BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0101.0011.p (317 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC1052 [O] COG0330 Membrane protease subunits, stomatin/prohibi... 234 1e-61 TM0866 [O] COG0330 Membrane protease subunits, stomatin/prohibit... 233 2e-61 MTH692 [O] COG0330 Membrane protease subunits, stomatin/prohibit... 228 8e-60 Rv1488 [O] COG0330 Membrane protease subunits, stomatin/prohibit... 226 3e-59 MT1533.2 [O] COG0330 Membrane protease subunits, stomatin/prohib... 226 3e-59 >CAC1052 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs Length = 322 Score = 234 bits (598), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 128/277 (46%), Positives = 191/277 (68%), Gaps = 4/277 (1%) Query: 39 ERLGKFHRLLTPGLNVLIPIIDQVRTYHDLRIQQANVPPQTVITKDNVQVQIDTIIFYQV 98 ERLG+FHR L PG N++IP D R + Q ++ PQ+VITKDNV++ ID +IFY+V Sbjct: 31 ERLGQFHRTLQPGWNIVIPFADFTRAKVSTKQQILDIQPQSVITKDNVKISIDNVIFYKV 90 Query: 99 VGPEEATYGISDYVYGVRNISTATMRQIIGKLELDETLSGREKISSDIRLALDEATEKWG 158 + +A Y I Y G+ + MR I+G + LDE LSGR+ I+ ++ +DE T+ +G Sbjct: 91 MNARDAIYNIESYKSGIIYSTITNMRNIVGNMTLDEVLSGRDIINQELLKVVDEITDAYG 150 Query: 159 VRIERVEVIDIKPPLDIQEAMDKQMKAERSKRAIVLEAEAAKQDMILRAEGDKQSKILKA 218 ++I VE+ +I PP +IQ+AM+KQM+AER KRA +L+AE KQ I +AEG+KQ KIL+A Sbjct: 151 IKILSVEIKNIIPPAEIQQAMEKQMRAERDKRATILQAEGQKQAQIAKAEGEKQGKILQA 210 Query: 219 EGDKEARIRQAEGLRQAQELEALGQAKAIQAVAEAEKSRIELIG----SAGLDERVLAYQ 274 E +K+A I++AEGL+++Q LEA G+AKAI+AVAEAE I + +G +E V+A + Sbjct: 211 EAEKQANIKRAEGLKESQLLEAEGKAKAIEAVAEAEAKAINKVNRSIIESGTNETVIALK 270 Query: 275 SFDALTEISKGAANKVFLPTSAVETLGTLGAMAEVFK 311 +AL E++KG +NK+ LP + +LG++ A+A++ K Sbjct: 271 QIEALKEMAKGPSNKLILPNETLSSLGSIAAIADILK 307 >TM0866 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs Length = 305 Score = 233 bits (595), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 127/281 (45%), Positives = 180/281 (64%), Gaps = 9/281 (3%) Query: 31 PQQRVGVVERLGKFHRLLTPGLNVLIPIIDQVRTYHDLRIQQANVPPQTVITKDNVQVQI 90 P +R G+VERLGKF R + G++ +IP +++ D+R + +VPPQ VIT+DNV V + Sbjct: 25 PYER-GLVERLGKFKREVGAGVHFIIPFFERM-IKVDMREKVIDVPPQEVITRDNVVVTV 82 Query: 91 DTIIFYQVVGPEEATYGISDYVYGVRNISTATMRQIIGKLELDETLSGREKISSDIRLAL 150 D +I+Y++ Y +S++ ++ +R +IG+LELD+TL+ RE+I+ +R L Sbjct: 83 DAVIYYEITDAYRVVYNVSNFEMATIKLAQTNLRNVIGELELDQTLTSRERINMKLRTVL 142 Query: 151 DEATEKWGVRIERVEVIDIKPPLDIQEAMDKQMKAERSKRAIVLEAEAAKQDMILRAEGD 210 DEAT+KWGVRI RVE+ I PP DI +AM KQMKAER+KRA +LEAE KQ IL+AEG Sbjct: 143 DEATDKWGVRITRVEIKKIDPPQDITDAMSKQMKAERTKRAAILEAEGYKQAEILKAEGQ 202 Query: 211 KQSKILKAEGDKEARIRQAEGLRQAQELEALGQAKAIQAVAEAEKSRIELIGSAGLDERV 270 K + IL+AEG+ EA R AE Q LEA GQA+AI+ V A I + + Sbjct: 203 KNAAILRAEGEAEAIKRVAEANMQKLILEARGQAEAIKLVFNA-------IHEGNPTKDL 255 Query: 271 LAYQSFDALTEISKGAANKVFLPTSAVETLGTLGAMAEVFK 311 L + + L E++ G A K+FLP A L +LGA++E+FK Sbjct: 256 LTVRYLETLKEMANGQATKIFLPFEASSILASLGAISEIFK 296 >MTH692 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs Length = 136 Score = 228 bits (582), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 0/275 (0%), Positives = 0/275 (0%), Gaps = 8/275 (2%) Query: 36 GVVERLGKFHRLLTPGLNVLIPIIDQVRTYHDLRIQQANVPPQTVITKDNVQVQIDTIIF 95 + R P ++ I +++ + V + + Sbjct: 28 FPSRQRRSLKRGFLPRQKKVLEKIRKIKKE-GKTEGRPPVIRTHCRDMIVLPEMVGMTFG 86 Query: 96 YQVVGPEEATYGISDYVYGVRNISTATMRQIIGKLELDETLSGREKISSDIRLALDEATE 155 Sbjct: 87 146 Query: 156 KWGVRIERVEVIDIKPPLDIQEAMDKQMKAERSKRAIVLEAEAAKQDMILRAEGDKQSKI 215 Sbjct: 147 206 Query: 216 LKAEGDKEARIRQAEGLRQAQELEALGQAKAIQAVAEAEKSRIELIGSAGLDERVLAYQS 275 Sbjct: 207 ------- 259 Query: 276 FDALTEISKGAANKVFLPTSAVETLGTLGAMAEVF 310 Sbjct: 260 294 >Rv1488 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs Length = 381 Score = 226 bits (577), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 118/273 (43%), Positives = 178/273 (65%), Gaps = 18/273 (6%) Query: 31 PQQRVGVVERLGKFHRLLTPGLNVLIPIIDQVRTYHDLRIQQANVPPQTVITKDNVQVQI 90 PQ V+ERLG++ R ++ L +L+P ID+VR DLR + + PPQ VIT+DN+ + I Sbjct: 30 PQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNI 89 Query: 91 DTIIFYQVVGPEEATYGISDYVYGVRNISTATMRQIIGKLELDETLSGREKISSDIRLAL 150 DT++++QV P+ A Y IS+Y+ GV ++T T+R ++G + L++TL+ R++I++ +R L Sbjct: 90 DTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVL 149 Query: 151 DEATEKWGVRIERVEVIDIKPPLDIQEAMDKQMKAERSKRAIVL-----------EAEAA 199 DEAT +WG+R+ RVE+ I PP IQ +M+KQMKA+R KRA++L +AE Sbjct: 150 DEATGRWGLRVARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQ 209 Query: 200 KQDMILRAEGDKQSKILKAEGDKEARIRQAEGLRQAQELEALGQAKAIQAVAEAEKSRIE 259 KQ IL AEG KQ+ IL AE D+++R+ +A+G R A L+A GQAKAI+ A Sbjct: 210 KQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAA------ 263 Query: 260 LIGSAGLDERVLAYQSFDALTEISKGAANKVFL 292 I + +LAYQ L E+++G ANKV++ Sbjct: 264 -IKAGRPTPEMLAYQYLQTLPEMARGDANKVWV 295 >MT1533.2 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs Length = 288 Score = 226 bits (577), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 0/273 (0%), Positives = 0/273 (0%), Gaps = 18/273 (6%) Query: 31 PQQRVGVVERLGKFHRLLTPGLNVLIPIIDQVRTYHDLRIQQANVPPQTVITKDNVQVQI 90 GL + + V Sbjct: 30 SLWAPTQSVAAYDAVAAGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPG 89 Query: 91 DTIIFYQVVGPEEATYGISDYVYGVRNISTATMRQIIGKLELDETLSGREKISSDIRLAL 150 D E + V + ++ + + + L Sbjct: 90 DVRGLAAGTQFEHDALAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCA 149 Query: 151 DEATEKWGVRIERVEVIDIKPPLDIQEAMDKQMKAERSKRAIVL-----------EAEAA 199 +E ++ + + S + + + Sbjct: 150 LSWMVYSLPGAPVLEHYELGDAEYALRSAVRSAAEALSTIGLGSSDVANPRGLVEQLLES 209 Query: 200 KQDMILRAEGDKQSKILKAEGDKEARIRQAEGLRQAQELEALGQAKAIQAVAEAEKSRIE 259 + + ++ + I + + A +A Sbjct: 210 SRQHRVPDHAPSRALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDAL------ 263 Query: 260 LIGSAGLDERVLAYQSFDALTEISKGAANKVFL 292 Sbjct: 264 - 295 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.315 0.132 0.355 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 19,454,088 Number of extensions: 735316 Number of successful extensions: 2064 Number of sequences better than 1.0e-05: 87 Number of HSP's gapped: 1858 Number of HSP's successfully gapped: 87 Length of query: 317 Length of database: 38,378,431 Length adjustment: 106 Effective length of query: 211 Effective length of database: 26,153,027 Effective search space: 5518288697 Effective search space used: 5518288697 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 116 (49.3 bits)