BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0023.0013.p (637 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase ... 645 0.0 Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase ... 488 e-137 Rv1272c [V] COG1132 ABC-type multidrug transport system, ATPase ... 462 e-130 MT1310 [V] COG1132 ABC-type multidrug transport system, ATPase a... 462 e-130 ML1113 [V] COG1132 ABC-type multidrug transport system, ATPase a... 458 e-128 >lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 605 Score = 645 bits (1665), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/592 (56%), Positives = 410/592 (69%), Gaps = 8/592 (1%) Query: 38 KAKDFKGTLRRLIRYLRPRQMQLIIVFIMAIASTVFSIFSPKIMGKATTKLFEGAFGIMK 97 K K+FK TL RL+ Y++PR + +I+VFI AI ST+F+IFSPK +GKATT++F+G Sbjct: 17 KPKNFKQTLFRLLGYMKPRSVAIIVVFIFAILSTIFNIFSPKELGKATTEIFKGV----- 71 Query: 98 GVPGAAIDFGYINDILIILGALYLLSSLFSYVQQYVMSGVAQKVVFDMREQINSKLERLP 157 + I+ I +IL+I+ LYL SSLFS++QQYVMS VAQ+ V+DMR+ + +K+ RLP Sbjct: 72 -MSPEGINNDKIFNILMIVLVLYLGSSLFSFIQQYVMSSVAQRTVYDMRKDLKAKMARLP 130 Query: 158 LKYFDSRTHGEILSRATNDVDNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 217 LKY+D+R++G+ILSR+ ND+DN Sbjct: 131 LKYYDTRSNGDILSRSVNDMDNIANTLQQSLTQAITAIVQMIGVLIMMLTISWQMTLIVL 190 Query: 218 XXXXXXFVVIMGITKRSQTYFIGQQKSLGQLNGHVEEMYTGHRIVKAFGREKHSLGEFDK 277 +++ I RSQ YF QQ++LG LN VEE Y G I+KAFG+EK +L +FD+ Sbjct: 191 VTVPISIILVAIIAGRSQRYFGAQQRNLGILNDTVEETYGGQTIIKAFGQEKKTLVKFDE 250 Query: 278 INDSLYDSGWRAQFISGIIMPLMMFIGNLGYVLVCVVGGIFVTKKIIDVGDIQAFIQYSR 337 +N+ + + +AQFISGI+MP+M F+GNLGYV VCV GGIFVT + VGDIQ+F QY + Sbjct: 251 VNEDYFKAAKKAQFISGIMMPVMQFVGNLGYVGVCVAGGIFVTNGTLQVGDIQSFTQYVQ 310 Query: 338 QFTMPITQTANIANIIQSTIASAXXXXXXXXXXXXXXXXSTSLAKRPVDAEEGSVEFRHV 397 FT PI+ ANIANIIQSTIASA ++ + V EE S+ F HV Sbjct: 311 LFTQPISSVANIANIIQSTIASAERVFEMMDEEEEKDEIPANVNQ--VAGEEHSIVFDHV 368 Query: 398 KFGYKEDAILIEDMNIEVSPGQTIAIVGPTGAGKTTLINLLMRFYEISGGEIIIDGVNIT 457 KFGY D L+ D+NI V GQ +AIVGPTGAGKTT+INLLMRFY++ GGEI + G++ Sbjct: 369 KFGYTPDKPLMTDLNIHVEEGQMVAIVGPTGAGKTTIINLLMRFYDVDGGEIRMRGIDTR 428 Query: 458 DMKRSELRSKFGMVLQDTWLFNGTIRDNIAYGREGATEXXXXXXXXXXXXXXFIRTLPLG 517 DM + +R KFGMVLQDTWLFNGTI DNIAYGREGAT+ FIR LP G Sbjct: 429 DMTKDAVREKFGMVLQDTWLFNGTIADNIAYGREGATKDEVIGAAKAAYADDFIRRLPNG 488 Query: 518 YDTILNEEASNISQGQKQLLTIARAILADPTILILDEATSSVDTRTEVQIQKAMNTLMNG 577 YDTILNEE SNISQGQKQLLTIARAIL+DP+ILILDEATSSVDTRTE+ IQ AM LM G Sbjct: 489 YDTILNEEGSNISQGQKQLLTIARAILSDPSILILDEATSSVDTRTELNIQLAMGNLMEG 548 Query: 578 RTSFVIAHRLSTIRDADLILVMNKGSVIEKGTHEELLKADGFYADLYNSQFS 629 RTSFVIAHRLSTIRDADLILVMN GSVIE+GTH+ELL A GFYADLYNSQF+ Sbjct: 549 RTSFVIAHRLSTIRDADLILVMNHGSVIEQGTHQELLDAKGFYADLYNSQFT 600 >Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 656 Score = 488 bits (1257), Expect = e-137, Method: Compositional matrix adjust. Identities = 273/628 (43%), Positives = 366/628 (58%), Gaps = 39/628 (6%) Query: 37 EKAKDFKGTLRRLIRYLRPRQMQLIIVFIMAIASTVFSIFSPKIMGKATTKLFEGAFGI- 95 +KA++F + +RL L + LI V +A+ S ++ P ++GKAT +FEG Sbjct: 20 QKAQNFGPSAKRLFGILGHDRNTLIFVIFLAVLSVGLTVLGPWLLGKATNVVFEGFLSKR 79 Query: 96 ----------------------------MKGVPGAAIDFGYINDIL-IILGALYLLSSLF 126 M VPG+ IDF + IL +++GA YL+ SL Sbjct: 80 MPAGASKEDIIAQLQAAGKHNQASMMEDMNLVPGSGIDFEKLAMILGLVIGA-YLIGSLL 138 Query: 127 SYVQQYVMSGVAQKVVFDMREQINSKLERLPLKYFDSRTHGEILSRATNDVDNXXXXXXX 186 S Q +++ + Q + +R ++ K+ RLPL YFDS G++LSR TNDVDN Sbjct: 139 SLFQARMLNRIVQSAMHRLRMEVEEKIHRLPLSYFDSIKRGDLLSRVTNDVDNIGQSLQQ 198 Query: 187 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVVIMGITKRSQTYFIGQQKSLG 246 VV + + RSQ F Q K G Sbjct: 199 TLSQAITSLLTVIGVLVMMFIISPLLALVALVSIPVTIVVTVVVASRSQKLFAEQWKQTG 258 Query: 247 QLNGHVEEMYTGHRIVKAFGREKHSLGEFDKINDSLYDSGWRAQFISGIIMPLMMFIGNL 306 LN VEE Y+GH +VK FG +K F++ N ++Y + + AQFISGIIMP MMF+GNL Sbjct: 259 ILNARVEETYSGHAVVKVFGHQKDVQEAFEEENQAVYKASFGAQFISGIIMPTMMFVGNL 318 Query: 307 GYVLVCVVGGIFVTKKIIDVGDIQAFIQYSRQFTMPITQTANIANIIQSTIASAXXXXXX 366 YV + VVGG+ V + +G +Q+FIQYSRQFT P++Q ++AN++QS +ASA Sbjct: 319 SYVAIAVVGGLQVASGSLSIGGVQSFIQYSRQFTQPLSQLGSMANLLQSGVASAERVFEL 378 Query: 367 XXXXXXXXXXSTSLAKRPVDAEEGSVEFRHVKFGYKEDAILIEDMNIEVSPGQTIAIVGP 426 S V A +EF+ V FGY ED LI ++++EV G TIAIVGP Sbjct: 379 IDEDEQD---SDPAQPNTVAAGANRLEFKDVSFGYSEDRPLINNLDLEVRSGSTIAIVGP 435 Query: 427 TGAGKTTLINLLMRFYEISGGEIII-----DGVNITDMKRSELRSKFGMVLQDTWLFNGT 481 TGAGKTTL+NL+MRFY+I+ G I + D V+I M R +LRS+ GMVLQDTWLF GT Sbjct: 436 TGAGKTTLVNLIMRFYDINSGSITLGETAQDAVDIRTMAREDLRSRTGMVLQDTWLFAGT 495 Query: 482 IRDNIAYGREGATEXXXXXXXXXXXXXXFIRTLPLGYDTILNEEASNISQGQKQLLTIAR 541 IRDNI YGR ATE F+R+LP GYDT+L++EA N+S G++QL+TIAR Sbjct: 496 IRDNILYGRPEATEEEMLAASKAAYVDRFVRSLPEGYDTVLDDEAMNLSVGERQLITIAR 555 Query: 542 AILADPTILILDEATSSVDTRTEVQIQKAMNTLMNGRTSFVIAHRLSTIRDADLILVMNK 601 A LA+P +LILDEATSSVDTRTE+ IQ+AM+ L RT+FVIAHRLSTIRDA+LIL+M Sbjct: 556 AFLANPRLLILDEATSSVDTRTELLIQRAMSKLRQDRTAFVIAHRLSTIRDANLILMMKD 615 Query: 602 GSVIEKGTHEELLKADGFYADLYNSQFS 629 G ++E+G H EL+ +G Y +LYNSQF+ Sbjct: 616 GEIVEQGNHRELMALEGAYWELYNSQFN 643 >Rv1272c [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 631 Score = 462 bits (1190), Expect = e-130, Method: Compositional matrix adjust. Identities = 257/612 (41%), Positives = 337/612 (55%), Gaps = 34/612 (5%) Query: 38 KAKDFKGTLRRLIRYLRPRQMQLIIVFIMAIASTVFSIFSPKIMGKATTKLFEGAFGI-- 95 +++DF G+ RL++ L P++ I V + IA T + P+I+G AT LF G G Sbjct: 19 RSRDFWGSAARLVKRLAPQRRLSIAVITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGL 78 Query: 96 ---------------------------MKGVPGAAIDFGYINDILIILGALYLLSSLFSY 128 M VPG +DF + L + ALYL ++L + Sbjct: 79 PGGITKAQAVASARARGDNTFADLLSGMNVVPGQGVDFAAVERTLALALALYLAAALMIW 138 Query: 129 VQQYVMSGVAQKVVFDMREQINSKLERLPLKYFDSRTHGEILSRATNDVDNXXXXXXXXX 188 Q +++ QK + +R + K+ RLPL YFD + GE+LSR TND+DN Sbjct: 139 AQARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTI 198 Query: 189 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVVIMGITKRSQTYFIGQQKSLGQL 248 +V IT+RSQ F+ S G+L Sbjct: 199 SQLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRL 258 Query: 249 NGHVEEMYTGHRIVKAFGREKHSLGEFDKINDSLYDSGWRAQFISGIIMPLMMFIGNLGY 308 N H+EE Y+G +VK FG + + F ++ND +Y +G+ AQF+SG++ P FIGNLGY Sbjct: 259 NAHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGY 318 Query: 309 VLVCVVGGIFVTKKIIDVGDIQAFIQYSRQFTMPITQTANIANIIQSTIASAXXXXXXXX 368 V V V GG+ V I +G IQAFIQY RQF MP++Q A + N +QS +ASA Sbjct: 319 VAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLD 378 Query: 369 XXXXXXXXSTSLAKRPVDAEEGSVEFRHVKFGYKEDAILIEDMNIEVSPGQTIAIVGPTG 428 L G VEF HV F Y +I D+++ PG T+AIVGPTG Sbjct: 379 EPEESPEPEPELPN-----LTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTG 433 Query: 429 AGKTTLINLLMRFYEISGGEIIIDGVNITDMKRSELRSKFGMVLQDTWLFNGTIRDNIAY 488 AGKTTL+NLLMRFYEI G I+IDGV+I + R LRS+ GMVLQDTWL++GTI +NIAY Sbjct: 434 AGKTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAY 493 Query: 489 GREGATEXXXXXXXXXXXXXXFIRTLPLGYDTILNEEASNISQGQKQLLTIARAILADPT 548 GR AT F+ TLP GY T ++ + +IS G+KQL+TIARA LA P Sbjct: 494 GRPEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQ 553 Query: 549 ILILDEATSSVDTRTEVQIQKAMNTLMNGRTSFVIAHRLSTIRDADLILVMNKGSVIEKG 608 +LILDEATSSVDTRTE+ IQ+AM L RTSF+IAHRLSTIRDAD ILV+ G ++E+G Sbjct: 554 LLILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERG 613 Query: 609 THEELLKADGFY 620 H ELL G Y Sbjct: 614 NHAELLARRGVY 625 >MT1310 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 631 Score = 462 bits (1190), Expect = e-130, Method: Compositional matrix adjust. Identities = 257/612 (41%), Positives = 337/612 (55%), Gaps = 34/612 (5%) Query: 38 KAKDFKGTLRRLIRYLRPRQMQLIIVFIMAIASTVFSIFSPKIMGKATTKLFEGAFGI-- 95 +++DF G+ RL++ L P++ I V + IA T + P+I+G AT LF G G Sbjct: 19 RSRDFWGSAARLVKRLAPQRRLSIAVITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGL 78 Query: 96 ---------------------------MKGVPGAAIDFGYINDILIILGALYLLSSLFSY 128 M VPG +DF + L + ALYL ++L + Sbjct: 79 PGGITKAQAVASARARGDNTFADLLSGMNVVPGQGVDFAAVERTLALALALYLAAALMIW 138 Query: 129 VQQYVMSGVAQKVVFDMREQINSKLERLPLKYFDSRTHGEILSRATNDVDNXXXXXXXXX 188 Q +++ QK + +R + K+ RLPL YFD + GE+LSR TND+DN Sbjct: 139 AQARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTI 198 Query: 189 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVVIMGITKRSQTYFIGQQKSLGQL 248 +V IT+RSQ F+ S G+L Sbjct: 199 SQLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRL 258 Query: 249 NGHVEEMYTGHRIVKAFGREKHSLGEFDKINDSLYDSGWRAQFISGIIMPLMMFIGNLGY 308 N H+EE Y+G +VK FG + + F ++ND +Y +G+ AQF+SG++ P FIGNLGY Sbjct: 259 NAHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGY 318 Query: 309 VLVCVVGGIFVTKKIIDVGDIQAFIQYSRQFTMPITQTANIANIIQSTIASAXXXXXXXX 368 V V V GG+ V I +G IQAFIQY RQF MP++Q A + N +QS +ASA Sbjct: 319 VAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLD 378 Query: 369 XXXXXXXXSTSLAKRPVDAEEGSVEFRHVKFGYKEDAILIEDMNIEVSPGQTIAIVGPTG 428 L G VEF HV F Y +I D+++ PG T+AIVGPTG Sbjct: 379 EPEESPEPEPELPN-----LTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTG 433 Query: 429 AGKTTLINLLMRFYEISGGEIIIDGVNITDMKRSELRSKFGMVLQDTWLFNGTIRDNIAY 488 AGKTTL+NLLMRFYEI G I+IDGV+I + R LRS+ GMVLQDTWL++GTI +NIAY Sbjct: 434 AGKTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAY 493 Query: 489 GREGATEXXXXXXXXXXXXXXFIRTLPLGYDTILNEEASNISQGQKQLLTIARAILADPT 548 GR AT F+ TLP GY T ++ + +IS G+KQL+TIARA LA P Sbjct: 494 GRPEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQ 553 Query: 549 ILILDEATSSVDTRTEVQIQKAMNTLMNGRTSFVIAHRLSTIRDADLILVMNKGSVIEKG 608 +LILDEATSSVDTRTE+ IQ+AM L RTSF+IAHRLSTIRDAD ILV+ G ++E+G Sbjct: 554 LLILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERG 613 Query: 609 THEELLKADGFY 620 H ELL G Y Sbjct: 614 NHAELLARRGVY 625 >ML1113 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 629 Score = 458 bits (1178), Expect = e-128, Method: Compositional matrix adjust. Identities = 247/616 (40%), Positives = 343/616 (55%), Gaps = 35/616 (5%) Query: 38 KAKDFKGTLRRLIRYLRPRQMQLIIVFIMAIASTVFSIFSPKIMGKATTKLFEGAFG--I 95 ++ DF T+RRL++ L P++ + V + I T I P ++G T LF G G + Sbjct: 10 RSCDFYCTIRRLLKQLVPQRRLSLTVITLGITGTAIGIIVPWVLGHTTDLLFNGVIGRQL 69 Query: 96 MKG---------------------------VPGAAIDFGYINDILIILGALYLLSSLFSY 128 KG VPG +DF + L + +LYL+ +L ++ Sbjct: 70 PKGISKTQAVAAARTRGDNALADLLSGMNLVPGQGVDFVAVGRTLGLALSLYLVYTLLTW 129 Query: 129 VQQYVMSGVAQKVVFDMREQINSKLERLPLKYFDSRTHGEILSRATNDVDNXXXXXXXXX 188 Q +++ Q+++F +R + K+ RLPL Y D+R GE+LSR TND+DN Sbjct: 130 AQARLLNVTVQRIMFALRSDVEDKVHRLPLSYCDTRQRGELLSRVTNDIDNLQSSLSITL 189 Query: 189 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVVIMGITKRSQTYFIGQQKSLGQL 248 + I +RSQ F+ Q S G+L Sbjct: 190 SQLLTSLLTVVAVLVVMVSVSPLLALVALLTVPMSLLATRAIAQRSQQLFVAQWTSAGRL 249 Query: 249 NGHVEEMYTGHRIVKAFGREKHSLGEFDKINDSLYDSGWRAQFISGIIMPLMMFIGNLGY 308 N H+EE Y+G +VK FG + + +F +N+ +Y + + AQF SG++ P MFI NLGY Sbjct: 250 NAHIEETYSGLTVVKTFGHQTAAREQFRNVNNDVYQASFSAQFFSGLVSPATMFISNLGY 309 Query: 309 VLVCVVGGIFVTKKIIDVGDIQAFIQYSRQFTMPITQTANIANIIQSTIASAXXXXXXXX 368 V+V +GG+ V I +G+IQAFIQY RQF MP++Q A I N +QS +ASA Sbjct: 310 VVVAALGGLQVATGHITLGNIQAFIQYVRQFNMPLSQVAGIYNTLQSGLASAERVFDLLD 369 Query: 369 XXXXXXXXSTSLAKRPVDAE----EGSVEFRHVKFGYKEDAILIEDMNIEVSPGQTIAIV 424 LA P + G VEF+ V F Y+ +I+D+++ V PG T+AIV Sbjct: 370 EPEELP--DPMLALPPPHGQVPRINGRVEFQQVSFAYRTGTPVIDDLSMVVEPGSTVAIV 427 Query: 425 GPTGAGKTTLINLLMRFYEISGGEIIIDGVNITDMKRSELRSKFGMVLQDTWLFNGTIRD 484 GPTGAGKTTL+NLLMRFY++ G+I+IDGV+IT + R LRS+ GMVLQD WLF+GTI + Sbjct: 428 GPTGAGKTTLVNLLMRFYDVDSGQILIDGVDITTVSRHALRSRIGMVLQDAWLFDGTIAE 487 Query: 485 NIAYGREGATEXXXXXXXXXXXXXXFIRTLPLGYDTILNEEASNISQGQKQLLTIARAIL 544 NIAYGR A+E F+ TL GY T ++ + NIS G+KQL+TIARA L Sbjct: 488 NIAYGRPQASEDEVMEAAKAAYVDRFVHTLSAGYQTRVSGDGDNISAGEKQLITIARAFL 547 Query: 545 ADPTILILDEATSSVDTRTEVQIQKAMNTLMNGRTSFVIAHRLSTIRDADLILVMNKGSV 604 A P +LILDEATSS+DTRTE I +A + L+ RTSF+IAH L TIRDAD ILV+ G + Sbjct: 548 ARPQLLILDEATSSIDTRTEALIARATHDLLQDRTSFIIAHHLPTIRDADHILVVAAGKI 607 Query: 605 IEKGTHEELLKADGFY 620 +E+G+H +LL G Y Sbjct: 608 VEQGSHAKLLARRGAY 623 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.321 0.138 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,923,233 Number of extensions: 1375721 Number of successful extensions: 19359 Number of sequences better than 1.0e-05: 1448 Number of HSP's gapped: 18246 Number of HSP's successfully gapped: 1600 Length of query: 637 Length of database: 38,378,431 Length adjustment: 113 Effective length of query: 524 Effective length of database: 25,345,689 Effective search space: 13281141036 Effective search space used: 13281141036 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 119 (50.4 bits)