BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0087.0003.p (194 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2748 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 96 4e-20 mll1286 [R] COG2249 Putative NADPH-quinone reductase (modulator ... 83 2e-16 HI1544 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 80 2e-15 PA1224 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 75 7e-14 SMc00379 [R] COG2249 Putative NADPH-quinone reductase (modulator... 71 9e-13 >BH2748 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Length = 346 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 10/205 (4%), Positives = 28/205 (13%), Gaps = 20/205 (9%) Query: 1 MNTLVIYTHPNHQSLNYAFLQEVLRGSRENAKVNEIQVLDLYEEGFNPVL------VFNE 54 M I S + E Q+ +G N + V Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEAD--AHAQLDYAVAQGINLIDVAEMYPVPPR 58 Query: 55 HKRRRDMHSDPALAKYREQLLWADKIVLVYPIWWGRPPAMLMGYIDQMFASGFAYRDXXX 114 + + + L I ++ Sbjct: 59 PETQGLTETY------VGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIRE 112 Query: 115 XXXXXXXXXXSVVCISTMQGP-THYPLLMLHNAHKVLMRKVLFNFVGIRKVKFFEFGSM- 172 + + + + + Sbjct: 113 ALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGK 172 Query: 173 ----ESKRGKHAQKLERIYRYFQTA 193 + ++ + Sbjct: 173 IRYIGVSNETAFGVMRYLHLADKHD 197 >mll1286 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Length = 346 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 10/155 (6%), Positives = 23/155 (14%), Gaps = 5/155 (3%) Query: 1 MNTLVIYTHPNHQSLNYAFLQEVLRGSRENAKVNEIQVLDLYEEGFNPVLVFNEHKRRRD 60 M I S + + Q+ +G N + V + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFG--EQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPR 58 Query: 61 MH-SDPALAKYREQLLWADKIVLVYPIWWGRPPAMLMGYIDQMFASGFAYR--DXXXXXX 117 L + P+ + + + Sbjct: 59 PETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSL 118 Query: 118 XXXXXXXSVVCISTMQGPTHYPLLMLHNAHKVLMR 152 + L + Sbjct: 119 KRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAP 153 >HI1544 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Length = 346 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 9/173 (5%), Positives = 27/173 (15%), Gaps = 3/173 (1%) Query: 1 MNTLVIYTHPNH-QSLNYAFLQEVLRGSRENAKVNEIQVLDLYEEGFNPVLVFNEHKRRR 59 M I +L + + S +A + + + R Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADA-HA-QLDYAVAQGINLIDVAEMYPVPPR 58 Query: 60 DMHSDPALAKYREQLLWADKIVLVYPIWWGRPPAMLMGYIDQMFASGFAYRDXXXXXXXX 119 L + P+ + + Sbjct: 59 PETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSL 118 Query: 120 XXXXXSVVCISTMQGPTHYPLLMLHNAHKVLMRKVLFNFVGIRKVKFFEFGSM 172 + + + P + + + + Sbjct: 119 KRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAG 171 >PA1224 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Length = 346 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 8/125 (6%), Positives = 18/125 (14%), Gaps = 18/125 (14%) Query: 1 MNTLVIYTHPNHQSLNYAFLQEVLRGSRENAKVNEIQVLDLYEEGFNPVLVFNEH-KRRR 59 M I S + + Q+ +G N + V + R Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFG--EQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPR 58 Query: 60 DMHSDPA---------------LAKYREQLLWADKIVLVYPIWWGRPPAMLMGYIDQMFA 104 ++ + + Sbjct: 59 PETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSL 118 Query: 105 SGFAY 109 Sbjct: 119 KRLQT 123 >SMc00379 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Length = 346 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 11/112 (9%), Positives = 20/112 (17%), Gaps = 7/112 (6%) Query: 1 MNTLVIYTHPNHQSLNYAFLQEVLRGSREN--AKVNEIQVLDLYEEGFNPVLVFNEHKRR 58 M I S L E Q+ +G N + V + Sbjct: 1 MQYHRIPHSSLEVS----TLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVP 56 Query: 59 RDMHSDPA-LAKYREQLLWADKIVLVYPIWWGRPPAMLMGYIDQMFASGFAY 109 + L + P+ + + Sbjct: 57 PRPETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRK 108 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.326 0.139 0.431 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 12,660,495 Number of extensions: 433287 Number of successful extensions: 842 Number of sequences better than 1.0e-05: 17 Number of HSP's gapped: 825 Number of HSP's successfully gapped: 17 Length of query: 194 Length of database: 38,378,431 Length adjustment: 101 Effective length of query: 93 Effective length of database: 26,729,697 Effective search space: 2485861821 Effective search space used: 2485861821 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 113 (48.1 bits)