BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0043.0028.p (367 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2089 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 353 3e-97 MA0365 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 320 3e-87 MA0360 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 309 4e-84 XF1739 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 279 4e-75 RSp1122 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 276 3e-74 >BH2089 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 353 bits (905), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 0/348 (0%), Positives = 0/348 (0%), Gaps = 2/348 (0%) Query: 21 MTFYPAFGRRASRKEKQIISRSLNYKDGKFVYPAATVMMENSAGSSLSILKDFIKGNPRS 80 + + + + A +++S Sbjct: 23 LLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQ-FV 81 Query: 81 RPPQPLIPEKLLPGSIQESGDTRVTWFGHSAVLLEMDGVTLFLDPMLGRSPSPFPFVGGR 140 I + + + + + + + Sbjct: 82 EADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVL 141 Query: 141 RYSKQLPIEISELPRIDAVLLSHDHYDHLDYGSIRQLKDKVGMFIVPLGVGAHLQRWGVS 200 + R + + + G + +P Sbjct: 142 MREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATG 201 Query: 201 REKIREKDWWDEFRYAGLTLTSAPARHFSGRSLLDRNSTLWCSWIIRGAETKIFFSGDSG 260 Sbjct: 202 261 Query: 261 YGPHFAEIGEKYGPFDLTLMECGQYDPRWADIHMLPEQTVQAHLDVRGALMIPIHWAAFT 320 Sbjct: 262 321 Query: 321 LSMHDWTDPVERVFAAAKAHGVRLATPRIGEPV-YTGSAEVPSLAWWK 367 Sbjct: 322 369 >MA0365 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 320 bits (819), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 0/346 (0%), Positives = 0/346 (0%), Gaps = 6/346 (1%) Query: 25 PAFGRRASRKEKQIISRSLNYKDGKFVYPAATVMMENSAGSSLSILKDFIKGNPRSRPPQ 84 A+R S ++ + + V + + + S Sbjct: 49 LQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQ--ALDLIFANASLQWL 106 Query: 85 PLIPEKLLPGSIQESGDTRVTWFGHSAVLLEMDGVTLFLDPMLGRSPSPFPFVGGRRYSK 144 P E + + L + + + G Sbjct: 107 PDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYY 166 Query: 145 QLPIE---ISELPRIDAVLLSHDHYDHLDYGSIRQLKDKVGMFIVPLGVGAHLQRWGVSR 201 + E ++ R H +D+ + L+ + + + Sbjct: 167 DILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLE 226 Query: 202 EKIREKDWWDEFRYAGLTLTSAPARHFSGRSLLDRNSTLWCSWIIRGAETKIFFSGDSGY 261 Sbjct: 227 286 Query: 262 GPHFAEIGEKYGPFDLTLMECGQYDPRWADIHMLPEQTVQAHLDVRGALMIPIHWAAFTL 321 Sbjct: 287 346 Query: 322 SMHDWTDPVERVFAAAKAHGVRLATPRIGEPVYTGS-AEVPSLAWW 366 Sbjct: 347 392 >MA0360 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 309 bits (792), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 0/352 (0%), Positives = 0/352 (0%), Gaps = 9/352 (2%) Query: 21 MTFYPAFGRRASRKEKQIISRSLNYKDGKFV--YPAATVMMENSAGSSLSILKDFIKGNP 78 + + + + + + + Sbjct: 23 LLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSAL---PDCQ 79 Query: 79 RSRPPQPLIPEKLLPGSIQESGDTRVTWFGHSAVLLEMDGVTLFLDPMLGRSPSPFPFVG 138 I + + + + + + + Sbjct: 80 FVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTH 139 Query: 139 GRRYSKQLPIE---ISELPRIDAVLLSHDHYDHLDYGSIRQLKDKVGMFIVPLGVGAHLQ 195 P + I + M + Sbjct: 140 VLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTA 199 Query: 196 RWGVSREKIREKDWWDEFRYAGLTLTSAPARHFSGRSLLDRNSTLWCSWIIRGAETKIFF 255 Sbjct: 200 259 Query: 256 SGDSGYGPHFAEIGEKYGPFDLTLMECGQYDPRWADIHMLPEQTVQAHLDVRGALMIPIH 315 Sbjct: 260 319 Query: 316 WAAFTLSMHDWTDPVERVFAAAKAHGVRLATPRIGEPVYTGS-AEVPSLAWW 366 Sbjct: 320 371 >XF1739 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 279 bits (714), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 0/349 (0%), Positives = 0/349 (0%), Gaps = 15/349 (4%) Query: 24 YPAFGRRASRKEKQIISRSLNYKDGKFVYPAATVMMENSAGSSLSILKDFIKGNPRSRPP 83 A S +L + + + Sbjct: 29 LENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMI-AEARSALPDCQFVEADIRN 87 Query: 84 QPLIPEKLLPGSIQESGDTRVTWFGHSAVLLEMDGVTLFLDPMLGRSPSPFP-----FVG 138 + L + + L+ + L + + V Sbjct: 88 WQPVQALDLIFANASLQWL-PDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVA 146 Query: 139 GRRYSKQLPIEISELPRIDAVLLSHDHYDHLDYGSIRQLKDKVGMFIVPLGVGAHLQRWG 198 + A + ++ + + + Sbjct: 147 WEQNYP------DRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTAT 200 Query: 199 VSREKIREKDWWDEFRYA-GLTLTSAPARHFSGRSLLDRNSTLWCSWIIRGAETKIFFSG 257 R +++ ++ + + Sbjct: 201 GLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQI- 259 Query: 258 DSGYGPHFAEIGEKYGPFDLTLMECGQYDPRWADIHMLPEQTVQAHLDVRGALMIPIHWA 317 Sbjct: 260 319 Query: 318 AFTLSMHDWTDPVERVFAAAKAHGVRLATPRIGEPVYTGSAEVPSLAWW 366 Sbjct: 320 368 >RSp1122 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Length = 252 Score = 276 bits (706), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 0/290 (0%), Positives = 0/290 (0%), Gaps = 9/290 (3%) Query: 79 RSRPPQPLIPEKLLPGSIQESGDTRVTWFGHSAVLLEMDGVTLFLDPMLGRSPSPFPFVG 138 +I E D + +F + L P + Sbjct: 60 GIDSSPAMIAEARS-----ALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFP 114 Query: 139 GRRYSKQLPIEISELPRIDAVLLSHDHYDHLDYGSIRQLKDKVGMFIVPLGVGAHLQRWG 198 P + + D L L G Sbjct: 115 HLVSLLN-PQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAG 173 Query: 199 VSREKIREKDWWDEFRYAGLTLTSAPARHFSGRSLLDRNSTLWCSWIIRGAETKIFFSGD 258 + R + + + L + + + + Sbjct: 174 CEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQE 233 Query: 259 SGYGPHFAEIGEKYGPFDLTLMECGQYDPRWADIHMLPEQTVQAHLDVRGALMIPIHWAA 318 Sbjct: 234 293 Query: 319 FTLSMHDWTDPVERVFAAAKAHGVRLATPRIGEPV-YTGSAEVPSLAWWK 367 Sbjct: 294 -- 341 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.322 0.138 0.443 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 28,159,959 Number of extensions: 1209675 Number of successful extensions: 2313 Number of sequences better than 1.0e-05: 21 Number of HSP's gapped: 2285 Number of HSP's successfully gapped: 21 Length of query: 367 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 259 Effective length of database: 25,922,359 Effective search space: 6713890981 Effective search space used: 6713890981 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 116 (49.3 bits)