BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4527.p (310 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PAB2381 [GER] COG0697 Permeases of the drug/metabolite transport... 92 1e-18 PH0593 [GER] COG0697 Permeases of the drug/metabolite transporte... 87 5e-17 FN0674 [GER] COG0697 Permeases of the drug/metabolite transporte... 86 1e-16 FN1465 [GER] COG0697 Permeases of the drug/metabolite transporte... 85 2e-16 TVN1496 [GER] COG0697 Permeases of the drug/metabolite transport... 79 2e-14 >PAB2381 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pab Pyrococcus abyssi Length = 280 Score = 92.4 bits (228), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 18/283 (6%) Query: 20 KPVEWLLLLVAVIWGGSYSAAKLATTELPVLQFLVLRFGLTFLLLAPALRGITSVASWKS 79 + E +L+L++ IWG ++ KL + P + F+ RF + LL+ LR K+ Sbjct: 5 RKAELILILISAIWGSTFPVMKLGIEDYPPITFVAFRFLIASLLMLIFLR-----KDIKT 59 Query: 80 SLAGASLL-GAILLAIFVCETFGVTQTTASNAAFLISLCVVFTPLCEWLFLGERPDQAAL 138 S A LL G L F + G+ TT+SN+AF+ SL +VFTP L L R Sbjct: 60 SQALPGLLVGLSLFLGFSFQVVGLKYTTSSNSAFITSLYMVFTPFVAILLLKTRVKLIDW 119 Query: 139 MACGLSFLGAALLAFQGGGDLSQLTLGDGLMVLAAVLRGVMVCLTRRQSLRFKLPALTLT 198 +A GL+ LG L++ ++ GD L VLAA+ + L F + L Sbjct: 120 VALGLALLGTYLIS-----NVGNFNYGDMLTVLAALSFAFQIVLVEY----FGNLGIGLA 170 Query: 199 AVQMGVMTVGSLMLMTLAPGPGWTAIPATPAFWWAMAFLVLLCTILAFFVQNYAAARTSP 258 Q+ ++ SL + G +P + +A+ + ++ T +AF VQ + Sbjct: 171 FWQVFWNSMFSLAYAAIFEG---LPMPREGSTLFAIIYTAIMATAIAFAVQVKYQPKIDS 227 Query: 259 SRVALLMGSEPLWGALIAVIWMKEHMSLQGWIGGLLIVSSTWL 301 R A++ +EP++G + + + E +S +G+IG LLI+ + WL Sbjct: 228 HRAAIIYSAEPVFGHFFSFLILGEVLSWKGYIGALLILIAVWL 270 >PH0593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pho Pyrococcus horikoshii Length = 284 Score = 87.0 bits (214), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 135/282 (47%), Gaps = 15/282 (5%) Query: 20 KPVEWLLLLVAVIWGGSYSAAKLATTELPVLQFLVLRFGLTFLLLAPALRGITSVASWKS 79 + E +LL ++ IWG ++ K+ + P + F+ RF L ++LA L+ + K Sbjct: 8 RKAELILLGLSAIWGTTFPVMKIGIKDFPPVSFIAFRFFLASIILAIVLKDKIT----KD 63 Query: 80 SLAGASLLGAILLAIFVCETFGVTQTTASNAAFLISLCVVFTPLCEWLFLGERPDQAALM 139 + L+G L A F + G+ TTASN+AF+ SL +VFTP + L + + + Sbjct: 64 QIFPGFLIGLSLFAGFGFQVVGLKYTTASNSAFITSLYMVFTPFVAFALLKSKITRVDAL 123 Query: 140 ACGLSFLGAALLAFQGGGDLSQLTLGDGLMVLAAVLRGVMVCLTRRQSLRFKLPALTLTA 199 A ++ LG L++ G L+ L+ GD L +LAA+ + L +K L L Sbjct: 124 ALAIAVLGTYLIS---GASLN-LSYGDLLTILAALSFAFQIVLIE----YYKDLGLGLAF 175 Query: 200 VQMGVMTVGSLMLMTLAPGPGWTAIPATPAFWWAMAFLVLLCTILAFFVQNYAAARTSPS 259 Q+ + SL+ +P + +A+ + ++ T LAF Q + Sbjct: 176 WQIFWNFIFSLVYSIYFES---LPLPKEGSTVFAILYTGIVATALAFLGQVKYQPKIESH 232 Query: 260 RVALLMGSEPLWGALIAVIWMKEHMSLQGWIGGLLIVSSTWL 301 R A+L +EP++G + + + E + +G++G LI+ + WL Sbjct: 233 RAAVLYSAEPVFGYFFSFLILGEILPFEGYVGAFLILVAIWL 274 >FN0674 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Fnu Fusobacterium nucleatum Length = 282 Score = 85.5 bits (210), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/283 (27%), Positives = 132/283 (46%), Gaps = 21/283 (7%) Query: 26 LLLVAVIWGGSYSAAKLA---TTELPVLQFLVLRFGLTFLL-LAPALRGITSVASWKSSL 81 + + + +G +Y K+ +TE ++ F RF + F++ L + I V ++ Sbjct: 11 MFIATIFFGMTYVLTKICLKYSTEFHIISF---RFLIAFVVSLIFLQKKIFPVK--RTEF 65 Query: 82 AGASLLGAILLAIFVCETFGVTQTTASNAAFLISLCVVFTPLCEWLFLGERPDQAALMAC 141 + LLGA+L +F+ T GV TTA+NA+FLISL V+F P W F E+P + + Sbjct: 66 LYSLLLGALLFLVFIAMTIGVKYTTATNASFLISLSVIFIPFFSWFFNKEKPKKRIFVVL 125 Query: 142 GLSFLGAALLAFQGGGDLSQLTLGDGLMVLAAVLRGVMVCLTRRQSLRFKLPALTLTAVQ 201 ++ +G LL + +GD L ++ A L V +T + AL Sbjct: 126 IIALIGIILLTLDKNLEFH---IGDILCLICATLFTFYVIMTEKIVKNNNPTAL------ 176 Query: 202 MGVMTVGSLMLMT-LAPGPGWT-AIPATPAFWWAMAFLVLLCTILAFFVQNYAAARTSPS 259 GV+ G + L + L P + IP FW +M L + CT + Q A S + Sbjct: 177 -GVLQFGWVFLFSFLVQYPIESFVIPKNKFFWLSMVLLGIFCTAFGYIAQTIAQKNLSST 235 Query: 260 RVALLMGSEPLWGALIAVIWMKEHMSLQGWIGGLLIVSSTWLV 302 V ++ EP++ + ++ E++S Q +IG L++ S V Sbjct: 236 VVGFILSLEPVFSGIFGYFFLNEYLSFQQYIGAFLLLISVIYV 278 >FN1465 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Fnu Fusobacterium nucleatum Length = 291 Score = 84.7 bits (208), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/285 (25%), Positives = 135/285 (47%), Gaps = 18/285 (6%) Query: 24 WLLLLVAVIWGGSYSAAKLATTELPVLQFLVLRFGLT-FLLLAPALRGITSVASWKSSLA 82 +L+LL+A+I G SY K + + RF LT +LL ++ ++ + L Sbjct: 10 FLVLLLAIIRGSSYIFIKNIIDNQSPFEIIFFRFFLTEIILLIFYIKEFKTLNHY--DLI 67 Query: 83 GASLLGAILLAIFVCETFGVTQTTASNAAFLISLCVVFTPLCEWLFLGERPDQAALMACG 142 L G L + F +T+G+ TT S +FL SL +V PL +++F + + + Sbjct: 68 FGLLAGIFLFSAFAFQTYGLKYTTVSKQSFLTSLYIVIIPLLDFIFFKNKIKKNVIALFF 127 Query: 143 LSFLGAALLAFQGGGDLS-QLTLGDGLMVLAAVLRGVMVCLTRRQSLRFKLPALTLTAVQ 201 L +G ++F+ + L GD L +L A+ + + L + +F + + +T +Q Sbjct: 128 LILVGLLFISFKDFKNFEFYLNFGDILTILCALGFALNILLFSKIK-KFNINVINITIIQ 186 Query: 202 MGVMTVGSLMLMTLAPGPGWTAIPATPAFWWAMAF----LVLLCTILAFFVQNYAAARTS 257 M +T+G L + + I ++M F L+L+CT+L F +QN + Sbjct: 187 M--LTIGILAFI-------FQIIFEKKVINFSMNFSLIYLILICTMLNFTIQNISQKYVP 237 Query: 258 PSRVALLMGSEPLWGALIAVIWMKEHMSLQGWIGGLLIVSSTWLV 302 + L++ E ++G + A+I++ E +S IG LI + L+ Sbjct: 238 AHIIGLILSLEAIFGTVFAIIFLNETISQNFIIGTFLIAIAVILI 282 >TVN1496 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Tvo Thermoplasma volcanium Length = 285 Score = 78.6 bits (192), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/266 (24%), Positives = 123/266 (46%), Gaps = 22/266 (8%) Query: 26 LLLVAVIWGGSYSAAKLATTELPVLQFLVLRFGLTFLLLAPA-LRGITSVAS--WKSSLA 82 L+ V IWG ++ K L + FL LRF ++ LL P ++ I V S WK+ L Sbjct: 12 LVFVTFIWGVTFPIIKDVFLYLSPVNFLALRFAVSTLLFLPVVIKKIKHVKSEEWKAGLI 71 Query: 83 GASLLGAILLAIFVCETFGVTQTTASNAAFLISLCVVFTPLCEWLFLGERPDQAALMACG 142 G +L + +T G+ T + + + + VVF P+ +L+L R + + Sbjct: 72 A----GTLLFIAYYLQTIGLLYTQPALSGTITGIYVVFVPIISYLYLRRRIAHVEVYSSA 127 Query: 143 LSFLGAALLAFQGGGDLSQLTLGDGLMVLAAVLRGVMVCLTRRQSLRFKLPALTLTAVQM 202 +F+G L+++ G ++S + LGD + + AAV + + + + + + +Q+ Sbjct: 128 FAFIGLVLMSYSGLSNVS-IELGDFMTLAAAVFYAMQLVYVSKHASH--IDTFVFSFIQI 184 Query: 203 GVMTVGSLMLMTLAPGPGWTAIPATPAFWWAMAFLVLLCTILAFFVQNY----AAARTSP 258 V S + + P P I + AF+VL + A F+ Y A ++ + Sbjct: 185 AVAAFFSAVFIPTFPEPFKITIYS--------AFVVLFTAVFATFLATYVYVSALSKMNV 236 Query: 259 SRVALLMGSEPLWGALIAVIWMKEHM 284 ++V +++ EP++ L +VI E + Sbjct: 237 TKVGVILIGEPIFADLTSVILYGEKI 262