BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4493.p (408 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc2694 [GEPR] COG0477 Permeases of the major facilitator superf... 257 3e-68 Rv2456c [GEPR] COG0477 Permeases of the major facilitator superf... 242 1e-63 MT2531 [GEPR] COG0477 Permeases of the major facilitator superfa... 242 1e-63 PH0667 [GEPR] COG0477 Permeases of the major facilitator superfa... 43 0.002 CAC0020_1 [GEPR] COG0477 Permeases of the major facilitator supe... 41 0.005 >AGc2694 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 498 Score = 257 bits (657), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 157/366 (42%), Positives = 216/366 (59%), Gaps = 3/366 (0%) Query: 6 RSIAWLSRLNFFLADVRDGLGPFLGVFLMGHGWAADDIGYVMTLGGIAGMLATTPAGALT 65 R++ L+ LNFFLAD RDGLGPFL FL GW++ +G + T+GG+ G+LAT GAL Sbjct: 100 RTLFALAALNFFLADARDGLGPFLDAFLATQGWSSLSLGMIATVGGLVGLLATPLCGALV 159 Query: 66 DAVRAKRLVVGLGSVLVVGGSLLLLVSPSFTITALSQVGTGIVGAVIGPAIAGLTLGIVG 125 D KR+++ + VLV G+L+ L+ P I Q+ T +VGAV+GPA+AGLTLG+VG Sbjct: 160 DGTTWKRMLIAIPVVLVTIGALITLIFPDAWIVWTGQIMTAVVGAVVGPALAGLTLGLVG 219 Query: 126 QQGLPAQLGRNEAWNHAGNVCSAALAGAIGYYWGLPAVFVLMAVMAVASLLCLARIRPDD 185 ++ Q+ RNE WNH GN S + ++G+ + LM + A +L+ A I P Sbjct: 220 ERLFSNQISRNEFWNHGGNFASLFATYVVVTFFGMNGIIGLMLLTAAGALVATAAIDPAR 279 Query: 186 IDHDVARGLDPQRAADAPQVSTWRVLAGSRPLLLLALAMMLFHLGNAAMLPLLSQSVVAR 245 IDH VARGL + P S VL R L+ LA+ +++FH GNA M L++Q A Sbjct: 280 IDHKVARGLAEDKGEPGP--SGINVLLHERGLIFLAIILLVFHFGNAPMGRLIAQD-FAI 336 Query: 246 GSADPALYTALTVIVAQLVMIPTALMAGRFAERNGYWLPITIALLVLPVRGMVAGVWDSP 305 P TA+ VAQ MI A MA R G +AL LP+RG++A + Sbjct: 337 ELQTPFRTTAIITGVAQFAMIFVAAMAPWLIRRFGLSTVFIVALAALPIRGLLASAFTDF 396 Query: 306 WALLPVQVLDGVGAGLLGVALPGSVARILQGSGHINIGLGAVTTIQSIGAAMSPALAGVV 365 W + PVQ LDGVGAGLLG+ P +V RIL+G+G N+GL +V +Q IGA++S +AG + Sbjct: 397 WVIFPVQFLDGVGAGLLGIVTPVAVERILKGTGRFNVGLASVMMVQGIGASLSNVVAGWL 456 Query: 366 AKHYGY 371 GY Sbjct: 457 VTKGGY 462 >Rv2456c [GEPR] COG0477 Permeases of the major facilitator superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 418 Score = 242 bits (617), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 159/381 (41%), Positives = 225/381 (59%), Gaps = 3/381 (0%) Query: 11 LSRLNFFLADVRDGLGPFLGVFLM-GHGWAADDIGYVMTLGGIAGMLATTPAGALTDAVR 69 L LNF LADVRDGLGP+L ++L+ H W IG+VM +GGIA ++A TP GAL D Sbjct: 16 LDLLNFSLADVRDGLGPYLSIYLLLIHDWDQASIGFVMAVGGIAAIVAQTPIGALVDRTT 75 Query: 70 AKR-LVVGLGSVLVVGGSLLLLVSPSFTITALSQVGTGIVGAVIGPAIAGLTLGIVGQQG 128 AKR LVV ++ + L + ++I+ L V TGI +V PA+A +TLG VG Q Sbjct: 76 AKRALVVAGAVLVTAAAVAMPLFAGLYSISVLQAV-TGIASSVFAPALAAITLGAVGPQF 134 Query: 129 LPAQLGRNEAWNHAGNVCSAALAGAIGYYWGLPAVFVLMAVMAVASLLCLARIRPDDIDH 188 ++GRNEA+NHAGN +A GA+ Y++G VF ++A MA+ S+L RI PD +DH Sbjct: 135 FARRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVLAGMALISVLATLRIPPDAVDH 194 Query: 189 DVARGLDPQRAADAPQVSTWRVLAGSRPLLLLALAMMLFHLGNAAMLPLLSQSVVARGSA 248 D+ARG+D PQ S + VLA +R L++ A++ FH NAAMLPL+ + + Sbjct: 195 DLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAFHFANAAMLPLVGELLALHNRD 254 Query: 249 DPALYTALTVIVAQLVMIPTALMAGRFAERNGYWLPITIALLVLPVRGMVAGVWDSPWAL 308 + + ++ AQ+VM+P A + G A+ G + VL RG + + D+ + L Sbjct: 255 EGTALMSSCIVAAQVVMVPVAYVVGTRADAWGRKPIFLVGFAVLTARGFLYTLSDNSYWL 314 Query: 309 LPVQVLDGVGAGLLGVALPGSVARILQGSGHINIGLGAVTTIQSIGAAMSPALAGVVAKH 368 + VQ+LDG+GAG+ G P V + G+GH NI LGAVTT IGAA+S +AG + Sbjct: 315 VGVQLLDGIGAGIFGALFPLVVQDVTHGTGHFNISLGAVTTATGIGAALSNLVAGWIVVV 374 Query: 369 YGYGAAFTVLTGIALMALLVW 389 GY AAF L +A L++ Sbjct: 375 AGYDAAFMSLGALAGAGFLLY 395 >MT2531 [GEPR] COG0477 Permeases of the major facilitator superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 418 Score = 242 bits (617), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 159/381 (41%), Positives = 225/381 (59%), Gaps = 3/381 (0%) Query: 11 LSRLNFFLADVRDGLGPFLGVFLM-GHGWAADDIGYVMTLGGIAGMLATTPAGALTDAVR 69 L LNF LADVRDGLGP+L ++L+ H W IG+VM +GGIA ++A TP GAL D Sbjct: 16 LDLLNFSLADVRDGLGPYLSIYLLLIHDWDQASIGFVMAVGGIAAIVAQTPIGALVDRTT 75 Query: 70 AKR-LVVGLGSVLVVGGSLLLLVSPSFTITALSQVGTGIVGAVIGPAIAGLTLGIVGQQG 128 AKR LVV ++ + L + ++I+ L V TGI +V PA+A +TLG VG Q Sbjct: 76 AKRALVVAGAVLVTAAAVAMPLFAGLYSISVLQAV-TGIASSVFAPALAAITLGAVGPQF 134 Query: 129 LPAQLGRNEAWNHAGNVCSAALAGAIGYYWGLPAVFVLMAVMAVASLLCLARIRPDDIDH 188 ++GRNEA+NHAGN +A GA+ Y++G VF ++A MA+ S+L RI PD +DH Sbjct: 135 FARRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVLAGMALISVLATLRIPPDAVDH 194 Query: 189 DVARGLDPQRAADAPQVSTWRVLAGSRPLLLLALAMMLFHLGNAAMLPLLSQSVVARGSA 248 D+ARG+D PQ S + VLA +R L++ A++ FH NAAMLPL+ + + Sbjct: 195 DLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAFHFANAAMLPLVGELLALHNRD 254 Query: 249 DPALYTALTVIVAQLVMIPTALMAGRFAERNGYWLPITIALLVLPVRGMVAGVWDSPWAL 308 + + ++ AQ+VM+P A + G A+ G + VL RG + + D+ + L Sbjct: 255 EGTALMSSCIVAAQVVMVPVAYVVGTRADAWGRKPIFLVGFAVLTARGFLYTLSDNSYWL 314 Query: 309 LPVQVLDGVGAGLLGVALPGSVARILQGSGHINIGLGAVTTIQSIGAAMSPALAGVVAKH 368 + VQ+LDG+GAG+ G P V + G+GH NI LGAVTT IGAA+S +AG + Sbjct: 315 VGVQLLDGIGAGIFGALFPLVVQDVTHGTGHFNISLGAVTTATGIGAALSNLVAGWIVVV 374 Query: 369 YGYGAAFTVLTGIALMALLVW 389 GY AAF L +A L++ Sbjct: 375 AGYDAAFMSLGALAGAGFLLY 395 >PH0667 [GEPR] COG0477 Permeases of the major facilitator superfamily Pho Pyrococcus horikoshii Length = 413 Score = 42.7 bits (99), Expect = 0.002, Method: Compositional matrix adjust. Identities = 81/386 (20%), Positives = 170/386 (44%), Gaps = 34/386 (8%) Query: 2 NPKARSIAWLSRLNFFLADVRDGLG-PFLGVFLMGHGWAADDIGYVMTLGGIAGMLATTP 60 N R+I + + + F A++ G+G P+L V++ G +G + + + + P Sbjct: 25 NTLKRNITFFA-IGMFFANLAWGIGYPYLTVYMKIIGGTMFLVGLLSVIYNLTSAIFQYP 83 Query: 61 AGALTDAVRAKRLVVGLGSVLVVGGSLLLLVSPSFTITALSQVGT-GIVGAVIGPAIAGL 119 G L+D + ++ + LG VL G + +L++ S I LS GT G +GA PA + L Sbjct: 84 FGYLSDKIGKRKPFIILG-VLFSGTTYVLVIFISTPILLLSLRGTQGALGASFAPAHSAL 142 Query: 120 TLGIVGQQGLPAQLGRNEAWNHAGNVCSAALAGAIGYYWGLPAVFVLMAVMAVASLLCLA 179 + + G + G + G + L G I G+ + F+ +++++ S+L L Sbjct: 143 ISELSTRVG--SMFGFFNFVENMGFMVGNFLGGYIVKKVGIKSAFLATSIVSLVSILFLT 200 Query: 180 RIRP-DDIDHDVARGLDPQRAADAPQV----STWRVL-AGSRPLLLLALAMMLFHLGNA- 232 +++ + ++ L + ++ +V S +++L G L++ + + G Sbjct: 201 QVKERERKKKNIGSFLPIREGRESEKVEMKSSAFKMLMKGELGAFYLSVLLAMIASGEVY 260 Query: 233 AMLPLLSQSVVARGSADPALYTALTVIVAQLVMIPTALMAGRFAERNGYWLPITIALLVL 292 A +P+ Q + + + L +L+ GR ++ G + +A+L Sbjct: 261 ATVPVYFQEKFGEE------FVGFLLGIDSLAAALGSLLIGRLIDKYGEKVFYKLAIL-- 312 Query: 293 PVRGMVAGVWDSPWA-----LLPVQVLDGVGAGLLGVALPGSVARIL--QGSGHINIGLG 345 G + WA + V +L GV ++ + VAR + + G G+G Sbjct: 313 ---GYILTFIGYAWATTIIIMALVSLLSGVKWAMITSSASTYVARRVPHRERGQ---GMG 366 Query: 346 AVTTIQSIGAAMSPALAGVVAKHYGY 371 + T+ ++G + P + G++A ++G+ Sbjct: 367 LLNTMMTLGWVIGPLIGGLIADNFGF 392 >CAC0020_1 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 458 Score = 41.2 bits (95), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/131 (26%), Positives = 67/131 (51%), Gaps = 4/131 (3%) Query: 270 LMAGRFAERNGYWLPITIALLVLPVRGMVAGVWDSPWALLPVQVLDGVGAGLLG-VALPG 328 + A +FA++ G + I +L+ V + G+ +S L+ ++ + G+G ++ +ALP Sbjct: 61 ITAAKFADQFGRKKLMIIGILIFGVSSALCGISNSLLFLIIMRFVQGIGGAIITPIALPM 120 Query: 329 SVARILQGSGHINIGLGAVTTIQSIGAAMSPALAGVVAKHYGYGAAFTVLTGIALMAL-L 387 + + G +NI +GA + + AA P L GV+ K+ + + F V A+ AL L Sbjct: 121 GIE--IFGKERMNIVVGASGAVVGLAAASGPPLGGVLIKYINWQSVFFVNVPFAIAALIL 178 Query: 388 VWGWLAERRDH 398 + + E D+ Sbjct: 179 IVICVNESYDN 189