BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0088.0008.p (256 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yddR [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 192 4e-49 ECs0400 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 192 4e-49 Z0443 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-... 191 1e-48 SA2259 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 189 4e-48 AGc2426 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 50 3e-06 >BS_yddR [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 192 bits (489), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 13/252 (5%), Positives = 36/252 (14%), Gaps = 6/252 (2%) Query: 7 LKIQLIRNAALWLEYGGITFLVDPMLSEQEANPPIPNSPNARR-NPLVPLPGPVQQWL-A 64 + + + E + + + + + Sbjct: 1 MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITG 60 Query: 65 PDAVLVTHLHQDHWDEAAVSLLPHELPVLCQD-GDEGTLSAQGFGHVSVVEDHAAKNFRG 123 D+ + D +A + Sbjct: 61 IDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHY--ELFPHLVS 118 Query: 124 VTLKRTGGRHGTGE-IGELMGKVSGFVFRAEGEPVLYVAGDTIWCDEVKVALDEHKPEVI 182 + + + E + V + P + + I Sbjct: 119 LLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDI 178 Query: 183 IVNAGGAQFLTGGHITMNEQDIIELCRYAPEASVIAVHMEAINHCLVTREQLAARLEQEG 242 Q + I H ++ + Q Sbjct: 179 WRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQIL 238 Query: 243 LLGRVKIPADGE 254 L Sbjct: 239 LAFPRLFIVARR 250 >ECs0400 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 192 bits (489), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 0/257 (0%), Positives = 0/257 (0%), Gaps = 10/257 (3%) Query: 6 ILKIQLIRNAALWLEYGGITFLVDPMLSEQEANPPIPNSPNAR-RNPLVPLPGPVQQWLA 64 + +A P+ + + N+ + + Sbjct: 4 WNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDS 63 Query: 65 PDAVLVTHLHQDHWDEAAVSLLPHELPVLCQD-GDEGTLSAQGFGHVSVVEDHAAKNFRG 123 A++ + + + + PV D H + + Sbjct: 64 SPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLV--SLLN 121 Query: 124 VTLKRTGGRHGTGE------IGELMGKVSGFVFRAEGEPVLYVAGDTIWCDEVKVALDEH 177 + E+ + + E ++ D + +V + Sbjct: 122 PQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRT 181 Query: 178 KPEVIIVNAGGAQFLTGGHITMNEQDIIELCRYAPEASVIAVHMEAINHCLVTREQLAAR 237 + + + +E + L A Sbjct: 182 TYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAF 241 Query: 238 LEQEGLLGRVKIPADGE 254 Sbjct: 242 258 >Z0443 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 191 bits (484), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 0/256 (0%), Positives = 0/256 (0%), Gaps = 10/256 (3%) Query: 7 LKIQLIRNAALWLEYGGITFLVDPMLSEQEANPPIPNSPNAR-RNPLVPLPGPVQQWLAP 65 + + + E + + + + + Sbjct: 1 MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITG 60 Query: 66 DAVLVTHLHQDHWDEAAVSLLPHELPVLCQD-GDEGTLSAQGFGHVSVVEDHAAKNFRGV 124 + + + ++ + + + + Sbjct: 61 IDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELF--PHLVS 118 Query: 125 TLKRTGGRHGTGE------IGELMGKVSGFVFRAEGEPVLYVAGDTIWCDEVKVALDEHK 178 L G LM +V+ + + + + Sbjct: 119 LLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDI 178 Query: 179 PEVIIVNAGGAQFLTGGHITMNEQDIIELCRYAPEASVIAVHMEAINHCLVTREQLAARL 238 + + +T E + + ++ L Sbjct: 179 WRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQIL 238 Query: 239 EQEGLLGRVKIPADGE 254 Sbjct: 239 254 >SA2259 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 16/251 (6%), Positives = 45/251 (17%), Gaps = 5/251 (1%) Query: 7 LKIQLIRNAALWLEYGGITFLVDPMLSEQEANPPIPNSPNA-RRNPLVPLPGPVQQWLAP 65 + + + E + + + + + Sbjct: 1 MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITG 60 Query: 66 -DAVLVTHLHQDHWDEAAVSLLPHELPVLCQDGDEGT-LSAQGFGHVSVVEDHAAKNFRG 123 D+ + + +A E + Sbjct: 61 IDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYEL--FPHLVS 118 Query: 124 VTLKRTGGRHGTGEIGELMGKVSGFVFRAEGEPVLYVAGDTIWCDEVKVALDEHKPEVII 183 + + + V E L E EV I Sbjct: 119 LLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDI 178 Query: 184 VNAGGAQFLTGGHITMNEQDIIELCRYAPEASVIAVHMEAINHCLVTREQLAARLEQEGL 243 + ++ L + + + + + + EQ + + L Sbjct: 179 WRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQIL 238 Query: 244 LGRVKIPADGE 254 L ++ Sbjct: 239 LAFPRLFIVAR 249 >AGc2426 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 0/253 (0%), Positives = 0/253 (0%), Gaps = 28/253 (11%) Query: 7 LKIQLIRNAALWLEYGGITFLVDPMLSEQEANPPIPNSPNARRNPLVPLPGPVQQWLAPD 66 + + A + + + + + Sbjct: 138 THVLMREVAWEQNYPDRGREPLAGVHA---YYDILSEAGCEVDIWRTT------------ 182 Query: 67 AVLVTHLHQDHWDEAAVSLLPHELPVLCQDGDEGTLSAQGFGHVSVVEDHAAKNFRGVTL 126 HQ D + L L L + + L Sbjct: 183 YYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFP 242 Query: 127 KRTGGRHGTGEIGE-----LMGKVSGFVFRAEGEPVLYVAGDTIWCDEVKVALDEHKPEV 181 Sbjct: 243 302 Query: 182 IIVNAGGAQFLTGGHITMNEQDIIELCRYAPEASVIAVHMEAINHCLVTREQLAARLEQE 241 Sbjct: 303 -------- 354 Query: 242 GLLGRVKIPADGE 254 Sbjct: 355 367 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.138 0.429 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 21,227,080 Number of extensions: 899639 Number of successful extensions: 1778 Number of sequences better than 1.0e-05: 6 Number of HSP's gapped: 1772 Number of HSP's successfully gapped: 6 Length of query: 256 Length of database: 38,378,431 Length adjustment: 104 Effective length of query: 152 Effective length of database: 26,383,695 Effective search space: 4010321640 Effective search space used: 4010321640 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 114 (48.5 bits)