BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0002.p (848 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, t... 1164 0.0 BS_gyrA [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1126 0.0 lin0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1053 0.0 SA0006 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, t... 1011 0.0 CAC0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1009 0.0 >BH0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Length = 833 Score = 1164 bits (3010), Expect = 0.0, Method: Compositional matrix adjust. Identities = 555/803 (69%), Positives = 678/803 (84%) Query: 1 MAEQNNPQVKDRDIGEEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILFAMSELGMFA 60 MAEQ+ +VK+ +I +EM+ SFMDYAMS+IVSRALPDVRDG+KPVHRRIL+AM+ELGM + Sbjct: 1 MAEQDQSRVKEINISQEMKTSFMDYAMSVIVSRALPDVRDGMKPVHRRILYAMNELGMTS 60 Query: 61 DKPHKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSMRYMLVDGHGNFGSIDGDMAAA 120 DK +KKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFS RYMLVDGHGNFGSIDGD AAA Sbjct: 61 DKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSYRYMLVDGHGNFGSIDGDAAAA 120 Query: 121 MRYTEARLSKIAGEMLRDLNKETVDFAPNYDGEENEPVVLPARYPNLLVNGVSGIAVGMA 180 MRYTEAR+SKI+ E++RD+NK+T+D+ NYDG E EPVV+P+R+PNLLVNG SGIAVGMA Sbjct: 121 MRYTEARMSKISMELVRDINKDTIDYQDNYDGSEKEPVVMPSRFPNLLVNGASGIAVGMA 180 Query: 181 TNIPPHNLGEVIDGVQAMIKNPDITPMELMEYIQGPDFPTAGYILGREGIRQAYRTGRGS 240 TNIPPH LGEVIDGV A+ KNPDI+ ELME+I GPDFPT ILGR GIR+AY+TGRGS Sbjct: 181 TNIPPHQLGEVIDGVLALSKNPDISVPELMEHIPGPDFPTGAEILGRSGIRKAYQTGRGS 240 Query: 241 VTMRAKADIEENNGKARIIVSELPYQVNKARLVEKIAELVREKRIEGITDLRDESDRNGM 300 +T+RAK +IEE++GK RIIV E+PYQVNKA+L+EKIAELVR+K+I+GITDLRDESDRNGM Sbjct: 241 ITLRAKTEIEEHHGKQRIIVHEIPYQVNKAKLIEKIAELVRDKKIDGITDLRDESDRNGM 300 Query: 301 RVVVEMRRDVNPNVVLNNLYKHTSMQSTFGINMLAIVNNEPKILNLRDVLYHYLQHQIEV 360 R+V+E+R+D N NV+LNNLYK T++Q++FGIN+LA+V +PK+LNL++ L HYL HQ+ V Sbjct: 301 RIVIEVRKDANANVLLNNLYKQTALQTSFGINLLALVEGQPKVLNLKECLEHYLAHQVIV 360 Query: 361 IRRRTIFDLKKAEARAHILEGLRIALDHLDEVIALIRASRTTDIARDGLMSTFSLSVEQA 420 IRRRT F+L+KAEARAHILEGLRIALDHLDEVI+LIR+S+TT+IAR+GLM F LS EQA Sbjct: 361 IRRRTAFELRKAEARAHILEGLRIALDHLDEVISLIRSSQTTEIARNGLMERFELSYEQA 420 Query: 421 QAILDMRMQRLTGLEREKIENEYNELLAKIAEYREILANEHLVLEIISNELQEIRDRYSD 480 QAILDMR+QRLTGLER+KIE EY EL+ +IAE + ILA+ VL+II EL E++++Y+D Sbjct: 421 QAILDMRLQRLTGLERDKIEAEYKELIERIAELKAILADHEKVLDIIREELLELKEKYND 480 Query: 481 DRRTEITIGEESILDEDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDTKDQ 540 +R+T I+ E+ DEDLIPR+ VVIT+TH GYIKRLP+STYRSQKRGGRG+ GM T + Sbjct: 481 ERKTAISASEDMFEDEDLIPRQNVVITLTHHGYIKRLPISTYRSQKRGGRGIQGMGTNED 540 Query: 541 DFVEHLFVSNSHNYLMFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKISAVI 600 DFV+HLF +NSH+ ++FFT+KGKVYR+K YEIPELGRTA+G PIINL+QIEQ E IS +I Sbjct: 541 DFVQHLFTTNSHHTILFFTNKGKVYRLKGYEIPELGRTAKGIPIINLLQIEQDEYISTII 600 Query: 601 QVEDADSDKYLFFATREGIVKKTPLEDYNNIRKGGLIAINLREEDSLIEVKLTDGEQNLI 660 +E+ D YLFF T++GI K+T L + NIR+GGL AINLRE D L V+LT+G++ +I Sbjct: 601 PIEEFTEDHYLFFMTKDGIAKRTQLSSFANIRRGGLFAINLREGDELHGVRLTNGDKEVI 660 Query: 661 IGTARGMSITFSENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKELEVLIVTSKGYGKR 720 +GT +GM+I F E DVR MGR+ATGVKGI+L +DHV+GMD V+ +VLIVT KG+GKR Sbjct: 661 VGTRQGMAIRFHETDVRLMGRTATGVKGISLTGDDHVVGMDIVEDGQDVLIVTEKGFGKR 720 Query: 721 TPALDYRSQTRGGKGIKTINLTDKNGPVVGLKVVKKDEDLMIITTSGTLIRTSMDGISTM 780 TP DYR QTRGGKGIKT N+T+KNGP+V LKVV D DLMIIT SG +IR + IS Sbjct: 721 TPIADYRIQTRGGKGIKTCNITEKNGPLVSLKVVSVDHDLMIITASGIIIRLHVKDISVT 780 Query: 781 GRYAQGVKLINIREDDAVATLCR 803 GR QGV LI + E + VAT+ R Sbjct: 781 GRITQGVTLIRVAEGEEVATVAR 803 >BS_gyrA [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Length = 821 Score = 1126 bits (2913), Expect = 0.0, Method: Compositional matrix adjust. Identities = 537/804 (66%), Positives = 675/804 (83%), Gaps = 2/804 (0%) Query: 1 MAEQNNPQVKDRDIGEEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILFAMSELGMFA 60 M+EQN PQV++ +I +EMR SF+DYAMS+IVSRALPDVRDGLKPVHRRIL+AM++LGM + Sbjct: 1 MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTS 60 Query: 61 DKPHKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSMRYMLVDGHGNFGSIDGDMAAA 120 DKP+KKSARIVGEVIGKYHPHGDSAVYE+MVRMAQDF+ RYMLVDGHGNFGS+DGD AAA Sbjct: 61 DKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAA 120 Query: 121 MRYTEARLSKIAGEMLRDLNKETVDFAPNYDGEENEPVVLPARYPNLLVNGVSGIAVGMA 180 MRYTEAR+SKI+ E+LRD+ K+T+D+ NYDG E EPVV+P+R+PNLLVNG +GIAVGMA Sbjct: 121 MRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMA 180 Query: 181 TNIPPHNLGEVIDGVQAMIKNPDITPMELMEYIQGPDFPTAGYILGREGIRQAYRTGRGS 240 TNIPPH LGE+IDGV A+ +NPDIT ELME I GPDFPTAG ILGR GIR+AY +GRGS Sbjct: 181 TNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGS 240 Query: 241 VTMRAKADIEE-NNGKARIIVSELPYQVNKARLVEKIAELVREKRIEGITDLRDESDRNG 299 +T+RAKA+IE+ ++GK RIIV+ELPYQVNKA+L+EKIA+LVR+K+IEGITDLRDESDR G Sbjct: 241 ITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTG 300 Query: 300 MRVVVEMRRDVNPNVVLNNLYKHTSMQSTFGINMLAIVNNEPKILNLRDVLYHYLQHQIE 359 MR+V+E+RRD N NV+LNNLYK T++Q++FGIN+LA+V+ +PK+L L+ L HYL HQ Sbjct: 301 MRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALVDGQPKVLTLKQCLEHYLDHQKV 360 Query: 360 VIRRRTIFDLKKAEARAHILEGLRIALDHLDEVIALIRASRTTDIARDGLMSTFSLSVEQ 419 VIRRRT ++L+KAEARAHILEGLR+ALDHLD VI+LIR S+T +IAR GL+ FSL+ +Q Sbjct: 361 VIRRRTAYELRKAEARAHILEGLRVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQ 420 Query: 420 AQAILDMRMQRLTGLEREKIENEYNELLAKIAEYREILANEHLVLEIISNELQEIRDRYS 479 AQAILDMR+QRLTGLEREKIE EY L+ IAE ++ILANE+ VLEII EL EI++R++ Sbjct: 421 AQAILDMRLQRLTGLEREKIEEEYQSLVKLIAELKDILANEYKVLEIIREELTEIKERFN 480 Query: 480 DDRRTEI-TIGEESILDEDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDTK 538 D+RRTEI T G E+I DEDLI RE +V+T+TH GY+KRLP STYRSQKRGG+GV GM T Sbjct: 481 DERRTEIVTSGLETIEDEDLIERENIVVTLTHNGYVKRLPASTYRSQKRGGKGVQGMGTN 540 Query: 539 DQDFVEHLFVSNSHNYLMFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKISA 598 + DFVEHL +++H+ ++FF++KGKVYR K YEIPE GRTA+G PIINL+++E+GE I+A Sbjct: 541 EDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINA 600 Query: 599 VIQVEDADSDKYLFFATREGIVKKTPLEDYNNIRKGGLIAINLREEDSLIEVKLTDGEQN 658 +I V + +++ YLFF T+ G+ K+T L + NIR GLIA++LRE+D L+ V+LTDG + Sbjct: 601 IIPVTEFNAELYLFFTTKHGVSKRTSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQ 660 Query: 659 LIIGTARGMSITFSENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKELEVLIVTSKGYG 718 +IIGT G+ I F E DVR MGR+A GVKGITL D+D V+GM+ +++E VLIVT KGYG Sbjct: 661 IIIGTKNGLLIRFPETDVREMGRTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYG 720 Query: 719 KRTPALDYRSQTRGGKGIKTINLTDKNGPVVGLKVVKKDEDLMIITTSGTLIRTSMDGIS 778 KRTPA +YR+Q+RGGKG+KT +T+ NG +V +K K +EDLMIIT SG LIR ++ IS Sbjct: 721 KRTPAEEYRTQSRGGKGLKTAKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDIS 780 Query: 779 TMGRYAQGVKLINIREDDAVATLC 802 GR QGV+LI + E++ VAT+ Sbjct: 781 ITGRVTQGVRLIRMAEEEHVATVA 804 Score = 67.8 bits (164), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 97/198 (48%), Gaps = 11/198 (5%) Query: 509 THTGYIKRLPVSTYRSQKRGGRGVMGMDTKDQDFVEHLFVSNSHNYLMFFTDKGKVYRIK 568 T G KR +S + + + G ++ + ++ D + + +++ ++ T G + R Sbjct: 617 TKHGVSKRTSLSQFANIRNNG--LIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFP 674 Query: 569 AYEIPELGRTARGTPIINLIQIEQGEKISAVIQVEDADSDKYLFFATREGIVKKTPLEDY 628 ++ E+GRTA G I L + V+ +E + + ++ T +G K+TP E+Y Sbjct: 675 ETDVREMGRTAAGVKGITLTDDD------VVVGMEILEEESHVLIVTEKGYGKRTPAEEY 728 Query: 629 NNIRKGG--LIAINLREED-SLIEVKLTDGEQNLIIGTARGMSITFSENDVRSMGRSATG 685 +GG L + E + L+ VK T GE++L+I TA G+ I ND+ GR G Sbjct: 729 RTQSRGGKGLKTAKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQG 788 Query: 686 VKGITLDDNDHVIGMDCV 703 V+ I + + +HV + V Sbjct: 789 VRLIRMAEEEHVATVALV 806 >lin0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Length = 301 Score = 1053 bits (2722), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/808 (0%), Positives = 0/808 (0%), Gaps = 2/808 (0%) Query: 1 MAEQNNPQVKDRDIGEEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILFAMSELGMFA 60 M+ + +G + ++ + + Sbjct: 1 MSIDKSYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGAYQAIY 60 Query: 61 DKPHKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSMRYMLVDGHGNFGSIDGDMAAA 120 + + S++ + + + R+ D +G Sbjct: 61 VDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLREGKAPVI 120 Query: 121 MRYTEARLSKIAGEMLRDLNKETVDFAPNYDGEENEPVVLPARYPNLLVNGVSGIAVGMA 180 + + + ++L L + L +V A Sbjct: 121 LAVNKVDNVQEKADLLPHLQFLASQMNFLDIVPISAETGLNVDTIAAIVRKHLPEATHHF 180 Query: 181 TNIPPHNLGEVIDGVQAMIKNPDITPMELMEYIQGPDFPTAGYILGREGIRQAYRTGRGS 240 + + + + + + Y + Sbjct: 181 PEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVSNERGGYDINGLILVERE 240 Query: 241 VTMRAKADIEE-NNGKARIIVSELPYQVNKARLVEKIAELVREKRIEGITDLRDESDRNG 299 + + I + ++ +A + ++ V+ + LR + Sbjct: 241 GQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDD 300 Query: 300 MRVVVEMRRDVNPNVVLNNLYKHTSMQSTFGINMLAIVNNEPKILNLRDVLYHYLQHQIE 359 Sbjct: 301 360 Query: 360 VIRRRTIFDLKKAEARAHILEGLRIALDHLDEVIALIRASRTTDIARDGLMSTFSLSVEQ 419 Sbjct: 361 420 Query: 420 AQAILDMRMQRLTGLEREKIENEYNELLAKIAEYREILANEHLVLEIISNELQEIRDRYS 479 Sbjct: 421 480 Query: 480 DDRRTEITIGE-ESILDEDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDTK 538 Sbjct: 481 540 Query: 539 DQDFVEHLFVSNSHNYLMFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKISA 598 Sbjct: 541 600 Query: 599 VIQVEDADSDKYLFFATREGIVKKTPLEDYNNIRKGGLIAINLREEDSLIEVKLTDGEQN 658 Sbjct: 601 660 Query: 659 LIIGTARGMSITFSENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKELEVLIVTSKGYG 718 Sbjct: 661 720 Query: 719 KRTPALDYRSQTRGGKGIKTINLTDKNGPVVGLKVVKKDEDLMIITTSGTLIRTSMDGIS 778 Sbjct: 721 780 Query: 779 TMGRYAQGVKLINIREDDAVATLCRADK 806 Sbjct: 781 808 >SA0006 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Length = 889 Score = 1011 bits (2613), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/809 (59%), Positives = 642/809 (79%), Gaps = 6/809 (0%) Query: 1 MAEQNNPQVKDRDIGEEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILFAMSELGMFA 60 MAE ++ +R+I EMRESF+DYAMS+IV+RALPDVRDGLKPVHRRIL+ ++E GM Sbjct: 1 MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTP 60 Query: 61 DKPHKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSMRYMLVDGHGNFGSIDGDMAAA 120 DK +KKSARIVG+V+GKYHPHGDS++YE MVRMAQDFS RY LVDG GNFGS+DGD AAA Sbjct: 61 DKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAA 120 Query: 121 MRYTEARLSKIAGEMLRDLNKETVDFAPNYDGEENEPVVLPARYPNLLVNGVSGIAVGMA 180 MRYTEAR++KI E+LRD+NK+T+DF NYDG E EP VLPAR+PNLL NG SGIAVGMA Sbjct: 121 MRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGMA 180 Query: 181 TNIPPHNLGEVIDGVQAMIKNPDITPMELMEYIQGPDFPTAGYILGREGIRQAYRTGRGS 240 TNIPPHNL E+I+GV ++ KNPDI+ ELME I+GPDFPTAG ILG+ GIR+AY TGRGS Sbjct: 181 TNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAYETGRGS 240 Query: 241 VTMRAKADIEE-NNGKARIIVSELPYQVNKARLVEKIAELVREKRIEGITDLRDESD-RN 298 + MR++A IEE G+ RI+V+E+P+QVNKAR++EKIAELVR+K+I+GITDLRDE+ R Sbjct: 241 IQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRT 300 Query: 299 GMRVVVEMRRDVNPNVVLNNLYKHTSMQSTFGINMLAIVNNEPKILNLRDVLYHYLQHQI 358 G+RVV+++R+D N +V+LNNLYK T +Q++FG+NM+A+VN PK++NL++ L HYL+HQ Sbjct: 301 GVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQK 360 Query: 359 EVIRRRTIFDLKKAEARAHILEGLRIALDHLDEVIALIRASRTTDIARDGLMSTFSLSVE 418 V+RRRT ++L+KA+ RAHILEGLRIALDH+DE+I+ IR S T +A + L F LS + Sbjct: 361 TVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEK 420 Query: 419 QAQAILDMRMQRLTGLEREKIENEYNELLAKIAEYREILANEHLVLEIISNELQEIRDRY 478 QAQAILDMR++RLTGLER+KIE EYNELL I+E ILA+E ++L+++ +EL EIRDR+ Sbjct: 421 QAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDELTEIRDRF 480 Query: 479 SDDRRTEITIGE-ESILDEDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDT 537 DDRRTEI +G E + DEDLIP E++VIT++H YIKRLPVSTYR+Q RGGRGV GM+T Sbjct: 481 GDDRRTEIQLGGFEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRGVQGMNT 540 Query: 538 KDQDFVEHLFVSNSHNYLMFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKIS 597 ++DFV L ++H++++FFT+KG+VY++K YE+PEL R ++G P++N I++E E IS Sbjct: 541 LEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELENDEVIS 600 Query: 598 AVIQVEDADS-DKYLFFATREGIVKKTPLEDYNNIRKGGLIAINLREEDSLIEVKLTDGE 656 +I V+D +S D +L FAT+ G+VK++ L +++ I + G IAI+ RE+D LI V+LT G+ Sbjct: 601 TMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAVRLTSGQ 660 Query: 657 QNLIIGTARGMSITFSENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKEL--EVLIVTS 714 ++++IGT+ I F E+ +R +GR+ATGVKGITL + D V+G+D EVL+VT Sbjct: 661 EDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDEVLVVTE 720 Query: 715 KGYGKRTPALDYRSQTRGGKGIKTINLTDKNGPVVGLKVVKKDEDLMIITTSGTLIRTSM 774 GYGKRTP DYR RGGKGIKT +T++NG VV + V +EDLMI+T +G +IR + Sbjct: 721 NGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLDV 780 Query: 775 DGISTMGRYAQGVKLINIREDDAVATLCR 803 IS GR AQGV+LI + +D V+T+ + Sbjct: 781 ADISQNGRAAQGVRLIRLGDDQFVSTVAK 809 Score = 58.9 bits (141), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 100/216 (46%), Gaps = 9/216 (4%) Query: 496 EDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDTKDQDFVEHLFVSNSHNYL 555 +DL + ++ T G +KR +S + R G+ + + ++ D + + +++ + Sbjct: 606 KDLESEDNFLVFATKRGVVKRSALSNFSRINRNGK--IAISFREDDELIAVRLTSGQEDI 663 Query: 556 MFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKISAVIQVEDADSDKYLFFAT 615 + T + R + LGRTA G + I + +G+++ + V A+S + T Sbjct: 664 LIGTSHASLIRFPESTLRPLGRTATG---VKGITLREGDEVVG-LDVAHANSVDEVLVVT 719 Query: 616 REGIVKKTPLEDYNNIRKGGL---IAINLREEDSLIEVKLTDGEQNLIIGTARGMSITFS 672 G K+TP+ DY +GG A +++ + GE++L+I T G+ I Sbjct: 720 ENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLD 779 Query: 673 ENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKELE 708 D+ GR+A GV+ I L D+ V + V ++ E Sbjct: 780 VADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAE 815 >CAC0007 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Length = 830 Score = 1009 bits (2610), Expect = 0.0, Method: Compositional matrix adjust. Identities = 477/803 (59%), Positives = 642/803 (79%), Gaps = 1/803 (0%) Query: 5 NNPQVKDRDIGEEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILFAMSELGMFADKPH 64 N +V DI EM++ ++DYAMS+IVSRALPDVRDGLKPVHRRIL++M ELG+ +K + Sbjct: 3 NEGKVLPVDISSEMKKCYIDYAMSVIVSRALPDVRDGLKPVHRRILYSMHELGLTPEKGY 62 Query: 65 KKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSMRYMLVDGHGNFGSIDGDMAAAMRYT 124 +K ARIVG+V+GKYHPHGDS+VY +VR+AQDF++RY +VDGHGNFGS+DGD AAAMRYT Sbjct: 63 RKCARIVGDVLGKYHPHGDSSVYGALVRLAQDFNLRYTVVDGHGNFGSVDGDSAAAMRYT 122 Query: 125 EARLSKIAGEMLRDLNKETVDFAPNYDGEENEPVVLPARYPNLLVNGVSGIAVGMATNIP 184 EA+++KIA EM+RD+ K TVDF PN+DGEE EPVVLP+R+PNLLVNG +GIAVGMATNIP Sbjct: 123 EAKMNKIALEMVRDIGKNTVDFIPNFDGEEKEPVVLPSRFPNLLVNGSAGIAVGMATNIP 182 Query: 185 PHNLGEVIDGVQAMIKNPDITPMELMEYIQGPDFPTAGYILGREGIRQAYRTGRGSVTMR 244 PHNLGEVIDG+ +I NP+ T +ELM I+GPDFPTAG I+G+ GIR AY TGRG +T+R Sbjct: 183 PHNLGEVIDGITMLIDNPEATILELMAQIKGPDFPTAGIIMGKSGIRAAYETGRGKITVR 242 Query: 245 AKADIE-ENNGKARIIVSELPYQVNKARLVEKIAELVREKRIEGITDLRDESDRNGMRVV 303 AK++IE E+NGK +II++E+PYQVNKARLVE IA+LV++KRI GI+DLRDESDR+GMR+V Sbjct: 243 AKSEIEVEDNGKQKIIITEIPYQVNKARLVESIADLVKDKRIVGISDLRDESDRDGMRIV 302 Query: 304 VEMRRDVNPNVVLNNLYKHTSMQSTFGINMLAIVNNEPKILNLRDVLYHYLQHQIEVIRR 363 +E+++D N N++LN LYKHT +Q TFGINMLA+V+N P++LNL+ +L HY++ Q +VIRR Sbjct: 303 IEIKKDANSNIILNQLYKHTRLQDTFGINMLALVDNRPEVLNLKQILQHYIKFQEQVIRR 362 Query: 364 RTIFDLKKAEARAHILEGLRIALDHLDEVIALIRASRTTDIARDGLMSTFSLSVEQAQAI 423 RT FDL+KA ARAHILEGL+IALDH+DEVI+LIR S+T A+ GLM F LS +QAQAI Sbjct: 363 RTEFDLEKASARAHILEGLKIALDHIDEVISLIRGSKTAQEAKLGLMDKFGLSEKQAQAI 422 Query: 424 LDMRMQRLTGLEREKIENEYNELLAKIAEYREILANEHLVLEIISNELQEIRDRYSDDRR 483 LD+++QRLTGLEREKIE+EYNEL+ IAE + ILA+E+ +L II +EL EI+ +Y D+R+ Sbjct: 423 LDLKLQRLTGLEREKIEDEYNELMKTIAELKSILADENKILAIIRDELNEIKAKYGDERK 482 Query: 484 TEITIGEESILDEDLIPREEVVITITHTGYIKRLPVSTYRSQKRGGRGVMGMDTKDQDFV 543 T I E I EDLI E VVIT+TH GYIKR+ TY SQKRGGRG+ M TK+ DFV Sbjct: 483 TAIERAENDIDIEDLIQEENVVITLTHAGYIKRINADTYTSQKRGGRGIQAMTTKEDDFV 542 Query: 544 EHLFVSNSHNYLMFFTDKGKVYRIKAYEIPELGRTARGTPIINLIQIEQGEKISAVIQVE 603 E++F++++HN ++FFT+KG++Y++KAY+IPE GR A+GT ++NL+Q++ EKI AVI ++ Sbjct: 543 ENIFITSTHNNILFFTNKGRMYKLKAYQIPEAGRAAKGTNVVNLLQLDPNEKIQAVISIK 602 Query: 604 DADSDKYLFFATREGIVKKTPLEDYNNIRKGGLIAINLREEDSLIEVKLTDGEQNLIIGT 663 + D + +L T++GI+KKT + Y NIRK GLIAINL ++D L+ V++T G+ ++II T Sbjct: 603 EFDEESFLVMCTKKGIIKKTVVGMYKNIRKSGLIAINLNDDDELVSVRITKGDDDIIIVT 662 Query: 664 ARGMSITFSENDVRSMGRSATGVKGITLDDNDHVIGMDCVDKELEVLIVTSKGYGKRTPA 723 +G++I F+E DVR +GR+A GVKGITL ++D V+GM+ ++E +VL+V+ G+GKRT Sbjct: 663 NKGLAIRFNEVDVRPLGRNALGVKGITLKEDDFVVGMEVPNQESDVLVVSENGFGKRTHV 722 Query: 724 LDYRSQTRGGKGIKTINLTDKNGPVVGLKVVKKDEDLMIITTSGTLIRTSMDGISTMGRY 783 +Y+ Q RGGKG+ T ++DK G +VG+++V+ ++LM+I G IR ++ IST R Sbjct: 723 GEYKCQHRGGKGLITYKVSDKTGKLVGVRMVEDGDELMLINNLGIAIRINVSDISTTSRN 782 Query: 784 AQGVKLINIREDDAVATLCRADK 806 A GV L+ D+ V L + +K Sbjct: 783 AMGVTLMRNNGDEKVLALAKINK 805 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.136 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 60,616,409 Number of extensions: 2626892 Number of successful extensions: 7380 Number of sequences better than 1.0e-05: 79 Number of HSP's gapped: 6780 Number of HSP's successfully gapped: 143 Length of query: 848 Length of database: 38,378,431 Length adjustment: 115 Effective length of query: 733 Effective length of database: 25,115,021 Effective search space: 18409310393 Effective search space used: 18409310393 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 120 (50.8 bits)