BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4602.p (407 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2172 [GEPR] COG0477 Permeases of the major facilitator superf... 360 4e-99 PA3573 [GEPR] COG0477 Permeases of the major facilitator superfa... 303 3e-82 CC1230 [GEPR] COG0477 Permeases of the major facilitator superfa... 256 7e-68 YPO1267 [GEPR] COG0477 Permeases of the major facilitator superf... 253 6e-67 Cj0035c [GEPR] COG0477 Permeases of the major facilitator superf... 237 4e-62 >RSc2172 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 407 Score = 360 bits (923), Expect = 4e-99, Method: Compositional matrix adjust. Identities = 188/390 (48%), Positives = 259/390 (66%), Gaps = 1/390 (0%) Query: 11 GKFPPWLAVLAALTAMGALAIDMYLPSFTAIAQDLGVGTNLVQLTLASFLIGLAVGQMFY 70 G P WL +L ALTA+G L++DMYLPS IA+DL + +TL +FL+ LA+GQ+ Y Sbjct: 16 GAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGITLTAFLVSLAIGQLIY 75 Query: 71 GPLSDRFGRKPPLFFGIALYFVCSLLCSFAQNIETLIVLRLFQGLGGSAGMVIPRAMVRD 130 GP SDRFGRKPPL+ G+ALY S+ C+FA + L VLR QG GG AGMVI RA VRD Sbjct: 76 GPASDRFGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGFGGCAGMVISRAAVRD 135 Query: 131 RMGAEGSAKAFSMLMLVFGLAPILAPFIGGLMLVFANWRGIFVVLTLFGLLCMVGTRKYL 190 RM G+A+A+S LMLV G+APILAP IGG +L +WR IF VL FG+L + + Sbjct: 136 RMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQVTSWRMIFAVLAAFGVLSLAAVHFLM 195 Query: 191 TETVDVSRAEPLHLGRTLRQYWGLLRHRQFMSFVLCGGLVQAGMFAYIAGGPFVVIELHG 250 E++D + A PL +GR LR YW LLR R + ++ CG + +GMFAYI PFV+I+ +G Sbjct: 196 RESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMFAYITASPFVLIDHYG 255 Query: 251 VKPQYFGFVFASNAIGLIAASQINARLVVKRSAERVLGKVLWVPAGLALMVALLVLAGLE 310 + P ++ +VF SNA G+IAAS+IN RL+ + + RVL + LW+PA ++ A +V AG Sbjct: 256 LSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPAATSVAAAAVVGAGFM 315 Query: 311 SLPLLLFGFFGFLTAYGFTGPNATAIALKHQGRQAGTAAALMGTLQFGMGVLSGVVMSLW 370 LPL+L F ++ + G PN A+A+ QG +AGT +ALMG +QFG+G+++G V++ + Sbjct: 316 PLPLVLAALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAF 375 Query: 371 HDGTALPLVSVMAFCGISALLLYHFVAKHE 400 G A PL+ +MA + AL L +HE Sbjct: 376 GQGAA-PLLGMMAVSAVLALWLGLRATQHE 404 >PA3573 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 392 Score = 303 bits (777), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 175/386 (45%), Positives = 244/386 (63%), Gaps = 5/386 (1%) Query: 17 LAVLAALTAMGALAIDMYLPSFTAIAQDLGVGTNLVQLTLASFLIGLAVGQMFYGPLSDR 76 L +L AL+A G LAID YLPSF +A+ VQL+LA++ GL++GQ+ YGP++DR Sbjct: 6 LLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADR 65 Query: 77 FGRKPPLFFGIALYFVCSLLCSFAQNIETLIVLRLFQGLGGSAGMVIPRAMVRDRMGAEG 136 +GR+ PL G++++ + S C+ A ++E LI R Q LGG AGMVI RA+VRD G Sbjct: 66 YGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIG 125 Query: 137 SAKAFSMLMLVFGLAPILAPFIGGLMLVFANWRGIFVVLTLFGLLCMVGTRKYLTETVDV 196 +AKAFS LMLV GLAPILAP GGL+L + W+ IFV LTLF L +G +L ET+ Sbjct: 126 AAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPA 185 Query: 197 SRAEPLHLGRTLRQYWGLLRHRQFMSFVLCGGLVQAGMFAYIAGGPFVVIELHGVKPQYF 256 P L L QY L R F+++ L GG+ AGMFAYIAG P+V I+L+G+ +++ Sbjct: 186 DGERP-PLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHY 244 Query: 257 GFVFASNAIGLIAASQINARLVVKRSAERVLGKVLWVPAGLALMVALLVLAGLESLPL-- 314 G++F SNA G I +Q+NARL+ R L +++W LA +ALL +A L+ L Sbjct: 245 GWLFGSNAAGFIVMAQVNARLLRYRGPAFWLRRIIW--GYLACGLALLGIASLQPATLWP 302 Query: 315 LLFGFFGFLTAYGFTGPNATAIALKHQGRQAGTAAALMGTLQFGMGVLSGVVMSLWHDGT 374 LL FG + + G PNA+A A+ QG+ AG+A+ALMG+LQF + + ++ + HDGT Sbjct: 303 LLVPLFGCVASLGCIIPNASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGT 362 Query: 375 ALPLVSVMAFCGISALLLYHFVAKHE 400 A+P+ V+A CG A LL + E Sbjct: 363 AIPMTLVIAVCGAVATLLAWQTGRLE 388 >CC1230 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 405 Score = 256 bits (654), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 155/377 (41%), Positives = 213/377 (56%), Gaps = 10/377 (2%) Query: 15 PWLAVL--AALTAMGALAIDMYLPSFTAIAQDLGVGTNLVQLTLASFLIGLAVGQMFYGP 72 PW VL ALTA ++IDMYL S +I + L + Q TLA+F G+A+GQ+FYGP Sbjct: 12 PWRLVLLLGALTAFAPMSIDMYLSSLPSIGRTLNAAPDQTQATLAAFFAGMAIGQVFYGP 71 Query: 73 LSDRFGRKPPLFFGIALYFVCSLLCSFAQNIETLIVLRLFQGLGGSAGMVIPRAMVRDRM 132 SDRFGR+PPL G+ L+ S++C+ A NIETLI R Q LGG AG VI RA+VRDR Sbjct: 72 ASDRFGRRPPLLVGVGLFIAASIVCAVAPNIETLIAARFVQALGGCAGPVIARAVVRDRF 131 Query: 133 GAEGSAKAFSMLMLVFGLAPILAPFIGGLMLVFANWRGIFVVLTLFGLLCMVGTRKYLTE 192 +A+ S++ L+ GLAP+LAP +GG++ A WRG+F L +FG+L LTE Sbjct: 132 SHTDTARVLSLMTLIMGLAPVLAPQLGGVVQFVAGWRGVFWTLVMFGVLIAAWVVLSLTE 191 Query: 193 TVDVSRAEPLHLGRTLRQYWGLLRHRQFMSFVLCGGLVQAGMFAYIAGGPFVVIELHGVK 252 + + L+ Y L R+ M + L G L A +F YI+G P +V+ +G Sbjct: 192 SRSAATEAQARSENPLKAYVALFGMRRLMGYALAGALNGAVLFTYISGAPDLVMGTYGHS 251 Query: 253 PQYFGFVFASNAIGLIAASQINARLVVKRSAERVLGKVLWVPAGLALMVALLVLAGL--- 309 P F VFA NA+G+I ASQIN L+ + + ++VL + AL++ L G Sbjct: 252 PLVFNLVFALNAVGIIGASQINRFLLRRSTPDQVLARASVASIVAALLLTLAAWTGFGGQ 311 Query: 310 -ESLPLLLFGFFGFLTAYGFTGPNATAIALKHQGRQAGTAAALMGTLQFGMGVLSGVVMS 368 LPLL F L+ YG G N A AL ++AG+ +ALMG+ FG G ++ + Sbjct: 312 WTVLPLL----FAALSLYGLMGGNTMAGALSVDPQRAGSTSALMGSASFGAGAVASWAGA 367 Query: 369 LWHDGTALPLVSVMAFC 385 HDGT P+ VM C Sbjct: 368 ALHDGTPRPVAGVMFAC 384 >YPO1267 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 253 bits (646), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 144/387 (37%), Positives = 234/387 (60%), Gaps = 3/387 (0%) Query: 19 VLAALTAMGALAIDMYLPSFTAIAQDLGVGTNLVQLTLASFLIGLAVGQMFYGPLSDRFG 78 +L L+ + LAIDMYLPS IAQ+ GV + VQ+TL+++++G A+GQMFYGP++D G Sbjct: 14 ILGLLSMLMPLAIDMYLPSMPIIAQEFGVESGRVQMTLSAYVLGFAIGQMFYGPMADSIG 73 Query: 79 RKPPLFFGIALYFVCSLLCSFAQNIETLIVLRLFQGLGGSAGMVIPRAMVRDRMGAEGSA 138 RKP +F+G ++ + + C+ Q++E LI +R GL +A V+ A++RD + + Sbjct: 74 RKPVIFWGTLIFALAGMACALVQSVEQLINMRFLHGLSAAAASVVINALMRDMFTKDEFS 133 Query: 139 KAFSMLMLVFGLAPILAPFIGGLMLVFANWRGIFVVLTLFGLLCMVGTRKYLTETVDVSR 198 + S ++LV +AP+LAP IGG +LV+ +W IF + L+ V ++ ET+ R Sbjct: 134 RMMSFVVLVMTIAPLLAPIIGGALLVWFSWHAIFWTMAGAALVGAVLVALFIQETLPPER 193 Query: 199 AEPLHLGRTLRQYWGLLRHRQFMSFVLCGGLVQAGMFAYIAGGPFVVIELHGVKPQYFGF 258 + HL T+ + L RH++ +S++L G AGMF++++ GPFV I+L+GV PQ FG+ Sbjct: 194 RQKFHLRTTIGNFGSLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIDLNGVSPQNFGY 253 Query: 259 VFASNAIGLIAASQINARLVVKRSAERVLGKVLWVPAGLALMVALLVLAGLESLPLLLFG 318 FA N + L + IN+R V + A ++ L V + + + ++ +AGL L+L G Sbjct: 254 YFALNIVFLFLMTFINSRNVRRFGALKMFRFGLIVQFVMGIWLVVVCVAGLGFWALVL-G 312 Query: 319 FFGFLTAYGFTGPNATAIALKHQGRQAGTAAALMGTLQFGMGVLSGVVMSLWHDGTALPL 378 ++ NA A+ L AGTA++L GTL+FG+G + G ++S+ +A P+ Sbjct: 313 VAAYVGCIAMITSNAMAVILDDFPHMAGTASSLAGTLRFGIGAVVGTLLSMASSRSAWPM 372 Query: 379 VSVMAFCGISALLLYHFVAK--HEPVT 403 VS MAFC I A+LLY + ++ H+ V+ Sbjct: 373 VSSMAFCIIVAMLLYLYASRPSHKTVS 399 >Cj0035c [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 400 Score = 237 bits (604), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 136/403 (33%), Positives = 213/403 (52%), Gaps = 6/403 (1%) Query: 1 MHKQDTSLSTGKFPPWLAVLAALTAMGALAIDMYLPSFTAIAQDLGVGTNLVQLTLASFL 60 M K KF + +LA ++++ L+ DMYLP+ + + Q + L QL++ASF Sbjct: 1 MQKHTKIHGFAKFK-LIVILALMSSIAPLSTDMYLPALSHVEQSFQTNSFLTQLSIASFF 59 Query: 61 IGLAVGQMFYGPLSDRFGRKPPLFFGIALYFVCSLLCSFAQNIETLIVLRLFQGLGGSAG 120 I A+GQ+ YGPLSD FGRK P GI + V SL C +I I LR F+ LGG AG Sbjct: 60 IAFALGQLIYGPLSDIFGRKIPALVGIFFFIVSSLFCVIIDDIYAFIALRFFEALGGCAG 119 Query: 121 MVIPRAMVRDRMGAEGSAKAFSMLMLVFGLAPILAPFIGGLMLVFANWRGIFVVLTLFGL 180 +VI RA+V D + +A F+++M+ LAP+L+P GG++L + +W IF L G+ Sbjct: 120 VVIARAIVNDLFEIKEAAGIFALMMVFSSLAPMLSPTFGGILLEYFSWHSIFATLFALGI 179 Query: 181 LCMVGTRKYLTETVDVSRAEPLHLGRTLRQYWGLLRHRQFMSFVLCGGLVQAGMFAYIAG 240 L + L E+ + + ++ Y +L ++F+ ++LC A MFAYI G Sbjct: 180 LLFLMILFGLKESAPHLKNKKFSHHEAMKSYKFVLSDKRFLVYILCASFALAAMFAYITG 239 Query: 241 GPFVVIELHGVKPQYFGFVFASNAIGLIAASQINARLVVKRSAERVLGKVLWVPAGLALM 300 FV + + Q F +F +NA+G + + INARLV+K +E++L K L + + + Sbjct: 240 SSFVFTQFFSLSEQKFALLFGANALGFVICANINARLVLKYESEKILAKALMI---MFIS 296 Query: 301 VALLVLAGLESLPLLLF--GFFGFLTAYGFTGPNATAIALKHQGRQAGTAAALMGTLQFG 358 +L++ LLF F + GF PN T +A+ +GTA+A++GT+QFG Sbjct: 297 TVILLVNAFFHPNFLLFELSIFTSIAMLGFIAPNTTTLAMARFKEHSGTASAVLGTVQFG 356 Query: 359 MGVLSGVVMSLWHDGTALPLVSVMAFCGISALLLYHFVAKHEP 401 L V+ + T + L VM C + A ++Y + E Sbjct: 357 FAGLISFVVGAINANTPIILAFVMCACVLVANMIYFLIKIKEK 399