BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4583.p (386 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3532 [GEPR] COG0477 Permeases of the major facilitator superfa... 182 2e-45 BMEI0267 [GEPR] COG0477 Permeases of the major facilitator super... 162 1e-39 SMc03889 [GEPR] COG0477 Permeases of the major facilitator super... 153 6e-37 mlr3825 [GEPR] COG0477 Permeases of the major facilitator superf... 153 7e-37 ECs0925 [GEPR] COG0477 Permeases of the major facilitator superf... 152 2e-36 >PA3532 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 383 Score = 182 bits (461), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 135/350 (38%), Positives = 198/350 (56%), Gaps = 10/350 (2%) Query: 20 KFAIPWFFLLLGVVFATWAARIPAIRDHLQLDAATLALVLLCGGIGAVGSFPLAAWITGH 79 + A +FF + G+V RIPA+++ QLD L LL G+GA+ +FPL+ ++ Sbjct: 10 RLACIYFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQR 69 Query: 80 YGARHSSLYAGLALLVSLPLLGLAPNLWTLMLVCTVYGAASSCFDVAINALGAQAERDAG 139 G+R + L +L+ PLLGL+ W L L V G + + DVA+N ER G Sbjct: 70 IGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLG 129 Query: 140 RPIMSMLHGWFCVGTFSGALTASAVAGMGIAPIWHFLLVAALFLYPLYAGYGALPDDRPA 199 +P MSMLHG + +G GAL+A+A+AG+ P WHFL++ AL L L AL P+ Sbjct: 130 KPCMSMLHGMYSLGCLVGALSAAALAGL--TPFWHFLILTALGLLSLPFFVRALLPPDPS 187 Query: 200 HDPERK--LFALPHGHLVVLGVIAFCGAIVEGSVADWSGIYMKDHIGASDGTTPLAYAAF 257 RK F LP L+ LG++ C + EG VADWS +++ + AS+ L +AAF Sbjct: 188 KAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAF 247 Query: 258 AGMMLIMRMVGDGLKARY-DARRVVWIGTLVASAGMALAVAAPGMVWAILGFAIAGTGVA 316 + M++ R+ GD L+ R DA + +G+L A+ GM +A+ +P +I GF + G G++ Sbjct: 248 SAAMVVGRLFGDRLRGRIDDAPLLRGLGSL-ATLGMLVALFSPWPALSIAGFGVVGLGLS 306 Query: 317 AVFPFVFSAAGRHGS----SALAAVATLGYSGSLIGPPLFGFLAHGWGLQ 362 + P V SAAG +AAV+T+GY G L+GPPL G LAH GL+ Sbjct: 307 VMVPIVISAAGNQPGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLR 356 >BMEI0267 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 397 Score = 162 bits (410), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 119/363 (32%), Positives = 187/363 (51%), Gaps = 15/363 (4%) Query: 8 SRSPSPLRLIWRKFAIPWFFLLLGVVFATWAARIPAIRDHLQLDAATLALVLLCGGIGAV 67 +R+P R + A+ FL+ G +F WA +IP + L LD+A + L++L G+G++ Sbjct: 13 ARAPIVTR---ERIAVALLFLMNGYIFGGWAPKIPEFAERLGLDSAGMGLMILVCGLGSL 69 Query: 68 GSFPLAAWITGHYGARHSSLYAGLALLVSLPLLGLAPNLWTLMLVCTVYGAASSCFDVAI 127 P+A ++ H G+ LA + +L ++ L PN+ T ++V +G + DV++ Sbjct: 70 AMMPVAGALSAHRGSGIVVRIFALAFIPALLIITLVPNVVTAVIVMLYFGGTMAAMDVSM 129 Query: 128 NALGAQAERDAGRPIMSMLHGWFCVGTFSGALTAS-AVAGMGIAPIWHFL--LVAALFLY 184 NA E+ R IMS H ++ +G GA T +A G I H L ++AA L Sbjct: 130 NANAVAVEKKMRRAIMSSCHAFWSLGGLIGAATGGFLIAQFG--SIVHALVTMIAATILI 187 Query: 185 PLYAGYGALPDDRPAH-DPERKLFALPHGHLV-VLGVIAFCGAIVEGSVADWSGIYMKDH 242 + A +PD H D E++ ALP L ++GV+A + EG++ DW +M+ Sbjct: 188 -IVAWPSIIPDTEHHHPDGEKQKLALPRNPLPWLVGVMALFSMVPEGAILDWGAYHMRQD 246 Query: 243 IGASDGTTPLAYAAFAGMMLIMRMVGDGLKARYDARRVVWIGTLVASAGMALAVAAPGMV 302 +GAS +AAF+G M +MR GD ++ R+ A + + T +A GM + Sbjct: 247 LGASVTVAGFGFAAFSGSMAVMRFAGDLVRDRFGAVKTLRACTAIAIIGMLIVGFGNSSA 306 Query: 303 WAILGFAIAGTGVAAVFPFVFSAAGR----HGSSALAAVATLGYSGSLIGPPLFGFLAHG 358 AI+GFAI G G++ + P FS AG + S L+ TLGYSG L+ P L GF+A Sbjct: 307 TAIIGFAICGIGISNMVPIAFSMAGNMPGVNPSVGLSIATTLGYSGMLVAPSLIGFVARH 366 Query: 359 WGL 361 G Sbjct: 367 SGF 369 >SMc03889 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 379 Score = 153 bits (387), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 124/359 (34%), Positives = 177/359 (49%), Gaps = 8/359 (2%) Query: 19 RKFAIPWFFLLLGVVFATWAARIPAIRDHLQLDAATLALVLLCGGIGAVGSFPLAAWITG 78 + A+ FL+ G V +WA +IP ++ L + + L L++L GIG++ P+A Sbjct: 4 NRLAVSLLFLMNGFVTGSWAPKIPEFKERLGIGESVLGLLILGFGIGSLVLMPIAGGFIA 63 Query: 79 HYGARHSSLYAGLALLVSLPLLGLAPNLWTLMLVCTVYGAASSCFDVAINALGAQAERDA 138 G++ + L L LL L PNLWT L + G DVA+NA + E+ Sbjct: 64 RLGSQKVVKVTAIILSPLLLLLTLLPNLWTAALGMFLLGGFVGAMDVAMNANAVEVEKSM 123 Query: 139 GRPIMSMLHG-WFCVGTFSGALTASAVAGMGIAPIWHFLLVAALFLYPLYAGYGALPDDR 197 R IMS H W G + +A G+ P H ++V L L L + + DR Sbjct: 124 RRAIMSSCHAYWSLGGLIGAGIGGFLMARFGVLP--HAIVVTCLCLAILAVAWPMILADR 181 Query: 198 PAHDPERKLFALPHGHLV-VLGVIAFCGAIVEGSVADWSGIYMKDHIGASDGTTPLAYAA 256 P R+ LP L ++G++A + EG+V DW +Y+KD +GAS + +AA Sbjct: 182 PHPAATREKLRLPMTPLPWLIGIMALFSMVPEGAVLDWGALYLKDELGASVELSGFGFAA 241 Query: 257 FAGMMLIMRMVGDGLKARYDARRVVWIGTLVASAGMALAVAAPGMVWAILGFAIAGTGVA 316 F+ M MR GD ++ R A + I T+ A AGM LA AP V AILGFA+AG G++ Sbjct: 242 FSATMAAMRFAGDHVRDRLGATLTLRICTVTALAGMVLAGLAPNAVLAILGFALAGIGIS 301 Query: 317 AVFPFVFSAAGR----HGSSALAAVATLGYSGSLIGPPLFGFLAHGWGLQAALALLGVL 371 + P FSAAG L+ T+GYSG L P L GF+A G A + VL Sbjct: 302 NMVPIAFSAAGNMPGLQPGIGLSVATTMGYSGMLFAPSLIGFIAEHSGFAIIFACVPVL 360 >mlr3825 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 391 Score = 153 bits (386), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 124/374 (33%), Positives = 192/374 (51%), Gaps = 11/374 (2%) Query: 20 KFAIPWFFLLLGVVFATWAARIPAIRDHLQLDAATLALVLLCGGIGAVGSFPLAAWITGH 79 ++A+ FL G + +WA +IP L + TL L++L G GAV + + Sbjct: 14 RWAVAAIFLANGFLTGSWAPQIPVFLTRLDISKFTLGLLILLFGAGAVTAMTWCGHLISK 73 Query: 80 YGARHSSLYAGLALLVSLPLLGLAPNLWTLMLVCTVYGAASSCFDVAINALGAQAERDAG 139 +G+R + GL + L ++ LAPNL + ++G + DVA+NA ER Sbjct: 74 HGSRTVLRWFGLCGSLGLLVVALAPNLPLAAIAMFIFGGSIGGMDVAMNANAVVVERKMS 133 Query: 140 RPIMSMLHG-WFCVGTFSGALTASAVAGMGIAPIWHFLLVAALFLYPLYAGYGALPDDRP 198 R IMS HG W G G L A+ G + V A + GY + +D+P Sbjct: 134 RAIMSSSHGFWSLGGFAGGGLGGFAIQHYGHLAHAAVVTVLAFAAIAMAVGY-LVAEDKP 192 Query: 199 AHDPERKLFALPHGHLVVL-GVIAFCGAIVEGSVADWSGIYMKDHIGASDGTTPLAYAAF 257 E FALP LV L G++A + EG+V DW+ +Y++ +GA LAYAAF Sbjct: 193 -QAAEHHKFALPANPLVYLIGLMALLTMVSEGAVLDWAALYLRQELGADLAIAGLAYAAF 251 Query: 258 AGMMLIMRMVGDGLKARYDARRVVWIGTLVASAGMALAVAAPGMVWAILGFAIAGTGVAA 317 +G+M IMR GDG++ R+ A + +VA+ GM +A +P +AI FA G G+A Sbjct: 252 SGVMAIMRFFGDGVRNRFGAVTTLRGSAVVAATGMLVAGLSPSPWFAIAAFATCGFGIAN 311 Query: 318 VFPFVFSAAGRH----GSSALAAVATLGYSGSLIGPPLFGFLAH--GWG-LQAALALLGV 370 + P +FSA G + ++ V T+GYSG L+ P GF+A +G + A+++L + Sbjct: 312 MVPIIFSAGGNQEGMSSGTGMSVVTTMGYSGILVAPSAIGFVAEHSSFGPIFIAMSVLLI 371 Query: 371 LCLAMSGSSRRAQW 384 + L M+G + RA++ Sbjct: 372 VVLLMAGLAHRAEF 385 >ECs0925 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 402 Score = 152 bits (383), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 119/373 (31%), Positives = 183/373 (49%), Gaps = 16/373 (4%) Query: 6 SISRSPSPLRLIWRKFAIPWFFLLLGVVFATWAARIPAIRDHLQLDAATLALVLLCGGIG 65 +++ S + L+ R +A+ FF L G++ A+WA R PAIRD L + A + VL IG Sbjct: 2 TVNSSRNALK--RRTWALFMFFFLPGLLMASWATRTPAIRDILSVSIAEMGGVLFGLSIG 59 Query: 66 AVGSFPLAAWITGHYGARHSSLYAGLALLVSLPLLGLAPNLWTLMLVCT---VYGAASSC 122 ++ +AW+ +G R+ L LV + +L LA L + +L V+GA+ Sbjct: 60 SMSGILCSAWLVKRFGTRNVILVTMSCALVGMMILSLALWLTSPLLFAVGLGVFGASFGS 119 Query: 123 FDVAINALGAQAERDAGRPIMSMLHGWFCVGTFSGALTASAVAGMGIAPIWHFLLVAALF 182 +VAIN GA ER+ + ++ M+HG++ +GT +GA A+ G+ H LL A + Sbjct: 120 AEVAINVEGAAVEREMNKTVLPMMHGFYSLGTLAGAGVGMALTAFGVPATVHILLAALVG 179 Query: 183 LYPLYAGYGALPD-------DRPAHDPERKLFALPHGHLVVLGVIAFCGAIVEGSVADWS 235 + P+Y A+PD D H E+ + L+++GV+ A EGS DW Sbjct: 180 IAPIYIAIQAIPDGTGKNAADGTQHG-EKGVPFYRDIQLLLIGVVVLAMAFAEGSANDWL 238 Query: 236 GIYMKDHIGASDGTTPLAYAAFAGMMLIMRMVGDGLKARYDARRVVWIGTLVASAGMALA 295 + M D G S + L YA F M + R G RY VV L+ + G+ L Sbjct: 239 PLLMVDGHGFSPTSGSLIYAGFTLGMTVGRFTGGWFIDRYSRVAVVRASALMGALGIGLI 298 Query: 296 VAAPGMVWAILGFAIAGTGVAAVFPFVFSAAGRHGSSA---LAAVATLGYSGSLIGPPLF 352 + A + + G G + FP SAA G A ++ VAT GY L+GPPL Sbjct: 299 IFVDSAWVAGVSVVLWGLGASLGFPLTISAASDTGPDAPTRVSVVATTGYLAFLVGPPLL 358 Query: 353 GFLAHGWGLQAAL 365 G+L +GL++A+ Sbjct: 359 GYLGEHYGLRSAM 371