BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0064.0013.p (394 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SA1913 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 453 e-127 SP0357 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 446 e-125 TM1034 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 424 e-118 SA0159 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 423 e-118 CAC2874 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 420 e-117 >SA1913 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Length = 376 Score = 453 bits (1165), Expect = e-127, Method: Compositional matrix adjust. Identities = 213/374 (56%), Positives = 282/374 (75%), Gaps = 1/374 (0%) Query: 15 KVMTIFGVRPEAIKMAPLVLELAKHPEHIESVVCVTAQHRELLDQVLEVFKITPDYDLDV 74 K+MTIFG RPEAIKMAPLV L + + +E +V VTAQHRE+LD VL F+I P YDL++ Sbjct: 4 KIMTIFGTRPEAIKMAPLVKALEQE-KMLEPIVVVTAQHREMLDSVLSTFEIKPKYDLNI 62 Query: 75 MKDRQTLNEITIRVLEGLEPVLREAKPDLVLVHGDTLTTFLASYASFLQQIQVGHVEAGL 134 MK QTL+EIT + + LE V++ KPD+VLVHGDT+TTF A+F Q+ +GHVEAGL Sbjct: 63 MKSGQTLSEITSKSITQLEQVIQLEKPDMVLVHGDTMTTFAGGLAAFYNQVPIGHVEAGL 122 Query: 135 RTWNKLSPYPEEMNRQLTGVLADLHFSPTDWSAGNLRHENKKESSIYITGNTVTDVFQYT 194 R+++K SP+PEE+NRQL GVLADLHF+PT +A +L E K S+ +TGNT D +YT Sbjct: 123 RSYDKYSPFPEEVNRQLVGVLADLHFAPTKNAASHLLSEGKYSESVVVTGNTAIDAMKYT 182 Query: 195 VQPDYRHPVLDFASGKRLILMTAHRRESQGEPHRHIFRAVKRIADEFEDVAIVYPVHPSP 254 V +Y+ ++D K+ ILMTAHRRE+ G+P +IF+AV+R+ DE+ D+A+VYP+H +P Sbjct: 183 VDDNYKSNIMDKYHDKKFILMTAHRRENIGKPMENIFKAVRRLIDEYTDLALVYPMHKNP 242 Query: 255 AVKEPAHEILGGHPRIKLIDPLDVVDLHNFYPHTHLILTDSGGLQEEAPSFGVPVLVLRD 314 V+E A +ILG H RI+LI+PLDVVD HNF ++ ILTDSGG+QEEAPSF PVLVLR Sbjct: 243 KVREVAQKILGSHDRIELIEPLDVVDFHNFAKKSYFILTDSGGIQEEAPSFNKPVLVLRS 302 Query: 315 TTERPEGIEAGTLELVGTDEEKVYQRTHALLTDQELYQSMSRAANPYGDGKASERIVNAI 374 TERPEG+EAGTL+++GT+++ VYQ L+ D+ LY MS A+NPYGDG ASERIVN I Sbjct: 303 VTERPEGVEAGTLKVIGTNKQNVYQAAKELIDDERLYHQMSEASNPYGDGFASERIVNHI 362 Query: 375 LHHFGVIQDRPEEF 388 ++ +I ++P +F Sbjct: 363 KYYLNLITEKPSDF 376 >SP0357 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Length = 365 Score = 446 bits (1146), Expect = e-125, Method: Compositional matrix adjust. Identities = 210/360 (58%), Positives = 272/360 (75%), Gaps = 1/360 (0%) Query: 15 KVMTIFGVRPEAIKMAPLVLELAKHPEHIESVVCVTAQHRELLDQVLEVFKITPDYDLDV 74 KV+ +FG RPEAIKM PLV EL + ++IE++VCVT QHR++LDQVL+ F I PD+DL + Sbjct: 3 KVVVVFGTRPEAIKMCPLVKEL-RTRKNIETLVCVTGQHRQMLDQVLDTFGIIPDFDLSI 61 Query: 75 MKDRQTLNEITIRVLEGLEPVLREAKPDLVLVHGDTLTTFLASYASFLQQIQVGHVEAGL 134 MKD+QTL ++TI +LEG++ +L KPDLVLVHGDT TTF +S A+F QI +GHVEAGL Sbjct: 62 MKDKQTLFDVTIGILEGMKAILESEKPDLVLVHGDTSTTFASSLAAFYLQIPIGHVEAGL 121 Query: 135 RTWNKLSPYPEEMNRQLTGVLADLHFSPTDWSAGNLRHENKKESSIYITGNTVTDVFQYT 194 RT++ SPYPEE NRQ GVLA HF+PT S NL E K SI++TGNT D Q T Sbjct: 122 RTYDIYSPYPEEFNRQAVGVLAQYHFTPTQLSKDNLLREGKTPESIFVTGNTAIDALQTT 181 Query: 195 VQPDYRHPVLDFASGKRLILMTAHRRESQGEPHRHIFRAVKRIADEFEDVAIVYPVHPSP 254 +Q DY HP L++ R IL+TAHRRE+ GEP RH+FRA++RI +E+ DV +YP+H +P Sbjct: 182 IQEDYTHPELEWIGESRFILITAHRRENLGEPMRHMFRAIRRIIEEYSDVKAIYPIHMNP 241 Query: 255 AVKEPAHEILGGHPRIKLIDPLDVVDLHNFYPHTHLILTDSGGLQEEAPSFGVPVLVLRD 314 V++ A E L G RIK+I+PL+V+D HNF ++LILTDSGG+QEEAPS G PVLV+RD Sbjct: 242 RVRQIAEEELSGCERIKMIEPLEVLDFHNFLSRSYLILTDSGGIQEEAPSLGKPVLVMRD 301 Query: 315 TTERPEGIEAGTLELVGTDEEKVYQRTHALLTDQELYQSMSRAANPYGDGKASERIVNAI 374 TTERPEGIEAGTL+LVG DE +Y+ LL + +YQ+MS+A+NPYGDG A ++I + + Sbjct: 302 TTERPEGIEAGTLKLVGADENNIYRHFKELLENDSVYQAMSQASNPYGDGTACKKIADIL 361 >TM1034 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Length = 378 Score = 424 bits (1090), Expect = e-118, Method: Compositional matrix adjust. Identities = 210/380 (55%), Positives = 285/380 (75%), Gaps = 9/380 (2%) Query: 14 IKVMTIFGVRPEAIKMAPLVLELAKHPEHIESVVCVTAQHRELLDQVLEVFKITPDYDLD 73 I+V+++FG RPEAIKMAPLV +L + +++ES+VCVTAQHR++LDQVLEVF I PD+DL+ Sbjct: 2 IRVLSVFGTRPEAIKMAPLVKKLEEE-QNVESLVCVTAQHRQMLDQVLEVFDIKPDFDLN 60 Query: 74 VMKDRQTLNEITIRVLEGLEPVLREAKPDLVLVHGDTLTTFLASYASFLQQIQVGHVEAG 133 +MK+RQ L++IT+ L GL ++ E KPD+VLV GDT TTF + A+F +I VGHVEAG Sbjct: 61 IMKERQNLSDITVNALSGLYDLIGELKPDIVLVQGDTTTTFAGALAAFYHRIPVGHVEAG 120 Query: 134 LRTWNKLSPYPEEMNRQLTGVLADLHFSPTDWSAGNLRHENKKESSIYITGNTVTDVFQY 193 LRT ++ SP+PEE+NR+LTGVL+ LHF+PT + NL EN IY+TGNTV D +Y Sbjct: 121 LRTNDRYSPFPEEINRRLTGVLSTLHFAPTKRNRENLLKENVM-GKIYVTGNTVIDALRY 179 Query: 194 TVQPD--YRHPVL---DFASGKRLILMTAHRRESQGEPHRHIFRAVKRIADEFEDVAIVY 248 TV+ + + P+L DF+ G R IL+T+HRRE+ G+P +I RAV+RI + FEDV ++Y Sbjct: 180 TVKENHVFEDPILRNMDFSDG-RYILLTSHRRENIGKPLENICRAVRRIVEGFEDVKVIY 238 Query: 249 PVHPSPAVKEPAHEILGGHPRIKLIDPLDVVDLHNFYPHTHLILTDSGGLQEEAPSFGVP 308 PVH +PAV+E +L R+ LIDP++V+D+HN ++LI+TDSGG+QEEAP+ G P Sbjct: 239 PVHMNPAVREIVFPMLENVERVFLIDPVNVIDMHNLMARSYLIMTDSGGIQEEAPALGKP 298 Query: 309 VLVLRDTTERPEGIEAGTLELVGTDEEKVYQRTHALLTDQELYQSMSRAANPYGDGKASE 368 V+VLR TERPE IEAG L G +EE++++ LL D+E Y+ M++A NP+GDG+ASE Sbjct: 299 VIVLRKETERPEAIEAGVAVLGGVEEERIFELAKKLLVDREEYEKMAKAVNPFGDGRASE 358 Query: 369 RIVNAILHHFGVIQDRPEEF 388 RIV AILH FG + D PEEF Sbjct: 359 RIVKAILHEFG-LSDPPEEF 377 >SA0159 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Length = 391 Score = 423 bits (1087), Expect = e-118, Method: Compositional matrix adjust. Identities = 198/374 (52%), Positives = 274/374 (73%), Gaps = 1/374 (0%) Query: 15 KVMTIFGVRPEAIKMAPLVLELAKHPEHIESVVCVTAQHRELLDQVLEVFKITPDYDLDV 74 K+M IFG RPEAIKMAPLV E+ H + E+ + +TAQHR++LD VL +F I D+DL++ Sbjct: 13 KIMVIFGTRPEAIKMAPLVKEI-DHNGNFEANIVITAQHRDMLDSVLSIFDIQADHDLNI 71 Query: 75 MKDRQTLNEITIRVLEGLEPVLREAKPDLVLVHGDTLTTFLASYASFLQQIQVGHVEAGL 134 M+D+QTL ++T L L+ ++ E +PD++LVHGDT TTF+ S A+F QI VGHVEAGL Sbjct: 72 MQDQQTLADLTANALAKLDSIINEEQPDMILVHGDTTTTFVGSLAAFYHQIPVGHVEAGL 131 Query: 135 RTWNKLSPYPEEMNRQLTGVLADLHFSPTDWSAGNLRHENKKESSIYITGNTVTDVFQYT 194 RT K SP+PEE+NR + +A+L+F+PT +A NL ENK + I+ITGNTV D T Sbjct: 132 RTHQKYSPFPEELNRVMVSNIAELNFAPTVIAAKNLLFENKDKERIFITGNTVIDALSTT 191 Query: 195 VQPDYRHPVLDFASGKRLILMTAHRRESQGEPHRHIFRAVKRIADEFEDVAIVYPVHPSP 254 VQ D+ +++ GK++IL+TAHRRE+ GEP IF+AV+ +ADE++DV +YP+H +P Sbjct: 192 VQNDFVSTIINKHKGKKVILLTAHRRENIGEPMHQIFKAVRDLADEYKDVVFIYPMHRNP 251 Query: 255 AVKEPAHEILGGHPRIKLIDPLDVVDLHNFYPHTHLILTDSGGLQEEAPSFGVPVLVLRD 314 V+ A + L G RI+LI+PLD ++ HNF ++L+LTDSGG+QEEAP+FG PVLVLR+ Sbjct: 252 KVRAIAEKYLSGRNRIELIEPLDAIEFHNFTNQSYLVLTDSGGIQEEAPTFGKPVLVLRN 311 Query: 315 TTERPEGIEAGTLELVGTDEEKVYQRTHALLTDQELYQSMSRAANPYGDGKASERIVNAI 374 TERPEG+EAGT ++GTD + + + L+ D E YQ MS+A NPYGDG+AS RI AI Sbjct: 312 HTERPEGVEAGTSRVIGTDYDNIVRNVKQLIEDDEAYQRMSQANNPYGDGQASRRICEAI 371 Query: 375 LHHFGVIQDRPEEF 388 ++FG+ D+P+EF Sbjct: 372 EYYFGLRSDKPDEF 385 >CAC2874 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Length = 385 Score = 420 bits (1080), Expect = e-117, Method: Compositional matrix adjust. Identities = 215/383 (56%), Positives = 285/383 (74%), Gaps = 7/383 (1%) Query: 11 MSKIKVMTIFGVRPEAIKMAPLVLELAKHPEHIESVVCVTAQHRELLDQVLEVFKITPDY 70 M +IKV++IFG RPEAIKMAPLV L ++ +++ES VCVTAQHR++LDQVL +F I PD+ Sbjct: 1 MKQIKVISIFGTRPEAIKMAPLVRRLNEN-KNVESKVCVTAQHRQMLDQVLNLFDINPDF 59 Query: 71 DLDVMKDRQTLNEITIRVLEGLEPVLREAKPDLVLVHGDTLTTFLASYASFLQQIQVGHV 130 DL++MK +QTL IT RVLEGL+ + + PD+VLVHGDT TTF A+ A+F ++I VGHV Sbjct: 60 DLNIMKTKQTLTGITARVLEGLDKIFADENPDIVLVHGDTTTTFAAALAAFYKKIAVGHV 119 Query: 131 EAGLRTWNKLSPYPEEMNRQLTGVLADLHFSPTDWSAGNLRHENKKESSIYITGNTVTDV 190 EAGLRT+NK P+PEEMNR+LTG +ADLHF+PT S NL E E +I+ITGNTV D Sbjct: 120 EAGLRTYNKYFPFPEEMNRKLTGAVADLHFAPTLGSKKNLLREAVNEKNIFITGNTVVDA 179 Query: 191 FQYTVQPDY-----RHPVLDFASGKRLILMTAHRRESQGEPHRHIFRAVKRIADEFEDVA 245 +TV+ DY LD+ + K++I++TAHRRE+ G+ +I A++RIA+E EDV Sbjct: 180 MNHTVEKDYVFENDELNKLDYKN-KKVIMVTAHRRENWGKGIENICTALRRIAEENEDVE 238 Query: 246 IVYPVHPSPAVKEPAHEILGGHPRIKLIDPLDVVDLHNFYPHTHLILTDSGGLQEEAPSF 305 IVY VH +P VK+ + L G + L+ PLD + HN +++TDSGGLQEEAP Sbjct: 239 IVYLVHLNPVVKDVVYNNLNGMKGVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHL 298 Query: 306 GVPVLVLRDTTERPEGIEAGTLELVGTDEEKVYQRTHALLTDQELYQSMSRAANPYGDGK 365 G PVLVLRD TERPE +EAGT++LVGTD +K+ + ++ D+E Y+ MS+A NPYGDGK Sbjct: 299 GKPVLVLRDVTERPEAVEAGTVKLVGTDIKKIVDEAYKIMKDEEEYEKMSKAINPYGDGK 358 Query: 366 ASERIVNAILHHFGVIQDRPEEF 388 AS+RIV+AIL+HFGV++DRP+EF Sbjct: 359 ASDRIVDAILYHFGVLKDRPDEF 381 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.137 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 30,941,524 Number of extensions: 1309878 Number of successful extensions: 8349 Number of sequences better than 1.0e-05: 13 Number of HSP's gapped: 8324 Number of HSP's successfully gapped: 13 Length of query: 394 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 286 Effective length of database: 25,922,359 Effective search space: 7413794674 Effective search space used: 7413794674 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 117 (49.7 bits)