BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4525.p (200 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MTH1589 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryl... 94 2e-19 MK0892 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryla... 94 2e-19 VNG0009G [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphory... 91 1e-18 PAB1115 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryl... 91 1e-18 PH1925 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryla... 91 2e-18 >MTH1589 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Mth Methanothermobacter thermautotrophicus Length = 423 Score = 94.4 bits (233), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 61/184 (33%), Positives = 97/184 (52%), Gaps = 17/184 (9%) Query: 26 PWQLTAQSDQIVRRMLADLDPS-QFRIENEVAIH------VTSVVEQGVILKGPVIISAD 78 PW+L S+ R++ DL+ S + +E+ V IH +++ G ++GPV I + Sbjct: 225 PWELLEASE----RLMKDLEDSVEGDVEDGVTIHGPVAIGEGTIIRSGTYIQGPVYIGRN 280 Query: 79 VFIGAHAYLRGGNWIDVNCSIGPGCELKSSFLFAESRLAHFNFIGDSIIGRDVNLEAGSV 138 IG ++YLR I SIG E+K+S + + + H +++GDS+IG + N+ AG+ Sbjct: 281 CDIGPNSYLRAHTCIGDGVSIGNAVEVKNSIIMDGTNINHLSYVGDSVIGMNCNIAAGTN 340 Query: 139 ICNHRNER------VDGDLVSTGITKFGAVVGDGSRLGANSVVAPGGLLQPGTLVGRGTV 192 I N R + V D+V TG K GAV GDG + G NS PG + + +G G V Sbjct: 341 IANLRFDDGPVRMVVKDDVVETGRRKLGAVFGDGVKTGINSSFNPGVKVGKDSCIGAGCV 400 Query: 193 WDQE 196 ++ Sbjct: 401 ISRD 404 >MK0892 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Mka Methanopyrus kandleri AV19 Length = 425 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 57/174 (32%), Positives = 91/174 (52%), Gaps = 25/174 (14%) Query: 44 LDPSQFRIENEVA-IHVTSVVEQGVILKGPVIISADVFIGAHAYLRGGNWIDVNCSIGPG 102 LD + + + N ++ V V+E+ V L+GPV ++ D + + A + G +I C IGP Sbjct: 227 LDANAWALRNAMSRPEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPN 286 Query: 103 C------------------ELKSSFLFAESRLAHFNFIGDSIIGRDVNLEAGSVICNHRN 144 C E+K+S + + ++H +++GDS+IG NL AG++I N R+ Sbjct: 287 CYIRPATTLVRDVRIGQAVEIKNSIIMEGTNVSHLSYVGDSVIGAKCNLGAGTIIANLRH 346 Query: 145 ER------VDGDLVSTGITKFGAVVGDGSRLGANSVVAPGGLLQPGTLVGRGTV 192 + V G+L TG KFGAV+GDG + G N+ + PG L P + TV Sbjct: 347 DERNVKVVVKGELEDTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTV 400 >VNG0009G [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Hbs Halobacterium sp. NRC-1 Length = 401 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 44/117 (37%), Positives = 73/117 (62%), Gaps = 6/117 (5%) Query: 63 VEQGVILKGPVIISADVFIGAHAYLRGGNWIDVNCSIGPGCELKSSFLFAESRLAHFNFI 122 V G ++GPV+I + +G +AY+RG + + +G E+K+S L A++ + H ++ Sbjct: 258 VRDGAYIEGPVVIQSGADVGPNAYVRGATVVGPDVRVGNAVEVKNSILMADTAVGHHAYV 317 Query: 123 GDSIIGRDVNLEAGSVICNHRNE------RVDGDLVSTGITKFGAVVGDGSRLGANS 173 GDS++G DVN AG+ + N R++ +V+G+LV TG KFG VVGD ++ G N+ Sbjct: 318 GDSVLGADVNFGAGTKVANLRHDDAPVQVQVNGELVDTGRRKFGVVVGDDTKTGINT 374 >PAB1115 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Pab Pyrococcus abyssi Length = 419 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 10/180 (5%) Query: 26 PWQLTAQSDQIVRRMLA-DLDPSQFR---IENEVAIHVTSVVEQGVILKGPVIISADVFI 81 PW L ++ I++ L D+ + I V I +VV G + GPV I + I Sbjct: 221 PWDLLEVNEYILKTKLKHDIRGTVEEGATIIPPVEIGEGTVVRSGSYIIGPVKIGKNCRI 280 Query: 82 GAHAYLRGGNWIDVNCSIGPGCELKSSFLFAESRLAHFNFIGDSIIGRDVNLEAGSVICN 141 G + ++R I NC IG E+K+S + S H N++GDSI+G + NL AG++ N Sbjct: 281 GPNCFIRPYTSIGDNCHIGNAVEIKNSIIMDNSNAPHLNYVGDSIVGENTNLGAGTITAN 340 Query: 142 HRNE------RVDGDLVSTGITKFGAVVGDGSRLGANSVVAPGGLLQPGTLVGRGTVWDQ 195 R++ + G L +G K GA++G + G N + PG + G LVG G + D+ Sbjct: 341 LRHDNRTIKVEIKGKLEDSGRRKLGAIIGHNVKTGINVTIYPGRKIGSGALVGPGVIVDK 400 >PH1925 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Pho Pyrococcus horikoshii Length = 419 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 58/187 (31%), Positives = 90/187 (48%), Gaps = 24/187 (12%) Query: 26 PWQLTAQSDQIVRRML-----------ADLDPSQFRIENEVAIHVTSVVEQGVILKGPVI 74 PW L ++ I++ L A + P V I ++V G + GPV Sbjct: 221 PWDLLEVNEYILKTKLKHNIRGTVEEGATIIPP-------VEIGEGTIVRSGSYIIGPVK 273 Query: 75 ISADVFIGAHAYLRGGNWIDVNCSIGPGCELKSSFLFAESRLAHFNFIGDSIIGRDVNLE 134 I + IG + ++R I NC IG E+K+S + S H N++GDSIIG + NL Sbjct: 274 IGKNCRIGPNCFIRPYTSIGDNCHIGNAVEVKNSIIMDNSNAPHLNYVGDSIIGENTNLG 333 Query: 135 AGSVICNHRNE------RVDGDLVSTGITKFGAVVGDGSRLGANSVVAPGGLLQPGTLVG 188 AG++ N R++ + G+L +G K GA++G + G N + PG + G LVG Sbjct: 334 AGTITANLRHDNKTVKVEIKGNLEDSGRRKLGAIIGHNVKTGINVSIYPGRKIGSGALVG 393 Query: 189 RGTVWDQ 195 G + D+ Sbjct: 394 PGVIVDK 400