BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4651.p (228 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4047 [H] COG0807 GTP cyclohydrolase II Pae Pseudomonas aeruginosa 272 4e-73 NMA1425 [H] COG0807 GTP cyclohydrolase II NmA Neisseria meningit... 243 3e-64 NMB1254 [H] COG0807 GTP cyclohydrolase II Nme Neisseria meningit... 240 2e-63 YPO2222 [H] COG0807 GTP cyclohydrolase II Ype Yersinia pestis 232 5e-61 ribA [H] COG0807 GTP cyclohydrolase II Eco Escherichia coli K12 232 5e-61 >PA4047 [H] COG0807 GTP cyclohydrolase II Pae Pseudomonas aeruginosa Length = 205 Score = 272 bits (696), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 134/195 (68%), Positives = 153/195 (78%) Query: 16 LVFVSSCKLPMPWATFELHAFYDEVSGKEHLALTLGEVGNGEPVLGRVHSECLTGDALFS 75 +VFV++ KLP P+ F +H F DE SGKEH+AL++G++ +G PVLGR+HSECLTGDALFS Sbjct: 3 VVFVAASKLPTPFGEFTMHGFLDEESGKEHVALSMGDIADGAPVLGRLHSECLTGDALFS 62 Query: 76 QRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERLG 135 RCDCG QLE AL IA+EGRGVL YLRQEGRGIGLLNKIRAY LQD GADTVEAN +LG Sbjct: 63 LRCDCGFQLEGALAAIAEEGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANLQLG 122 Query: 136 FPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIGY 195 F AD R Y + PMLAHL ++SLRLMTNNPRKVKALE ITVAER+ L N N Y Sbjct: 123 FGADQRDYAMCQPMLAHLGVSSLRLMTNNPRKVKALESYAITVAERVPLQKGLNKHNRRY 182 Query: 196 LGTKARKLGHLLPGL 210 L TKA KLGH+L L Sbjct: 183 LATKAGKLGHMLGSL 197 >NMA1425 [H] COG0807 GTP cyclohydrolase II NmA Neisseria meningitidis Z2491 Length = 197 Score = 243 bits (619), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 114/194 (58%), Positives = 144/194 (74%), Gaps = 1/194 (0%) Query: 14 EKLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALTLGEVGNGEPVLGRVHSECLTGDAL 73 E L +V+SC+LP W F +H F +E G+EH+ALT+G+ +G PVL R+HSECLTGDAL Sbjct: 3 ELLNYVASCRLPTEWGVFTMHGF-EEAGGQEHVALTVGDCSDGNPVLTRIHSECLTGDAL 61 Query: 74 FSQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANER 133 FS++CDCG QLEAA+K + EGRG++ YLRQEGRGIGL+NKIRAYHLQDQG DTVEAN Sbjct: 62 FSKKCDCGPQLEAAMKAVQAEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANVA 121 Query: 134 LGFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNI 193 LG P D R + + + +L I S++L+TNNP K++ L+D+GI V ERI L N N Sbjct: 122 LGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENK 181 Query: 194 GYLGTKARKLGHLL 207 YL TKA KLGHL+ Sbjct: 182 RYLQTKADKLGHLM 195 >NMB1254 [H] COG0807 GTP cyclohydrolase II Nme Neisseria meningitidis MC58 Length = 197 Score = 240 bits (612), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 113/194 (58%), Positives = 143/194 (73%), Gaps = 1/194 (0%) Query: 14 EKLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALTLGEVGNGEPVLGRVHSECLTGDAL 73 E L V+SC+LP W F +H F +E +G+EH+ALT+G +G PVL R+HSECLTGDAL Sbjct: 3 EMLNHVASCRLPTEWGVFTMHGF-EEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDAL 61 Query: 74 FSQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANER 133 FS++CDCG QLEAA++ + EGRG++ YLRQEGRGIGL+NKIRAYHLQDQG DTVEAN Sbjct: 62 FSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLA 121 Query: 134 LGFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNI 193 LG P D R + + + +L I S++L+TNNP K++ L+D+GI V ERI L N N Sbjct: 122 LGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENK 181 Query: 194 GYLGTKARKLGHLL 207 YL TKA KLGHL+ Sbjct: 182 RYLQTKADKLGHLM 195 >YPO2222 [H] COG0807 GTP cyclohydrolase II Ype Yersinia pestis Length = 196 Score = 232 bits (591), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 114/189 (60%), Positives = 136/189 (71%) Query: 19 VSSCKLPMPWATFELHAFYDEVSGKEHLALTLGEVGNGEPVLGRVHSECLTGDALFSQRC 78 V+ KLP PW F + F + +G +HLAL G++ +PVL RVHSECLTGDALFS RC Sbjct: 6 VAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRC 65 Query: 79 DCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERLGFPA 138 DCG QLE AL +IA+EGRGVL Y RQEGR IGLLNKIRAY LQD GADTVEAN +LGF A Sbjct: 66 DCGFQLEVALTRIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAA 125 Query: 139 DMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIGYLGT 198 D R +T+ M L I ++RL+TNNP+KV+ L +GI + ER+ LI NP N YL T Sbjct: 126 DERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQAGINIVERVPLIVGENPKNEHYLAT 185 Query: 199 KARKLGHLL 207 KA K+GHLL Sbjct: 186 KAAKMGHLL 194 >ribA [H] COG0807 GTP cyclohydrolase II Eco Escherichia coli K12 Length = 196 Score = 232 bits (591), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 113/193 (58%), Positives = 138/193 (71%) Query: 15 KLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALTLGEVGNGEPVLGRVHSECLTGDALF 74 +L V+ KLP PW F + F + +G +H+AL G++ PVL RVHSECLTGDALF Sbjct: 2 QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61 Query: 75 SQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERL 134 S RCDCG QLEAAL +IA+EGRG+L Y RQEGR IGLLNKIRAY LQDQG DTVEAN +L Sbjct: 62 SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121 Query: 135 GFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIG 194 GF AD R +T+ M L + +RL+TNNP+KV+ L ++GI + ER+ LI NP N Sbjct: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181 Query: 195 YLGTKARKLGHLL 207 YL TKA K+GHLL Sbjct: 182 YLDTKAEKMGHLL 194