BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0115.0009.p (447 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0746 [FR] COG0402 Cytosine deaminase and related metal-depende... 662 0.0 VNG1205C [FR] COG0402 Cytosine deaminase and related metal-depen... 320 2e-87 MA1276 [FR] COG0402 Cytosine deaminase and related metal-depende... 288 1e-77 MTH1505 [FR] COG0402 Cytosine deaminase and related metal-depend... 274 2e-73 MJ1541 [FR] COG0402 Cytosine deaminase and related metal-depende... 254 2e-67 >BH0746 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Length = 445 Score = 662 bits (1708), Expect = 0.0, Method: Compositional matrix adjust. Identities = 314/443 (70%), Positives = 370/443 (83%), Gaps = 1/443 (0%) Query: 3 MENILIRNAEIITMNKQEEIIYGDIRIRDNLIAEIGSGLVAQGDERVIDARNRTVIPGFV 62 M ILI+ AE++TMN +E+I+YGD+ I+D LI IG L +G E+VIDA RTVIPGFV Sbjct: 1 MTTILIKQAEMVTMNPKEDIVYGDLLIKDGLICAIGQDLSEEGVEKVIDATGRTVIPGFV 60 Query: 63 QTHIHLCQTLFRGKGDDLELMDWLRKRIWPLEAAHDEESLYYSAMLGIGELISSGTTTIV 122 QTHIHLCQTLFRGKGDDLELMDWL+KRIWPLEAAHD ES+YYSA+LGIGELI SGTTTIV Sbjct: 61 QTHIHLCQTLFRGKGDDLELMDWLKKRIWPLEAAHDSESIYYSALLGIGELIESGTTTIV 120 Query: 123 DMETVHHTDFAFQALAKSGIRALSGKVMMDQKNADAPAALQEETAASLQESVDLLEKWNG 182 DMETVHHTD AF A+A SGIRA+SGKVMMD K + P LQE+TA S+++S++LLE+W+ Sbjct: 121 DMETVHHTDSAFAAIASSGIRAISGKVMMD-KGEEVPLPLQEKTAQSIEKSIELLEEWHS 179 Query: 183 YGNGRIQYAFSPRFVISCTEPLLREVRDLSERYGVRVHTHASENLGEIEIVQAMTGMRNI 242 + GRI+YAFSPRFV+SCTE LLREV LS Y V VHTHASEN GEIE+VQ TGMRNI Sbjct: 180 FDGGRIRYAFSPRFVVSCTEELLREVGKLSAHYQVHVHTHASENRGEIEMVQQETGMRNI 239 Query: 243 VYLDHLGLANERLILAHCVWXXXXXXXXXXXXGVHVSHCPGSNLKLASGIANTPGMLHDH 302 YLDH+GLANERLILAHC+W G+HVSHCPGSNLKLASGIA+ PG+L Sbjct: 240 EYLDHVGLANERLILAHCIWLSENEKRIIKERGIHVSHCPGSNLKLASGIADIPGLLDQA 299 Query: 303 IHLSLGADGAPCNNNLDMFNEMRLAAMIQKPQHGPTTMDARSVFRMATIGGAKAVGMEDQ 362 I +SLGADGAPCNNNLDMFNEMRLAA+IQKP HGPT MDAR+VF+MATI GA+A+GM+ + Sbjct: 300 IPVSLGADGAPCNNNLDMFNEMRLAALIQKPVHGPTAMDARTVFKMATINGARAIGMDQE 359 Query: 363 IGSIEVGKKADLAILNLYNFHTFPSFDVDPISRIVYSATRADVETTIADGEILMDKGLLK 422 IGS+EVGKKADLAILNL +FHT+PSFDVDPISRIVYSATRADVETT+ +G ++M+ ++K Sbjct: 360 IGSLEVGKKADLAILNLRHFHTYPSFDVDPISRIVYSATRADVETTMINGRVVMENRVMK 419 Query: 423 TVDKDTVLHEANRSIKRLLAQTP 445 T+D VL E++RSI+RLL + P Sbjct: 420 TIDPAIVLRESDRSIERLLKRMP 442 >VNG1205C [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Length = 431 Score = 320 bits (821), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 181/414 (43%), Positives = 240/414 (57%), Gaps = 12/414 (2%) Query: 10 NAEIITMNKQEEIIYGDIRIRDNLIAEIGSGLV---AQGDERVIDARNRTVIPGFVQTHI 66 A+ + + + G + + D+ I +G A D ID + PG V H+ Sbjct: 5 TADTVVQDADRVLQDGAVVVVDDRITAVGDRAALADAHPDHERIDVD--VLAPGLVGAHV 62 Query: 67 HLCQTLFRGKGDDLELMDWLRKRIWPLEAAHDEESLYYSAMLGIGELISSGTTTIVDMET 126 H Q+L RG DD EL+DWL + P+EA D + +A L E + SGTT +VD + Sbjct: 63 HSVQSLGRGIADDQELLDWLFDHVLPMEAGLDAAEMRAAADLAYLEFVESGTTGVVDHLS 122 Query: 127 VHHTDFAFQALAKSGIRALSGKVMMDQKNADAPAALQEETAASLQESVDLLEKWNGYGNG 186 V H AF A A SG+RA GKV+MD+ D+P LQE+T A+L E+ L+ +W+G +G Sbjct: 123 VDHAGEAFGAAADSGVRARLGKVLMDK---DSPDGLQEDTDAALAETEALIREWDGACDG 179 Query: 187 RIQYAFSPRFVISCTEPLLREVRDLSERYGVRVHTHASENLGEIEIVQAMTGMRNIVYLD 246 RIQYA +PRF +SCTE LR R L++ YGVR+HTHASEN GEIE V+ TG RNI +LD Sbjct: 180 RIQYAITPRFAVSCTEACLRGCRALADEYGVRIHTHASENQGEIETVETETGKRNIHWLD 239 Query: 247 HLGLANERLILAHCVWXXXXXXXXXXXXGVHVSHCPGSNLKLASGIANTPGMLHDHIHLS 306 +GL E ++LAHCVW G HV+HCP SN+KLASG+A I+++ Sbjct: 240 DVGLTGEDVVLAHCVWTDDSERALLAETGTHVTHCPSSNMKLASGVAPVADYRERGINVA 299 Query: 307 LGADGAPCNNNLDMFNEMRLAAMIQKPQH-GPTTMDARSVFRMATIGGAKAVGMEDQIGS 365 LG DG PCNN LD F EMR A+++ K PT + ARSVF MAT GAKA G E+ +G Sbjct: 300 LGTDGPPCNNTLDGFAEMRQASLLGKVDALDPTALPARSVFEMATHNGAKAAGFEN-VGR 358 Query: 366 IEVGKKADLAILNLYNFHTFPSFDVDPISRIVYSATRADVETTIADGEILMDKG 419 I G ADL L+ + P DP S +VY+A DV T+ G++L G Sbjct: 359 IAEGWTADLVGLSTDAARSTPIH--DPYSHLVYAAHGDDVTLTMVAGDVLYRDG 410 >MA1276 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Length = 442 Score = 288 bits (737), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 166/443 (37%), Positives = 247/443 (55%), Gaps = 16/443 (3%) Query: 3 MENILIRNAEIITMNKQE-EIIYGDIRIRDNLIAEIGSGLVAQGDERVIDARNRTVIPGF 61 M +I+I+NA ++TM+ ++ G + I D I EIG D VIDA+ V+PG Sbjct: 11 MADIIIKNAYVLTMDPDAGDLKNGTVVIEDGKITEIGENTKENAD-TVIDAKGSVVMPGL 69 Query: 62 VQTHIHLCQTLFRGKGDDLELMDWLRKRIWPLEAAHDEESLYYSAMLGIGELISSGTTTI 121 TH H TLFRG DDL+L +WL K IWP EA E +Y ++L E+I SGTT+ Sbjct: 70 ANTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQLKAEDVYKGSLLACLEMIKSGTTSF 129 Query: 122 VDMETVHHTDFAFQALAKSGIRALSGKVMMDQKNADAPAALQEETAASLQESVDLLEKWN 181 DM + D +A+ SG+RA +++ N +E+ A L+E + W Sbjct: 130 ADM--YFYMDETAKAVEASGLRASLSHGLIELWN-------EEKGEADLKEGKRFVRAWQ 180 Query: 182 GYGNGRIQYAFSPRFVISCTEPLLREVRDLSERYGVRVHTHASENLGEIEIVQAMTGMRN 241 G +GRI+ + P +C+E L +V++ + R G +H H E E+ ++ G + Sbjct: 181 GAADGRIKTMYGPHAPNTCSEEFLTKVKEEAHRDGAGLHIHVLETEAELNAMKERYGKCS 240 Query: 242 IVYLDHLGLANERLILAHCVWXXXXXXXXXXXXGVHVSHCPGSNLKLASGIANTPGMLHD 301 + L+ +G ++ AHCVW V+VSH P SN+KLASGIA ML Sbjct: 241 VHLLEDIGFFGPDVLAAHCVWLSDGDIEILRQREVNVSHNPISNMKLASGIAPVYKMLEK 300 Query: 302 HIHLSLGADGAPCNNNLDMFNEMRLAAMIQKPQHG-PTTMDARSVFRMATIGGAKAVGME 360 ++++LG DG NNNLD+F E++ AA++ K G PT + AR V MAT+ GAKA+G E Sbjct: 301 GVNVTLGTDGCASNNNLDLFEEIKTAALLHKVSTGNPTALPARQVLEMATVNGAKALGTE 360 Query: 361 DQIGSIEVGKKADLAILNLYNFHTFPSFDVDPISRIVYSATRADVETTIADGEILMDKGL 420 G ++VGKKAD+ ++++ H P FDV S +VYSA DV TTI DG++LMD Sbjct: 361 --TGMLKVGKKADMIVVDMKKPHLTPCFDVP--SHLVYSAKGCDVRTTIVDGKVLMDNYR 416 Query: 421 LKTVDKDTVLHEANRSIKRLLAQ 443 + +D++ V+ EA + + L+A+ Sbjct: 417 VLVMDEEKVIEEARTAAEELVAR 439 >MTH1505 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Length = 268 Score = 274 bits (701), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 0/431 (0%), Positives = 0/431 (0%), Gaps = 17/431 (3%) Query: 1 MKMENILIRNAEIITMNKQEEIIYGDIRIRDNLIAEIGSGLVAQGDERVIDARNRTVIPG 60 M ++ I + +T + LIA S + D + Sbjct: 1 MNRVDLSIFIPDSLTAET---GDLKIKTYKVVLIARAASIFGVKRIVIYHDDADGEARFI 57 Query: 61 FVQTHIHLCQTLFRGKGDDLELMDWLRKRIWPLEAAHDEESLYYSAMLGIGELISSGTTT 120 R K + + PL H + G + Sbjct: 58 RDILTYMDTPQYLRRKVFPIMRELKHVGILPPLRTPHHPTGKPVTGEYRQGLTVKRVKKG 117 Query: 121 IVDMETVHHTDFAFQALAKSGIRALSGKVMMDQKNADAPAALQEETAASLQESVDLLEKW 180 + + A + R +S +V+ K ++ E Sbjct: 118 TLVD--IGADKLALCREKLTVNRIMSFRVVRLGKEI-------LIEPDEPEDRYWGYEVL 168 Query: 181 NGYGNGRIQYAFSPRFVISCTEPLLREVRDLSERYGVRVHTHASENLGEIEIVQAMTGMR 240 + N V+ T + + + R+ + + + + Sbjct: 169 DTRRNLAESLKTVGADVVVATSRNASPITSILDEVKTRMRGAREAAILFGGPYKGLPEID 228 Query: 241 NIVYLDHLGLANERLILAHCVWXXXXXXXXXXXXGVHVSHCPGSNLKLASGIANTPGMLH 300 Sbjct: 229 288 Query: 301 DHIHLSLGADGAPCNNNLDMFNEMRLAAMIQKPQ-HGPTTMDARSVFRMATIGGAKAVGM 359 Sbjct: 289 348 Query: 360 EDQIGSIEVGKKADLAILNLYNFHTFPSFDVDPISRIVYSATRADVETTIADGEILMDKG 419 Sbjct: 349 ---- 404 Query: 420 LLKTVDKDTVL 430 Sbjct: 405 415 >MJ1541 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Length = 420 Score = 254 bits (648), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 153/415 (36%), Positives = 230/415 (55%), Gaps = 25/415 (6%) Query: 26 DIRIRDNLIAEIGSGLVAQ-GDERVIDARNRTVIPGFVQTHIHLCQTLFRGKGDDLELMD 84 DI I N I +IG + + +ID +N+ IPG + TH H+ TLFRG DDL LM+ Sbjct: 15 DILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPMTLFRGVADDLPLME 74 Query: 85 WLRKRIWPLEAAHDEESLYYSAMLGIGELISSGTTTIVDMETVHHTDFAFQALAK----S 140 WL IWP+EA +EE +Y+ +LG E+I SGTTT DM F + +AK S Sbjct: 75 WLNNYIWPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMY------FFLEGIAKAVDES 128 Query: 141 GIRALSGKVMMDQKNADAPAALQEETAASLQESVDLLEKWNGYGNGRIQYAFSPRFVISC 200 G+RA+ M+D + +E L+ + + N N RI A P +C Sbjct: 129 GMRAVLAYGMIDLFD-------EERRERELKNAEKYINYINSLNNSRIMPALGPHAPYTC 181 Query: 201 TEPLLREVRDLSERYGVRVHTHASENLGEIEIVQAMTGMRNIVYLDHLGLANE-RLILAH 259 ++ LL EV +L+++Y V +H H +E L EI++V+ TGM +YL+ G ++ R I AH Sbjct: 182 SKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAAH 241 Query: 260 CVWXXXXXXXXXXXXGVHVSHCPGSNLKLASGIANTPGMLHDHIHLSLGADGAPCNNNLD 319 CV ++VSH P SNLKLASG+A P +L + I+++LG DG NNNL+ Sbjct: 242 CVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNLN 301 Query: 320 MFNEMRLAAMIQKPQH-GPTTMDARSVFRMATIGGAKAVGMEDQIGSIEVGKKADLAILN 378 +F E++++A++ K + PT + A F AT GAKA+ + + G I G AD+ ++N Sbjct: 302 LFEEIKVSAILHKGVNLNPTVVKAEEAFNFATKNGAKALNI--KAGEIREGYLADIVLIN 359 Query: 379 LYNFHTFPSFDVDPISRIVYSATRADVETTIADGEILMDKGLLKTVDKDTVLHEA 433 L + +P ++ +S +VY A V+ I DG I+M G + TVD++ V +A Sbjct: 360 LDKPYLYPKENI--MSHLVY-AFNGFVDDVIIDGNIVMRDGEILTVDEEKVYEKA 411 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.135 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 31,508,181 Number of extensions: 1300918 Number of successful extensions: 4301 Number of sequences better than 1.0e-05: 47 Number of HSP's gapped: 4141 Number of HSP's successfully gapped: 49 Length of query: 447 Length of database: 38,378,431 Length adjustment: 110 Effective length of query: 337 Effective length of database: 25,691,691 Effective search space: 8658099867 Effective search space used: 8658099867 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 117 (49.7 bits)