BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0001.4584.p         (199 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

aq_2027_1 [T] COG2206 HD-GYP domain Aae Aquifex aeolicus              129   3e-30
TM1699_2 [T] COG2206 HD-GYP domain Tma Thermotoga maritima            123   2e-28
TM1170_3 [T] COG2206 HD-GYP domain Tma Thermotoga maritima            123   2e-28
TM1467_2 [T] COG2206 HD-GYP domain Tma Thermotoga maritima            118   1e-26
TM1147 [KT] COG3437 Response regulator containing a CheY-like re...   117   2e-26

>aq_2027_1 [T] COG2206 HD-GYP domain Aae Aquifex aeolicus
          Length = 180

 Score =  129 bits (325), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 62/175 (35%), Positives = 102/175 (58%)

Query: 15  DALIAMHRLTDGYTPNHEDQTAELAVMIGQHLNLPRGRIDVLHMAAQVHDIGKARIPLDL 74
           +  I +  L D YT  H ++    A +IG+ L L    I++L +   +HD+GK  IP  +
Sbjct: 6   EFFIRLIGLRDAYTRGHTERGVFYAQLIGKELGLTSQEIELLKLGGYIHDVGKVAIPDVI 65

Query: 75  LTKPGRITADEYGVLKTHVQFGYEILNKISFPFNLAEIVWCHHEYLDGSGYPRGIGAEAL 134
           L KP ++T +EY ++K HV+ GYE++  +  P+   E++  H E  DG+GYP G   E +
Sbjct: 66  LLKPAKLTPEEYEIMKLHVELGYEMVKDLEIPWESLEVLLYHQEKYDGTGYPFGKKGEEI 125

Query: 135 PLEARILTVADIVESMSADRPYRKSLGMRVALEEIQRQSGSRLDPMVVEACVQVV 189
           PL ARI T+AD  E+M+  R Y+++     AL+E++  +G + DP +V   V+ +
Sbjct: 126 PLLARIYTIADSFEAMTTRRIYKRAKSWNEALKELEELAGKQFDPDIVPYAVRAL 180


>TM1699_2 [T] COG2206 HD-GYP domain Tma Thermotoga maritima
          Length = 172

 Score =  123 bits (309), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 60/164 (36%), Positives = 102/164 (62%)

Query: 23  LTDGYTPNHEDQTAELAVMIGQHLNLPRGRIDVLHMAAQVHDIGKARIPLDLLTKPGRIT 82
           L D YT  H  + A+ +  I +   LP   ++ + +AA +HDIGK  +   +L K  ++T
Sbjct: 3   LKDPYTSGHSLRVADYSQEIARRKGLPDQVVERIRIAAVLHDIGKIGVKGAILNKTSKLT 62

Query: 83  ADEYGVLKTHVQFGYEILNKISFPFNLAEIVWCHHEYLDGSGYPRGIGAEALPLEARILT 142
            +EY  +K H + G ++++KI    ++A+IV  HHE+  G GYP G+  E +PLE+RI+ 
Sbjct: 63  KEEYEEVKKHPELGEKLISKIEDFSDIAKIVRHHHEWYSGQGYPDGLRGEEIPLESRIIA 122

Query: 143 VADIVESMSADRPYRKSLGMRVALEEIQRQSGSRLDPMVVEACV 186
           VAD  ++M++DRPYRK++  + ALE ++R  G + DP +++  +
Sbjct: 123 VADAFDAMTSDRPYRKAMDRKTALEILRRNEGPQWDPEILKIAL 166


>TM1170_3 [T] COG2206 HD-GYP domain Tma Thermotoga maritima
          Length = 185

 Score =  123 bits (309), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 58/166 (34%), Positives = 102/166 (61%)

Query: 25  DGYTPNHEDQTAELAVMIGQHLNLPRGRIDVLHMAAQVHDIGKARIPLDLLTKPGRITAD 84
           D YT  H ++ A  AV IG+  +L   +++ L+ A  +HDIGK  +P  +L K  ++   
Sbjct: 9   DYYTKGHSEEAAYYAVEIGRMFDLGDEKLEKLYWAGLLHDIGKIYVPQVVLNKTSKLDER 68

Query: 85  EYGVLKTHVQFGYEILNKISFPFNLAEIVWCHHEYLDGSGYPRGIGAEALPLEARILTVA 144
           E+ ++K H   GYE++ +I    ++A  +  HHE  DG GYP G+  E +P EAR+L VA
Sbjct: 69  EFELIKIHPVRGYELVKEIEGFEDVAIWIRHHHERWDGKGYPDGLKGEEIPFEARVLCVA 128

Query: 145 DIVESMSADRPYRKSLGMRVALEEIQRQSGSRLDPMVVEACVQVVK 190
           D  ++M +DRPY++   +  +++E++R +G + DP++VE  ++ ++
Sbjct: 129 DSYQAMRSDRPYKRGKSVEESIQELRRNAGRQFDPVIVEKFIEFLE 174


>TM1467_2 [T] COG2206 HD-GYP domain Tma Thermotoga maritima
          Length = 180

 Score =  118 bits (295), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 64/168 (38%), Positives = 100/168 (59%), Gaps = 4/168 (2%)

Query: 25  DGYTPNHEDQTAELAVMIGQHLNLPRGRIDVLHMAAQVHDIGKARIPLDLLTKPGRITAD 84
           D YT  H ++ AELA  I + L      ++ ++ AA +HDIGK  IP  +L KP  ++ +
Sbjct: 5   DEYTRGHSEKVAELAKKIAKRLGFSPKMVERIYNAAFLHDIGKIGIPDHILKKPTILSKE 64

Query: 85  EYGVLKTHVQFGYEILNKISFPFNLAEIVWC--HHEYLDGSGYPRGIGAEALPLEARILT 142
           E  ++K H   G +IL ++   FN  E  W   HHE  DG GYP G+  E +PL +RI++
Sbjct: 65  EMMIVKNHPIMGEDILREVDI-FNNRESKWVRHHHERWDGKGYPDGLRGEEIPLPSRIIS 123

Query: 143 VADIVESMSADRPYRKSLGMRVALEEIQRQ-SGSRLDPMVVEACVQVV 189
           VAD+ E++++DRPYRK+L    A E + +   G+ LDP +V+   +++
Sbjct: 124 VADVYEALTSDRPYRKALSHEEAKEIMMKNMKGTVLDPRLVDLLFEIL 171


>TM1147 [KT] COG3437 Response regulator containing a CheY-like receiver
           domain and an HD-GYP domain Tma Thermotoga maritima
          Length = 387

 Score =  117 bits (292), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 64/178 (35%), Positives = 97/178 (54%), Gaps = 6/178 (3%)

Query: 23  LTDGYTPNHEDQTAELAVMIGQHLNLPRGRIDVLHMAAQVHDIGKARIPLDLLTKPGRIT 82
           L D  T  H  +   ++ ++ + +      ++++  AA  HDIGK  IP  +L K G++T
Sbjct: 179 LKDYETHEHTLRVGRISALVAEAMGCSSEFVELIEKAAPFHDIGKVFIPESILLKRGKLT 238

Query: 83  ADEYGVLKTHVQFGYEILNKISFP-FNL-AEIVWCHHEYLDGSGYPRGIGAEALPLEARI 140
           +DEY ++K H  FGYE+L     P  +L AE+   HHE  +G GYP G+  + +PL A+I
Sbjct: 239 SDEYEIMKLHTIFGYELLKTSKNPVLSLAAEVALFHHEKYNGKGYPHGLKGDEIPLSAQI 298

Query: 141 LTVADIVESMSADRPYRKSLGMRVALEEIQRQSGSRLDPMVVEACVQVV----KQQNW 194
             VAD  ++M + RPY+       A+ EI+  SG    P VV+A VQ +    K  NW
Sbjct: 299 AAVADSFDAMVSHRPYKIRKSFDEAIREIKDLSGRFYSPFVVKAFVQTIDEIRKLYNW 356