BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0001.p (366 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0008 [T] COG2206 HD-GYP domain 205 1e-52 BH3794 [T] COG2206 HD-GYP domain 161 1e-39 CAC2620 [T] COG2206 HD-GYP domain 148 1e-35 CAC0277 [T] COG2206 HD-GYP domain 126 6e-29 TP0912 [T] COG2206 HD-GYP domain 116 6e-26 >BH0008 [T] COG2206 HD-GYP domain Length = 360 Score = 205 bits (521), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 125/374 (33%), Positives = 196/374 (52%), Gaps = 30/374 (8%) Query: 4 ISVGEVKPGTKIIKDVVTPLGGVLFTKGKIILPRDIEILQAFLIQHIEIEGAQEENKAPE 63 + + ++ PG ++K ++ L+ + ++ DI+ L FLI IE+E N Sbjct: 3 VKLNQLVPGCIVLKPIMAETTTPLYKEKTVLTAEDIQTLSKFLIDEIEVE-----NVLAN 57 Query: 64 TAKAVTKPAASKPGALINESQLAKSNSPLHDEYEKMLALIKKSYXXXXXXQ--------- 114 K + P+ + GA + L ++ D Y + +A KK + Sbjct: 58 GEKFI--PSDNGLGA--EAAALMETGDRFKDRYMQAVANYKKVFQEWAAGTPVEMECVRH 113 Query: 115 --LPILELRSQLEALISHLKDYHILKFAPRVLFDQDYNYHNAVLSALTSYKIAQWCGYPQ 172 LP+ E + + ++ L Y +DY YH+AV L S + GY + Sbjct: 114 ILLPLFEEIVEKKDVLLQLHHYST---------KEDYLYHHAVSVGLLSAFLGAKLGYEK 164 Query: 173 KDWMQTAFAGLLHDIGNVKVDSSLLQKPTPLTADEIEEVRRHTTYGYQLLRNVTAINEGV 232 +W++ A AG L D G K+ +SLL K T E E+R H Y YQ+L+ I+ + Sbjct: 165 GEWLKIALAGALADCGMAKLPTSLLTKNGLYTLKEKHEMRDHPKYSYQMLKKRPEIDGSL 224 Query: 233 RLAALQHHEKIDGSGYPLRLEGSQIHFYAKIVAVADIFHAMTLEKAYRKAQSPYLVLEQL 292 A LQHHE+ DG+GYPL + G +IHFYA+I+AVAD++HAM E+ YRK +SPY+VLE L Sbjct: 225 LSAVLQHHEREDGTGYPLGVRGQKIHFYAQILAVADVYHAMISERKYRKKKSPYMVLEDL 284 Query: 293 QAESFGKLDPVIVQTFIQKTTDFYNGTRIRLSDGRHGEIIFTDRSNPTRPMVKVE-GTIV 351 E FGK +P IV + + T T +RL++ R GEI+F D PTRPMV+++ G ++ Sbjct: 285 AKERFGKFNPRIVHVLVSQLTQLSVRTSVRLTNNRLGEIVFIDPMAPTRPMVQLQTGEMI 344 Query: 352 NLMLERELYIQEII 365 LM ++I++++ Sbjct: 345 YLMKNYTVHIEDVL 358 >BH3794 [T] COG2206 HD-GYP domain Length = 231 Score = 161 bits (408), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 83/218 (38%), Positives = 130/218 (59%), Gaps = 1/218 (0%) Query: 148 DYNYHNAVLSALTSYKIAQWCGYPQKDWMQTAFAGLLHDIGNVKVDSSLLQKPTPLTADE 207 DY Y + V ++ S I W + + +LHDIG V++ ++L KP LT DE Sbjct: 9 DYTYRHTVGVSILSRLIGTWLKLDEVILKELTLGAVLHDIGKVEIPDAILNKPGALTKDE 68 Query: 208 IEEVRRHTTYGYQLLRNVTAINEGVRLAALQHHEKIDGSGYPLRLEGSQIHFYAKIVAVA 267 ++ HT GY++++ ++ V L AL+HHE+ DG+GYP + ++IH +KI+AVA Sbjct: 69 YRIIQDHTVKGYRIIQESGIYSDTVALMALEHHEREDGTGYPYQKTRNEIHLLSKILAVA 128 Query: 268 DIFHAMTLEKAYRKAQSPYLVLEQLQAESFGKLDPVIVQTFIQKTTDFYNGTRIRLSDGR 327 D+FHAMT ++ YRK + Y VL Q++ + FGKL+P I F+++ + G++ RL+DG Sbjct: 129 DVFHAMTSDRIYRKGMALYDVLLQMRQDRFGKLEPRITDFFVRRFMEQCIGSKARLNDGS 188 Query: 328 HGEIIFTDRSNPTRPMVKVEGTIVNLMLERELYIQEII 365 EI+F NP P+VK ++L + LYIQE+I Sbjct: 189 RVEIVFIPYENPICPIVKQGTNYIDLRMS-PLYIQELI 225 >CAC2620 [T] COG2206 HD-GYP domain Length = 345 Score = 148 bits (374), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 74/216 (34%), Positives = 123/216 (56%), Gaps = 4/216 (1%) Query: 151 YHNAVLSALTSYKIAQWCGYPQKDWMQTAFAGLLHDIGNVKVDSSLLQKPTPLTADEIEE 210 Y ++V A S+ + +W G +++ +A LLHD G ++D+S+L+K + LT +E Sbjct: 134 YRHSVNVAAISFILGKWLGMNEEEINLLTYASLLHDFGKTQLDNSILKKESSLTPEEYAV 193 Query: 211 VRRHTTYGYQLLRNVTAINEGVRLAALQHHEKIDGSGYPLRLEGSQIHFYAKIVAVADIF 270 + H Y L++ + IN V L L HHE+IDGSGYPL ++ ++IH +AKI+A+ADIF Sbjct: 194 YKTHPVIAYHLIKEIPDINASVGLGVLMHHEQIDGSGYPLGIKDNKIHKFAKIIAIADIF 253 Query: 271 HAMTLEKAYRKAQSPYLVLEQLQAESFGKLDPVIVQTFIQKTTDFYNGTRIRLSDGRHGE 330 + + P+ L+ ++ S GKLD FI ++Y G + LSD R + Sbjct: 254 DKVNSD----NTNGPFEGLKAIKDLSLGKLDCSYSNMFINHAVNYYMGESVTLSDNRSCK 309 Query: 331 IIFTDRSNPTRPMVKVEGTIVNLMLERELYIQEIIA 366 II D N T+P++ + ++L E++LY++ +I Sbjct: 310 IIKLDTENLTKPLLLADDGFLDLKSEKDLYVKSLIV 345 >CAC0277 [T] COG2206 HD-GYP domain Length = 372 Score = 126 bits (316), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 69/202 (34%), Positives = 108/202 (53%), Gaps = 1/202 (0%) Query: 145 FDQDYNYHNAVLSALTSYKIAQWCGYPQKDWMQTAFAGLLHDIGNVKVDSSLLQKPTPLT 204 FD DY Y ++V A+ S I + + + LLHD+G + + S +L K LT Sbjct: 136 FD-DYTYQHSVNVAVISLIIGIKLKFHKYELFDLCIGALLHDVGKMFIPSEILNKKGELT 194 Query: 205 ADEIEEVRRHTTYGYQLLRNVTAINEGVRLAALQHHEKIDGSGYPLRLEGSQIHFYAKIV 264 +E + ++ HT GY L+ + I+ R+ +LQHHE+ G GYP G +I ++IV Sbjct: 195 EEEFKIMKEHTVRGYDYLKGLYEISVPARIISLQHHERAGGQGYPEGRSGERISILSRIV 254 Query: 265 AVADIFHAMTLEKAYRKAQSPYLVLEQLQAESFGKLDPVIVQTFIQKTTDFYNGTRIRLS 324 AVAD++ AMT ++ YR+A +P LE + A S K D +VQ F + + G+ +RLS Sbjct: 255 AVADVYDAMTSDRVYRRAIAPNEALEYIMANSGSKFDYKVVQAFSKSVIPYPEGSIVRLS 314 Query: 325 DGRHGEIIFTDRSNPTRPMVKV 346 + G + P RP +K+ Sbjct: 315 NNEIGVVTKIHEDFPLRPEIKI 336 >TP0912 [T] COG2206 HD-GYP domain Length = 440 Score = 116 bits (290), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 66/193 (34%), Positives = 103/193 (53%) Query: 154 AVLSALTSYKIAQWCGYPQKDWMQTAFAGLLHDIGNVKVDSSLLQKPTPLTADEIEEVRR 213 AV +A+ S +AQ G+ +KD A LLHDIG V + +L+K L E + V Sbjct: 208 AVDTAIFSIIVAQHLGFSEKDIFDLVVASLLHDIGMQHVPADILKKSGRLHFQEQQAVDA 267 Query: 214 HTTYGYQLLRNVTAINEGVRLAALQHHEKIDGSGYPLRLEGSQIHFYAKIVAVADIFHAM 273 HT Y + + N V L+ LQHHE +G GYP L G++I A+I+AV D F AM Sbjct: 268 HTIYAHSYIVNTLKYPNSVGLSVLQHHEHWNGKGYPQSLSGNKITIGARILAVTDNFAAM 327 Query: 274 TLEKAYRKAQSPYLVLEQLQAESFGKLDPVIVQTFIQKTTDFYNGTRIRLSDGRHGEIIF 333 K+YRK S Y ++ L A++ + DP +++ IQ + G+ + L++ ++ Sbjct: 328 LAPKSYRKPFSGYQAMKSLLADNARRFDPDVIKAMIQSVGIYPIGSLVLLNNSAVARVVK 387 Query: 334 TDRSNPTRPMVKV 346 T + P RP +++ Sbjct: 388 TTATAPLRPCLRI 400 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.136 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 26,635,138 Number of extensions: 1081010 Number of successful extensions: 1840 Number of sequences better than 1.0e-05: 41 Number of HSP's gapped: 1813 Number of HSP's successfully gapped: 41 Length of query: 366 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 258 Effective length of database: 25,922,359 Effective search space: 6687968622 Effective search space used: 6687968622 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 116 (49.3 bits)