BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4589.p (546 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4198 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ... 667 0.0 mlr7293 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid... 624 e-178 mlr6974 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid... 509 e-144 DR0336 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ... 386 e-107 VNG0162G [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-aci... 282 1e-75 >PA4198 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Pae Pseudomonas aeruginosa Length = 540 Score = 667 bits (1722), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/539 (61%), Positives = 392/539 (72%), Gaps = 7/539 (1%) Query: 1 MADFDTGLGRNAANYAALTPIDFIARAAAVYGQRTAILHGALRQNWDQTYRRTRRLASAL 60 M+ F+ GL A N+ ALTP+ FI R A+VY A++HG +R++W QTY+R RRLASAL Sbjct: 1 MSIFEQGLAPAAVNHIALTPLSFIERTASVYPHYPAVIHGNIRRDWAQTYQRCRRLASAL 60 Query: 61 QQLGVGKNDTVSAMLPNTPAMVEAHFGVPMAGAVLNALNIRLDAESIVFMLRHGEAKVLL 120 G+G+ DTV+ MLPN P M+EAH+GVPM GAVLN LN+RLDAE+I FML+HGEAKVL+ Sbjct: 61 AGRGIGQGDTVAVMLPNIPEMLEAHYGVPMIGAVLNTLNVRLDAEAIAFMLQHGEAKVLI 120 Query: 121 IDSEFAALAQQLRTQL--PGLKIVEVFDELGPPAVAGERFGHLEYEALLATGDEHFEWKM 178 D EF + L P L +V+V D P G G L+YEALLA GD F W+ Sbjct: 121 TDYEFHEVIHAAIGMLDHPPL-VVDVND---PEYGEGRPVGELDYEALLAEGDPQFAWEW 176 Query: 179 PADEWDAIALNYTSGTTGDPKGVVYHHRGAALNAVSNILEWDLPKHPVYLWTLPMFHCNG 238 P DEW AI+LNYTSGTTG+PKGVVYHHRGA LNA+ N + W + +HPVYLWTLPMFHCNG Sbjct: 177 PRDEWQAISLNYTSGTTGNPKGVVYHHRGAYLNALGNQMTWSMGQHPVYLWTLPMFHCNG 236 Query: 239 WCFPWTVAARAGVNVCLRKFEPKLVFDLIAEHGITHYCAAPIVHAALANAPEGWRAGIRG 298 WC+PWTV A AGV+VCLR+ +P+ V LI EH ++H C APIV AL N P+ +A I Sbjct: 237 WCYPWTVTALAGVHVCLRRVDPQKVLTLIREHQVSHLCGAPIVLNALINMPDSAKAAIDH 296 Query: 299 PVKAMVAGAPPPAAVLAKMEAMQFELTHVYGLTEVYGPAAVCAEQDAWSALSVDQRAVAK 358 PV AMVAGA PPA V+ +E M +THVYGLTEVYGP VCA W L +++RA K Sbjct: 297 PVHAMVAGAAPPAKVIGAVEEMGIRVTHVYGLTEVYGPVTVCAWHGEWDDLPLERRAAIK 356 Query: 359 SRQGVRYHLQSGVTVLSPDTMEPVAADGEEIGEIMFRGNICMKGYLKNDRATHEAFAGGW 418 SRQGVRY GV V P T+EPV DG+ IGEI RGN MKGYLKN AT EAFAGGW Sbjct: 357 SRQGVRYPTLEGVMVADPKTLEPVPRDGQSIGEIFMRGNTVMKGYLKNPSATEEAFAGGW 416 Query: 419 FHTGDLGVMNADGYIKIKDRSKDIIISGGENISSVEVEDVLYRHPAVLAAAVVAQPDEKW 478 FHTGDL V + DGYI+I+DR KDIIISGGENIS++E+E VLYRHPAVL AAVVA+PDEKW Sbjct: 417 FHTGDLAVCHPDGYIEIRDRLKDIIISGGENISTIELEGVLYRHPAVLEAAVVARPDEKW 476 Query: 479 GETPCAFVELKEGAETGA-VELTEFCRSHLAGFKVPKAIYFGPLPKTSTGKIQKFELRK 536 GETPCAF+ LK + A E+ FCR HLA FK+P+ + F LPKTSTGKIQK+ LR+ Sbjct: 477 GETPCAFITLKSDHQGLAESEIVAFCREHLAAFKIPRTVVFSELPKTSTGKIQKYVLRE 535 >mlr7293 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Mlo Mesorhizobium loti Length = 546 Score = 624 bits (1609), Expect = e-178, Method: Compositional matrix adjust. Identities = 305/540 (56%), Positives = 379/540 (70%), Gaps = 4/540 (0%) Query: 4 FDTGLGRNAANYAALTPIDFIARAAAVYGQRTAILHGALRQNWDQTYRRTRRLASALQQL 63 ++ L RNAAN+ LTP+ ++ RAA Y AI+HG R ++ +RR+ ++ASALQ+ Sbjct: 5 YEQDLDRNAANHQPLTPLTYLERAAKTYPDHIAIIHGRQRISYRDFWRRSLKVASALQKR 64 Query: 64 GVGKNDTVSAMLPNTPAMVEAHFGVPMAGAVLNALNIRLDAESIVFMLRHGEAKVLLIDS 123 G+GK DTV+ ML NTP M+EAHFGVPM AVL++LN RLDA I F L H E KVL++D Sbjct: 65 GIGKGDTVTVMLSNTPPMLEAHFGVPMTKAVLHSLNTRLDAAVIAFQLDHAETKVLIVDR 124 Query: 124 EFAALAQQ---LRTQLP-GLKIVEVFDELGPPAVAGERFGHLEYEALLATGDEHFEWKMP 179 EF+ + +Q L P + + P GER G L+YE +A GDE F W MP Sbjct: 125 EFSGVVRQALDLAKVTPLVIDYDDPDYAADAPYPKGERIGALDYEDFVAGGDEDFAWSMP 184 Query: 180 ADEWDAIALNYTSGTTGDPKGVVYHHRGAALNAVSNILEWDLPKHPVYLWTLPMFHCNGW 239 DEWDAI+LNYTSGTTG+PKGVVYHHRGAAL A +N + + KH VYLWTLPMFHCNGW Sbjct: 185 DDEWDAISLNYTSGTTGNPKGVVYHHRGAALMAYTNTIHAGMAKHAVYLWTLPMFHCNGW 244 Query: 240 CFPWTVAARAGVNVCLRKFEPKLVFDLIAEHGITHYCAAPIVHAALANAPEGWRAGIRGP 299 CFPWT+A +AG +VCLR PK ++D IA+HG+TH C AP+V + L NA + + Sbjct: 245 CFPWTLAVQAGTHVCLRWVRPKPIYDAIADHGVTHLCGAPVVMSVLINARDEDKRTFAQT 304 Query: 300 VKAMVAGAPPPAAVLAKMEAMQFELTHVYGLTEVYGPAAVCAEQDAWSALSVDQRAVAKS 359 V A APPP AVL+ M F +TH+YGLTE YGPA V W L+ +R+ K+ Sbjct: 305 VTFNTAAAPPPEAVLSGMADAGFAVTHLYGLTETYGPAVVNEWHGEWDDLAKGERSAKKA 364 Query: 360 RQGVRYHLQSGVTVLSPDTMEPVAADGEEIGEIMFRGNICMKGYLKNDRATHEAFAGGWF 419 RQGVRY G+TV+ P+TM+ ADGE IGE+MFRGNI MKGYLKN +A+ EAFAGGWF Sbjct: 365 RQGVRYAALEGLTVMDPETMQATPADGETIGEVMFRGNIVMKGYLKNRKASDEAFAGGWF 424 Query: 420 HTGDLGVMNADGYIKIKDRSKDIIISGGENISSVEVEDVLYRHPAVLAAAVVAQPDEKWG 479 H+GDLGVM+ DGYI++KDRSKDIIISGGENISS+EVED LY+HP+V + VVA+ D+KWG Sbjct: 425 HSGDLGVMHPDGYIQLKDRSKDIIISGGENISSIEVEDALYKHPSVASCGVVARHDDKWG 484 Query: 480 ETPCAFVELKEGAETGAVELTEFCRSHLAGFKVPKAIYFGPLPKTSTGKIQKFELRKRMK 539 E P A+VELK G E+ E CR+ LA FKVPKA+ F +PKTSTGKIQKF LR+ K Sbjct: 485 EVPVAYVELKPGKTASEAEIIEHCRALLARFKVPKAVIFAEIPKTSTGKIQKFRLREMAK 544 >mlr6974 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Mlo Mesorhizobium loti Length = 541 Score = 509 bits (1312), Expect = e-144, Method: Compositional matrix adjust. Identities = 259/527 (49%), Positives = 334/527 (63%), Gaps = 6/527 (1%) Query: 10 RNAANYAALTPIDFIARAAAVYGQRTAILHGALRQNWDQTYRRTRRLASALQQLGVGKND 69 R+ AN AL+P+ F+ RA VYG R+A+ +G +R+ W QT R R +A+ L LGVG D Sbjct: 10 RDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGLAALGVGPGD 69 Query: 70 TVSAMLPNTPAMVEAHFGVPMAGAVLNALNIRLDAESIVFMLRHGEAKVLLIDSEFAALA 129 TVS + PN P + E H+ VP+ GAVLN +N RL+ E++ ++L H ++ +++ D+ FA L Sbjct: 70 TVSVLSPNIPELFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVIADTAFAPLL 129 Query: 130 QQ-LRTQLPGLKIVEVFDELGPPAVAGERFGHLEYEALLATGDEHFEWKMPADEWDAIAL 188 ++ R L +V+V D A A FG YE L A W++P DEW A+AL Sbjct: 130 REAFRLNGNTLPVVDVVDAQ---AQASAEFGERSYEDLAA--HPPMGWELPKDEWQALAL 184 Query: 189 NYTSGTTGDPKGVVYHHRGAALNAVSNILEWDLPKHPVYLWTLPMFHCNGWCFPWTVAAR 248 NYTSGT+G PKGV+YHHRGA L A+ I W LP+HP YL +PMFHCNGW PW++A Sbjct: 185 NYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWSMAIV 244 Query: 249 AGVNVCLRKFEPKLVFDLIAEHGITHYCAAPIVHAALANAPEGWRAGIRGPVKAMVAGAP 308 V R P + + +A H +TH AAPIV L + ++ M AGAP Sbjct: 245 GANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMTAGAP 304 Query: 309 PPAAVLAKMEAMQFELTHVYGLTEVYGPAAVCAEQDAWSALSVDQRAVAKSRQGVRYHLQ 368 PP AVL K M ++ VYGLTE YG + C QD W ALSV RA ++ QGV + + Sbjct: 305 PPPAVLEKAAQMGLDVMQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVAFPMV 364 Query: 369 SGVTVLSPDTMEPVAADGEEIGEIMFRGNICMKGYLKNDRATHEAFAGGWFHTGDLGVMN 428 + V+ DT V DG GEI RGN MKGY K+ +T AF GWF +GD V++ Sbjct: 365 EDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYYKDATSTAAAFESGWFWSGDAAVVH 424 Query: 429 ADGYIKIKDRSKDIIISGGENISSVEVEDVLYRHPAVLAAAVVAQPDEKWGETPCAFVEL 488 DGYI+I+DR KD+IISGGENISSVEVE VLYRHPA+ AAVVA+P KWGE+PCAFVEL Sbjct: 425 PDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCAFVEL 484 Query: 489 KEGAETGAVELTEFCRSHLAGFKVPKAIYFGPLPKTSTGKIQKFELR 535 +EGA E+ FCR+++A FK PK + FGPLPKT+TGKIQKF LR Sbjct: 485 REGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILR 531 >DR0336 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Dra Deinococcus radiodurans Length = 524 Score = 386 bits (991), Expect = e-107, Method: Compositional matrix adjust. Identities = 235/525 (44%), Positives = 302/525 (57%), Gaps = 20/525 (3%) Query: 18 LTPIDFIARAAAVYGQRTAILH-GALRQNWDQTYRRTRRLASALQQLGVGKNDTVSAMLP 76 LTP+ + R +Y TA++ G R + + RR +LA A+Q G G V+ + P Sbjct: 7 LTPLTLVRRGLKLYPDHTAVIEPGGPRFTYREWGRRIYQLARAIQAAGYGGQH-VAVLSP 65 Query: 77 NTPAMVEAHFGVPMAGAVLNALNIRLDAESIVFMLRHGEAKVLLIDSEFAALAQQLRTQL 136 NT + + GVP AG+VL LN RL E F LRH E ++LL+D +L ++R Sbjct: 66 NTHGGLLTYAGVPWAGSVLVPLNTRLTPEEYEFQLRHAEVRLLLVDE---SLHDRVREVA 122 Query: 137 PGLKIVEVFDELGPPAVAGERFGHLEYEALLATGDEHFEWKMPA-DEWDAIALNYTSGTT 195 GL I EV+ + R +EA LA D+ +P DE I LN+TSGTT Sbjct: 123 AGLGI-EVW------VMGDARGAGTAFEAKLAAQDDS-PLPLPVQDENGTITLNFTSGTT 174 Query: 196 GDPKGVVYHHRGAALNAVSNILEWDLPKHPVYLWTLPMFHCNGWCFPWTVAARAGVNVCL 255 DPKGV+ HR LNA+ I + + VYL TLP FH NGW W+ +V L Sbjct: 175 SDPKGVMMTHRSTMLNAIETIYYFKADQDTVYLHTLPDFHANGWGGVWSPFGVGATHVTL 234 Query: 256 RKFEPKLVFDLIAEHGITHYCAAPIVHAALANAPEGWRAGIRGPVKAMVAGAPPPAAVLA 315 +D I +HG+TH CAAP V + L + P R R ++ AG+PP A ++A Sbjct: 235 PTVRADAAYDAIEQHGVTHLCAAPTVLSMLTD-PAHARPLSRQ-IRVATAGSPPHARIIA 292 Query: 316 KMEAMQFELTHVYGLTEVYGPAAVCAEQDAWSA-LSVDQRAVAKSRQGVRYHLQSGVTVL 374 M A+ F +T VYGLTE P AE A L +RA ++QGV L V VL Sbjct: 293 DMNALGFHVTQVYGLTET-SPLITVAELSAQQEELPTPRRAALIAKQGVEMILAGEVEVL 351 Query: 375 SPDTMEPVAADGEEIGEIMFRGNICMKGYLKNDRATHEAFAGGWFHTGDLGVMNADGYIK 434 P+ + PV DGE +GEIM RGN+ MKGY +N+ AT +A GGWFHTGD+ V++ DG I+ Sbjct: 352 DPE-LRPVPGDGETLGEIMVRGNLVMKGYYRNEEATAKALEGGWFHTGDVAVVHPDGRIE 410 Query: 435 IKDRSKDIIISGGENISSVEVEDVLYRHPAVLAAAVVAQPDEKWGETPCAFVELKEGAET 494 I+DR+KD+IISGGENISSVEVE VLY HPAV A VVA P EKWGE PCAF+ L +G E Sbjct: 411 IRDRNKDVIISGGENISSVEVEGVLYAHPAVREAVVVAMPHEKWGEVPCAFIALHQGQEV 470 Query: 495 GAVELTEFCRSHLAGFKVPKAIYF-GPLPKTSTGKIQKFELRKRM 538 +LT R HLAGFKVPK F LPKT++GK QKF LR + Sbjct: 471 TPEDLTAHVREHLAGFKVPKHYEFRDDLPKTASGKFQKFILRAEL 515 >VNG0162G [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Hbs Halobacterium sp. NRC-1 Length = 600 Score = 282 bits (721), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 192/527 (36%), Positives = 263/527 (49%), Gaps = 24/527 (4%) Query: 22 DFIARAAAVYGQRTAILHGALRQ-NWDQTYRRTRRLASALQQLGVGKNDTVSAMLPNTPA 80 DFI RA YG TA++ R+ + + R R ++ LQ G+ D V+ + PNT Sbjct: 71 DFIDRARTYYGDETAVVATTGRRYTYSELADRADRFSAVLQAAGIDSGDRVAVLDPNTHY 130 Query: 81 MVEAHFGVPMAGAVLNALNIRLDAESIVFMLRHGEAKVLLIDSEFAALAQQLRTQLPGLK 140 +EA +G GA+ LN RL + ++L A + D+ +A + +R Q+P Sbjct: 131 HLEAAYGAMQLGAIHTPLNYRLTPDDYAYILADAGADAIYADAAYADRVEAVRDQIP--- 187 Query: 141 IVEVFDELGPPAVAGERFGHLEYEALLATGDEHFEWKMP-ADEWDAIALNYTSGTTGDPK 199 F P AV G+ + L + ++ P E D I +NYTSGTTGDPK Sbjct: 188 -TTTFITDDPAAVDGD----WQDADALLADADPDDYDRPDMAEDDVITINYTSGTTGDPK 242 Query: 200 GVVYHHRGAALNAVSNILEWDLPKHPVYLWTLPMFHCNGWCFPWTVAARAGVNVCLRKFE 259 GV HR ++A+ + YLWTLPMFH NGW + + +VC R + Sbjct: 243 GVCRTHRNEVVHALLLSTHHTITDTDTYLWTLPMFHANGWGHIFAITGAGATHVCTRGVD 302 Query: 260 PKLVFDLIAEHGITHYCAAPIVHAALANAPEGWRAGIRG--PVKAMVAGAPPPAAVLAKM 317 VFD I +++ CAAP V L + E G V+ AG+ PP A + + Sbjct: 303 AASVFDTIQAEAVSYLCAAPTVLNMLLDYHEAHDVAATGDADVRVATAGSAPPEATIRAV 362 Query: 318 E-AMQFELTHVYGLTEVYGPAAVCAEQDAWSALSVDQRAVAKSRQGVRYHLQSGVTVLSP 376 E A+ + L HVYG TE GP ++ D A RA + RQG+ L + + V+ Sbjct: 363 ESALDWSLMHVYGATET-GPLIATSDADRLLAAGGGSRAAMQKRQGIGL-LGTELRVVDE 420 Query: 377 DTMEPVAADGEEIGEIMFRGNICMKGYLKNDRATHEAFA---GGWFHTGDLGVMNADGYI 433 + V D E IGEI+ GN M Y AT AF G+FH GD V++ G++ Sbjct: 421 HGND-VPRDNETIGEIVVSGNQVMDRYWNKPDATERAFTDRVDGYFHMGDFAVVDDTGFV 479 Query: 434 KIKDRSKDIIISGGENISSVEVEDVLYRHPAVLAAAVVAQPDEKWGETPCAFVELKEGAE 493 I DR KDIIISGGENISS+E+ED L+ H AV AVV P + WGETP AFV G Sbjct: 480 SILDRKKDIIISGGENISSIELEDTLFEHDAVGEVAVVPSPHDDWGETPKAFVVPASGDP 539 Query: 494 TG----AVELTEFCRSHLAGFKVPKAIYF-GPLPKTSTGKIQKFELR 535 L E+ R+ LA FK + + F LP T+TGK+QK+ELR Sbjct: 540 NNPGVTTTALVEYTRAELASFKTVRRVEFVDELPTTATGKVQKYELR 586