BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0021.0011.p (333 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SA0123 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 75 1e-13 PH1742 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 75 2e-13 Rv0112 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 72 1e-12 MT0121 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 72 1e-12 CAC2334 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 67 5e-11 >SA0123 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Length = 323 Score = 75.5 bits (184), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/252 (26%), Positives = 111/252 (44%), Gaps = 24/252 (9%) Query: 5 RILITGASGFTGRHAVAYFHAAGXXXXXXXXXXXXXSGIFPAGVKQQVCDLSDRR--AVQ 62 R+LITG +GF G H V I + V +L R AV+ Sbjct: 3 RVLITGGAGFIGSHLVDDLQQDYDVYVLDNYRTGKRENI-KSLADDHVFELDIREYDAVE 61 Query: 63 SMIEEVEPEEVLHLAGKNSVPESWQDPLLYMETNVMSTLYLLEGLRTRPA--RRILVAGS 120 +++ + + V+HLA SV ES + P+L E NV++TL LLE ++ + +R + A S Sbjct: 62 QIMKTYQFDYVIHLAALVSVAESVEKPILSQEINVVATLRLLEIIKKYNSHIKRFIFASS 121 Query: 121 RLKFK--PGLAEG------PPHPYSLSKTLEELVSLAWCTLFKQPVLLAEPCNLIGP--G 170 + P L + P PY++ K E +L +C+L+ P + + N+ GP Sbjct: 122 AAVYGDLPDLPKSDQSLILPLSPYAIDKYYGERTTLNYCSLYNIPTAVVKFFNVFGPRQD 181 Query: 171 PSTGFCSLLAQHIVRSEAAAGTSETLPPFR-LSSRFALRDFLDVRDAVRAYDCILRSGEP 229 P + + ++++ + E PF RDF+ V D V++ I+ + Sbjct: 182 PKSQYSGVISKMF-------DSFEHNKPFTFFGDGLQTRDFVYVYDVVQSVRLIMEHKDA 234 Query: 230 -GKVYRIDSGTL 240 G Y I +GT Sbjct: 235 IGHGYNIGTGTF 246 >PH1742 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Length = 306 Score = 75.1 bits (183), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/246 (25%), Positives = 107/246 (43%), Gaps = 17/246 (6%) Query: 1 MKTRRILITGASGFTGRHAVAYFHAAGXXXXXXXXXXXXXSGIFPAGVKQQVCDLSDRRA 60 MK + I+ITG +GF G H I P GVK D+ D + Sbjct: 1 MKNKLIVITGGAGFIGSHLAEALKDENDVIIIDNLYSGRIENI-PEGVKFIRADVRDYES 59 Query: 61 VQSMIEEVEPEEVLHLAGKNSVPESWQDPLLYMETNVMSTLYLLEGLRTRPARRILVAGS 120 + +I E + V H A + SV ES +DP+ E NV+ T+ +L L + I + + Sbjct: 60 IAEVISE--ADYVFHEAAQISVKESIEDPVFTEEVNVIGTINVLRALSQGDGKLIFASSA 117 Query: 121 RLKFKPG---LAE----GPPHPYSLSKTLEELVSLAWCTLFKQPVLLAEPCNLIGPGPST 173 + +P + E P PY ++K E + +L+ PV++ N+ GP S+ Sbjct: 118 AVYGEPKELPITEDTLTNPISPYGITKLAAEHYCRVYQSLYGIPVVILRYFNVYGPRQSS 177 Query: 174 GFCSLLAQHIVRSEAAAGTSETLPPFRLSSRFALRDFLDVRDAVRAYDCILRS-GEPGKV 232 + +++ + R A E L F + RDF+ V+D V A + + G++ Sbjct: 178 AYAGVISIFLER----AIKGEPLIIFGDGKQ--TRDFIYVKDVVEANILVAKKRSANGRI 231 Query: 233 YRIDSG 238 + + +G Sbjct: 232 FNVATG 237 >Rv0112 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Length = 318 Score = 72.0 bits (175), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 104/253 (41%), Gaps = 39/253 (15%) Query: 5 RILITGASGFTGRHAVAYFHAAGXXXXXXXXXXXXXSGIFPAGVKQQ--VCDLSDRRAVQ 62 ++ ITGA G G H AAG I P+ ++ D++D +V Sbjct: 2 KVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPT----IDPSDLQFNGAEVDITDWCSVY 57 Query: 63 SMIEEVEPEEVLHLAGKNSVPESWQDPLLYMETNVMSTLYLLEGL-RTRPARRILVAGSR 121 I P+ V HLA ++ SW P+ + TN++ T + E L R RP +I+VAGS Sbjct: 58 DSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSS 117 Query: 122 LKFKPGLAE------------GPPHPYSLSKTLEELVSLAWCTLFKQPVLLAEPCNLIGP 169 ++ G + P HPY +SK ++++ + + ++A N GP Sbjct: 118 AEY--GFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVVARIFNCTGP 175 Query: 170 ----GPSTGF---CSLLAQHIVRSEAAAGTSETLPPFRLSSRFALRDFLDVRDAVRAYDC 222 + F C+ L H +S G +T R +DVRD RA Sbjct: 176 RKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKT-----------KRTIVDVRDLNRALML 224 Query: 223 ILRSGEPGKVYRI 235 +L GE G Y + Sbjct: 225 MLDKGEAGADYNV 237 >MT0121 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Length = 318 Score = 72.0 bits (175), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 104/253 (41%), Gaps = 39/253 (15%) Query: 5 RILITGASGFTGRHAVAYFHAAGXXXXXXXXXXXXXSGIFPAGVKQQ--VCDLSDRRAVQ 62 ++ ITGA G G H AAG I P+ ++ D++D +V Sbjct: 2 KVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPT----IDPSDLQFNGAEVDITDWCSVY 57 Query: 63 SMIEEVEPEEVLHLAGKNSVPESWQDPLLYMETNVMSTLYLLEGL-RTRPARRILVAGSR 121 I P+ V HLA ++ SW P+ + TN++ T + E L R RP +I+VAGS Sbjct: 58 DSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSS 117 Query: 122 LKFKPGLAE------------GPPHPYSLSKTLEELVSLAWCTLFKQPVLLAEPCNLIGP 169 ++ G + P HPY +SK ++++ + + ++A N GP Sbjct: 118 AEY--GFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVVARIFNCTGP 175 Query: 170 ----GPSTGF---CSLLAQHIVRSEAAAGTSETLPPFRLSSRFALRDFLDVRDAVRAYDC 222 + F C+ L H +S G +T R +DVRD RA Sbjct: 176 RKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKT-----------KRTIVDVRDLNRALML 224 Query: 223 ILRSGEPGKVYRI 235 +L GE G Y + Sbjct: 225 MLDKGEAGADYNV 237 >CAC2334 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Length = 301 Score = 66.6 bits (161), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 101/247 (40%), Gaps = 23/247 (9%) Query: 5 RILITGASGFTGRHAVAYFHAAGXXXXXXXXXXXXXSGIFPAGVKQQVCDLSDRRAVQSM 64 IL+TG +GF G H V G S P V D+S+ +++ Sbjct: 2 NILVTGGAGFIGSHVVKSLLEHGHKVSVIDNMVHGNSSNLPDEVNIYKYDISEAE-IENA 60 Query: 65 IEEVEPEEVLHLAGKNSVPESWQDPLLYMETNVMSTLYLLEGLRTRPARRILVAGSRLKF 124 + PE V+H A + SV +S +DPL + NV+ ++ +LE R R+++ S F Sbjct: 61 FKIERPEVVIHNAAQISVADSVKDPLYDAKVNVLGSINILEMCRKYAVRKVIYPASAAIF 120 Query: 125 -KPG-LAEGPPHP------YSLSKTLEELVSLAWCTLFKQPVLLAEPCNLIGPGPST--- 173 +P L HP Y +SK E + L+ + N+ GPG + Sbjct: 121 GEPKYLPIDEKHPLNMISSYGVSKHTVEHYLNVYKKLYNINYTVLRYSNVYGPGQDSSGE 180 Query: 174 -GFCSLLAQHIVRSEAAAGTSETLPPFRLSSRFALRDFLDVRDAVRAYDCILRSGEPGKV 232 G S+ A+ + + E P + +RDF+ V+D A L S + + Sbjct: 181 GGVVSIFAEKLTKGE---------PLCIYGNGNQIRDFVYVKDVTEANILALNSLD-NDI 230 Query: 233 YRIDSGT 239 Y + + T Sbjct: 231 YNVSTNT 237 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.136 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 20,476,099 Number of extensions: 714658 Number of successful extensions: 1404 Number of sequences better than 1.0e-05: 33 Number of HSP's gapped: 1390 Number of HSP's successfully gapped: 33 Length of query: 333 Length of database: 38,378,431 Length adjustment: 107 Effective length of query: 226 Effective length of database: 26,037,693 Effective search space: 5884518618 Effective search space used: 5884518618 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 116 (49.3 bits)