BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0028.p (245 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc630 [K] COG1396 Predicted transcriptional regulators 210 1e-54 AGc637 [G] COG0524 Sugar kinases, ribokinase family 210 1e-54 PA3151 [E] COG0107 Imidazoleglycerol-phosphate synthase 82 5e-16 AGc627 [R] COG1253 Hemolysins and related proteins containing CB... 82 6e-16 AGc620 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins 82 6e-16 >AGc630 [K] COG1396 Predicted transcriptional regulators Length = 247 Score = 210 bits (535), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 109/236 (46%), Positives = 152/236 (64%) Query: 4 FIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHP 63 I++PAID++DG+CVRL+ GD Q T+YN+ P + AK++E+QG +++H+VDL+GA AG Sbjct: 1 MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGET 60 Query: 64 VNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKY 123 VN A + AI K+ PVQ+GGG+RTL +E L G++RVI+GT A+ D ++ Sbjct: 61 VNGAAVDAILKSTKNPVQLGGGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRF 120 Query: 124 GDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGPNIE 183 +VA+GIDA+GG VA GW SE+ +LAK G IYTDI RDG++ G N Sbjct: 121 PGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGVAAIIYTDIDRDGILAGINWA 180 Query: 184 GILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEAL 239 L +A VIASGG+ S+DD+ R+ + + GAI G+ALY G ID EAL Sbjct: 181 STLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEAL 236 >AGc637 [G] COG0524 Sugar kinases, ribokinase family Length = 247 Score = 210 bits (535), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 109/236 (46%), Positives = 152/236 (64%) Query: 4 FIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHP 63 I++PAID++DG+CVRL+ GD Q T+YN+ P + AK++E+QG +++H+VDL+GA AG Sbjct: 1 MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGET 60 Query: 64 VNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKY 123 VN A + AI K+ PVQ+GGG+RTL +E L G++RVI+GT A+ D ++ Sbjct: 61 VNGAAVDAILKSTKNPVQLGGGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRF 120 Query: 124 GDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGPNIE 183 +VA+GIDA+GG VA GW SE+ +LAK G IYTDI RDG++ G N Sbjct: 121 PGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGVAAIIYTDIDRDGILAGINWA 180 Query: 184 GILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEAL 239 L +A VIASGG+ S+DD+ R+ + + GAI G+ALY G ID EAL Sbjct: 181 STLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEAL 236 >PA3151 [E] COG0107 Imidazoleglycerol-phosphate synthase Length = 251 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 104/212 (49%), Gaps = 9/212 (4%) Query: 6 VYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHPVN 65 V P + ++D V+ + +E Y P++ + + E+ + L+D+D ++ N Sbjct: 6 VIPCLLLKDRGLVKTVKF---KEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQEPN 62 Query: 66 DAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKYGD 125 +I +A +P+ GGG++TL EK+ LGV +V I TAA+ D + + K+G Sbjct: 63 YELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKFGS 122 Query: 126 KVAIG-IDARGGYVATHGWLN---TSEVRAEDL--AKELASKGAETFIYTDISRDGMMQG 179 + +G ID R G+ H + T +++ L A+ L G I RDG+ +G Sbjct: 123 QSVVGSIDCRKGFWGGHSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSIDRDGVQKG 182 Query: 180 PNIEGILSMAATSGKTVIASGGVTSLDDLLRL 211 + + ++A+ VIA GG S+ DL+ L Sbjct: 183 FDNALVENIASNVHVPVIACGGAGSIADLIDL 214 >AGc627 [R] COG1253 Hemolysins and related proteins containing CBS domains Length = 258 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 108/214 (50%), Gaps = 13/214 (6%) Query: 6 VYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHPVN 65 + P +D++DG+ V+ G + I PV AK+++ G + +D+ + Sbjct: 7 IIPCLDVKDGRVVK---GVNFVDLIDAGDPVEAAKAYDAAGADELCFLDITASSDNRDTI 63 Query: 66 DAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKYGD 125 ++ A + +PV VGGG+R++AD+ KLL G +V I +AA+ D F K+G+ Sbjct: 64 FDVVSRTADHCFMPVTVGGGVRSVADIRKLLLCGADKVSINSAAVKDPDFVAQAADKFGN 123 Query: 126 K-VAIGIDAR---------GGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDG 175 + + + IDA+ + THG + + A + A ++ +GA + T + RDG Sbjct: 124 QCIVVSIDAKRVSKDGEADRWEIFTHGGRQPTGIDAVEFAIKMVERGAGELLVTSMDRDG 183 Query: 176 MMQGPNIEGILSMAATSGKTVIASGGVTSLDDLL 209 G +I S+A VIASGGV +LDDL+ Sbjct: 184 TKSGYDIGLTRSIADQVRVPVIASGGVGTLDDLV 217 >AGc620 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins Length = 258 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 108/214 (50%), Gaps = 13/214 (6%) Query: 6 VYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHPVN 65 + P +D++DG+ V+ G + I PV AK+++ G + +D+ + Sbjct: 7 IIPCLDVKDGRVVK---GVNFVDLIDAGDPVEAAKAYDAAGADELCFLDITASSDNRDTI 63 Query: 66 DAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKYGD 125 ++ A + +PV VGGG+R++AD+ KLL G +V I +AA+ D F K+G+ Sbjct: 64 FDVVSRTADHCFMPVTVGGGVRSVADIRKLLLCGADKVSINSAAVKDPDFVAQAADKFGN 123 Query: 126 K-VAIGIDAR---------GGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDG 175 + + + IDA+ + THG + + A + A ++ +GA + T + RDG Sbjct: 124 QCIVVSIDAKRVSKDGEADRWEIFTHGGRQPTGIDAVEFAIKMVERGAGELLVTSMDRDG 183 Query: 176 MMQGPNIEGILSMAATSGKTVIASGGVTSLDDLL 209 G +I S+A VIASGGV +LDDL+ Sbjct: 184 TKSGYDIGLTRSIADQVRVPVIASGGVGTLDDLV 217 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.315 0.135 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 18,912,847 Number of extensions: 886815 Number of successful extensions: 1772 Number of sequences better than 1.0e-05: 11 Number of HSP's gapped: 1754 Number of HSP's successfully gapped: 11 Length of query: 245 Length of database: 38,378,431 Length adjustment: 104 Effective length of query: 141 Effective length of database: 26,383,695 Effective search space: 3720100995 Effective search space used: 3720100995 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 114 (48.5 bits)