BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4622.p (495 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yer... 204 3e-52 ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Esche... 204 5e-52 ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 204 5e-52 yfhK [T] COG0642 Signal transduction histidine kinase Eco Escher... 203 7e-52 STM2564 [T] COG0642 Signal transduction histidine kinase Sty Sal... 199 1e-50 >YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 483 Score = 204 bits (520), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 159/469 (33%), Positives = 241/469 (51%), Gaps = 13/469 (2%) Query: 28 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSSNSRETARQAVQLTESAQRLAERTVAME 87 S RQL+L AFLL+ L + A +LD +S+ + + R + ++ + + ME Sbjct: 18 SLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEME 77 Query: 88 RSARQYLVLDDPAFHARFNEAREQARQALGELSDSLPMAPRELFSQWSLYG--DEAASVL 145 RS RQY VLDD + R+Q Q L + P+ P + Q +L G ++ + Sbjct: 78 RSYRQYCVLDDATLATLYQHQRKQYTQMLVAHA---PILPDARYYQ-TLQGLLNQLTDIK 133 Query: 146 EAESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALDQQRQLLTAQVLG 205 S DK E + L + F+R N + +R + R L + ++ Q Q L Sbjct: 134 CKNSGPDK-EASILLEQFSRS---NAEMVQATRDVIFSRGQQLQKDIAERGQFFGWQSLL 189 Query: 206 AIVLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIEVRGPADIRRLGQQLDWLRQ 264 +++VLL F + P+ +E+ I RLG+ R +GP ++R L Q++ WL + Sbjct: 190 LFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRIIWLSE 249 Query: 265 RLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLNDNQREIARILRQNTQSL 324 RLA LE+++ FLRH+SHELKTPLA++ EG LL D VAG L +Q+E+ IL +++ L Sbjct: 250 RLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHL 309 Query: 325 QTQIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARTLTVEIEGAARTVVV 384 Q IE LL YN D P VDL ++ VI L A+ + E E AR Sbjct: 310 QQLIEQLLDYNRKLADGPG-EPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWA 368 Query: 385 DPEKMAIVLSNLLSNAVRFSPEGGCIRFLLAEGPGVVRVECIDQGPGVAPTDAARIFEPF 444 +P + VL NL SNAV + E G I + V+++ + G + ++ IFEPF Sbjct: 369 EPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIFEPF 428 Query: 445 YQGLHQPTGARRGNGIGLSVVREYVLAHSGKVYLVPREGGA-HFRIELP 492 +QG HQ GA +G+G+GLS+ ++ + G + LV + A FRIELP Sbjct: 429 FQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELP 477 >ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 496 Score = 204 bits (518), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 149/470 (31%), Positives = 239/470 (50%), Gaps = 9/470 (1%) Query: 28 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSSNSRETARQAVQLTESAQRLAERTVAME 87 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 88 RSARQYLVLDDPAFHARFNEAREQARQALGELSDSLPMAPRELFSQWSLYGDEAASVLEA 147 RS RQY VLDDP + R++ + L + LP +L+ +L D + L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLP--DDKLYQ--ALRQD--LNNLAQ 144 Query: 148 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALDQQRQLLTAQVLGAI 207 + G A + N + +R V R L + ++ Q Q L Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 208 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIEVRGPADIRRLGQQLDWLRQRL 266 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 267 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLNDNQREIARILRQNTQSLQT 326 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G L Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 327 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARTLTVEIEGAARTVVVDP 386 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 387 EKMAIVLSNLLSNAVRFSPEGGCIRFLLAEGPGVVRVECIDQGPGVAPTDAARIFEPFYQ 446 + VL NL SNAV + E G I + V ++ I+ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 447 GLHQPTGARRGNGIGLSVVREYVLAHSGKVYLVPREG-GAHFRIELPDEK 495 G HQ GA +G+G+GLS+ R+ + G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 496 Score = 204 bits (518), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 149/470 (31%), Positives = 239/470 (50%), Gaps = 9/470 (1%) Query: 28 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSSNSRETARQAVQLTESAQRLAERTVAME 87 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 88 RSARQYLVLDDPAFHARFNEAREQARQALGELSDSLPMAPRELFSQWSLYGDEAASVLEA 147 RS RQY VLDDP + R++ + L + LP +L+ +L D + L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLP--DDKLYQ--ALRQD--LNNLAQ 144 Query: 148 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALDQQRQLLTAQVLGAI 207 + G A + N + +R V R L + ++ Q Q L Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 208 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIEVRGPADIRRLGQQLDWLRQRL 266 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 267 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLNDNQREIARILRQNTQSLQT 326 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G L Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 327 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARTLTVEIEGAARTVVVDP 386 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 387 EKMAIVLSNLLSNAVRFSPEGGCIRFLLAEGPGVVRVECIDQGPGVAPTDAARIFEPFYQ 446 + VL NL SNAV + E G I + V ++ I+ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 447 GLHQPTGARRGNGIGLSVVREYVLAHSGKVYLVPREG-GAHFRIELPDEK 495 G HQ GA +G+G+GLS+ R+ + G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >yfhK [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 496 Score = 203 bits (517), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 147/470 (31%), Positives = 235/470 (50%), Gaps = 9/470 (1%) Query: 28 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSSNSRETARQAVQLTESAQRLAERTVAME 87 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 88 RSARQYLVLDDPAFHARFNEAREQARQALGELSDSLPMAPRELFSQWSLYGDEAASVLEA 147 RS RQY VLDDP + R++ + L + LP + L+ L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDDKLYQALRQDLHN------LAQ 144 Query: 148 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALDQQRQLLTAQVLGAI 207 + G A + N + +R V R L + ++ Q Q L Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 208 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIEVRGPADIRRLGQQLDWLRQRL 266 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 267 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLNDNQREIARILRQNTQSLQT 326 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G L Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 327 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARTLTVEIEGAARTVVVDP 386 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 387 EKMAIVLSNLLSNAVRFSPEGGCIRFLLAEGPGVVRVECIDQGPGVAPTDAARIFEPFYQ 446 + VL NL SNAV + E G I + V ++ I+ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 447 GLHQPTGARRGNGIGLSVVREYVLAHSGKVYLVPREG-GAHFRIELPDEK 495 G HQ GA +G+G+GLS+ R+ + G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >STM2564 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 480 Score = 199 bits (507), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 149/467 (31%), Positives = 232/467 (49%), Gaps = 9/467 (1%) Query: 28 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSSNSRETARQAVQLTESAQRLAERTVAME 87 S RQL++ AFLLI L + A +L+ +S + T R + ++ + + ME Sbjct: 14 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEME 73 Query: 88 RSARQYLVLDDPAFHARFNEAREQARQALGELSDSLPMAPRELFSQWSLYGDEAASVLEA 147 RS RQY VLDDP + R++ L + LP +L+ +L D A L Sbjct: 74 RSYRQYCVLDDPTLAKVYQSQRKRYSDMLDAHAGVLP--DDKLYQ--ALRQDLNA--LAQ 127 Query: 148 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALDQQRQLLTAQVLGAI 207 KD G +A N + +R V R L + ++ Q Q L Sbjct: 128 LQCKDSGPEAAAAARLEAFANANTEMVQATRTVVYSRGQQLQQEIAERGQFFGWQALVLF 187 Query: 208 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIEVRGPADIRRLGQQLDWLRQRL 266 ++++ + F + P+ +E+ I RLG+ R + GP ++R +GQ++ WL +RL Sbjct: 188 LVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRIIWLSERL 247 Query: 267 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLNDNQREIARILRQNTQSLQT 326 A LE+++ +FLRH+SHELKTPLA++ EG LL D V G L Q+E+ IL ++++LQ Sbjct: 248 AWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNLQK 307 Query: 327 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARTLTVEIEGAARTVVVDP 386 IE LL YN D+ VD+ L+ V+ L A+ + +++ A + +P Sbjct: 308 LIEQLLDYNRKLVDSA-TELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIAEP 366 Query: 387 EKMAIVLSNLLSNAVRFSPEGGCIRFLLAEGPGVVRVECIDQGPGVAPTDAARIFEPFYQ 446 + VL NL SNAV + E G I V ++ ++ G + T+ IFEPF+Q Sbjct: 367 MLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVVNSGEPIPQTEREMIFEPFFQ 426 Query: 447 GLHQPTGARRGNGIGLSVVREYVLAHSGKVYLVPREGG-AHFRIELP 492 G HQ GA +G+G+GLS+ R+ + G++ LV FRI LP Sbjct: 427 GSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLP 473