BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0016.0002.p (285 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value alr4386 [H] COG0294 Dihydropteroate synthase and related enzymes 220 2e-57 slr2026 [H] COG0294 Dihydropteroate synthase and related enzymes 219 4e-57 STM0040 [K] COG0583 Transcriptional regulator 211 1e-54 ML0224 [H] COG0294 Dihydropteroate synthase and related enzymes 203 2e-52 HI1464 [H] COG0294 Dihydropteroate synthase and related enzymes 187 2e-47 >alr4386 [H] COG0294 Dihydropteroate synthase and related enzymes Length = 359 Score = 220 bits (560), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 11/265 (4%), Positives = 34/265 (12%), Gaps = 9/265 (3%) Query: 20 GERTLIMGILNVTPDSFSDGGLWAEPEKAVEHALQMAEEGADIIDIGGESTRPGHQPVGL 79 + + + + + + Sbjct: 15 HNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEALRLRAGGITKP 74 Query: 80 EEELARVLPVIESIHRAAPQLVLSIDTYKAEVARRAIQAGAHIINDVWGAKADPDMAPVA 139 L + + + Q + + ++A + + V Sbjct: 75 VLLLEGFFDARD-LPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVR 133 Query: 140 AEAGCPVILMHNR-------RERNYRELVSDMCADLGDSVKQALAAGVKRENIILDPGIG 192 E + +D + A+ Sbjct: 134 PEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAA 193 Query: 193 FAKDYAENLQTMMNLDRLTELGYPLLLATSRKKFIRTVLDLP-PDDVVEGTAATVAFGIA 251 + L L + + A Sbjct: 194 SGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKAGEPV 253 Query: 252 QGCQIVRVHDVARIKRTVQMCDAML 276 R+ Sbjct: 254 GYGGTWVSERDTRLGVVAMGYGDGY 278 >slr2026 [H] COG0294 Dihydropteroate synthase and related enzymes Length = 289 Score = 219 bits (557), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 124/272 (45%), Positives = 167/272 (61%), Gaps = 9/272 (3%) Query: 12 LGAAELALGERTLIMGILNVTPDSFSDGGLWAEPEKAVEHALQMAEEGADIIDIGGESTR 71 +G G+RT +MGILN TPDSFSDGG + A+ A M + GA IIDIGG+STR Sbjct: 17 VGQTLFDWGKRTYVMGILNTTPDSFSDGGEFNSLPTAIHQAKTMVQGGAHIIDIGGQSTR 76 Query: 72 PGHQPVGLEEELARVLPVIESIHRAAPQLVLSIDTYKAEVARRAIQAGAHIINDVWGAKA 131 PG + V L+EEL R +P+I+++ R + +SIDT +AEVAR+A+QAGA ++ND+ GA Sbjct: 77 PGAETVSLKEELERTIPIIQAL-RQELDIPISIDTTRAEVARQALQAGADMVNDISGATF 135 Query: 132 DPDMAPVAAEAGCPVILMHNRRE-------RNYRELVSDMCADLGDSVKQALAAGVKREN 184 +P++ VAA+ P+ILMH R +Y +L+ +M V A GV E Sbjct: 136 EPEILAVAAQHKAPIILMHIRGNPQTMQNLTDYGDLIGEMRQFFSAQVDLARHYGVLPEQ 195 Query: 185 IILDPGIGFAKDYAENLQTMMNLDRLTELGYPLLLATSRKKFIRTVLDLP-PDDVVEGTA 243 IILDPGIGFAK +N+ + L L LG+PLL+ SRK FI +LD P P + V GT Sbjct: 196 IILDPGIGFAKTAEQNITLLRQLPELKRLGFPLLVGPSRKSFIGKILDQPDPKERVWGTG 255 Query: 244 ATVAFGIAQGCQIVRVHDVARIKRTVQMCDAM 275 AT IA G IVRVHDV + + ++ DA+ Sbjct: 256 ATCCRAIAGGADIVRVHDVEAMAQICKVADAL 287 >STM0040 [K] COG0583 Transcriptional regulator Length = 299 Score = 211 bits (537), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 16/264 (6%), Positives = 51/264 (19%), Gaps = 11/264 (4%) Query: 22 RTLIMGILNVTPDSFSDGGLWAEPEKAVEHALQMAEEGADIIDIGGESTRPGHQPVGLEE 81 + V + ++ + G E + G + Sbjct: 15 WHVYKEGSVVGAAEALFLTPQTITGQIKALEERLQGKLFKRKGRGLEPSELGELVFRYAD 74 Query: 82 ELARVLPVIESIHRAAPQLVLSIDTYKAEVARRAIQAGAHIINDVWGAKADPDMAPVAAE 141 ++ + + I + + A + + V + + Sbjct: 75 KMFTLSQEMLDI-VNYRKESNLLFDVGVADALSKRLVSSVLDAAVVVDEPIHLRCFESTH 133 Query: 142 AGCPVILMHNR-------RERNYRELVSDMCADLGDSVKQALAAGVKRENIILDPGIGFA 194 L ++ + + +G+ P Sbjct: 134 EMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVKIGECSVSFWCTNPLP--EKAFPACLEE 191 Query: 195 KDYAENLQTMMNLDRLTELGYPLLLATSRKKFIRTVL-DLPPDDVVEGTAATVAFGIAQG 253 + + M +L L + + Sbjct: 192 RRLLVPGRRSMLGRKLLNWFNSQGLQVEILGEFDDAALMKAFGATHDAIFVAPSLYSLDF 251 Query: 254 CQIVRVHDVARIKRTVQMCDAMLY 277 V ++ R++ ++ A+ Sbjct: 252 YADESVIEIGRVENVMEEYHAIFA 275 >ML0224 [H] COG0294 Dihydropteroate synthase and related enzymes Length = 395 Score = 203 bits (517), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 14/268 (5%), Positives = 43/268 (16%), Gaps = 16/268 (5%) Query: 25 IMGILNVTPDSFSDGGLWAEPEKAVEHALQMAEEGADIIDIGGESTRPGHQPVGLEEELA 84 G ++ + + E + + L Sbjct: 8 NAGSSSLKWQLYEMPEETVIAKGIFERIGLSGSISTTKFNNEEHFRKQEIVDHRQAVLLL 67 Query: 85 RVLPVIESIHRAAPQLVLSIDTYKAEVARRAIQAGAHIINDVWGAKADPDMAPVAAEAGC 144 + + ++ ++ + I +V + Sbjct: 68 MDELIHFKL--IHEFREITGIGHRVVAGGEFFKTSTVISPEVLAEIKNLSTLAPLHNPAN 125 Query: 145 PVILMHNR---RER-----NYRELVSDMCADLGDSVKQALAAGVKRENIILDPGIGFAKD 196 + + + + S + G Sbjct: 126 VLGIEAFQRLLPDALAVAVFDTAFHSTLPEKAYRYPIPTKYYEDYSIRKYGAHGTSHMYV 185 Query: 197 YAENLQTMMNLDRLTELGYPLLLATSRKKFIRTVLD------LPPDDVVEGTAATVAFGI 250 E + + +L + + I P V Sbjct: 186 AQEAEKVLGKPLEDLKLITAHIGNGASITAIEAGKSVDTSMGFTPLAGVMMGTRAGEMDA 245 Query: 251 AQGCQIVRVHDVARIKRTVQMCDAMLYA 278 + ++ R + V Sbjct: 246 SVIPYMLESDPSLRNAQDVIDILNKDSG 273 >HI1464 [H] COG0294 Dihydropteroate synthase and related enzymes Length = 275 Score = 187 bits (475), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 105/246 (42%), Positives = 143/246 (58%), Gaps = 9/246 (3%) Query: 25 IMGILNVTPDSFSDGGLWAEPEKAVEHALQMAEEGADIIDIGGESTRPGHQPVGLEEELA 84 IMGILN TPDSFSD G + +KA+ +M EEGA IIDIGGESTRP V +EEL Sbjct: 17 IMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELH 76 Query: 85 RVLPVIESIHRAAPQLVLSIDTYKAEVARRAIQAGAHIINDVWGAKADPDMAPVAAEAGC 144 RV+PV+E++ R +S+D+ KA V R A G +IND+ A +P+ A + Sbjct: 77 RVVPVVEAV-RNRFDCWISVDSSKAVVMREAANVGMDLINDI-RALQEPNALETAVKLAL 134 Query: 145 PVILMHNRRERN-------YRELVSDMCADLGDSVKQALAAGVKRENIILDPGIGFAKDY 197 PV +MH + + Y +V D+ A L + L+AG+K+EN+I D G GF K Sbjct: 135 PVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSV 194 Query: 198 AENLQTMMNLDRLTELGYPLLLATSRKKFIRTVLDLPPDDVVEGTAATVAFGIAQGCQIV 257 N Q + NL+ ++GYP+L SRK I VLD P D + G+AA + +G +I+ Sbjct: 195 QHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSAAGALIAVQKGAKIL 254 Query: 258 RVHDVA 263 RVHDVA Sbjct: 255 RVHDVA 260 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.136 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 20,504,948 Number of extensions: 785907 Number of successful extensions: 2173 Number of sequences better than 1.0e-05: 17 Number of HSP's gapped: 2123 Number of HSP's successfully gapped: 17 Length of query: 285 Length of database: 38,378,431 Length adjustment: 105 Effective length of query: 180 Effective length of database: 26,268,361 Effective search space: 4728304980 Effective search space used: 4728304980 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 115 (48.9 bits)