKSINSXXXXXXX 651 AQ +D++R GA L + + Y ++ DDL ++ Sbjct: 623 AQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRK 682 Query: 652 XXXXXDGVQKVTSNMEDTKPVFAFKVNPVAANAQEISMQLAAMLNPVPLGQIELDG---- 707 + V S+ +D + I +Q A L GQ ++ Sbjct: 683 KLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQP 742 Query: 708 -SPAGVVLEPVLQPKGQKDLENI----TIMTAGGPQPLSTLAALEVTDQPAMLYHKDGKP 762 + VV+E + P+ +D+ + I G PLS A + + P + H+ Sbjct: 743 MNQYKVVME--VDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800 Query: 763 YVRITAEVDP-KKVSAIGADIQKQTDRITLPAGVT-LFAGGASADQAGDFNDLGMTALIS 820 I+ + K +S A I + ++ +P+ V FAG A Q N + + + Sbjct: 801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQE-TMNSQVILIIAA 859 Query: 821 IGLVYLIMVLTFKTLRAPLAIMFSLPXXXXXXXXXXXXXXXTPDFTALFGALMLIGIVVT 880 I VY+++ + +++ PL I+ +LP AL G ++LIGIV Sbjct: 860 IATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKK 919 Query: 881 NAIVLIDRIKQNEEH--MSVRESIIEAARTRLRPILMTAIATICAMLPLLFGHSEQGSIV 938 NAI+++D + + H ++ +E+I +A R RPI+MT +A + LPL+ + GS + Sbjct: 920 NAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGD-GSEL 978 Query: 939 SQSLAIVVIGGXXXXXXXXXXXXXXIYELLYFRK 972 Q L I ++GG +Y L+F + Sbjct: 979 RQPLGITIVGGLVMSQLLTLYTTPVVY--LFFDR 1010 >ECs2884 [V] COG0841 Cation/multidrug efflux pump Length = 1025 Score = 176 bits (446), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 228/1007 (22%), Positives = 409/1007 (40%), Gaps = 53/1007 (5%) Query: 16 YTSLPMEFMPEADNPQVTVTVLGPGQDAHSMEANVTKPIEAATSAVKGKTEQMSTSGDGY 75 + LP+ +P+ D P + V+ PG +M ++V P+E + + G +E S+S G Sbjct: 29 FRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGS 88 Query: 76 AKVDIYFDGKTDMKDAAQEVEKAVGALH--FPEGV-MDPFIVQLNTSMIPISQLTVSFDE 132 ++ + FD D+ AA++V+ A+ A P G+ P + N S PI LT++ D Sbjct: 89 TRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDT 148 Query: 133 GITKDNLKLAEETILPELQKIDGVANVALYGKTAPQVNVKLNPQAMAAKGIATAQVLGLL 192 + A + P + +IDGV +V + G + P V V LNPQA+ +G++ V + Sbjct: 149 YSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAI 208 Query: 193 QGRSVSASIGEQTIGGQTGNVNVVSSIDSIDTLKKLPV----APGVTLQDIAAV-EAVTD 247 +V G G + + + + L + V L D+A V ++V D Sbjct: 209 SNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQD 268 Query: 248 QESVSRSNGKDVLFAVITKEANANAVDVGGKVRDVAKDLTASVKNA-EVAVIFSTSDMVV 306 + +N K + +I K AN + +R +L ++ A ++ + S + Sbjct: 269 VRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIR 328 Query: 307 TSVNSMMREVLLGALFATLVILVFLRNVRATLITAVSIPLSLAVTLYLLDVSGITLNIVT 366 S+ + + +++ LV+ +FLR+ RAT+I AV++P+SL T + + G +LN ++ Sbjct: 329 ASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAVPVSLIGTFAAMYLCGFSLNNLS 388 Query: 367 LXXXXXXXXRLVDDSIVVIENIHRRMQKEPFSIHMIISATREXXXXXXXXXXXXXXXFLP 426 L +VDD+IVV+ENI R ++ + + TRE FLP Sbjct: 389 LMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLP 448 Query: 427 MGLLNGSLQAFLLPFAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEHEPSRRFGHF- 485 + L+ G L FA +E + R FG Sbjct: 449 LLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRML 508 Query: 486 ----------LEWNLRHKWIXXXXXXXXXXXSVAAYVTMPKGALDASNASNVTVQLVYPN 535 L+W L H + ++ Y+++PK + + + Sbjct: 509 VALQQGYGKSLKWVLNHTRLVGMVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQ 568 Query: 536 DVPVKEVLEKGKQLEAELMKQPQAETVIMMTGNSADSAQWGSVTSLTQVDYTVMMKKDAD 595 + + + K + + P + V TG S ++ +T L D ++ Sbjct: 569 SISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFIT-LKPRD-----ERSET 622 Query: 596 AQVFLDQVRGWQKSYAGATL---TANEXXXXXXXXTSEY-VDIVGDDLKSINSXXXXXXX 651 AQ +D++R GA L + + Y ++ DDL ++ Sbjct: 623 AQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRK 682 Query: 652 XXXXXDGVQKVTSNMEDTKPVFAFKVNPVAANAQEISMQLAAMLNPVPLGQIELDG---- 707 + V S+ +D + I +Q A L GQ ++ Sbjct: 683 KLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQP 742 Query: 708 -SPAGVVLEPVLQPKGQKDLENI----TIMTAGGPQPLSTLAALEVTDQPAMLYHKDGKP 762 + VV+E + P+ +D+ + I G PLS A + + P + H+ Sbjct: 743 MNQYKVVME--VDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800 Query: 763 YVRITAEVDP-KKVSAIGADIQKQTDRITLPAGVT-LFAGGASADQAGDFNDLGMTALIS 820 I+ + K +S A I + ++ +P+ V FAG A Q N + + + Sbjct: 801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQE-TMNSQVILIIAA 859 Query: 821 IGLVYLIMVLTFKTLRAPLAIMFSLPXXXXXXXXXXXXXXXTPDFTALFGALMLIGIVVT 880 I VY+++ + +++ PL I+ +LP AL G ++LIGIV Sbjct: 860 IATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKK 919 Query: 881 NAIVLIDRIKQNEEH--MSVRESIIEAARTRLRPILMTAIATICAMLPLLFGHSEQGSIV 938 NAI+++D + + H ++ +E+I +A R RPI+MT +A + LPL+ + GS + Sbjct: 920 NAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGD-GSEL 978 Query: 939 SQSLAIVVIGGXXXXXXXXXXXXXXIY------ELLYFRKSAKERTQ 979 Q L I ++GG +Y L + RKS + T+ Sbjct: 979 RQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKSKQTVTE 1025 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.132 0.360 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 55,675,470 Number of extensions: 2035416 Number of successful extensions: 5945 Number of sequences better than 1.0e-05: 127 Number of HSP's gapped: 5556 Number of HSP's successfully gapped: 245 Length of query: 986 Length of database: 38,378,431 Length adjustment: 116 Effective length of query: 870 Effective length of database: 24,999,687 Effective search space: 21749727690 Effective search space used: 21749727690 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 121 (51.2 bits)