BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0063.0006.p (488 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0020_3 [F] COG0516 IMP dehydrogenase/GMP reductase 450 e-126 BS_guaB_3 [F] COG0516 IMP dehydrogenase/GMP reductase 428 e-120 lin2901_3 [F] COG0516 IMP dehydrogenase/GMP reductase 417 e-116 L21264_3 [F] COG0516 IMP dehydrogenase/GMP reductase 407 e-113 CAC2701_3 [F] COG0516 IMP dehydrogenase/GMP reductase 405 e-113 >BH0020_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 450 bits (1157), Expect = e-126, Method: Compositional matrix adjust. Identities = 22/282 (7%), Positives = 50/282 (17%) Query: 207 KAIQFPNGAKDAQGRLLVGAAIGISKDTFERTEALIKAGVDLITVDSAHGHHINIIDAVR 266 + L +G +++ A + V + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 267 KLRELYPDLTIVAGNVATGEATRELIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIY 326 + + E + G + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 327 DCATVAREYGIPIIADGGIKYSGEITKAIAAGASAVMMGSLFAGTEESPGESEIYQGRKF 386 Y + + + + ++ +L A E Y G Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 387 KVYRGMGSMSAMKQGSKDRYFQDDDKKLVPEGIEGRVAFKGSLSDTVHQLLGGLRSGMGY 446 + G+ + V +LL G G Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 447 CGTKTLTELRNDTSFIRITGAGLRESHPHDVQITKEAPNYSL 488 K L + + + R S + + + Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIAR 282 >BS_guaB_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 428 bits (1101), Expect = e-120, Method: Compositional matrix adjust. Identities = 22/282 (7%), Positives = 50/282 (17%) Query: 207 KAIQFPNGAKDAQGRLLVGAAIGISKDTFERTEALIKAGVDLITVDSAHGHHINIIDAVR 266 + L +G +++ A + V + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 267 KLRELYPDLTIVAGNVATGEATRELIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIY 326 + + E + G + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 327 DCATVAREYGIPIIADGGIKYSGEITKAIAAGASAVMMGSLFAGTEESPGESEIYQGRKF 386 Y + + + + ++ +L A E Y G Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 387 KVYRGMGSMSAMKQGSKDRYFQDDDKKLVPEGIEGRVAFKGSLSDTVHQLLGGLRSGMGY 446 + G+ + V +LL G G Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 447 CGTKTLTELRNDTSFIRITGAGLRESHPHDVQITKEAPNYSL 488 K L + + + R S + + + Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIAR 282 >lin2901_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 417 bits (1071), Expect = e-116, Method: Compositional matrix adjust. Identities = 22/282 (7%), Positives = 50/282 (17%) Query: 207 KAIQFPNGAKDAQGRLLVGAAIGISKDTFERTEALIKAGVDLITVDSAHGHHINIIDAVR 266 + L +G +++ A + V + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 267 KLRELYPDLTIVAGNVATGEATRELIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIY 326 + + E + G + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 327 DCATVAREYGIPIIADGGIKYSGEITKAIAAGASAVMMGSLFAGTEESPGESEIYQGRKF 386 Y + + + + ++ +L A E Y G Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 387 KVYRGMGSMSAMKQGSKDRYFQDDDKKLVPEGIEGRVAFKGSLSDTVHQLLGGLRSGMGY 446 + G+ + V +LL G G Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 447 CGTKTLTELRNDTSFIRITGAGLRESHPHDVQITKEAPNYSL 488 K L + + + R S + + + Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIAR 282 >L21264_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 407 bits (1046), Expect = e-113, Method: Compositional matrix adjust. Identities = 17/283 (6%), Positives = 43/283 (15%), Gaps = 3/283 (1%) Query: 209 IQFPNGAKDAQGRLLVGAAIGISKDTFERTEALIKAGVDLITVDSAHGHHINIIDAVRKL 268 + L + + E ++ + + + Sbjct: 2 QYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPET 61 Query: 269 RELYPDLTIVAGNVATGEATRELIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIYDC 328 + L + + + I ++ Sbjct: 62 QGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 329 ATVAREYGIPIIADGGIKYSGEITKAIAAGASAVMMGSLFAGTEESPGESEIYQGRKFKV 388 T + G++ + A AV + E +I Sbjct: 122 QTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNE 181 Query: 389 YRGMGSMSAMKQGSKDRYFQ---DDDKKLVPEGIEGRVAFKGSLSDTVHQLLGGLRSGMG 445 D + L+ E +A L G Sbjct: 182 TAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTL 241 Query: 446 YCGTKTLTELRNDTSFIRITGAGLRESHPHDVQITKEAPNYSL 488 + + + Sbjct: 242 TGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRH 284 >CAC2701_3 [F] COG0516 IMP dehydrogenase/GMP reductase Length = 346 Score = 405 bits (1042), Expect = e-113, Method: Compositional matrix adjust. Identities = 25/278 (8%), Positives = 59/278 (21%) Query: 211 FPNGAKDAQGRLLVGAAIGISKDTFERTEALIKAGVDLITVDSAHGHHINIIDAVRKLRE 270 + +G + +EA A +D + + + V E Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 271 LYPDLTIVAGNVATGEATRELIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIYDCAT 330 GN +RE + + V + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 331 VAREYGIPIIADGGIKYSGEITKAIAAGASAVMMGSLFAGTEESPGESEIYQGRKFKVYR 390 + +Y + + K + + SL + + R V Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 391 GMGSMSAMKQGSKDRYFQDDDKKLVPEGIEGRVAFKGSLSDTVHQLLGGLRSGMGYCGTK 450 D++ + +F+ L++ L + Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 451 TLTELRNDTSFIRITGAGLRESHPHDVQITKEAPNYSL 488 + N + + T++A + Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYV 278 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.135 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 35,016,160 Number of extensions: 1500615 Number of successful extensions: 14637 Number of sequences better than 1.0e-05: 196 Number of HSP's gapped: 14456 Number of HSP's successfully gapped: 196 Length of query: 488 Length of database: 38,378,431 Length adjustment: 110 Effective length of query: 378 Effective length of database: 25,691,691 Effective search space: 9711459198 Effective search space used: 9711459198 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 118 (50.1 bits)