BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4639.p (309 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1953 [GER] COG0697 Permeases of the drug/metabolite transport... 189 5e-48 BH0390 [GER] COG0697 Permeases of the drug/metabolite transporte... 152 1e-36 BS_yetK [GER] COG0697 Permeases of the drug/metabolite transport... 124 4e-28 RSp0685 [GER] COG0697 Permeases of the drug/metabolite transport... 95 2e-19 SMc00428 [GER] COG0697 Permeases of the drug/metabolite transpor... 84 3e-16 >RSc1953 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 336 Score = 189 bits (481), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 125/292 (42%), Positives = 178/292 (60%), Gaps = 5/292 (1%) Query: 14 LILSMSLVGAYVALTKPLAAMLPVFLLAWLRFAIGAVAMLRWMKKPAAEQALSTQSRWL- 72 LI +M+LVG+ V K + A++PV L A LRF I M W + + T+ W Sbjct: 25 LIAAMALVGSNVGFGKSIVAVMPVMLFALLRFVIAVACMAPWYRPSRMRRV--TRGEWTN 82 Query: 73 VFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKERISLRVWGAVA 132 +FL++ G F FTL M+ GV +T+A++AG+I S+IPA VA++SW+ L+E+ S R +V Sbjct: 83 LFLQALFGTFGFTLLMLNGVRLTSALAAGIITSTIPATVALLSWLVLREKPSGRTLVSVT 142 Query: 133 CGAIGIGLLSLAKDTHGAAGSSGAAPAQYAWLGNVLVFCAVLCEAAYAVIGKKLTAVLTP 192 G+ LL+ D G + A A A LGN LV AVLCE+ Y V+ ++LT L Sbjct: 143 LAVAGVALLN--ADRGGEFAGAAPADAARALLGNALVMGAVLCESVYVVLSRRLTQTLPA 200 Query: 193 KRISAVINLWGLLLMTPMGLYTALKFDFSTVPLNIWLLLVFYGLAASVWTVWLWMTGLKV 252 I A +L G LLM P+GL L FD S+VP +IW L+V+Y L+AS+++ WLWM G++ Sbjct: 201 IEICAYTHLIGALLMLPLGLAPLLTFDLSSVPPHIWGLVVWYALSASLFSFWLWMKGIRH 260 Query: 253 VPAARAGVFTVMLPVSAAVVGVLALGERLSALQAGAFAVALAGMFLATLPGR 304 VPA AGVFT +LP++AA G++ALGE A A +AG+ +A+ P R Sbjct: 261 VPAHLAGVFTSVLPIAAAAYGIIALGEAPGWAHGAALACVVAGILVASWPAR 312 >BH0390 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 311 Score = 152 bits (383), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 96/300 (32%), Positives = 166/300 (55%), Gaps = 14/300 (4%) Query: 14 LILSMSLVGAYVALTKPLAAMLPVFLLAWLRFAIGAVAMLRWMKKPAAEQALSTQSRWLV 73 ++ +M +VG+ V K L PVFL + LRF I A+ ++ + K S + ++ Sbjct: 11 IMFAMVIVGSSVVAGKMLVESFPVFLASELRFLIAALILVPMLLKKEGIPTFSKKEVGIL 70 Query: 74 FLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKERIS-LRVWGAV- 131 FL++ G FLF++ M+ G+ T A+ G+IMS++PAVVA+M+++ LKE+++ L + G + Sbjct: 71 FLQALSGVFLFSIFMLYGLMYTTAMEGGIIMSTLPAVVALMAFITLKEKLTRLTIIGILL 130 Query: 132 ACGAIGIGLLSLAKDTHGAAGS--SGAAPAQYAWLGNVLVFCAVLCEAAYAVIGKKLTAV 189 A G +LA +T G G AP LGN+L+ AV+ EA + + GK ++ Sbjct: 131 AVGG------TLAINTSGTLSDVERGVAP----LLGNLLIIGAVISEALFIIFGKSISQR 180 Query: 190 LTPKRISAVINLWGLLLMTPMGLYTALKFDFSTVPLNIWLLLVFYGLAASVWTVWLWMTG 249 ++P IS +++++G++L P +Y A +F + V LN WL++ ++G+ +V L G Sbjct: 181 VSPLAISTMVSVFGVVLFLPFAIYEATRFPLTDVSLNDWLIIFYFGVVVTVIAFVLMYQG 240 Query: 250 LKVVPAARAGVFTVMLPVSAAVVGVLALGERLSALQAGAFAVALAGMFLATLPGRAATDN 309 ++ VPA+ GV T +LP+SA ++ L L E S + LA + L ++ Sbjct: 241 IEKVPASTVGVLTGVLPISAVLLSALILKESFSTFHVAGMGLVLAAILLISIDSNVEKKE 300 >BS_yetK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 330 Score = 124 bits (310), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 89/300 (29%), Positives = 161/300 (53%), Gaps = 18/300 (6%) Query: 11 YGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFAIGAVAMLRWMKKPAAEQ---ALST 67 Y L +M++VG+ V + K + +PVFL + LRF I +V +L + E+ AL+ Sbjct: 30 YVSLAAAMAIVGSSVVVGKLMVERIPVFLSSGLRFLIASVVLLMLLF--CIEKGFPALTK 87 Query: 68 QSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKERISLRV 127 + +++ ++SF G FLF++C++ GV T +G++ S+ P ++ ++S+ L+E+I + Sbjct: 88 KDVFVLLVQSFTGVFLFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKT 147 Query: 128 WGAV---ACGAIGIGLLSLAKDTHGAAGSSGAAPAQYAWLGNVLVFCAVLCEAAYAVIGK 184 + CG + I L AGS P +A GN+L+ AV+ EA + ++ K Sbjct: 148 LIGILLAVCGVMAINLF--------GAGSQDGTP--HALFGNMLIIAAVIGEALFTLMAK 197 Query: 185 KLTAVLTPKRISAVINLWGLLLMTPMGLYTALKFDFSTVPLNIWLLLVFYGLAASVWTVW 244 L+ ++ IS ++L+G L P L+ A FD+S + W +++Y L +V + Sbjct: 198 LLSPHISALAISTFVSLFGFLFFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFY 257 Query: 245 LWMTGLKVVPAARAGVFTVMLPVSAAVVGVLALGERLSALQAGAFAVALAGMFLATLPGR 304 LW +G+ VPA +G+FT +LPVSA ++ + L E + A + G+F+ + + Sbjct: 258 LWYSGVTKVPAGVSGIFTSVLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKK 317 >RSp0685 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 300 Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 96/296 (32%), Positives = 153/296 (51%), Gaps = 27/296 (9%) Query: 6 SRPLGYGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFAIG-----AVAMLRWMKKPA 60 +R +GY L L+M VG+ V +K +A LP F LRFA+ A+ +LR + P Sbjct: 3 NRTIGYLLLSLAMMTVGSTVIASKLIAGNLPPFPATALRFAVALPFLFALVLLRGQRWPR 62 Query: 61 AEQALSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLK 120 LS ++ L+ L++ G+ +T +I+G++ A AGV++ ++PAV A+ S + L Sbjct: 63 ----LSGRAWGLLVLQAGAGSVGYTTLLISGLAHLPAADAGVVIGTLPAVSALFSVIVLG 118 Query: 121 ERISLRVWGAVACGAIGIGLLSLAKDTHGAAGSSGAAPAQYAWLGNVLVFCAVLCEAAYA 180 ER LR+ +V IG+ +A G SG+AP G + + AV+CE+A+ Sbjct: 119 ERPKLRLMVSVLLATIGV----MAVAWTG----SGSAPLT----GVLFILGAVVCESAFI 166 Query: 181 VIGKKLTAVLTPKRISAVINLWGLLLMTPMGLYTALKFDFSTVPLNIWL-LLVFYGLAAS 239 ++ K++ L P + + GLL+ P + L+F +TVP + +V+Y L + Sbjct: 167 LLNKRMPVPLPPLLQATAMTALGLLVSLP---FAVLEFP-ATVPSTAAIAAVVWYALVPT 222 Query: 240 VWTVWLWMTGLKVVPAARAGVFTVMLPVSAAVVGVLALGERLSALQA-GAFAVALA 294 V LW G V + A FT + P++A + L L ER+ A QA G AV LA Sbjct: 223 VGGFLLWYAGAARVSGSEAATFTAVAPLTAVALAALFLNERIGATQAFGVVAVILA 278 >SMc00428 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 298 Score = 84.3 bits (207), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 85/277 (30%), Positives = 135/277 (48%), Gaps = 13/277 (4%) Query: 10 GYGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFAIGAVAMLRWMKKPAAEQALSTQS 69 GY L L+M LVG+ V +K +AA LP F LRFAI L M+ A +S Sbjct: 7 GYVFLSLAMVLVGSTVIASKIIAAGLPPFTATALRFAIAFPLFLGLMRATGASWPKLPKS 66 Query: 70 RWLVFL-ESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKERISLRVW 128 WLV L ++ G+ +T +I+G+ +T+A AGVI+ ++P V A ++ + L ER V Sbjct: 67 DWLVLLFQAGAGSVGYTTLLISGLKLTSAADAGVIIGTLPVVSAAIAIMVLGERPHRSVL 126 Query: 129 GAVACGAIGIGLLSLAKDTHGAAGSSGAAPAQYAWLGNVLVFCAVLCEAAYAVIGKKLTA 188 A A G+ + D + A ++ G+ L+F AV+CE + ++ K+++ Sbjct: 127 AAACLAAAGVLAIVFRPDAN----------AAHSLAGSALIFGAVICEGLFILLNKRVSV 176 Query: 189 VLTPKRISAVINLWGLLLMTPMGLYTALKFDFSTVPLNIWLLLVFYGLAASVWTVWLWMT 248 + P +SA++ +G + P L + VP + +V LW Sbjct: 177 AIPPLGLSALMTGFGGAIALPFALAELPSMGATGVPALAAVAYYAL--VPTVGGFVLWYA 234 Query: 249 GLKVVPAARAGVFTVMLPVSAAVVGVLALGERLSALQ 285 GL+ V A VFT + PVSA ++ LGE ++A Q Sbjct: 235 GLQKVSGTEASVFTALAPVSALLLAAAVLGETITANQ 271